Clinical trials: Pre-diabetic State
Prediabetes
Cocoa and Metabolic Health in Prediabetes
The purpose of this study is to determine the impact of consuming cocoa on blood glucose levels, glucose metabolism, and other markers of pre-diabetes in overweight and/or obese individuals.
- Trial name
- NCT02203240
- Testing
- Cocoa
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Polytechnic Institute and State University
Cardiometabolic Syndrome, Obesity and Cardiovascular Risk
Lifestyle Changes, Mushroom Supplementation, and Bupropion to Reduce Adiposity and Cardiometabolic Risk
The increasing prevalence of obesity, its serious health consequences, and the substantial economic burden on healthcare systems underscore a pressing need for effective, long-term prevention strategies that can be implemented in…
- Conditions
- Cardiometabolic Syndrome, Obesity and Cardiovascular Risk, Overweight , Obesity
- Trial name
- NCT07806279
- Testing
- Bupropion 150 mg, Lyophilized powder from edible mushrooms, Lifestyle Management
- Where
- 3 sites in Sweden
- Volunteers
- 250 people
- Sponsor
- Uppsala University
Impaired Glucose Tolerance, Prediabetic State
Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance
The purpose of this study is to determine whether cardiovascular disease (CVD) risk markers, β-cell function, and insulin sensitivity can be improved by targeting mechanisms of both diabetes and CVD - using an antioxidant, an…
- Trial name
- NCT00122447
- Testing
- Aspirin, Alpha lipoic acid, Olmesartan
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Prediabetes
Evaluation of Chiglitazar Sodium With Lifestyle Intervention for Reversing Prediabetes
This multicenter, randomized, double-blind, placebo-controlled trial aims to evaluate the efficacy and safety of Chiglitazar Sodium combined with lifestyle intervention for reversing prediabetes to normal glucose metabolism.
- Trial name
- NCT07558525
- Testing
- Chiglitazar sodium
- Where
- 30 sites in China
- Volunteers
- 472 people
- Sponsor
- Second Xiangya Hospital of Central South University
PreDiabetes
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
This project uses both transcriptomic- and genomic-level data to identify mechanisms of individual responses to glucagon-like peptide-1 (GLP-1) in Mexican-Americans with prediabetes.
- Trial name
- NCT05119179
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The University of Texas Health Science Center, Houston
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Assessing the Impact of a Plant-Based Diet for Diabetes Prevention
The primary purpose of this study is to determine the sex-specific metabolic and molecular response, among adults with prediabetes, when moving from a Western Diet to plant-based diet.
- Trial name
- NCT06571279
- Testing
- Plant-based diet
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Jean L. Fry
PreDiabetes, Metabolic Syndrome
Strawberries and Risk of Diabetes in Adults
Strawberries can be categorized as a functional food based on results from several clinical trials in improving cardiometabolic health beyond providing nutrition.
- Trial name
- NCT05362968
- Testing
- Freeze-dried strawberry powder
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Prediabetes
Effects of Blueberry Dry Powder on Glycemic Status in Subjects With Prediabetes
The purpose of the present study is to evaluate the effect of blueberry dry powder on glycemic status (fasting plasma glucose, 2h glucose concentration after the oral glucose tolerance test (OGTT), or HbA1c) in subjects with…
- Trial name
- NCT02023320
- Testing
- Low dose of blueberry dry powder, High dose of blueberry dry powder
- Where
- Japan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Prediabetic State, Metabolic Syndrome
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects
The aim of this prospective interventional study is to investigate the metabolic effects of consuming artificial and natural sweeteners in persons with prediabetes.
- Conditions
- Prediabetic State, Metabolic Syndrome, Insulin Resistance, Thrombosis
- Trial name
- Sweetheart (NCT07377097)
- Testing
- Saccharin, Sucralose, Erythritol
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
PreDiabetes, Obesity
Effect of Nutritional Supplements on Clinical Outcomes in Patients With Prediabetes and Obesity
This study aims to improve blood glucose and weight in patients with prediabetes and obesity through health education, nutritional supplement interventions, clinical evaluation, and close clinical follow-up.100 patients with…
- Trial name
- NCT05273840
- Testing
- Ivital Control, lifestyle intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ningbo No. 1 Hospital
PreDiabetes
Shanghai Community Prediabetes Standardized Management Project
Participants with prediabetes is the key targets for diabetes prevention. So, in order to further strengthen and standardize the management of participants with prediabetes in the communities, the investigators start this project…
- Trial name
- NCT04256460
- Testing
- Healthy diet, regular exercises and peer support
- Where
- 53 sites in China
- Volunteers
- 2,500 people
- Sponsor
- Shanghai 6th People's Hospital
Obesity, Insulin Resistance
Effects of Obesity and Intensity of Exercise on Ghrelin Levels
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin…
- Conditions
- Obesity, Insulin Resistance, Cardiovascular Risk Factor
- Trial name
- NCT04581980
- Testing
- Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Obesity, Cardiovascular Risk Factor
Coordinating Pragmatic Primary Care Population Management for Obesity
The C3PO pilot and feasibility study uses a rigorous, mixed-method research design to provide information needed to refine and implement a technology-mediated primary care outreach intervention approach before conducting a larger…
- Trial name
- C3PO (NCT03998046)
- Testing
- Outreach Support for Weight Loss Goal Setting and Self-Weighing, Outreach Decision Support to Encourage Linkages to Intensive Community Lifestyle Interventions, Adaptive Tailoring of Information Delivery and Intensity of Primary Care Outreach Support
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Prediabetic State
Effects of Clinical Pilates Exercises on Glycemic Control, Blood Lipids and Physical Fitness Parameters in Prediabetes
To examine the effects of clinical pilates exercise on glycemic control, blood lipids and physical fitness parameters in prediabetics.
- Trial name
- NCT06452940
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Eastern Mediterranean University
PreDiabetes, Overweight and Obesity
Effect of Dairy Product Matrices on Insulin Resistance in People with Overweight and Obesity and Prediabetes
The objective of the study is to determine the effect of dairy product matrices on insulin sensitivity in overweight and obese adults with prediabetes. Females and males (30-65 y) will be recruited from the greater Montreal area.
- Trial name
- NCT06322940
- Testing
- 250 mL serving size, 3.25% fat content, 175 g serving size, ≥2% fat content, 50 g serving size, ≥28% fat content
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Overweight, Obesity
Effects of Obex in Overweight and Obese Patients
Obesity is an important and growing public health worldwide Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer An extensive body of evidence from efficacy trials has…
- Trial name
- NCT02145442
- Testing
- Obex
- Where
- Cuba
- Volunteers
- 40 people
- Sponsor
- Catalysis SL
Isolated Impaired Fasting Glucose
HIIT in Isolated IFG: A Proof-of-Concept Study
This pilot randomized controlled trial will involve 34 physically inactive adults aged 35-65 years with overweight or obesity and isolated impaired fasting glucose (i-IFG).
- Trial name
- NCT06143345
- Testing
- High-intensity interval training and eucaloric diet, No intense physical activity and eucaloric diet, Continuous glucose monitoring (CGM) (Dexcom G6 Pro CGM sensor)
- Sponsor
- Emory University
Overweight and Obesity, PreDiabetes
Clinical Effectiveness of Body Fat Distribution Imaging in Real-World Practice: The BODY-REAL Study
The overall goal is to determine the real-world feasibility and utility of body fat imaging using rapid MRI to enhance risk perception, induce behavioral change, and improve clinical outcomes in overweight and obese individuals.
- Conditions
- Overweight and Obesity, PreDiabetes, Type 2 Diabetes, Cardiovascular Risk Factor
- Trial name
- BODY-REAL (NCT04763772)
- Testing
- Body Fat Distribution Imaging Report, Basic Weight Information, Patient Provided
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University Hospitals Cleveland Medical Center
PreDiabetes, NAFLD
Effects of Almonds in Glucose-intolerant Adults (AGAMEMNON)
Tree nuts - such as almonds - contribute to beneficial effects of the Mediterranean diet on risk for cardiovascular events, type 2 diabetes, dyslipidemia, hypertension, inflammation and non-alcoholic fatty liver disease.
- Trial name
- AGAMEMNON (NCT06413069)
- Testing
- Raw whole almonds
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
Sense of Coherence, Salutogenesis
Resources-Oriented Salutogenic (ROS) Intervention for Pre-diabetes
This pilot randomized control trial (RCT) is to assess whether the newly developed resources-oriented intervention is feasible and acceptable to people with pre-diabetes and has preliminary efficacy on sense of coherence (SoC).
- Conditions
- Sense of Coherence, Salutogenesis, PreDiabetes
- Trial name
- ROS (NCT06515119)
- Testing
- Resources-Oriented Salutogenic (ROS) intervention
- Where
- Hong Kong
- Volunteers
- 66 people
- Sponsor
- The Hong Kong Polytechnic University