Clinical trials: Pre-diabetic State
PreDiabetes, Older Adults
Vivo Prediabetes Study: Online, Live, and Interactive Strength Training for Older Adults With Prediabetes
This research trial studies the effect of an online, live and interactive strength training program on physical function and strength in older adults with prediabetes.
- Conditions
- PreDiabetes, Older Adults, Muscle Loss, Muscle Weakness
- Trial name
- NCT05497960
- Testing
- Vivo workout
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eric Levian
PreDiabetes
Small Steps for Big Changes: A Lifestyle Program to Reduce the Risk of Developing Type 2 Diabetes
The purpose of this study is to address whether inactive individuals with prediabetes who take part in the Small Steps for Big Changes program, which is a 3-week supervised exercise and lifestyle change program with brief…
- Trial name
- NCT03096002
- Testing
- Lifestyle change
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of British Columbia
Prediabetic State
RCT of a Polyherbal Dietary Supplement for Prediabetes
The primary purpose of this study is to evaluate the impact of a polyherbal dietary supplement (Designs for Health - GlucoSupreme™ Herbal) on markers of glycemic control and other structure/function outcomes among a sample of…
- Trial name
- NCT03388762
- Testing
- GlucoSupreme™ Herbal
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Prediabetes, Vitamin D Deficiency
Effect of Vitamin D Deficiency and Vitamin D Supplementation on Glucose Metabolism
This study was intended to evaluate the effect of vitamin D supplementation on insulin sensitivity and pancreatic islet beta-cell function.
- Trial name
- NCT00749918
- Testing
- Cholecalciferol (vitamin D3)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Prediabetes
Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Fat
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function and increase the risk of CVD.
- Trial name
- NCT02482610
- Testing
- Glucose, Glucose with Whole Fat Milk, Glucose with Non-fat Milk
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ohio State University
PreDiabetes
β-hydroxybutyrate, Glucose Metabolism and Prediabetes
The study aims to investigate changes in blood glucose metabolism after administration of a ketone ester drink.
- Trial name
- CETUS (NCT03889210)
- Testing
- HVMN Ketone
- Where
- New Zealand
- Volunteers
- 18 people
- Sponsor
- University of Auckland, New Zealand
Sleep Apnea, PreDiabetes
Technology-Supported Treatment of Sleep Apnea in Prediabetes
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular…
- Conditions
- Sleep Apnea, PreDiabetes, Overweight or Obesity
- Trial name
- TECH (NCT04225507)
- Testing
- Diet and exercise coaching, CPAP Treatment
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Chicago
PreDiabetes
Prevention of Microvascular Complications in Prediabetes e-PREDICE Study
Background: A significant proportion of pre-diabetics, show macro and micro vascular complications associated with hyperglycaemia.
- Trial name
- ePREDICE (NCT03222765)
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Evidem Consultores SL
Prediabetic State
Restoring 24-hour Substrate Rhythmicity to Improve Glycemic Control by Timing of Lifestyle Factors
Exercise is well-known to improve skeletal muscle energy metabolism and is an established intervention to improve muscle insulin sensitivity and to counter the development of type 2 diabetes (T2D).
- Trial name
- TIMED (NCT05123963)
- Testing
- High-intensity interval training
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Université de Sherbrooke
Prediabetes, Hyperglycemia
Personalized Smartphone-assisted Coaching System to Improve Glucose Homeostasis in Adults With Prediabetes - Main Study
Sweetch is a personalized mobile-health platform coaching system (mobile phone app) designed to promote adherence to physical activity guidelines for people with prediabetes.
- Conditions
- Prediabetes, Hyperglycemia, Postprandial Hyperglycemia, Impaired Glucose Tolerance
- Trial name
- NCT03315663
- Testing
- Sweetch App & DBWS, Sweetch App Alone
- Where
- 2 sites in United States
- Sponsor
- Johns Hopkins University
Type 2 Diabetes
Characterization of the Variability Of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Prediabetes
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT01663207
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Foundation for the National Institutes of Health
Overweight and Obesity, Prediabetes
TREAT to Improve Cardiometabolic Health
Over half of American adults have overweight or obesity and are at high risk of developing type 2 diabetes and cardiovascular diseases.
- Trial name
- NY-TREAT (NCT04465721)
- Testing
- TRE, HABIT
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Columbia University
Type 2 Diabetes
Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT01663220
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Foundation for the National Institutes of Health
Overweight, Obesity
Long-term Health and Economic Effects of an Individualized Lifestyle Intervention (LI-PAD-Extended)
The goal of this clinical trial is to learn if an individualized lifestyle intervention works to improve weight, diet, physical activity, cardiovascular health, health-related quality of life, and cost-effectiveness in overweight…
- Conditions
- Overweight, Obesity, Prediabetic State
- Trial name
- LI-PAD-EXTENDE (NCT07605169)
- Testing
- Individualized physical activity and diet
- Where
- Sweden
- Volunteers
- 103 people
- Sponsor
- Vastra Gotaland Region
Prediabetes / Type 2 Diabetes
Heterogeneity of Diabetes: Integrated Muli-Omics to Identify Physiologic Subphenotypes and Evaluate Targeted Prevention
The study team will invite participants with prediabetes or mild diabetes (HbA1c 5.7-7.0) to join a 5-year research study that will define subphenotypes of type 2 diabetes based on underlying physiology (eg insulin resistance…
- Trial name
- NCT06682351
- Testing
- Metformin, GLP-1A, MED
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Prediabetic State
Efficacy and Safety of Vildagliptin in Subjects With Impaired Glucose Tolerance
The purpose of this study is to assess the safety and effectiveness of vildagliptin, an unapproved drug, compared to placebo in lowering post-meal blood glucose levels in people with pre-diabetes who have high blood sugar levels…
- Trial name
- NCT00237250
- Testing
- vildagliptin
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Novartis
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Risk-informed Shared-decision Making Engagement Strategy for Patients With Prediabetes
The goal of this clinical trial is to learn if knowing risk for diabetes can help adult patients with prediabetes take steps to get care and prevent diabetes.
- Trial name
- RISE (NCT07553325)
- Testing
- Risk Informed Shared Decision-Making Strategy (RISE), Low Touch Messaging Strategy (LTM)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Johns Hopkins University
Obesity, Prediabetic State
Physical Activity and Obesity
The purpose of the study is to see if a twelve-week exercise intervention in overweight or obese subjects with pre-diabetes or early disease course type 2 diabetes can lead to improved skeletal muscle capillary blood flow by…
- Conditions
- Obesity, Prediabetic State, Sedentary Lifestyle
- Trial name
- NCT02060240
- Testing
- High Activity
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
PreDiabetes, Overweight and Obesity
Using the Lumen Device for Prediabetes Prevention
To examine the effect of using Lumen on metabolic parameters and anthropometric variables. This will be done from baseline to the end of a 12 weeks intervention in adults with prediabetes..
- Trial name
- NCT04555421
- Testing
- Lumen
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Prediabetes
The Prevalence of Prediabetes in Primary Care Medicine in Tunisia
The study is national, observational and cross-sectional and aims to estimate the prevalence of prediabetes in primary care in Tunisia.
- Trial name
- TUN-PREDIAB (NCT06825533)
- Testing
- Fasting blood sugar level, Glycated hemoglobin
- Volunteers
- 5,000 people
- Sponsor
- Dacima Consulting