Clinical trials: Pre-Diabetes
Prediabetes, Type 2 Diabetes
Vitamin D and Type 2 Diabetes Study
The goal of the Vitamin D and type 2 diabetes (D2d) study is to determine if vitamin D supplementation works to delay the onset of type 2 diabetes in people at risk for the disease and to gain a better understand how vitamin D…
- Trial name
- D2d (NCT01942694)
- Testing
- Vitamin D (Cholecalciferol)
- Where
- 25 sites in United States
- Volunteers
- 2,423 people
- Sponsor
- Tufts Medical Center
Metabolic Syndrome X, Overweight
Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS)
Metabolic syndrome consists of a group of co-occuring conditions that increase an individual's risk of developing heart disease, stroke, and diabetes.
- Conditions
- Metabolic Syndrome X, Overweight, Hypertension, Dyslipidemias
- Trial name
- ARCH-MS (NCT00455403)
- Testing
- Chloroquine
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Washington University School of Medicine
Pre-diabetes
Short-term Health Effects of Wild Blueberry Juice Consumption
Researchers at the University of Prince Edward Island want to learn about the health effects of wild blueberry juice.
- Trial name
- NCT02139878
- Testing
- Wild blueberry juice
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Prince Edward Island
Metabolic Syndrome, PreDiabetes
Exercise, Sleep Quality and Nocturnal Fat Oxidation in Metabolic Syndrome
The purpose of the Exerci-Zzz Study is to learn more about how the time of day that exercise is performed influences sleep quality and fat metabolism overnight in adults with metabolic syndrome.
- Conditions
- Metabolic Syndrome, PreDiabetes, Hypertension, Obesity
- Trial name
- ExerciZzz (NCT04105218)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Hypertension
Effects of Use of a Connected Pillbox On Medication Adherence
Medication adherence is defined as the extent to which a patient takes his or her medication as prescribed by their healthcare provider.
- Conditions
- Diabetes Mellitus, Hypertension, Hyperlipidemia
- Trial name
- (TVHST2DM) (NCT02593032)
- Testing
- Pre-filled trays
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Prediabetes, Obese
Inflammation Inhibition in Prediabetic Humans
Prediabetes, characterized by elevated fasting blood sugar or exaggerated blood sugar response to sugar ingestion, effects over 79 million adult Americans and is a precursor to the development of Type 2 diabetes.
- Trial name
- INCITE (NCT01977417)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Obesity, PreDiabetes
Cardiovascular Effects of GLP-1 Receptor Activation
This project tests the principle hypothesis that stable glucagon like peptide-1 (GLP-1) analogues have specific GLP1R-dependent beneficial effects on vascular endothelial function, fibrinolysis and inflammation in obesity that…
- Trial name
- NCT03101930
- Testing
- Liraglutide, Sitagliptin, hypocaloric diet
- Where
- United States
- Volunteers
- 329 people
- Sponsor
- Vanderbilt University Medical Center
Prediabetes, Type 2 Diabetes
RISE Pediatric Medication Study
The RISE Pediatric Medication Study is a 2-arm, 4-center, clinical trial of children with prediabetes and early type 2 diabetes to address the hypothesis that aggressive glucose lowering will lead to recovery of beta-cell…
- Trial name
- RISE Peds (NCT01779375)
- Testing
- Metformin, Glargine
- Where
- 4 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- RISE Study Group
PreDiabetes, Weight Loss
The National Diabetes Prevention Program in Rural Communities
The purpose of this pilot trial is to compare feasibility and effectiveness of remote delivery (social media or video conferencing) of the National Diabetes Prevention Program (N-DPP) to adults in rural communities.
- Conditions
- PreDiabetes, Weight Loss, Lifestyle Risk Reduction
- Trial name
- Rural NDPP (NCT05387434)
- Testing
- Diabetes Prevention Program-Remote (DPP-R), Diabetes Prevention Program-Facebook (DPP-FB)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Kansas Medical Center
Hyperinsulinemia, Insulin Resistance
Glycemic Effect of Diazoxide in NAFLD
The goal of this clinical trial is to compare a two-week course of diazoxide (at two different doses) and placebo in people with overweight/obesity and insulin resistance (IR) with, or at high risk for, non-alcoholic fatty liver…
- Conditions
- Hyperinsulinemia, Insulin Resistance, Non-Alcoholic Fatty Liver Disease, Prediabetic State
- Trial name
- NCT05729282
- Testing
- Diazoxide oral suspension, 1 mg per kg per dose, Diazoxide oral suspension, 2 mg per kg per dose, FreeStyle Libre Pro
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Diabetes Mellitus, Type 2, Obesity
Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy
To assess whether holding incretin-based therapy before endoscopy reduces the likelihood of clinically relevant Residual Gastric Volume (RGV).
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Gastroparesis
- Trial name
- NCT06533527
- Testing
- GLP-1 medication
- Where
- 2 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Type 2 Diabetes Mellitus
The Effect of Exenatide Compared to Lantus Insulin on Vascular Function in Type 2 Diabetes
The main goals of the study are to evaluate the effect of Exenatide on endothelial-dependent vasodilation, as measured by flow mediated dilation (FMD), to evaluate the effect on endothelial-independent vasodilation, as measured…
- Trial name
- NCT00353834
- Testing
- Exenatide, Glargine Insulin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus, Type 2
A Research Study to Compare a New Weekly Insulin, Insulin Icodec Used With DoseGuide App, and Daily Insulins in People With Type 2 Diabetes Who Have Not Used Insulin Before
This study compares insulin icodec to different daily insulins in people with type 2 diabetes. The study will look at how well insulin icodec taken once weekly controls blood sugar compared to the insulins taken once daily.
- Trial name
- ONWARDS 5 (NCT04760626)
- Testing
- Insulin icodec, Insulin Glargine 100U/mL, Insulin Degludec
- Where
- 311 sites in United States, Bulgaria and 8 more
- Volunteers
- 1,085 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Surgical Procedure, Unspecified
Multifactorial Pre-operative Intervention in Diabetes Mellitus
The purpose of this study is to advance the quality of care among inpatients with diabetes in the VHA. When patients with diabetes are admitted to the hospital, there is a greater chance that they will have a complication that…
- Trial name
- NCT00753766
- Testing
- Multifactorial Intervention
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development