Clinical trials: Pre Eclampsia
Preeclampsia, Preterm Birth
Pregnancy Complications - A Probiotic Interventional Study
Investigators hypothesize that a) probiotics decrease the overall inflammatory state in the pregnant woman, especially in women with high risk pregnancies.
- Trial name
- NCT02693041
- Testing
- probiotic
- Where
- Sweden
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Preeclampsia
Progesterone in Expectantly Managed Early-onset Preeclampsia
Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks postpartum
- Trial name
- NCT04077853
- Testing
- 17 Hydroxyprogesterone Capronate
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Preeclampsia, Pregnancy Complications
The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications
It is known that if there isn't an efficient exposure to the paternal antigens before conception, there is an increased risk for the pre-eclampsia (PE) cascade and other pregnancy complications to take place.
- Conditions
- Preeclampsia, Pregnancy Complications, Insemination; Complication, Immune Tolerance
- Trial name
- NCT04314518
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Preeclampsia
Development of a Next Generation Sequencing (NGS) -Based Assay to Detect Preeclampsia Molecular Markers
Sample Collection Study
- Trial name
- NCT02808494
- Where
- 10 sites in United States
- Volunteers
- 242 people
- Sponsor
- Illumina, Inc.
Severe Pre-eclampsia
Nitroglycerin Versus Labetalol in Acute Severe Pre-eclampsia
Two hundred patients with severe PE were admitted prepartum to the ICU to stabilize blood pressure. They were randomly assigned to one of two groups (100 in each group): Group N received nitroglycerine intravenous infusion in a…
- Trial name
- NCT05310929
- Testing
- Labetalol and Glyceril trinitrate
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Telocytes in Umbilical Cord of Pregnancies Complicated by Chronic Hypertension, Gestational Hypertension and Preeclampsia
Telocytes in Umbilical Cord of Patients With and Without Pre-eclampsia
Studying the ultrastructural and immunohistochemical characteristics of Telocytes from umbilical cord vessels wall in PE patients compared to control and its relation to severity of disease whether controlled or uncontrolled.
- Trial name
- NCT05305339
- Testing
- Placental and Umbilical cord biopsy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Preeclampsia, Preeclampsia Severe
Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial
This is an open label, randomized control trial (RCT) in which high risk for pre-eclampsia pregnant subjects will be randomly assigned to either an intervention group (metformin 1 gm twice daily plus aspirin 100 mg per day and…
- Conditions
- Preeclampsia, Preeclampsia Severe, High Risk Pregnancy, Eclampsia
- Trial name
- PREMET (NCT04855513)
- Testing
- Metformin
- Where
- Qatar
- Volunteers
- 414 people
- Sponsor
- Hamad Medical Corporation
Gestational Diabetes Mellitus, Preeclampsia
User Testing and Feedback for a Mobile Health Program for Postpartum Women: A Pilot Study
Refine content and delivery of the mHealth delivered lifestyle intervention program through iterative testing with small groups of users who provide feedback through on-line asynchronous focus groups.
- Conditions
- Gestational Diabetes Mellitus, Preeclampsia, Gestational Hypertension, Pre-term Delivery
- Trial name
- NCT02384226
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Colorado, Denver
Hypertension, Pregnancy-Induced, Hypertension in Pregnancy
Meditation as Complementary Treatment for Chronic Hypertension in Pregnancy
Pregnancy relates to arterial hypertension; it is an aggravating factor for pre-existing chronic arterial hypertension or a trigger for preeclampsia in normotensive women.
- Conditions
- Hypertension, Pregnancy-Induced, Hypertension in Pregnancy, Hypertension
- Trial name
- NCT03873194
- Testing
- Meditation, conventional treatment
- Where
- Brazil
- Volunteers
- 47 people
- Sponsor
- University of Sao Paulo General Hospital
Preeclampsia and Intrauterine Growth Restriction
Placental Insufficiency Microcirculation Quantification by Ultrafast Doppler (MICRODOPPLER PLACENTA)
To identify fetuses small for their gestational-age who have reached their appropriate growth potential from growth-restricted fetuses due to placental insufficiency is uneasy.
- Trial name
- NCT03860103
- Where
- France
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Preeclampsia, Preterm Birth
Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications
The Biobank includes data and biological specimens of women from three original studies: 1) First-trimester Prediction of Preeclampsia (PREDICTION Study, NCT02189148), 2) Pre-Eclampsia And growth Retardation, an evaluative…
- Conditions
- Preeclampsia, Preterm Birth, Pregnancy Complications, Fetal Anomalies
- Trial name
- NCT02744365
- Testing
- Observational
- Where
- Canada
- Volunteers
- 7,845 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Preeclampsia, Preterm Birth
Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening
Preterm birth (PTB), preeclampsia (PE), fetal growth restriction (FGR) and intra-uterine fetal death (IUFD) constitutes the main causes of perinatal morbidity and mortality and are called "Great Obstetrical Syndromes".
- Conditions
- Preeclampsia, Preterm Birth, Fetal Growth Restriction, Intra Uterine Fetal Death
- Trial name
- PREDICTION2 (NCT03067298)
- Where
- Canada
- Volunteers
- 805 people, healthy volunteers welcome
- Sponsor
- Emmanuel Bujold
Preeclampsia, Hypertension
Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers
Preeclampsia (Pre-E) is a hypertensive disease of pregnancy with multi-system involvement that usually occurs in the second half of pregnancy. Pre-E occurs in 5% to 7% of U.S. pregnancies, and is the third-leading cause of U.S.
- Conditions
- Preeclampsia, Hypertension, Proteinuria, Thrombocytopenia
- Trial name
- NCT02780414
- Where
- 20 sites in United States
- Volunteers
- 1,730 people
- Sponsor
- Progenity, Inc.
Preeclampsia, Intrauterine Growth Restriction
First Trimester Placental Assessment in the Screening of Preeclampsia and Intrauterine Growth Restriction
Preeclampsia (PE) and intrauterine growth restriction (IUGR) are clinical manifestations of placental insufficiency. These complications affect 5-15% of pregnancies, and are responsible for up to 20% of preterm births.
- Trial name
- NCT02879942
- Testing
- Ultrasound study of the placenta, Measurement of angiogenic and anti-angiogenic factors (sFlt-1 and PlGF) in the first trimestre blood test
- Where
- Spain
- Volunteers
- 1,390 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Woman's Role, Preeclampsia
Women's Perspective on First-trimester Preeclampsia Screening
The aim of this study is to evaluate women's perception on first-trimester preeclampsia screening as it is performed currently in daily practice.
- Conditions
- Woman's Role, Preeclampsia, Screening
- Trial name
- NCT05123560
- Testing
- Anonymous online questionnaire
- Where
- Spain
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Posterior Reversible Encephalopathy Syndrome, Pregnancy Outcomes
The Clinical and Prognostic Features of PRES
The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.
- Conditions
- Posterior Reversible Encephalopathy Syndrome, Pregnancy Outcomes, Preeclampsia, Eclampsia
- Trial name
- NCT05143710
- Testing
- PRES in PE or E
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Dunjin Chen
Preeclampsia
Anti-Angiogenic Preeclampsia Milieu Impairs Infant Lung and Vascular Development
Pregnant mothers who develop high blood pressure and other vascular problems (preeclampsia) deliver babies with increased neonatal health problems, which include lung disease and vascular complications, later in life.
- Trial name
- NCT02639676
- Testing
- Diffusion Lung Capacity (DLCO), Vascular Challenge, Video Imaging, Specimen Collections
- Where
- United States
- Volunteers
- 292 people
- Sponsor
- Indiana University
Intracranial Pressure Control in Pre-eclampsia
Dexamedtomidine in Control of Intracranial Pressure in Preeclampsia
The present study is designed to evaluate the differences in the effect of Mg sulphate alone and dexmedetomidine as an adjuvant to Mg sulphate on intracranial pressure when administered intravenously in cases of pre-eclampsia
- Trial name
- NCT05119101
- Testing
- Dexamedotomidine added to Magnesium sulfate, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pre-Eclampsia
Detection of False Positives From First-trimester Preeclampsia Screening (StopPRE) at the Second-trimester of Pregnancy
Pregnant women at a higher risk for pre-eclampsia (PE) should be offered preventive daily treatment with acetylsalicylic acid (ASA) started before 16 weeks of gestation.
- Trial name
- StopPRE (NCT03741179)
- Testing
- ASA-withdrawn group
- Where
- Spain
- Volunteers
- 974 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute