Clinical trials: Pre-diabetic State
Prediabetes
Trial of an Herb and Mineral Combination Product on Fasting Glucose in Adults at Risk for Developing Diabetes
This is a multi-center, randomized, double-blind, placebo-controlled study in approximately 104 subjects (52 per group) to evaluate the effectiveness of an herb and mineral combination product on fasting serum glucose levels in…
- Trial name
- NCT02146157
- Testing
- herb and mineral combination product
- Where
- 6 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- NewChapter, Inc.
Diabetes Mellitus, Diabetes Mellitus, Type 2
A Virtual Cardiometabolic Health Program for African Immigrants: The Afro-DPP Program
A pilot study titled "A Virtual Cardiometabolic Health Program for African Immigrants (The Afro-DPP Program) will be conducted to address the cardiometabolic of community-dwelling African immigrants who have multiple…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, PreDiabetes, Hypertension
- Trial name
- NCT05144737
- Testing
- The Diabetes Prevention Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
PreDiabetes
Effects of Bitter Melon on Cardiometabolic Health
The objectives of this study are to assess the effects of a bitter melon product at two doses, compared to control, on indicators of cardiometabolic health among men and women with prediabetes.
- Trial name
- NCT05540405
- Testing
- Low-dose bitter melon, High-dose bitter melon
- Where
- 3 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Obesity, Appetite Regulation
Tailoring Obesity Treatment Trial
The two main aims of this clinical study is; 1. To investigate if the results from a series of physiological tests and questionnaires prior to treatment, can be used to predict the treatment response to obesity medication 2.
- Conditions
- Obesity, Appetite Regulation, PreDiabetes
- Trial name
- TOTT (NCT06619015)
- Testing
- Pramlintide Acetate 1 MG/ML, Semaglutide Pen Injector, Sodium Chloride 0.9% Inj
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Obesity, Prediabetes
ADRB3 Signaling Pathway in Human Adipose Tissue
This study will examine the gene expression of the adrenergic Beta-3 receptor (ADRB3) regulation in human subcutaneous adipose tissue before and after treatment with mirabegron, an ADRB3 agonist.
- Trial name
- NCT05634174
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
PreDiabetes, Obesity
The Time-Restricted Intake of Meals Study
TRIM is a randomized, controlled feeding study to evaluate if eating earlier in the day vs. later in the day impacts weight and glucose homeostasis.
- Trial name
- TRIM (NCT03527368)
- Testing
- Time-restricted feeding, Usual feeding pattern
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
PreDiabetes, Nutrition
Zinc, Chromium, Vitamin C, and Copper Combination Supplement for Prediabetes Progression
Currently, the incidence of diabetes mellitus is increasing worldwide. People with prediabetes have higher risk to develop diabetes mellitus type 2.
- Trial name
- CHANGE (NCT04511468)
- Testing
- Zinc, Chromium, Vitamin C, and Copper Supplementation, Standard healthy lifestyle intervention
- Where
- Indonesia
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Prediabetes, Hyperlipidemia
Safety and Efficacy Study of Herbal Supplements in Prediabetic and Mild to Moderate Hyperlipidemic Patients
Objective of this study is to determine the safety and efficacy of administration of herbal supplements (Salacia leaf extract, Salacia root extract and Sesame seed extract) for 6 weeks in the management of prediabetes and mild to…
- Trial name
- NCT01680211
- Testing
- Salacia bark extract, Salacia leaf extract, Sesame seed extract
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Olive Lifesciences Pvt Ltd
NAFLD, Diabetes Mellitus, Type 2
Liver Fat as a Dietary Target for Treating Cardiometabolic Disorders in Prediabetes and Type 2 Diabetes
The overall aim of this study is to investigate the long-term impact of a customized diet aimed at reducing liver fat specifically and a healthy Nordic diet on ectopic fat (liver, pancreatic and visceral) and cardiometabolic risk…
- Conditions
- NAFLD, Diabetes Mellitus, Type 2, PreDiabetes
- Trial name
- NAFLDiet (NCT04527965)
- Testing
- Customized diet to reduce liver fat, Healthy Nordic diet, Control
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Type 2 Diabetes, Obese
The Effects of the GOLO for Life® Plan With Release Supplement on Glycemic Control and Weight in Overweight and Obese Adults With Prediabetes or Type 2 Diabetes
The objective of this study is to investigate the efficacy and safety of the GOLO for Life® Plan (G4LP) and Release supplementation on glycemic control and weight in overweight and obese adults with Prediabetes or Type 2…
- Conditions
- Type 2 Diabetes, Obese, Overweight, Prediabetes
- Trial name
- NCT05844644
- Testing
- Release
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Golo
Diabetes, Prediabetes
Maintaining Resistance Training in Older Prediabetic Adults
The aim of this Phase II Clinical Trial is to demonstrate the efficacy of social cognitive theory (SCT) based intervention for initiating, and most importantly, maintaining resistance training in older adults with pre-diabetes…
- Trial name
- NCT01112709
- Testing
- SCT-based Resistance Training exercise program, Standard Intervention with minimal contact
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Virginia Polytechnic Institute and State University
Prediabetic State
DPP-4 Inhibition and TZD for DM Prevention
To determine whether treatment with the diabetes medication, Januvia (sitagliptin), with or without another diabetes medicine, Actos (pioglitazone), will improve insulin secretion and insulin response individuals with Impaired…
- Trial name
- DInT DM (NCT01006018)
- Testing
- Sitagliptin + Pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University
PreDiabetes
Prevention and Treatment of Diabetes in Adults
Currently, an estimated 3.9 million Malaysians continue to live with diabetes with many more who live with prediabetes. Diabetes was the one of the leading causes of death in the Malaysia and the leading cause for kidney failure…
- Trial name
- NCT04832984
- Testing
- Mobile health, Usual care
- Where
- Malaysia
- Volunteers
- 91 people
- Sponsor
- Monash University
PreDiabetes
Combination of Ketogenic Diet and Exercise on Prediabetes in Female With Normal Weight
Individuals with prediabetes have a high risk of developing type 2 diabetes. The purpose of this study was to compare the effect of combination of ketogenic diet and aerobic exercise interventions versus ketogenic diet alone on…
- Trial name
- NCT04705558
- Testing
- continuous moderate intensity aerobic training, ketogenic diet
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Badr University
PreDiabetes
The Effect of Lifestyle Modification on the Risk of Prediabetes Among Patients Attending Outpatient Clinic.
Diabetes mellitus is a major global health challenge, with type 2 diabetes (T2DM) accounting for nearly 90% of all cases worldwide.
- Trial name
- NCT07462078
- Testing
- Lifestyle modification
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Insulin Resistance, Prediabetic State
Dexamethasone/Pancreatic Clamp P&F
This is a single-center, prospective, randomized, controlled (crossover) clinical study designed to investigate the specific dose-response impact of insulin infusion rate (IIR) on blood glucose levels during a pancreatic clamp…
- Conditions
- Insulin Resistance, Prediabetic State, Non-Alcoholic Fatty Liver Disease, Overweight and Obesity
- Trial name
- NCT06126354
- Testing
- Insulin human, Octreotide Acetate, Glucagon
- Where
- United States
- Sponsor
- Columbia University
PreDiabetes, Prediabetic State
Couple-Based Lifestyle Intervention to Prevent Type 2 Diabetes
The goal of this randomized pilot clinical trial is to describe the feasibility of a couple-based lifestyle intervention and the study protocol in preparation for a future definitive randomized clinical trial.
- Conditions
- PreDiabetes, Prediabetic State, Overweight and Obesity
- Trial name
- NCT05695170
- Testing
- PreventT2 (Individual intervention), PreventT2 Together (Couple-based intervention)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Utah
PreDiabetes
Influence of Social Determinants on Lifestyle Modification Adherence in People With Prediabetes
A sequential explanatory mixed-methods study analyzing the influence of social determinants on adherence to healthy lifestyle recommendations in individuals with prediabetes.
- Trial name
- NCT06488677
- Testing
- Lifestyle changes (diet and physical activity)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of the Balearic Islands
PreDiabetes
Association of β-amyloid 40 and 42 With Prediabetes
Background: Previous epidemiological and animal studies have suggested a strong relationship between prediabetes and Alzheimer's disease.
- Trial name
- NCT05035966
- Testing
- Plasma β-amyloid 40 and 42 concentration
- Volunteers
- 1,442 people, healthy volunteers welcome
- Sponsor
- Liegang Liu
Obesity, PreDiabetes
ADI-PEG20, Obesity and Prediabetes
Th purpose of this study is to determine whether ADI-PEG20 (PEGylated arginine deiminase), an arginine catabolizing enzyme preparation, improves insulin sensitivity, mitochondrial respiration, and energy utilization in…
- Trial name
- NCT05829239
- Testing
- ADI-PEG20
- Where
- United States
- Sponsor
- Washington University School of Medicine