Clinical trials: Pre- and Postoperative Analgesia
Pain
Dental Pain 3rd Molar Tooth Extraction GW842166
This phase IIa (proof of concept) study will be conducted as a multi-centre study within the European Union (EU). It will be conducted to a randomised, single blind, placebo- controlled, parallel group design with a positive…
- Trial name
- NCT00444769
- Testing
- GW842166
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 112 people
- Sponsor
- GlaxoSmithKline
Pain, Postoperative, Delirium
Study to Determine if Pre- and Post- Operative TAP Catheters With Ropivacaine Versus Placebo Affects Anesthetic, Narcotic Dosing, and Pain Scores
A randomized controlled trial to determine if pre- and post- operative regional pain control (transversus abdominis plane block) with ropivacaine versus placebo leads to lower anesthetic and narcotic dosing, and alters pain…
- Conditions
- Pain, Postoperative, Delirium, Anesthesia, Local
- Trial name
- TAP RCT (NCT03149783)
- Testing
- Ropivacaine HCL, sodium chloride
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Postoperative Pain
Pain Control of Thoracoscopic Major Pulmonary Resection
The purpose of this study is to evaluate whether pre-emptive local bupivacaine injection is a better alternative pain control modality than the conventional intravenous patient controlled analgesia.
- Trial name
- NCT01758809
- Testing
- Pre-emptive bupivacaine wound infiltration, intravenous patient controlled analgesia
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Bundang Hospital
Tonsil Disease, Surgical Wound
Effect of Pre-operative Oral Hydration on Post-operative Pain and Nausea in Adults Undergoing Tonsillectomy
Tonsillectomy is commonly described as one of the most painful procedures that an adult can undergo. This study's aim is to evaluate if pre-operative oral hydration has an impact in reducing post-operative pain, nausea and…
- Conditions
- Tonsil Disease, Surgical Wound, Pain, Postoperative
- Trial name
- NCT05507918
- Testing
- Oral water and clear liquids
- Sponsor
- Corewell Health East
Analgesia
Postoperative Analgesia After Shoulder Replacement
A comparison was made regarding opioid analgesic usage immediately after elective shoulder replacement and for seven days at home between patients randomly given either 0.5% or 0.75% ropivacaine via interscalene block prior to…
- Trial name
- NCT01003860
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Hip Fracture
Comparison of Intraoperative- Postoperative Effects of Pericapsular Nerve Block and Fascia Iliaca Block in Hip Fracture
The aim of this study is to apply pericapsular nerve group (PENG) block or fascia iliaca plan block using ultrasonography to patients who will undergo hip fracture surgery, while giving sitting position before spinal anaesthesia…
- Trial name
- NCT06001996
- Testing
- Pericapsular nerve group (PENG) block, Suprainguinal fascia iliaca plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Fracture, Pain, Postoperative
Methadone Versus Morphine for Orthopedic Surgery Patients
The investigators propose to compare analgesia by methadone and ketamine with a combination of morphine and ketamine in orthopedic surgery patients with moderate to severe pain.
- Trial name
- NCT00892606
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Louisville
PENG Block
Effectiveness Of The Pericapsular Nerve Group (PENG) Block In Hip Surgery
The target population of hip surgery is usually the elderly patients with systemic comorbidity. Especially hip fractures are common in society and cause high morbidity and mortality for geriatric patients .
- Trial name
- NCT05997940
- Testing
- PENG block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Aydin Adnan Menderes University
Orthopaedic Fractures, Orthopaedic Trauma Fractures and Non-unions
Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery
Breaking a bone is not only physically painful but also emotionally overwhelming. Patients often experience intense pain, anxiety, and uncertainty as they are rushed to hospital, undergo emergency treatment, and prepare for…
- Conditions
- Orthopaedic Fractures, Orthopaedic Trauma Fractures and Non-unions, Orthopaedic Trauma, Orthopaedic Surgery
- Trial name
- MIRROR (NCT07486505)
- Testing
- Mindfulness Based Intervention, Educational Recording
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Kidney Calculi, Pain, Postoperative
Pre-induction Analgesia: Multimodel Regimen vs Aceteminophen for Post Ureteroscopy Pain
Adult patients with kidney stones undergoing surgical intervention with ureteroscopy with laser lithotripsy will be randomized to receive one of two different regimens of oral medications administered prior to induction of…
- Trial name
- MMPITR (NCT03549611)
- Testing
- Multimodal Oral Drug Regimen, Acetaminophen
- Sponsor
- Kevin J Flynn MD
Arthroplasty, Replacement Material
Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when…
- Conditions
- Arthroplasty, Replacement Material, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- CRYO-TKA (NCT07425457)
- Testing
- CT-guided Cryoneurolysis of the Genicular Nerves
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Pain, Postoperative, Morbid Obesity
Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic
The purpose of this study is to determine if pre-incisional lidocaine injection, instilled liquid bupivacaine, intra-abdominal aerosolized bupivacaine, or post-operative bupivacaine injection is superior in post-operative pain…
- Trial name
- NCT00508976
- Testing
- Injected bupivacaine post-operatively, Streamed bupivacaine versus streamed normal saline, Aerosolized bupivacaine versus aerosolized saline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pinnacle Health System
Post Operative Pain, Appendicitis
Evaluation of Local Anesthetic at Incision Site
Patient will have usual appendectomy surgery with an injection of local or saline at incision site either before or after the incision at random.
- Trial name
- NCT02483689
- Testing
- Pre Incisional Local Anesthetic, Pre-Incisional Saline, Post-Closure Local Anesthetic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Postoperative Pain, Postoperative Nausea and Vomiting
Pre-pectoral AlloDerm® to Reinforce Tissues in Tissue Expander Breast Reconstruction
Primary Objective: To describe postoperative static pain scores on the Pain Visual Analog Scale at Day 1 in a population of women undergoing bilateral mastectomy followed by immediate, bilateral pre-pectoral tissue expander…
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting, Quality of Life, Breast Cancer
- Trial name
- NCT03195322
- Testing
- Pre-pectoral Tissue Expander
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Inflammatory Bowel Diseases, Anesthesia
HYSTERIA Evaluation of Clinical HYpnosis After Surgical Resection for Crohn Disease on Post-operative Analgesia
The aim of this study will be to show a decrease in postoperative morphine consumption by the practice of perioperative self-hypnosis in patients undergoing laparoscopic ileo-caecal resection for Crohn's disease
- Trial name
- HYSTERIA (NCT03261414)
- Testing
- Hypnosis, usual care
- Where
- France
- Volunteers
- 77 people
- Sponsor
- University Hospital, Lille
Pain, Supratentorial Brain Tumor
Effects of Pre-emptive Scalp Infiltration With Low-dose Ketorolac and Ropivacaine for Postoperative Pain
The PAINLESS study is a single-center, prospective, randomized, open-label, blinded-endpoint (PROBE) controlled clinical pilot study to compare the efficacy and safety of pre-emptive scalp infiltration with ropivacaine plus…
- Trial name
- PAINLESS (NCT04380298)
- Testing
- Ketorolac, Ropivacaine, Epinephrine
- Volunteers
- 40 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Pain, Outpatient Surgery
A Before and After Study Studying the Impact of an Analgesia Protocol After Discharge From Outpatient Surgery
The goal of this before and after study is to measure the effectiveness of a home analgesia protocol after outpatient surgery in a tertiary hospital.
- Trial name
- NCT06268587
- Testing
- Measure the impact of the home analgesia protocol on the proportion of patients with a VAS > 3/10 on day one and who did not take analgesics.
- Where
- Belgium
- Volunteers
- 1,423 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Post-craniotomy, Pain
Pre-emptive Scalp Infiltration With Low-dose Flurbiprofen and Ropivacaine for Postoperative Analgesia After Craniotomy
Post-craniotomy pain is common and often associated with poor outcomes. Flurbiprofen axetil (FA) is an injectable NSAID for postoperative analgesia, however, the impact of local FA, remains elusive on post-craniotomy pain.
- Trial name
- NCT07209345
- Testing
- FA+Ropivacaine, Ropivacaine
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Beijing Tiantan Hospital
Cesarean Section, Cesarean Delivery
Pain Management After Cesarean Section - A Before-and-After Cohort Study
Inadequate pain relief remains a challenge after Cesarean section (CS) and may significantly impair postoperative recovery. A recent Danish single-center study (n=100) revealed that 66% of elective CS patients experienced severe…
- Conditions
- Cesarean Section, Cesarean Delivery, Pain Management, Pain Management in Postoperative Care
- Trial name
- NCT06813638
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Nordsjaellands Hospital
Uterine Fibroid, Adenomyosis
Paracervical Block in Laparoscopic Hysterectomy
It remains controversial whether paracervical block should be performed as a powerful strategy for pain relief in total laparoscopic hysterectomy (TLH), because convincing conclusions are difficult to draw because of the…
- Trial name
- PALAPA (NCT03792009)
- Testing
- Paracervical block, 5% bupivacaine, Normal saline
- Where
- 3 sites in South Korea
- Volunteers
- 86 people
- Sponsor
- Kangbuk Samsung Hospital