Clinical trials: Pre-diabetic State
Cystic Fibrosis, Prediabetes
Prevention of Cystic Fibrosis Diabetes
Acute systemic hyperglycemia causes oxidative stress and a pro-inflammatory response. The pro-inflammatory cytokines induced by hyperglycemia are toxic to islet insulin producing cells, and thus worsen glucose intolerance.
- Trial name
- Prevent (NCT00967798)
- Testing
- Sitagliptin
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Emory University
PreDiabetes
Investigation of Nutrilite Glucose Health Herbal Drink on Prediabetes Persons
The goal of this two arms, randomized, double-blind controlled trial is to study whether Nutrilite herbal drink could ameliorate blood glucose level in prediabetes population.
- Trial name
- NCT07690735
- Testing
- Nutrilite Glucose health herbal drink
- Where
- China
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Amway (China) R&D Center
Prediabetes, Lipid Profile
How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes
The goal of this clinical trial is to is to determine the effects of baked potato with the skin (BP) + nutrition education focused on adherence for a Mediterranean Dietary Pattern (MEDNE) on glycemic control, cardiometabolic…
- Conditions
- Prediabetes, Lipid Profile, Hypertension, Glycemic Control
- Trial name
- MEDPOT-PREDM (NCT06817252)
- Testing
- Mediterranean Diet Nutrition Education, Mediterranean Diet Nutrition Education with Baked White Potato
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Nevada, Las Vegas
Metabolic Syndrome, Overweight or Obesity
Impact of Time-Restricted Eating on Metabolic Homeostasis, Inflammation and Oxidative Stress in Metabolic Syndrome
The main purpose of the clinical trial is to determine the health impact of a dietary intervention known as time-restricted eating (TRE) in patients with metabolic syndrome (defined as the presence of elevated fasting plasma…
- Conditions
- Metabolic Syndrome, Overweight or Obesity, PreDiabetes, Weight Loss
- Trial name
- TREMNIOS (NCT04328233)
- Testing
- Time-Restricted Eating
- Where
- Poland
- Volunteers
- 27 people
- Sponsor
- Nicolaus Copernicus University
Obese Impaired Glucose Tolerance, Newly Diagnosed Obese Type 2 Diabetic Patients
Characterization and Mechanism Research of the Pre-disease State of Obese Type 2 Diabetes Mellitus
Establish a comprehensive evaluation system for the progression of obese impaired glucose tolerance (IGT) to type 2 diabetes mellitus (T2DM) through cross-sectional studies; Constructing and validating a T2DM risk prediction…
- Trial name
- NCT06495814
- Testing
- 1/bag of Jinlida granules, 3 times/day, taken with hot water.
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Fengmei Lian
Diabetes, Prediabetes
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
Vegetarian diets have been associated with a reduced risk of preventable diseases such as type 2 diabetes and cardiovascular disease. These effects may be mediated through direct or indirect pathways.
- Conditions
- Diabetes, Prediabetes, Metabolic Syndrome, Dysglycemia
- Trial name
- NCT02037321
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Type 2 Diabetes, PreDiabetes
Digital Lifestyle Intervention For Diabetes/Pre-Diabetes
The study aims to evaluate the acceptability, feasibility, and preliminary efficacy of a digital lifestyle intervention, called Fitness Digital (FitD), for individuals with prediabetes or type 2 diabetes.
- Conditions
- Type 2 Diabetes, PreDiabetes, Obesity
- Trial name
- NCT05247437
- Testing
- Digital Intensive Lifestyle Intervention, Digital Self-Help Control Condition
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong
Metabolism Disorder, Lipid, Metabolism Disorder, Glucose
Compare the Impact of Xuezhikang and Atorvastatin on Glucose Metabolism in Dyslipidemia Patients With Prediabetes
This study is a prospective, randomized, open-label, multi-center trial. The primary objective of the study is to assess whether XZK 1200mg/d, compared to atorvastatin 20mg/d, has a favorable impact on HbA1c levels at 24 weeks of…
- Trial name
- XTREME (NCT05238012)
- Testing
- Xuezhikang Capsule, Atorvastatin Calcium Tablets
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Heart Health Research Center
Prediabetes
INcreasing Veteran EngagemeNT to Prevent Diabetes (INVENT)
This study will evaluate a VA MyHealtheVet Secure Messaging intervention that uses different intervention messaging strategies designed to increase engagement in behaviors to prevent type 2 diabetes.
- Trial name
- INVENT (NCT03403231)
- Testing
- INVENT Secure Messaging Intervention
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Prediabetes, Type 2 Diabetes
Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and Diabetes
The objective of this study is to investigate the impact of hypocaloric time-restricted eating (TRE) at different day times (early versus late TRE) on glucose metabolism and other cardiometabolic parameters in individuals with…
- Conditions
- Prediabetes, Type 2 Diabetes, Obesity &Amp; Overweight
- Trial name
- GLYCOTIME (NCT07171281)
- Testing
- Early Time-Restricted Eating, Late Time-Restricted Eating
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Prediabetic State, Impaired Fasting Glucose
Evaluation of the Safety and Efficacy of SGLT2 Inhibitors in Pre-diabetic Patients
Pre-diabetes is a state characterized by subclinical impairment in glycemic variables that is intermediate between normal glucose tolerance (NGT) and diabetes.
- Conditions
- Prediabetic State, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT05914857
- Testing
- Dapagliflozin 10mg Tab, lifestyle interventions
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Yangjin
Prediabetes
Prospective Observational Study Assessing Treatment and Outcomes of Patients With Prediabetes
The purpose of this observational study is to assess the treatment and outcomes of patients with prediabetes in community-based clinical practices.
- Trial name
- NCT01869101
- Volunteers
- 560 people
- Sponsor
- Tethys Bioscience, Inc.
PreDiabetes, Obesity
Tolerability, Acceptance, and Utility of Intermittent CGM Use in Youth With Prediabetes
We are evaluating whether intermittent use of continuous glucose monitors (CGMs) in addition to standard nutritional counseling and physical activity counseling is associated with improved metabolic health for youth with…
- Conditions
- PreDiabetes, Obesity, Insulin Resistance
- Trial name
- NCT05505565
- Testing
- Abbott Freestyle Libre 2, Standard physical activity and nutritional counseling for prediabetes management
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Alabama at Birmingham
Prediabetes, Impaired Glucose Tolerance
Step Up For Health Study: A Pedometer and Website Intervention in Those With Prediabetes
This study will examine whether a physical activity program, specifically increasing walking steps, offered over the internet is able to increase physical activity in adults with prediabetes.
- Trial name
- NCT05412264
- Testing
- Website intervention
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Newly Diagnosed Type 1 and Type 2 Diabetes and Prediabetes
A Prospective Cohort Study for Establishing Clinical Excellence in Patients With Newly Diagnosed Type 1 and Type 2 Diabetes and Prediabetes
Diabetes mellitus is recognized as a metabolic disease that causes global economic and health burdens with an estimated number of patients 135 million in 1995 to 300 million in 2025.
- Trial name
- NCT05401708
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Yonsei University
PreDiabetes
Precision Medicine for Preventing Type 2 Diabetes: a Step Forward
The prevalence of type 2 diabetes (T2D) has been rising rapidly with an increased burden to the healthcare system. As such T2D prevention is highly recommendable, and, theoretically, it can definitely be successful.
- Trial name
- PRE-MED2 (NCT05147961)
- Testing
- Digital Health, Standard care
- Where
- 2 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Prediabetes, Brain Insulin Sensitivity
Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with…
- Conditions
- Prediabetes, Brain Insulin Sensitivity, Cerebral Blood Flow, Satiety and Food Intake
- Trial name
- NCT07752225
- Testing
- Avocados
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Maastricht University Medical Center
Pre Diabetes
Asian Indian Prediabetes Study
Compared to other races, Indians have higher insulin resistance, poorer pancreatic function and a greater risk of developing diabetes, highlighting the importance of early strategies for improving insulin sensitivity and…
- Trial name
- AIPS (NCT04507685)
- Testing
- Lifestyle (Diet and Exercise)
- Where
- Singapore
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Dietary Habits
Study to Investigate the Effect of Dietary Fibre Supplementation on Long-term Glucose Control in Prediabetic Subjects
The purpose of the study is to explore the potential metabolic health benefits of a dietary fibre intervention by using Soluble Fibre in a human intervention study in Healthy Obese Pre-diabetic participants over a period of 16…
- Trial name
- NCT05157815
- Testing
- Soluble Fibre, Calorie Matched Control
- Where
- Ireland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Tate & Lyle
PreDiabetes, Insulin Resistance
Brown Seaweed Extract on Glycemic Control and Body Weight
The overall goal of this study is to investigate the effects of a daily dietary supplement of brown seaweed (2 capsules of InSea2®) on body weight, glycemic control and insulin secretion in overweight prediabetic men and women in…
- Trial name
- Algues (NCT03075943)
- Testing
- InSea2
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Laval University