Clinical trials: Pre-Eclampsia; Complicating Pregnancy
Pregnant Women, Preeclampsia
Antioxidant Supplementation in Pregnant Women
The purpose of this study is to investigate the benefit of several micro nutrients of antioxidants (using milk) in a cohort of women with low antioxidant status and the changes in cell-free mRNA.
- Trial name
- ASIP1 (NCT01232205)
- Testing
- micronutrient antioxidant, Control
- Where
- Indonesia
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Showa University
Premature Birth, Pre-Eclampsia
Select Nutrient and Gene Variant Analysis in a Targeted Diet and Lifestyle Intervention Reduces Preterm Birth
Preterm birth (PTB) rates in the US are among the highest in wealthy nations across the globe, and they are particularly high in our most socio-economically disadvantaged populations.
- Conditions
- Premature Birth, Pre-Eclampsia, Small for Gestational Age Infant
- Trial name
- SNGLI-PTB (NCT05436119)
- Testing
- GrowBaby
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- GrowBaby Life Project
Severe Pre-eclampsia, Postpartum Condition or Complication
Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol
We aim to compare carbetocin with misoprostol for the prevention of postpartum hemorrhage in patients with severe preeclampsia. The primary outcome is postpartum haemorrhage (blood loss of ≥ 500 ml) while our Secondary outcomes…
- Trial name
- carbetocin (NCT02086994)
- Testing
- misoprostol, carbetocin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- khalid abd aziz mohamed
Gestational Hypertension
Relation Between Protein 13 and Gestational Hypertensive Disorder
the attendants of the clinic with a one-missed period (T0) underwent determination of baseline blood pressure (BP) measures and gave blood samples for estimation of levels of placental growth factor (PLGF), soluble fms-like…
- Trial name
- NCT05517512
- Testing
- Estimation of Protein 13
- Where
- Egypt
- Volunteers
- 138 people
- Sponsor
- Benha University
Hypertension, Pregnancy-Induced
Evaluation of an Information Pamphlet for Postpartum Women That Had a Hypertensive Pregnancy
It is known that preeclampsia is a risk factor for cardiovascular diseases, diabetes, chronic hypertension, nephropathy and thromboembolism.
- Trial name
- NCT02523781
- Testing
- information pamphlet
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Preeclampsia
Mild Preeclampsia Near Term: Deliver or Deliberate?
Preeclampsia with new-onset hypertension and proteinuria is a pregnancy-specific disease that affects 5-7% of gestations usually after the 20th week.
- Trial name
- NCT00789919
- Testing
- Delivery of infant
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- University of Mississippi Medical Center
Preeclampsia, Preterm Birth
Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications
The Biobank includes data and biological specimens of women from three original studies: 1) First-trimester Prediction of Preeclampsia (PREDICTION Study, NCT02189148), 2) Pre-Eclampsia And growth Retardation, an evaluative…
- Conditions
- Preeclampsia, Preterm Birth, Pregnancy Complications, Fetal Anomalies
- Trial name
- NCT02744365
- Testing
- Observational
- Where
- Canada
- Volunteers
- 7,845 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Hypertension (HTN), Preeclampsia
Mobile Health Program for Post-Preeclampsia Hypertension
Strategies targeted to optimize hypertension (HTN) control for midlife women after hypertensive disorders of pregnancy (HDP) have not been studied, despite evidence of a critical need.
- Conditions
- Hypertension (HTN), Preeclampsia, Hypertensive Disorders of Pregnancy (HDP)
- Trial name
- NCT07599579
- Testing
- Coaching application, Home-based blood pressure monitoring, WebMD
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Preeclampsia (PE)
Non-Invasive Preeclampsia Screening and Biobank
Women pregnant between 11-14 weeks gestation will be enrolled with blood samples collected to evaluate for preeclampsia.
- Trial name
- NCT06643741
- Where
- 21 sites in United States
- Volunteers
- 6,550 people, healthy volunteers welcome
- Sponsor
- Sequenom, Inc.
Pre-Eclampsia
Impact of Antichlamydial Treatment on the Rate of Preeclampsia
This randomized, double blinded controlled trial included 1200 healthy primigravidae who attended an outpatient clinic at 16-20weeks of pregnancy.
- Trial name
- NCT03233880
- Testing
- Azithromycin 1gm
- Where
- Egypt
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Pregnancy-Associated Hypertension, Gestational Hypertension
Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure
High blood pressure during or after pregnancy (such as preeclampsia, gestational hypertension, eclampsia, or Hemolysis, Elevated Liver enzymes, and Low Platelet (HELLP) syndrome) raises a mother's risk of heart disease later in…
- Conditions
- Pregnancy-Associated Hypertension, Gestational Hypertension, Preeclampsia, Eclampsia
- Trial name
- AW2H (NCT07778966)
- Testing
- Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- University of Alabama at Birmingham
Hypertensive Disorder of Pregnancy, Premature Preterm Rupture of Membranes
HOME: Home Monitoring of High-risk Pregnancies
High-risk pregnancies often require long-term hospitalization or outpatient maternal and/or fetal monitoring, placing a burden on patients, hospital resources and society.
- Conditions
- Hypertensive Disorder of Pregnancy, Premature Preterm Rupture of Membranes, Preeclampsia, High Risk Pregnancy
- Trial name
- NCT05763069
- Testing
- Home surveillance of pregnancies at risk
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Oslo University Hospital
Preeclampsia
Blood Collection to Validated New Therapeutics Strategies Against Preeclampsia
The aim of the study is to setup a collection of maternal plasma and serum from patients with preeclampsia and normal pregnancy for in vitro validation of new therapeutics based on extra-corporal removal of sFlt-1
- Trial name
- APHERESE (NCT03188900)
- Testing
- A collection of maternal plasma and serum
- Where
- France
- Volunteers
- 236 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Pregnancy-Induced
Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by…
- Trial name
- REPAIR (NCT06220721)
- Testing
- Nifedipine ER
- Where
- 2 sites in United States
- Volunteers
- 618 people
- Sponsor
- Medical College of Wisconsin
Diabetes, Gestational, Pre-eclampsia
Usability Evaluation of Gen AI-based Nutrition Chatbot for Pregnant Women
Background: Pregnancy imposes significant physical demands, with complications like gestational diabetes (GDM) and pre-eclampsia posing serious risks.
- Conditions
- Diabetes, Gestational, Pre-eclampsia, AI Chatbot for Prenatal Nutrition Guidance
- Trial name
- NCT07458997
- Testing
- a culturally tailored nutrition AI chatbot for pregnant women
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Hong Kong Metropolitan University
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Preeclampsia
microRNAs Role in Pre-eclampsia Diagnosis
Pre-eclampsia is one of the most threatening pregnancy complications. So far neither a secure, competent therapy for PE nor effective biomarkers for a premature discovery has been achieved.The aim of our study was to identify…
- Trial name
- NCT03562715
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hypertension Induced by Pregnancy, Pre-Eclampsia
Placental Growth and Adverse Pregnancy Outcomes
The purpose of this study to determine if measurement of maternal serum biomarkers and evaluation of the placenta by ultrasound can improve prediction of adverse pregnancy outcomes.
- Conditions
- Hypertension Induced by Pregnancy, Pre-Eclampsia, IUGR
- Trial name
- NCT01669525
- Where
- United States
- Volunteers
- 1,043 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Preeclampsia, Superimposed Preeclampsia
Influence of Conditional Workout Postpartum on Arterial Stiffness Among Women With Status After Preeclampsia, Superimposed Preeclampsia or HELLP-syndrome
Evaluation of practicability in survey and test procedures and of successful implementation of complex interventions - feasibility analysis based on a pilot study: Influence of conditional workout postpartum on arterial stiffness…
- Conditions
- Preeclampsia, Superimposed Preeclampsia, HELLP Syndrome
- Trial name
- RedCarRisk (NCT02754778)
- Testing
- conditional workout
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Obstructive Sleep Apnea of Adult, Preeclampsia
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of…
- Conditions
- Obstructive Sleep Apnea of Adult, Preeclampsia, Obstetrical Complications
- Trial name
- SLEEP (NCT03487185)
- Testing
- Continuous Positive Airway Pressure, Sleep Advice Control
- Where
- 14 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- The George Washington University Biostatistics Center