Clinical trials: Pre-dementia
Agitation
Pre-hospital Agitation and Sedation Trial: A Randomized Controlled Trial of Haloperidol Versus Midazolam for the Sedation of the Agitated Patient
PREHOSPITAL AGITATION AND SEDATION TRIAL (PHAST) The goal of the PHAST is to demine whether haloperidol is superior to midazolam for the sedation of agitated patients in the prehospital environment The primary outcome is the time…
- Trial name
- PHAST (NCT01501123)
- Testing
- Haloperidol, Midazolam
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Catholic Health East
Mild Cognitive Impairment, Alzheimer Disease
Alzheimer's Disease Neuroimaging Initiative 4
The Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4) is a non-randomized, longitudinal, natural history study designed to validate biomarkers, improve clinical trial design, and advance understanding of Alzheimer's disease…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- ADNI4 (NCT05617014)
- Testing
- Neuraceq, Amyvid, Tauvid
- Where
- 65 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Dementia, Dementia, Mild
Chocolate and Physical Exercise to Reduce Malnutrition in Pre-dementia Aged People
We hypothesize that the antioxidant and cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols and physical activity may help prevent the age-dependent decline of mitochondrial…
- Conditions
- Dementia, Dementia, Mild, Dementia Moderate, Dementia Senile
- Trial name
- Choko-AGE (NCT05343611)
- Testing
- Combination of High Protein Diet and Physical Exercise protocol, HPP Choko, HPP/VE Choko
- Where
- 4 sites in Italy
- Volunteers
- 102 people
- Sponsor
- Massimo Venturelli, PhD
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sexually Transmitted Diseases, Safe Sex
P3 (Prepared, Protected, emPowered)
P3 (Prepared, Protected, emPowered) is an interactive smartphone app for HIV-uninfected YMSM and YTW that utilizes social networking and game-based mechanics as well as a comprehensive understanding of what constitutes "best…
- Conditions
- Sexually Transmitted Diseases, Safe Sex, Adherence, Medication
- Trial name
- P3 (NCT03320512)
- Testing
- P3, P3+, Control
- Where
- 9 sites in United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Vascular Cognitive Impairment no Dementia
Mexidol® Efficacy and Safety in Treatment of VCIND in Older Adults
The primary objective of this study is to evaluate the efficacy of Mexidol® sequential parenteral and oral administration as part of comprehensive therapy in older adults with chronic brain ischemia and vascular cognitive…
- Trial name
- NCT07700615
- Testing
- Mexidol, Standard Therapy
- Where
- 4 sites in Russia
- Volunteers
- 120 people
- Sponsor
- Pharmasoft
Huntington's Disease
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139)
This study will test the safety, tolerability, pharmacokinetics and pharmacodynamics of RO7234292 administered intrathecally to adult patients with Huntington's Disease.
- Trial name
- NCT03342053
- Testing
- RO7234292 (RG6042)
- Where
- 9 sites in Canada, Germany and 1 more
- Volunteers
- 46 people
- Sponsor
- Hoffmann-La Roche
Huntington's Disease
Cognitive Assessment Battery (CAB) Beta Study
The overall objective of this study is to identify a 60 minute cognitive battery, for subsequent use in clinical trials, that detects cognitive deficits in early HD and late pre-manifest HD compared to controls, and that has a…
- Trial name
- CAB (NCT01290861)
- Where
- 20 sites in United States, Australia and 2 more
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- CHDI Foundation, Inc.
Caregiver Burden
Pre-Pilot: Problem Adaptation THerapy in Caregivers
The proposed pre-pilot project seeks to adapt an evidence-based psychosocial intervention-Pain Adaptation Therapy (PATH)-that employs emotion regulation, behavioral activation, and problem-solving skills training, that will be…
- Trial name
- PATH-Care (NCT05567120)
- Testing
- PATH-Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Alzheimer's Disease
Safety Study of TRx0237 in Patients Already Taking Medications for Mild and Moderate Alzheimer's Disease
The primary purpose of this study is to assess the safety and tolerability of TRx0237 when taken at the same time as acetylcholinesterase inhibitors (i.e., donepezil, galantamine, or rivastigmine) and / or memantine to treat…
- Trial name
- NCT01626391
- Testing
- TRx0237
- Where
- 12 sites in Germany, United Kingdom
- Volunteers
- 9 people
- Sponsor
- TauRx Therapeutics Ltd
Diabetes Mellitus, Type 2, Pre-diabetes
Tau PET Imaging in the Northern Manhattan Study of Metabolism and Mind.
This is a single center brain Positron Emission Tomography (PET) study of 18F-MK-6240. Eligible participants are persons from Northern Manhattan who self-identify as Hispanic, non-Hispanic Black, or Non-Hispanic White, who are 55…
- Trial name
- NOMEM-Tau (NCT03389100)
- Testing
- 18F-MK6240 injection
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Columbia University
Dementia, Delirium
The Effect of a Pre- and Postoperative Orthogeriatric Service
The investigators' aim is to assess the effect of a model of preoperative as well as early postoperative care, treatment and rehabilitation in a dedicated orthogeriatric ward in a single-blind randomised study.
- Trial name
- NCT01009268
- Testing
- Orthogeriatric intervention
- Where
- Norway
- Volunteers
- 332 people
- Sponsor
- Ullevaal University Hospital
Intellectual Disability, Developmental Disability
Clinical Trial of Nabilone for Aggression in Adults With Intellectual and Developmental Disabilities
Innovative treatments are urgently needed for severe behavioural problems (SBPs) in adults with intellectual and developmental disabilities (IDD).
- Conditions
- Intellectual Disability, Developmental Disability, Aggression, Behavior Problem
- Trial name
- N-AND (NCT05273320)
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Hsiang-Yuan Lin
Substance Use Disorder (SUD)
A Study of a Mobile Phone Application Measuring the Eyes Before and After Medication
This is a post-market clinical follow-up study on an approved CE-marked eHealth system where a mobile phone application is used to measure the pupils and eye measurements to monitor the use of different drug substances.
- Trial name
- NCT06629740
- Testing
- Measurements with a eHealth system
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Dementia (Diagnosis), Mild Cognitive Impairment
Choose Myself (Before) Losing Myself
The purpose of this study is to see if an educational interactive booklet about how dementia progresses throughout a person's life can be a helpful tool for patients to think about future decisions that might need to be made…
- Conditions
- Dementia (Diagnosis), Mild Cognitive Impairment, Alzheimer's Disease Dementia, Alzheimer's Disease
- Trial name
- CYOA (NCT07846566)
- Testing
- CYOA booklet
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Alzheimer Disease, Mild Cognitive Impairment
LEADing Dementia End-of-Life Planning Conversations
Advance care planning is important for all adults, but perhaps even more so for the 5.7 million persons with Alzheimer's disease or related dementia (ADRD), due to the progressive and protracted cognitive deterioration associated…
- Trial name
- LEAD (NCT05909189)
- Testing
- LEADing Dementia End-of-Life Planning Conversations
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Alzheimer's Disease
Imaging Characteristics of a Follow-up 18F-AV-1451 Scan
This study will evaluate the imaging characteristics of flortaucipir in subjects with a previous flortaucipir scan in order to assess the rate of change of tau deposition over time.
- Trial name
- NCT02051764
- Testing
- Flortaucipir F18, Florbetapir F 18, Brain PET Scan
- Where
- 4 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Huntington Disease
A Pre-Cellular Therapy Observational Study in Early Huntington's Disease
This observational study will establish a clinical baseline and measure changes over time in movement, thinking, behavior, brain imaging, blood and spinal fluid markers in subjects with early stage Huntington's disease.
- Trial name
- PRE-CELL (NCT01937923)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of California, Davis
Pre Diabetes
Assessment of the Impact of a Personalised Nutrition Intervention in Impaired Glucose Regulation
This study will determine if DNA-based dietary guidelines can improve glucose regulation in pre-diabetic individuals significantly more than standard dietary guidelines following 6 weeks of the intervention.
- Trial name
- ASPIRE-DNA (NCT03702465)
- Testing
- DNA-based dietary intervention, DNA-based dietary intervention using an app, Control arm
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Alzheimer Disease, Dementia
TAS Test: Online Motor-cognitive Tests for Early Detection of Alzheimer's Disease
Global dementia prevalence is rising. Alzheimer's disease (AD), the most common cause, has devastating effects on people's quality of life.
- Conditions
- Alzheimer Disease, Dementia, Age-related Cognitive Decline
- Trial name
- TASTest (NCT05194787)
- Testing
- Cognitive test scores, clinical diagnosis and blood biomarkers
- Where
- Australia
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Tasmania