Clinical trials: Pre-diabetic State
Type2 Diabetes, PreDiabetes
Secular Trends in the Prevalence of Diabetes in India
Series of epidemiological studies have been carried out by the research team since 1988 studying the changes in the prevalence of type 2 diabetes, prediabetes and associated risk factors.
- Trial name
- STRiDE-I (NCT03490136)
- Where
- India
- Volunteers
- 9,848 people, healthy volunteers welcome
- Sponsor
- India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals
PreDiabetes, Aging
A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes
The goal of this pilot and feasibility study is to investigate the effects of a short course of metformin therapy on a surrogate marker of cellular senescence and autophagy among adult patients with prediabetes.
- Trial name
- NCT03309007
- Testing
- Metformin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of New Mexico
Kidney Failure, Chronic, Prediabetic State
The Effect of Liraglutide in Patients With Prediabetes and Kidney Failure
The present study will examine the effects of liraglutide treatment during 26 weeks on several cardiovascular risk factors in patients with prediabetes and end-stage renal disease (ESRD).
- Trial name
- LiRA2 (NCT02284230)
- Testing
- Liraglutide
- Where
- Denmark
- Sponsor
- Bo Feldt-Rasmussen
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Risk-informed Shared-decision Making Engagement Strategy for Patients With Prediabetes
The goal of this clinical trial is to learn if knowing risk for diabetes can help adult patients with prediabetes take steps to get care and prevent diabetes.
- Trial name
- RISE (NCT07553325)
- Testing
- Risk Informed Shared Decision-Making Strategy (RISE), Low Touch Messaging Strategy (LTM)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Johns Hopkins University
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Pharmacists' Delivery of Education to Prevent Diabetes in the New Orleans Hospitality Industry
This is a one-year pilot study focused on prediabetes among hospitality workers in New Orleans, Louisiana. The project will assess prediabetes rates among the target population, evaluate the impact of pharmacist led lifestyle…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetic State &Amp; High Risk Individuals on the Basis of Diabetes Risk Score
- Trial name
- NCT07451314
- Testing
- Linkage to Care, Educational, Healthy Lifestyle Tools
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xavier University of Louisiana.
Prediabetes
Nested Pilot Study Comparing Two Treatments to Reduce Type 2 Diabetes Risk in At-Risk Delawareans
This nested pilot Randomized Clinical Trial will determine whether the Diabetes Prevention Program (DPP) enhanced with evidence-based sleep health and time restricted eating interventions ("DPP++") is more effective than the DPP…
- Trial name
- NCT07450118
- Testing
- National Diabetes Prevention Program (DPP), Sleep Health Digital Application, Time-Restricted Eating (TRE)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Delaware
Prediabetes, Dietary Self-Management
Continuous Glucose Monitoring and Dietary Self-Management in Adults in Namwon
This study will test whether adding a continuous glucose monitoring (CGM) device, which shows personal glucose patterns, improves dietary self-management over the first 6 weeks.
- Conditions
- Prediabetes, Dietary Self-Management, Diabetes Mellitus, Type 2
- Trial name
- NCT07890740
- Testing
- Continuous Glucose Monitoring With Application-Based Biofeedback, Common Standardized Education and Behavioral Goal Setting, Common Digital Health Program and Basic Health Counseling
- Where
- 4 sites in South Korea
- Volunteers
- 860 people
- Sponsor
- Ji-Yeob Choi
Prediabetes
Blood Sugar Take Care and Glucose Metabolism
This prospective international clinical trial is a two-arm, double-blind, randomized, placebo-controlled, parallel-group, multicenter study. 112 prediabetic subjects will be randomized to Blood Sugar Take Care or placebo.
- Trial name
- NCT01554020
- Testing
- Blood Sugar Take Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NewChapter, Inc.
Healthy, Prediabetic State (IGT)
Noninvasive Transcutaneous Glucometer Development
The objective of this study is to assist in the development of a noninvasive device for the accurate measurement of blood glucose levels.
- Conditions
- Healthy, Prediabetic State (IGT), Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT01168076
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- InLight Solutions
Insulin Resistance, Metabolic Endotoxemia
The Effect of Ketogenic-caloric Restricted Diet on Metabolic Endotoxemia in Prediabetic Obese Adults
Insulin resistance increases the risk of type 2 diabetes and cardiovascular disease, with gut dysbiosis emerging as a contributing factor.
- Conditions
- Insulin Resistance, Metabolic Endotoxemia, Inflammation Biomarkers, Ketogenic Diet
- Trial name
- NCT06911879
- Testing
- Ketogenic diet with caloric restriction, Normal diet with caloric restriction, Normal diet without caloric restriction
- Where
- Jordan
- Volunteers
- 90 people
- Sponsor
- University of Jordan
Obesity, Insulin Resistance
Effects of Obesity and Intensity of Exercise on Ghrelin Levels
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin…
- Conditions
- Obesity, Insulin Resistance, Cardiovascular Risk Factor
- Trial name
- NCT04581980
- Testing
- Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
PreDiabetes
Influence of Exercise on the Gut Microbiome of Overweight and Obese Adults With Prediabetes
Purpose: The investigators propose a 20-participant randomized 2-arm parallel trial with a delayed-intervention control examining how 8 weeks of moderate-intensity walking exercise alters the gut microbiome, short chain fatty…
- Trial name
- NCT04124354
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Obesity, Prediabetic State
Lifestyle-Related Health Outcomes in Prediabetes and Diabetes
This study looks as how a health education intervention strategy effects health outcomes in overweight and obese adolescents.
- Conditions
- Obesity, Prediabetic State, Type 2 Diabetes
- Trial name
- NCT02535169
- Testing
- Health Education and Coaching Strategy, Dietary consult
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Indiana University
Prediabetes, Insulin Resistance
Pilot Study on Metabolic Effects of Fish Peptides and Vitamin D
The overall goal of this study is to investigate the effects and the mechanisms of action of a fish peptide and vitamin D on glucose metabolism, insulin secretion, and cardiometabolic risk profile in overweight men.
- Trial name
- BONITO (NCT02668159)
- Testing
- Fish peptide supplement, Vitamin D supplement, Fish peptide + Vitamin D3 supplements
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Laval University
Prediabetes
Cardiometabolic & Cognitive Effects of Peanut Butter in Prediabetes
The purpose of this study is to look at the effect of consuming peanut butter at breakfast on blood sugar control, cognitive function, and heart disease risk factors in middle-aged adults with prediabetes.
- Trial name
- NCT07714096
- Testing
- Peanut butter, Usual diet
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Penn State University
Pre Diabetes, Polycystic Ovary Syndrome
Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
There is a growing need to develop pharmacologic interventions to improve metabolic function in women with polycystic ovary syndrome (PCOS).
- Conditions
- Pre Diabetes, Polycystic Ovary Syndrome, Obesity Android
- Trial name
- SAXAPCOS (NCT03480022)
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Woman's
Type 2 Diabetes Mellitus, Prediabetic State
Antimicrobial Photodynamic Therapy in Chronic Periodontitis and Diabetes Mellitus
With this design, this study hypothesizes that; (i) ICG-PDT would produce superior clinical, microbiological, and immune-inflammatory outcomes as compared to RSD and (ii) ICG-PDT would produce equal efficacy among different forms…
- Conditions
- Type 2 Diabetes Mellitus, Prediabetic State, Chronic Periodontitis
- Trial name
- NCT04857346
- Testing
- Indocyanine green
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Saud University
PreDiabetes
Effect of the SCL16A11 Risk Haplotype on Treatments to Prevent Type 2 Diabetes
The goal of this randomized clinical trial is to determine the impact of the risk haplotype on SLC16A11 on early therapeutic responses in treatments to prevent T2D in Mexican mestizos with prediabetes.
- Trial name
- PRED2 (NCT05990205)
- Testing
- Life Style Intervention + Metformin, Life Style Intervention
- Where
- Mexico
- Volunteers
- 437 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Obesity; Endocrine, Diabete Type 2
Molecular, Metabolomic and Nutritional Changes After Metabolic Surgery
Obesity is a major risk factor for Type 2 Diabetes (T2D) and cardiovascular diseases, such as hypertension and dyslipidemia. Recently, weight loss surgery (i.e., metabolic or bariatric surgery) has been shown to result in very…
- Conditions
- Obesity; Endocrine, Diabete Type 2, PreDiabetes
- Trial name
- MoMen (NCT05322551)
- Where
- Malaysia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Malaysia
Obesity, Overweight
Smart Technology for Weight Loss and Metabolic Health
The study will evaluate whether a technology-based lifestyle intervention program using primarily a smartphone platform is an acceptable and effective way for treating obesity.
- Conditions
- Obesity, Overweight, Prediabetes, Weight Loss
- Trial name
- NCT02742662
- Testing
- Wearable technology, smartscale, Smartphone applications, Standard Weight Management Visits
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Temple University