Clinical trials: Pre-diabetic State
Prediabetes
Interdisciplinary and Family Intervention to Prevent Type 2 Diabetes
The purpose of the study is to evaluate the effect of a family and interdisciplinary approach on individual and family insulin resistance and insulin secretion in patients with prediabetes.
- Trial name
- CARE-in-DEEP (NCT02635646)
- Testing
- Family and interdisciplinary approach, individual approach
- Where
- Mexico
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universidad de Guanajuato
Cardiac Disease, PreDiabetes
Effectiveness of Continuous Glucose Monitoring System Among Cardiac Surgery Patients
The aim of this study is to assess the level of glycemic control and the incidence of surgery-related complications in cardiac patients post-surgery when Continuous Glucose Monitoring (CGM) is utilized, as compared to traditional…
- Conditions
- Cardiac Disease, PreDiabetes, Diabetes Mellitus
- Trial name
- NCT06275971
- Testing
- Dexcom G6, SMBG or venous/arterial blood glucose
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Kangbuk Samsung Hospital
Prediabetes
Effects of Aerobic Exercise in Patients With Pre-diabetes
It is well known that diabetes and excessive or high blood sugars causes blood vessel and blood cell damage. It is also possible, then, that people with pre-diabetes may also start to have blood vessel and blood cell damage as…
- Trial name
- NCT01860599
- Testing
- Exercise, Without exercise
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baystate Medical Center
PreDiabetes
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
We recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1.
- Trial name
- NCT06967558
- Testing
- Exendin 9-39, Saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prediabetes
Returning to Normoglycemia With Targeted Use of Real-time CGM Data and Nutrition-focused Lifestyle Changes
The purpose of the ReTURN study is to understand how glycemia, specifically percent of time above 140 mg/dL (TA140), changes over time in people who are randomized to receive either continuous glucose monitoring (CGM)-guided care…
- Trial name
- RETURN (NCT07832474)
- Testing
- CGM-guided care
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- HealthPartners Institute
Prediabetes, Brain Insulin Sensitivity
Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with…
- Conditions
- Prediabetes, Brain Insulin Sensitivity, Cerebral Blood Flow, Satiety and Food Intake
- Trial name
- NCT07752225
- Testing
- Avocados
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Maastricht University Medical Center
PreDiabetes, Diabetes
New Diabetes Mellitus and Pre-Diabetes With First-time Diagnosed Coronary Artery Disease
A prospective analytic study to evaluate the incidence, clinical and laboratory characteristics, extent of coronary artery disease and short-term outcome of newly diagnosed diabetes and pre-diabetes in patients with first-time…
- Conditions
- PreDiabetes, Diabetes, Coronary Artery Disease
- Trial name
- DMCAD (NCT05208424)
- Testing
- Coronary angiography
- Where
- Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- Saud Al Babtain Cardiac Center
PreDiabetes, Diabetes Mellitus, Type 2
Metabolic and Inflammatory Outcomes of the Ketogenic Diet Comparing Saturated and Unsaturated Fat Sources
The goal of this clinical trial is to compare a healthy KETO diet supplemented with canola oil (KETO-Can) compared to a traditional KETO diet high in saturated fat (KETO-Sat) and low-fat diet (LFD) in adults at high risk of or…
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Overweight and Obesity
- Trial name
- KETO-IM (NCT05681468)
- Testing
- Keto-SAT, Keto-CAN, LFD
- Where
- Canada
- Volunteers
- 164 people
- Sponsor
- University of Alberta
Type 2 Diabetes, PreDiabetes
Butyrate-enriched Triglyceride and Diabetes Prevention
A body of animal studies as well as observational studies in humans demonstrated that butyrate is one SCFA that has pronounced positive effects on body weight control, inflammation, and insulin resistance.
- Conditions
- Type 2 Diabetes, PreDiabetes, Obesity
- Trial name
- NCT06384313
- Testing
- butyrate/hexanoate-enriched triglycerides
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metabolic Syndrome, Overweight and Obesity
The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
Strategies to reduce sugar-sweetened beverages (SSB) have become one of the leading public health targets to address the epidemics of obesity and diabetes.
- Conditions
- Metabolic Syndrome, Overweight and Obesity, PreDiabetes, Diabetes
- Trial name
- NCT05191160
- Testing
- Soy Milk, Cow's Milk, Sugar Sweetened Beverages
- Where
- Canada
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Prediabetes, Impaired Fasting Glucose
Effect of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes
Pre diabetes (PD) is a term that refers to alterations in glucose homeostasis, including impaired fasting glucose (IFG), Imparied glucose tolerance (IGT) or both, involving a higher risk to develop type 2 diabetes mellitus (T2DM)…
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT03029390
- Testing
- Berberine, Metformin
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- University of Guadalajara
Obesity, Prediabetes
ADRB3 Signaling Pathway in Human Adipose Tissue
This study will examine the gene expression of the adrenergic Beta-3 receptor (ADRB3) regulation in human subcutaneous adipose tissue before and after treatment with mirabegron, an ADRB3 agonist.
- Trial name
- NCT05634174
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
PreDiabetes, Obesity
Promotora-Led Intervention for Metabolic and Mental Health
Evidence-based programs to prevent diabetes among high-risk individuals are less effective among those who also have mental health needs.
- Conditions
- PreDiabetes, Obesity, Metabolic Disease, Body Weight Changes
- Trial name
- PRIME2 (NCT03372018)
- Testing
- Promotora-led Intervention (PLI), Usual care (UC)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
PreDiabetes
Insulin Modelling Based on Plasma Glucose Measures Via a Minimally-Invasive Glucose Sensor
The study aims to evaluate insulin as a potential biomarker for prediabetes in Singapore Chinese subjects.
- Trial name
- NCT06119035
- Testing
- Single dose of 75 grams glucose in 200ml water
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Overweight , Obesity, Prediabetes
Smartwatch-based Intervention for Cardiovascular Health (SWITCH)
This study aims to employ a cluster randomized controlled trial to evaluate the effectiveness of an mHealth-Based Multi-faceted Cardiovascular Health Intervention Model among metabolically at-risk people with overweight/obesity…
- Conditions
- Overweight , Obesity, Prediabetes, High-normal Blood Pressure, Borderline Elevated Blood Lipids
- Trial name
- NCT07372729
- Testing
- Smartwatch-Based Multi-Faceted Behavioral Intervention Model Led by Exercise and Dietary Interventions, Supported by Primary Medical Staff, Along with the Distribution of Health Education Manuals, Face-to-face health education sessions
- Where
- 3 sites in China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Prediabetes, Exercise
Optimization of Exercise Protocol for Prediabetic Population in Postprandial State
The core purpose of the project is to find out optimal exercise protocol for control of hyperglycemia and insulin resistance in prediabetic.
- Conditions
- Prediabetes, Exercise, Blood Glucose Profile, Lipid Profile
- Trial name
- NCT06656377
- Testing
- exercise intervention
- Where
- Pakistan
- Volunteers
- 25 people
- Sponsor
- Khyber Medical University Peshawar
PreDiabetes
Impact of Alpha-Lipoic Acid Ingestion on Glucose Tolerance in Subjects With Pre-Diabetes
Obesity, with a prevalence of over 35% in American adults, is considered the most critical threat to the health and well-being of Americans.
- Trial name
- NCT03612037
- Testing
- alpha lipoic acid, Cellulose
- Volunteers
- 12 people
- Sponsor
- State University of New York at Buffalo
Type 2 Diabetes, Prediabetes
Effects of an Amino Acid and Chromium-picolinate Containing Drink on Glucose Metabolism
It has previously been shown in healthy overweight subjects, that table water including a defined amount of amino acids and chromium can decrease the postprandial glucose and insulin response.
- Trial name
- NCT02235194
- Testing
- Amino Acid and chromium-picolinate containing drink
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Stoffwechselzentrum Rhein - Pfalz
Insulin Resistance, Prediabetic State
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.
This study is being done to understand metformin's mechanisms of action regarding glucose production, protein metabolism, and mitochondrial function.
- Trial name
- NCT01956929
- Testing
- Metformin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prediabetes
Safety and Dose-Response of Bletilla Formosana in Prediabetic Subjects
This study evaluates the safety and preliminary efficacy of Bletilla formosana (BF), a traditional herbal medicine, in adults with prediabetes.
- Trial name
- NCT07704944
- Testing
- Bletilla formosana (BF) powder
- Where
- 3 sites in Taiwan
- Volunteers
- 94 people
- Sponsor
- Chang Gung Memorial Hospital