Clinical trials: Pre-diabetic State
Gum Disease, Prediabetes
Improving Oral and Systemic Health in Individuals With Prediabetes Through Personalized Oral Hygiene Advice Provided by Dentists or by AI
Prediabetes is an intermediate stage before the development of diabetes, characterized by elevated blood glucose levels but lower than the diagnostic criteria of diabetes and is associated with multiple long-term complications.
- Trial name
- NCT06980701
- Testing
- AI OHI group, Dental professionals OHI group
- Where
- Hong Kong
- Volunteers
- 148 people
- Sponsor
- The University of Hong Kong
Obesity, PreDiabetes
Mechanisms of Inflammation, Immunity, Islet Cell and Intestinal Hormone Changes in Youth at Risk for Diabetes
This study intends to assess the role of inflammation in insulin resistant conditions (i.e., obesity and pre-diabetes) and the subsequent development of disease, such as type 2 diabetes (T2D) and cardiovascular disease (CVD), in…
- Conditions
- Obesity, PreDiabetes, Adolescent Obesity, Inflammation
- Trial name
- MI4D (NCT04031222)
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- The Hospital for Sick Children
PreDiabetes, Impaired Glucose Tolerance
Almonds and Health Effects on Metabolism, Vascular Function and Cognition
The primary objective of the proposed study is to examine and understand the impact of long-term almond consumption on chronic glucose metabolism in subjects with impaired glucose tolerance and/or impaired fasting glucose.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Impaired Fasting Glucose, Overweight and Obesity
- Trial name
- NCT03419702
- Testing
- Almonds
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Maastricht University Medical Center
Elevated Body Mass Index
Effect of LIK066 on Body Weight in Patients With Elevated Body Mass Index
A 12-week study to assess LIK066 effect on body weight in diabetics, prediabetics and normoglycemic patients with elevated body mass index (BMI)
- Trial name
- NCT02470403
- Testing
- LIK066
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance (Prediabetes)
Exercise Training and Glucose Metabolism in Aging
Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are…
- Trial name
- NCT00701051
- Testing
- Aerobic exercise training, Detraining (cessation of exercise)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
PreDiabetes, Overweight
Night Owl Metabolism
The proposed study uses a novel and rigorous randomized cross-over study design in youth (18-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test…
- Conditions
- PreDiabetes, Overweight, Impaired Glucose Tolerance
- Trial name
- NCT06507722
- Testing
- Timing of OGTT, Timing of Standardized Meal
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 2 Diabetes Mellitus (T2DM), Chronic Pancreatitis
Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes Pathophysiology
The EXPAND study is a prospective observational study designed to investigate the biological mechanisms underlying the heterogeneity of type 2 diabetes and related metabolic disorders.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Chronic Pancreatitis, Prediabetes, Pancreatic Neoplasms
- Trial name
- EXPAND (NCT07670871)
- Volunteers
- 440 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
PreDiabetes, Obesity
Intermittent Eating on Glucose Homeostasis in Prediabetes
Prediabetes is a high-risk state for diabetes development, lifestyle modification is the cornerstone of diabetes prevention. Two novel types of intermittent fasting recently have received more attention: the 5:2 diet and…
- Trial name
- NCT05717387
- Testing
- Time-restricted eating, The 5:2 diet
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Schizophrenia, PreDiabetes
Bromocriptine for Patients With Schizophrenia and Prediabetes
This is a multicenter open-label, pilot study to evaluate the safety and tolerability of bromocriptine, a dopamine D2/D3 receptor and serotonin 5-HT2C receptor agonist, as an adjunct to preexisting standard-of-care antipsychotic…
- Trial name
- NCT03575000
- Testing
- Bromocriptine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Pittsburgh Healthcare System
Obesity, Diabetes Mellitus, Type 2
Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology
The primary aim is to test the effectiveness of an innovative 24-month pragmatic and scalable weight-loss centric approach using a collaborative care model that connects patients with a non-Primary Care Practitioner (PCP) health…
- Conditions
- Obesity, Diabetes Mellitus, Type 2, PreDiabetes
- Trial name
- PROPEL-IT (NCT05523375)
- Testing
- Intensive Lifestyle Intervention
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Pennington Biomedical Research Center
Diabetes Mellitus, Type 2, Atherosclerosis
Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either T2DM or IGT Patients
This study will evaluate the effect of ACZ885 on vascular function in patients with documented atherosclerotic disease and T2DM or IGT.
- Conditions
- Diabetes Mellitus, Type 2, Atherosclerosis, Prediabetic State
- Trial name
- NCT00995930
- Testing
- ACZ885
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 189 people
- Sponsor
- Novartis Pharmaceuticals
Oxidative Stress, Healthy Aging
Efficacy of Solarplast for Health and Oxidative Stress
Solarplast is a unique mixture of antioxidant enzymes and single antioxidant molecules that are capable of attack oxidants that cause damage to the cells in the human body and cause premature aging.
- Conditions
- Oxidative Stress, Healthy Aging, Skin Health
- Trial name
- NCT04144777
- Testing
- Solarplast
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes
Diabetes, Prediabetes
The Use of CGMS to Detect Alterations of Blood Glucose in Thalassemic Patients
The aim of the study is to: Assess the pattern of glucose homeostasis in patients with B thalassemia . To detect early impairment in glucose metabolism and prediabetic state in B thalassemia patients using continuous glucose…
- Conditions
- Diabetes, Prediabetes, B-Thalassemia
- Trial name
- NCT03591900
- Testing
- insulin pump/CGMS
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Apical Periodontitis, Insulin Resistance
Serum Pro-Diabetes Inflammation Biomarkers in Patients With Apical Periodontitis.
Inflammation is a common factor of chronic periodontitis and diabetes. However, to date, there is no scientific evidence supporting a causal effect of the inflammation created by apical periodontitis on the onset of insulin…
- Conditions
- Apical Periodontitis, Insulin Resistance, PreDiabetes, Diabetes; Stable
- Trial name
- NCT04824209
- Where
- 2 sites in Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Kidney Diseases, Hypertension
Real Clinical Practice Register of AlbUminuRia Detection in Patients With Previously undiAgnosed Chronic Kidney Disease
Real clinical practice register of Albuminuria detection in patients with previously undiagnosed chronic kidney disease
- Conditions
- Chronic Kidney Diseases, Hypertension, Chronic Heart Failure, Ischemic Heart Disease
- Trial name
- AURA (NCT05690009)
- Where
- Russia
- Volunteers
- 4,580 people
- Sponsor
- Eurasian Association of Therapists
Prediabetes, Metabolic Syndrome
Evaluation of Group Lifestyle Balance DVD in Primary Care Practice
The purpose of this study is to examine different methods of delivering the Group Lifestyle Balance (GLB) intervention (1). The GLB is a 12-week lifestyle change program based on the highly successful lifestyle program that was…
- Trial name
- STEPUP (NCT00480779)
- Testing
- GLB Group, GLB DVD
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Metabolic Syndrome
A Pilot Study of a Lifestyle Intervention on the Metabolic Syndrome (3ELM Study)
Approximately 24% of the US adult population meet criteria for metabolic syndrome (MetS), diagnosed by a combination of abdominal obesity, elevated blood pressure, high triglyceride and low HDL-cholesterol level, and…
- Trial name
- 3ELM (NCT02233088)
- Testing
- ELM Group, ELM Classes, ELM Individual
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Rush University Medical Center
Prediabetic State, Diabetes Mellitus
A Mobile Phone-based Program for Adults With Prediabetes
Type 2 diabetes mellitus (T2DM) can be prevented through weight loss and increased physical activity, yet its prevalence continues to rise.
- Trial name
- NCT03025607
- Testing
- JOOL Health Mobile Phone Application
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Michigan
Prediabetic State
Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes (NMR-based Metabonomics)
This study evaluates the efficacy of a 12-month resistance training on metabolic control and reducing the risk of diabetes.
- Trial name
- NCT02561377
- Testing
- resistance training, aerobic training
- Where
- 2 sites in China
- Volunteers
- 276 people
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Prediabetes
Effect of the Extract of the Flour Fermented With Bacillus Subtilis Var Natto DC-15 on Postprandial Glucose
The purpose of the present study is to evaluate the effect of the extract of the flour fermented with Bacillus subtilis var natto DC-15 on postprandial glucose level in subjects with prediabetes.
- Trial name
- NCT02300181
- Testing
- Bacillus subtilis var natto DC-15
- Where
- Japan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hiroshima University