Clinical trials: Pre-Menopause
Metabolic Syndrome
Early Vascular Wall Changes by Magnetic Resonance Imaging (MRI) in Metabolic Syndrome Versus Metabolically Normal Pre-Menopausal Women: A Pilot Study
The purpose of this study is to compare the vascular permeability of blood vessel walls (of the carotid artery) in pre-menopausal women who have metabolic syndrome (syndrome of having at least 3/5 following features- increased…
- Trial name
- NCT01068535
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Washington
Breast Cancer, Genitourinary Syndrome of Menopause
Sexual and Vaginal Health in Breast Cancer Women Receiving Aromatase Inhibitors Before and After CO2 Laser Therapy
Background: Vulvovaginal health, directly linked to sexual health, is a key factor for female pleasure. BCS receiving AI are likely to present severe GSM and sexual complaints.
- Trial name
- LIGHT (NCT04619485)
- Testing
- CO2 LASER
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Hospital Clinic of Barcelona
Breast Cancer
A Pre-operative Window Study of Letrozole Plus PR Agonist (Megestrol Acetate) Versus Letrozole Alone in Post-menopausal Patients With ER-positive Breast Cancer
Around 75% of breast cancers are defined and driven by Oestrogen receptor alpha (ERα) transcriptional activity. Standard treatment is endocrine therapy however clinical outcomes vary considerably, and a proportion of women with…
- Trial name
- PIONEER (NCT03306472)
- Testing
- Megestrol Acetate 40 MG, Megestrol Acetate 160 MG, Letrozole
- Where
- United Kingdom
- Volunteers
- 198 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Periodontitis, Menopause
Evaluation of Periodontal Response to Non Surgical Therapy in Pre and Post Menopausal Women With Periodontitis
The present study was evaluated periodontal status in pre and post-menopausal women with periodontitis following non-surgical therapy.
- Conditions
- Periodontitis, Menopause, Plaque, Inflammation
- Trial name
- EPRNPPMP (NCT02718014)
- Testing
- scaling and root planing (srp)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Breast Cancer
Clinical Trial Assessing the Safety of Neoadjuvant Palbociclib in Combination With Endocrine Therapy
Patients with estrogen receptor positive (ER+) and/or progesterone receptor positive (PR+) breast cancer do not achieve good responses with pre-operative chemotherapy.
- Trial name
- NCT05069038
- Testing
- Palbociclib 125mg
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Nebraska
Postmenopause, Premenopause
Marine n-3 Polyunsaturated Fatty Acids in Pre- and Postmenopausal Women
The study is a randomised placebo controlled double-blinded clinical trial where a group of healthy pre- and postmenopausal women is randomised to the intake of fish oil capsules or placebo oil capsules for 12 weeks.
- Trial name
- NCT00901589
- Testing
- marine n-3 polyunsaturated fatty acids, thistle oil
- Where
- Denmark
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Contraception
Dose-finding Study of MR-130A-01 Contraceptive Transdermal Patch
A single-center, randomized, open-label, parallel-group, multi-arm, phase II clinical trial in healthy women aged 18 to 35 years who have a documented ovulatory cycle prior to randomization.
- Trial name
- NCT06048536
- Testing
- MR-130A-01 Transdermal patch
- Where
- Germany
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Uterine Fibroids, Anemia
Safety and Efficacy of Proellex in Pre-menopausal Anemic Women With Symptomatic Uterine Fibroids
Eligible female subjects will be randomly assigned to one of the three treatment groups. Subjects will receive 325 mg (65 mg elemental iron) iron supplements to be taken twice daily during study drug treatment.
- Trial name
- NCT00702702
- Testing
- Proellex 25 mg, Proellex 50 mg
- Where
- 30 sites in United States
- Volunteers
- 56 people
- Sponsor
- Repros Therapeutics Inc.
Menopause, Pre-menopause
Following Lipectomy to Understand Adipose Tissue Re-accumulation
The typical female pattern of accumulating fat in the hips and thighs has long been thought to confer less risk for disease than the typical male abdominal fat pattern.
- Trial name
- FLARE (NCT00995631)
- Testing
- Femoral lipectomy
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sleep Disturbance
Kneipp Water Applications for Insomnia
The purpose of this study is to ascertain whether warm footbathes are effective on sleep disturbances in women before climacteric.
- Trial name
- KWAI (NCT03114189)
- Testing
- footbath, care of sleep
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universität Duisburg-Essen
Breast Cancer, Cancer of the Breast
Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer
This purpose of this trial is to show that the combination of Avastin and hormone therapy should be more effective than hormone therapy alone for the treatment of breast cancer.
- Conditions
- Breast Cancer, Cancer of the Breast, Breast Neoplasm
- Trial name
- NCT00530868
- Testing
- Letrozole (Femara), Letrozole; Avastin
- Where
- 7 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Alabama at Birmingham
Premenopause, Healthy
Effect of Race on Gonadotropin Responses
The purpose of this study is to attempt to determine why estrogen levels are increased in African-American women as compared to Caucasian women by evaluating estrogen feedback on the brain.
- Trial name
- NCT00455962
- Testing
- Estradiol steroid infusion, Progesterone steroid infusion
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Breast Atypical Hyperplasia, Breast Carcinoma
Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer
This phase IIA trial compares the effect of acolbifene versus low dose tamoxifen in preventing breast cancer in premenopausal women at high risk for developing breast cancer.
- Conditions
- Breast Atypical Hyperplasia, Breast Carcinoma, Breast Ductal Carcinoma In Situ, Breast Lobular Carcinoma In Situ
- Trial name
- NCT05941520
- Testing
- Acolbifene Hydrochloride, Biospecimen Collection, Mammography
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Obesity
Acupuncture for Obesity on Serum Metabolic Parameters
This research is planned to build a basis about the effect of acupuncture on serum metabolic parameters in pre-menopausal obese women with economic evaluation.
- Trial name
- NCT02066090
- Testing
- Real acupuncture
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Heavy Uterine Bleeding, Uterine Fibroids
Safety and Efficacy of Elagolix in Pre-Menopausal Women With Heavy Uterine Bleeding and Uterine Fibroids
The purpose of this proof-of-concept study is to assess the safety and effectiveness of elagolix versus placebo to reduce uterine bleeding associated with uterine fibroids, and to reduce fibroid volume and uterine volume in…
- Trial name
- NCT01441635
- Testing
- Elagolix, Estradiol/Norethindrone acetate (E2/NETA), Estradiol
- Volunteers
- 271 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Hormone, Cardiovascular
Cardiometabolic and Hormonal Adaptations to 4-Month Zumba Training in Overweight/Obese Women
This study aims to evaluate the effects of a 4 month Zumba training program on cardiometabolic, hormonal, inflammatory, hepatic, renal, and functional parameters in overweight and obese women.
- Conditions
- Hormone, Cardiovascular, Obesity & Overweight
- Trial name
- NCT07264348
- Testing
- Zumba training
- Volunteers
- 73 people
- Sponsor
- High Institute of Sports and Physical Education of Kef
Endometriosis
A Study to Investigate the Safety, Tolerability, Food Effect, Pharmacokinetics and Pharmacodynamics of FOR-6219
This is a randomised, double-blind, placebo-controlled, Phase I/Ib study which will assess the safety, tolerability, food effect, pharmacokinetics and pharmacodynamics of FOR-6219, a hydroxysteroid (17B) dehydrogenase (HSD17B1)…
- Trial name
- NCT03709420
- Testing
- FOR-6219
- Where
- United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Forendo Pharma Ltd
Breast Neoplasm
Everolimus and Letrozole as Preoperative Therapy of Primary Breast Cancer in Post-menopausal Women
The purpose of this study is to examine the effect of the combination of everolimus and letrozole compared to placebo and letrozole as pre-surgical therapy in patients with newly diagnosed estrogen receptor positive breast cancer.
- Trial name
- NCT00107016
- Testing
- RAD001, Letrozole 2.5mg, Letrozole 2.5mg
- Where
- 46 sites in United States, Austria and 8 more
- Volunteers
- 267 people
- Sponsor
- Novartis Pharmaceuticals
Advanced Breast Cancer
Study of Zoladex Given Every 12 Weeks Versus Given Every Month in Advanced Breast Cancer (ABC) Pre-menopausal Women
The primary objective is to evaluate whether Zoladex 10.8 mg (12-weekly) is non-inferior to Zoladex 3.6 mg (4-weekly) in pre-menopausal women with oestrogen receptor positive advanced breast cancer by assessment of…
- Trial name
- NCT00322348
- Testing
- Goserelin acetate
- Where
- 14 sites in Czechia, Russia and 1 more
- Volunteers
- 98 people
- Sponsor
- AstraZeneca
Infertile Women Undergoing Assisted Reproductive Technology (ART)
A Study to Compare the Safety and Efficacy of Cetrotide® 3 Milligram (mg) Versus Antagon™ in Women Undergoing Ovarian Stimulation
To demonstrate the comparative safety and efficacy of Cetrotide® 3 milligram (mg) and Antagon™ in the inhibition of a premature luteinizing hormone (LH) surge in women undergoing ovarian stimulation with recombinant human…
- Trial name
- NCT00298025
- Testing
- Cetrotide®, Antagon ™, Recombinant human follicle stimulating hormone (r-hFSH)
- Volunteers
- 185 people
- Sponsor
- EMD Serono