Clinical trials: Pre-diabetic State
Prediabetic State, Overweight and Obesity
Diabetes Prevention for Mexican Americans
This study tests a culturally tailored lifestyle intervention designed to prevent, or delay onset of, T2DM in Mexican Americans with prediabetes.
- Trial name
- NCT03208010
- Testing
- Diabetes Prevention Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas at Austin
PreDiabetes
Effect of the SCL16A11 Risk Haplotype on Treatments to Prevent Type 2 Diabetes
The goal of this randomized clinical trial is to determine the impact of the risk haplotype on SLC16A11 on early therapeutic responses in treatments to prevent T2D in Mexican mestizos with prediabetes.
- Trial name
- PRED2 (NCT05990205)
- Testing
- Life Style Intervention + Metformin, Life Style Intervention
- Where
- Mexico
- Volunteers
- 437 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
PreDiabetes
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes.
- Trial name
- NCT06424106
- Testing
- Glucagon, Glucose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prediabetes
Mediterranean Diet and Blood Sugar Study
The purpose of this research study is to determine if a healthy Mediterranean diet containing one medium potato/day has equivalent or non-different effects on risk factors for type 2 diabetes and heart disease compared to a…
- Trial name
- NCT07229781
- Testing
- Mediterranean-style diet with potatoes, Traditional-style Mediterranean diet
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Penn State University
Prediabetes, microRNA
Effect of Exercise on MiR-126 in Individuals With Prediabetes
This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes.
- Conditions
- Prediabetes, microRNA, Exercise
- Trial name
- EMiR-126-PD (NCT06809257)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
PreDiabetes, Diabetes Mellitus
Diabetes Risk Education and Communication Trial
A large body of research has demonstrated that intensive lifestyle interventions and metformin are effective treatments to prevent or delay diabetes among high-risk adults, yet neither treatment is routinely used in practice.
- Conditions
- PreDiabetes, Diabetes Mellitus, Diabetes Mellitus, Type 2, Body Weight
- Trial name
- DiRECT (NCT03283657)
- Testing
- DiRECT, Usual care (UC)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Postprandial Hyperglycemia
Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia
The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).
- Trial name
- NCT02654301
- Testing
- Test 1, Test 2, Test 3
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Prediabetes
Almond Effects on Glucose Intolerance Study
Diabetes is a major cause of morbidity and mortality worldwide. Prevention of diabetes is an important goal. The progression from impaired glucose tolerance to diabetes is thought to be promoted by the toxic effects of…
- Trial name
- AEGIS (NCT02260895)
- Testing
- Almond pre-test snack
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Memorial Hermann Health System
Alzheimer's Disease, Mild Cognitive Impairment
Wake Forest Alzheimer's Disease Clinical Core
Efforts to find treatments for AD have yielded only modest benefits, likely because longstanding AD pathological processes induce irreversible neurological compromise.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Prediabetic State
- Trial name
- ADCC (NCT03140865)
- Where
- United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes
Outpatient Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT02346344
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Foundation for the National Institutes of Health
PreDiabetes, Pre Diabetes
STAR Study Investigating Performance and Safety of the Medical Device SiPore15™
The primary objective of STAR01 is to evaluate the performance and safety of the medical device (class IIb) SiPore15™ after a 12-week long treatment in the target population of obese and overweight subjects with prediabetes or…
- Conditions
- PreDiabetes, Pre Diabetes, Prediabetic State, Type2 Diabetes
- Trial name
- NCT03823027
- Testing
- SiPore15™
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 43 people
- Sponsor
- Sigrid Therapeutics AB
Hyperinsulinemia, PreDiabetes
Hyperinsulinemia in Prediabetes Mediated by Interleukin-1β
The goal of this clinical study is to test whether postprandial insulin secretion in subjects with prediabetes is mediated by Interleukin-1β and may be influenced by administration of the medicinal product anakinra (Kineret®).
- Trial name
- Hyper-PreDIL (NCT05854251)
- Testing
- Anakinra
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Basel, Switzerland
Impaired Glucose Tolerance, Oxidative Stress
Effect of Dietary Glycemic Index on Beta-cell Function
The study will determine if increasing the highs and lows of blood glucose levels (glycemic variability) impairs insulin secretion in people with impaired glucose tolerance and/or impaired fasting glucose who are at risk for…
- Conditions
- Impaired Glucose Tolerance, Oxidative Stress, Prediabetes, Impaired Fasting Glucose
- Trial name
- GIdiet (NCT01386645)
- Testing
- low glycemic index (LGI) diet, high glycemic index diet plus N-acetylcysteine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Overweight, Obesity
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight
This is a study of tirzepatide in participants with overweight and obesity. The main purpose is to learn more about how tirzepatide affects body weight. The study has two phases: A main phase and an extension phase.
- Trial name
- SURMOUNT-1 (NCT04184622)
- Testing
- Tirzepatide
- Where
- 118 sites in United States, Argentina and 8 more
- Volunteers
- 2,539 people
- Sponsor
- Eli Lilly and Company
Prediabetes
Prevention of Type 2 Diabetes With Vitamin D
The work plan will have the following S\&T components. Component 1: Cross-sectional Study Cross-sectional study will be of 1.5 years where 400 women from rural will be screened randomly for the vitamin D deficiency and its…
- Trial name
- PREVENT-WIN (NCT02513875)
- Testing
- vitamin D
- Where
- India
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Prediabetes, Insulin Resistance
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity
This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.
- Conditions
- Prediabetes, Insulin Resistance, Overweight/Obesity
- Trial name
- MOTS-MET (NCT07505745)
- Testing
- MOTS-c (MDP), Route Subcutaneous injection, Regimen
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hudson Biotech
Prediabetic State
Mobile App for Risk Reduction of Type 2 Diabetes
The aim of this feasibility study is to investigate whether a full scale RCT on the efficacy of a mobile app for risk reduction on type 2 diabetes can be conducted in the way it is planned or whether it needs to be modified.
- Trial name
- NCT06117098
- Testing
- Mobile application, Group-based lifestyle intervention at a Healthy Lifestyle Centre + mobile application", Group-based lifestyle intervention
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo Metropolitan University
Type 2 Diabetes, PreDiabetes
Evaluating a Type 2 Diabetes Prevention Program
This study aims to test the effectiveness of a Type 2 Diabetes (T2D) prevention program for individuals who have been diagnosed with prediabetes compared to a T2D educational control group.
- Trial name
- NCT05822648
- Testing
- Project Health, Educational Video Control
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Stanford University
Prediabetes
Effect of a Nutritional Product Containing Carob Extract on Carbohydrate Metabolism in Glucose-intolerant Subjects
Randomized, controlled, double-blind clinical trial with two parallel arms based on the product consumed (experimental product and placebo product) and conducted at a single center, to measure the efficacy of the liquid NUTIFOOD…
- Trial name
- NUTIFOOD (NCT07420998)
- Testing
- Experimental Product, Control product
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Prediabetes
The Association Between Body Constitution and Meridian Energy in Prediabetes
Traditional Chinese medicine (TCM) theories assert that body constitution and meridian energy are the foundations for disease prevention. However, few studies have incorporated TCM concepts into risk factors.
- Trial name
- NCT05475587
- Testing
- Routine care
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation