Clinical trials: Pre-diabetic State
PreDiabetes, Acute Myocardial Infarction
Metformin and Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Prediabetes (MIMET)
Prediabetes is associated to an increased risk of cardiovascular disease and mortality. Although metformin can delay progression to diabetes there is a lack of RCTs evaluating the effect of metformin on cardiovascular outcomes.
- Conditions
- PreDiabetes, Acute Myocardial Infarction, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- MIMET (NCT05182970)
- Testing
- Metformin
- Where
- Sweden
- Volunteers
- 5,160 people
- Sponsor
- Karolinska Institutet
PreDiabetes, Prediabetic State
Small Steps for Big Changes - Recipe for Health
The purpose of this study is to evaluate changes in HbA1c levels, diet, weight and waist circumference in Small Steps for Big Changes (SSBC) diabetes prevention program participants two year after program completion compared to…
- Trial name
- RFH (NCT05962983)
- Testing
- Small Steps for Big Changes Program
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University of British Columbia
Diabetes Mellitus, Cigarette Smoking
The Effectiveness of Smoking Cessation in Prediabetic Smokers
Existing literature investigating the impact of smoking cessation on new-onset diabetes mellitus (DM) risk is conflicting. Combing the need for smoking cessation and body weight self-management to prevent the progression of…
- Conditions
- Diabetes Mellitus, Cigarette Smoking, Prediabetes
- Trial name
- NCT01926041
- Testing
- Varenicline for tobacco smoking cessation, Individualized counseling about both smoking cessation and weight control techniques
- Where
- Taiwan
- Volunteers
- 589 people
- Sponsor
- National Taiwan University Hospital
Healthy
Efficacy of Different Doses of Amino Acids in 5AA+CrPic Water on Glucose Homeostasis in a Healthy Population.
It has previously been shown that a carbonated water including a defined amount of amino acids and chromium can decrease the postprandial glucose response.
- Trial name
- NCT03411395
- Testing
- 5AA+CrPic Water
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- DoubleGood AB
PreDiabetes, Glucose Tolerance Impaired
A Study to Evaluate Efficacy and Safety of Distal Jejunal-release Dextrose Beads Formulation in Subjects With a Pathological Oral Glucose Tolerance Test
The primary purpose of the study is to evaluate the efficacy and safety of APHD-012 (distal jejunal-release dextrose [Aphaia technology, AT]) in participants with pre-diabetes (pathological Oral Glucose Tolerance Test (OGTT)).
- Trial name
- NCT05803772
- Testing
- APHD-012, APH-012P
- Where
- 3 sites in Slovakia
- Volunteers
- 31 people
- Sponsor
- Aphaia Pharma US LLC
Coronary Artery Disease, PreDiabetes
Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes
The purpose of the study is to compare the anti-atherosclerotic efficacy of oral treatment with a GLP-1 analogue (semaglutide) or an SGLT-2 (so-called "flozin") inhibitor (dapagliflozin) versus routine treatment (metformin) in…
- Trial name
- CASCADES (NCT07254572)
- Testing
- Semaglutide 14 MG [Rybelsus], Dapagliflozin (Forxiga), Metformin
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Prediabetes, Prediabetic State
Feasibility and Preliminary Effects of Fasting-Mimicking Diet in Asian Americans With Prediabetes
This is a pilot study to determine the feasibility of studying the Fasting-Mimicking Diet (FMD), a dietary approach that involves the consumption of a specifically formulated, calorie-restricted nutrition regimen with a…
- Trial name
- NCT06518798
- Testing
- Fasting Mimicking Diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Irvine
Prediabetes
Effect of Science Research Wellness Ndo1 on Glycaemia in Adults With Pre-diabetes
The objective of this study is to test the effect of 12 weeks of supplementation SRW Ndo1 on metabolic health and general health in adults with prediabetes.
- Trial name
- NCT06897462
- Testing
- SRW Ndo1
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wellizen Australia
Obesity, Prediabetic State
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.
The study aims to investigate the effects of oral inositols on insulin-resistance and metabolic variables (triglycerides, total cholesterol, HDL cholesterol) in children aged 8-12 years with obesity and insulin-resistance.
- Conditions
- Obesity, Prediabetic State, Dyslipidemias, Insulin Resistance
- Trial name
- ONIRICO (NCT05701813)
- Testing
- INOSITOLS, CELLULOSE
- Volunteers
- 56 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Prediabetic State
Instrument Development of Screening Prediabetes Patients
It will be more effective if we can work on the primary prevention for the high risk groups of diabetes and prediabetes such as the early detection.
- Trial name
- NCT00308646
- Volunteers
- 3,000 people
- Sponsor
- China Medical University Hospital
PreDiabetes
Influence of Social Determinants on Lifestyle Modification Adherence in People With Prediabetes
A sequential explanatory mixed-methods study analyzing the influence of social determinants on adherence to healthy lifestyle recommendations in individuals with prediabetes.
- Trial name
- NCT06488677
- Testing
- Lifestyle changes (diet and physical activity)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of the Balearic Islands
PreDiabetes
Study to Determine the Effect of Synbiotics in Patients With Pre-diabetes
The aim of this study is to examine the effect of Metabolic Rheostat™ and Butyrate Ultra on blood glucose levels after a liquid meal challenge in patients with prediabetes.
- Trial name
- Rheostat (NCT04428606)
- Testing
- Metabolic Rheostat, Butyrate Ultra
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhaoping Li
PreDiabetes
The Effect of Lifestyle Modification on the Risk of Prediabetes Among Patients Attending Outpatient Clinic.
Diabetes mellitus is a major global health challenge, with type 2 diabetes (T2DM) accounting for nearly 90% of all cases worldwide.
- Trial name
- NCT07462078
- Testing
- Lifestyle modification
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Prediabetic State
Effects of TCM on Beta-cell Function and Insulin Resistance in High Risk Chinese Individuals for T2D (TCM_PDiab_P01)
This study involves prediabetes volunteers who are at high risk of developing diabetes, including those with family history of diabetes, metabolic syndrome, fatty liver, polycystic ovary syndrome and history of gestational…
- Trial name
- NCT04441216
- Testing
- Rhizoma Coptidis, Radix Astragali and Flos Lonicerae, Rhizoma Coptidis, Radix Astragali and Flos Lonicerae, Ophiopogonis Radix
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Diabetes, PreDiabetes
Study of Diabetes' Risk Factors and Accelerated Aging According to Socio-economic Status in a Population From the North of France
Populations in precarious situations or with low socio-economic status have an increased risk of diabetes and accelerated aging.
- Trial name
- PREVENDIAB (NCT05717491)
- Testing
- Biological analysis, Physical examination and Questionnaires, Physical examination and Questionnaires
- Where
- France
- Volunteers
- 2,014 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Prediabetes, Type 2 Diabetes (T2DM)
Vitamin D and Type 2 Diabetes - Treat-To-Target
This study tests whether taking a weekly dose of vitamin D, with the dose adjusted to reach a target blood vitamin D level, can help control blood sugar levels in adults at high risk of developing type 2 diabetes (prediabetes).
- Trial name
- D2d-TTT (NCT07448974)
- Testing
- Vitamin D (Cholecalciferol )
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Tufts Medical Center
Prediabetic State
Flaxseed Supplementation in Prediabetic Adults (LINAPRED)
Prediabetes is the term used to describe the condition where blood glucose level is higher than normal but lower than the diagnosis criteria of type 2 diabetes mellitus (T2DM).
- Trial name
- LINAPRED (NCT05245825)
- Testing
- Flaxseed, Dietary plan
- Where
- Mexico
- Volunteers
- 96 people
- Sponsor
- Centro Universitario de Ciencias de la Salud, Mexico
PreDiabetes, Metabolic Syndrome
Strawberries and Risk of Diabetes in Adults
Strawberries can be categorized as a functional food based on results from several clinical trials in improving cardiometabolic health beyond providing nutrition.
- Trial name
- NCT05362968
- Testing
- Freeze-dried strawberry powder
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Prediabetic State
Characterization of the "Transfusion-dependent Prediabetes" Using Continuous Glucose Monitoring
Dysglycemia is a frequent finding in transfusion-dependent thalassemia (TDT). The oral glucose tolerance test (OGTT) remains the only validated screening test, but the procedure is complex and time-consuming.
- Trial name
- NCT06533618
- Testing
- Continuous glucose monitoring system
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Prediabetes
ForgIng New Paths to Prevent DIabeTes (FINDIT)
This study will evaluate the effects of screening for type 2 diabetes mellitus (T2DM) and brief counseling about screening test results on weight and key health behaviors among Veterans with risk factors for T2DM.
- Trial name
- FINDIT (NCT02747108)
- Testing
- Blood Test Group Intervention, Brochure Group Intervention
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development