Clinical trials: Pre-diabetic State
Prediabetes, Impaired Fasting Glucose
Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes
Prediabetes is a term that refers to alterations in glucose homeostasis, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both, involving a higher risk of progression type 2 diabetes mellitus (T2DM).
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT02700334
- Testing
- Dapagliflozin
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
Prediabetic State, Atherosclerosis
Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.
- Conditions
- Prediabetic State, Atherosclerosis, Metformin
- Trial name
- VA-IMPACT (NCT02915198)
- Testing
- Metformin XR
- Where
- 40 sites in United States
- Volunteers
- 7,410 people
- Sponsor
- VA Office of Research and Development
Diabetes, Obesity
Polish Registry of Diabetes (PolReD)
The aim of this project is to create a registry of diabetic patients, containing a detailed clinical profile of each patient, along with omics data, which will be analyzed using artificial intelligence algorithms, and their…
- Conditions
- Diabetes, Obesity, PreDiabetes, Dysglycemia
- Trial name
- PolReD (NCT04657367)
- Testing
- Observational study - registry
- Where
- Poland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Aging
Metformin in Longevity Study (MILES).
Metformin, an FDA approved first-line drug for the treatment of type 2 diabetes, has known beneficial effects on glucose metabolism.
- Trial name
- MILES (NCT02432287)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
PreDiabetes
Insulin and Insulin Pulses During Fasting
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes.
- Trial name
- NCT06424015
- Testing
- Intralipid and heparin, Saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Ethnic Group, Young Adults
Diabetes Prevention in Prediabetic Patients
This study will evaluate the feasibility and efficacy of two interventions of lifestyle ( intensive and less intensive) to prevent diabetes in patients from Ethiopian origin, aged 25 to 55 years old with prediabetes living in…
- Conditions
- Ethnic Group, Young Adults, Prediabetes, Community Health Services
- Trial name
- DPEP (NCT01659697)
- Testing
- intensive lifestyle counseling
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
PreDiabetes, Obesity, Morbid
Metabolic Effects of a Low Carbohydrate Versus a Standard Diet in Morbidly Obese With Prediabetes
To investigate the metabolic effects of a low carbohydrate versus energy-matched standard diet in morbidly obese individuals with prediabetes awaiting bariatric surgery.
- Conditions
- PreDiabetes, Obesity, Morbid, Bariatric Surgery Candidate
- Trial name
- CaPrO (NCT03880162)
- Testing
- Low carbohydrate diet, Energy-matched standard diet
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators
This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder
The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body…
- Conditions
- Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators, Cardiometabolic Risk Factors, Metabolic Syndrome
- Trial name
- ROACH (NCT07804680)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Virginia
Pre-Gestational Diabetes, Type2diabetes
A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE
DIP : To conduct a pragmatic, non-blinded randomized controlled trial (pRCT) of immediate in-patient postpartum OGTT prior to delivery discharge (intervention) versus 4-12 week outpatient postpartum OGTT (current standard care)…
- Conditions
- Pre-Gestational Diabetes, Type2diabetes, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT05909046
- Testing
- Immediate inpatient postpartum OGTT, Standard of care 4-12 week postpartum OGTT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Ohio State University
Prediabetes
Evaluation of Empagliflozin vs Standard Care in Veterans With Prediabetes
Prediabetes effects 96 million people 18 years of age or older. It is important to identify treatment options to slow or prevent progression to diabetes.
- Trial name
- PREVNT (NCT06828731)
- Testing
- Empagliflozin 10mg daily, Lifestyle education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Charles George VA Medical Center
Prediabetes
Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity
The purpose of the study is to examine the effect of Saxagliptin in the newly diagnosed people with pre-diabetes and obesity besides lifestyle intervention ,there to evaluate DPP 4 inhibitors of reversing pre-diabetes curative…
- Trial name
- NCT01960205
- Testing
- Saxagliptin, metformin, lifestyle intervention
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shandong Provincial Hospital
Prediabetes, Diabetes Mellitus
Food Sequencing in Food Insecurity
The purpose of this study is study the impact of meal sequencing when added to standard care in individuals with diabetes mellitus/prediabetes who receive produce boxes as part of a food insecurity program.
- Conditions
- Prediabetes, Diabetes Mellitus, Food Insecurity
- Trial name
- NCT07488767
- Testing
- Food Order/Meal Sequencing, Standard of Care Counseling
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Weill Medical College of Cornell University
Prediabetes
Integrating a Prescription Produce Program Within a Diabetes Prevention Program
Type 2 Diabetes remains a major chronic disease among adults in the United States. A way to prevent Type 2 Diabetes is to engage in a diabetes prevention program.
- Trial name
- NCT07472712
- Testing
- Diabetes Prevention Program (DPP), Produce Prescription Plan (PPP)
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Virginia Commonwealth University
Sleep Apnea, PreDiabetes
Technology-Supported Treatment of Sleep Apnea in Prediabetes
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular…
- Conditions
- Sleep Apnea, PreDiabetes, Overweight or Obesity
- Trial name
- TECH (NCT04225507)
- Testing
- Diet and exercise coaching, CPAP Treatment
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Chicago
Diabetes Mellitus, Type 2, PreDiabetes
A Comparison Between the Effects of Conventional Diets vs Intermittent Fasting Diabetic and Pre-diabetic Patients
This research aims to find an effective dietary intervention among the Pakistani population. According to WHO, diabetes is on the rise in developing countries; the current prevalence among the Pakistani population is 11.2% which…
- Trial name
- NCT04463277
- Testing
- Calorie Restriction, Time Restricted Feeding, Time Restricted Feeding with Calorie Restriction
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Usman Bin Hameed
Obesity, Prehypertension
Weight Inclusive and Adaptive Strategies to Enhance Cardiometabolic Health in Black Adults
The proposed 6-month pilot Sequential Multiple Assignment Randomize Trial (SMART) has two aims. The first and primary aim is to determine the feasibility of conducting a full-scale SMART to compare weight-focused (i.e., weight…
- Conditions
- Obesity, Prehypertension, Hypertension, PreDiabetes
- Trial name
- WISE Health (NCT06284681)
- Testing
- Weight-focused health coaching, Weight-neutral health coaching, Intensify lifestyle approach
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Alabama at Birmingham
Prediabetes, Metabolic Diseases
The Effects of Freshwater Clam Extract on Blood Sugar, and Lipid Profile in Prediabetes Patients
The purpose of this study is to determine whether the freshwater clam extract and its combination is effective on the improvement of glucose and lipid metabolism, also evaluate its ability to postpone prediabetes patients to…
- Conditions
- Prediabetes, Metabolic Diseases, Glucose Metabolism Disorders, Dietary Supplement
- Trial name
- NCT04429737
- Testing
- clam protein capsules, Clam peptide plus Chlorella capsules
- Where
- 2 sites in Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
Obesity, Overweight
Hybridized Three Steps Intervention to Prevent Diabetes in Venezuela
The American Diabetes Association recommends implementing the Diabetes Prevention Program (DPP) in subjects with prediabetes. In the DPP, weight reduction was the main predictor of a lower incidence of type 2 diabetes (T2D), each…
- Conditions
- Obesity, Overweight, PreDiabetes, Diabetes Mellitus, Type 2
- Trial name
- HITS (NCT04927871)
- Testing
- Total Diet Replacement (TDR), Medical Nutritional Therapy (MNT), Diabetes Prevention Program 4 months
- Where
- 2 sites in Venezuela
- Volunteers
- 156 people
- Sponsor
- Foundation for Public Health and Epidemiological Research of Venezuela
PreDiabetes, Obesity
Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes
Purpose of the Study: This study is to learn more about how exercising at different times of the day (morning versus evening) affects metabolism of glucose in the body, sleep, activity outside of exercise, and other factors.
- Conditions
- PreDiabetes, Obesity, Inactivity/Low Levels of Exercise
- Trial name
- TExIS (NCT06292000)
- Testing
- AM Exercise, PM Exercise
- Where
- United States
- Sponsor
- University of Colorado, Denver
Schizophrenia, PreDiabetes
Bromocriptine for Patients With Schizophrenia and Prediabetes
This is a multicenter open-label, pilot study to evaluate the safety and tolerability of bromocriptine, a dopamine D2/D3 receptor and serotonin 5-HT2C receptor agonist, as an adjunct to preexisting standard-of-care antipsychotic…
- Trial name
- NCT03575000
- Testing
- Bromocriptine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Pittsburgh Healthcare System