Clinical trials: Pre-frail Elderly
Pre-frail Elderly, Frail Elderly
Dose Finding Study in Physically Frail Elderly to Measure 25(OH) Vitamin D Levels After Supplementation With Hy.D Calcifediol 25 SD/S and Vitamin D3
The purpose of this study is to assess the dose of Hy.D Calcifediol 25 SD/S (a metabolite of vitamin D3) which will achieve the range of mean serum 25(OH)D between 75-100nmol/L in physically frail elderly people after 24 weeks of…
- Trial name
- D-DOSE (NCT01868945)
- Testing
- 5 µg/day Hy.D Calcifediol, 10 µg/day Hy.D Calcifediol, 15 µg/day Hy.D Calcifediol
- Where
- Netherlands
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Delirium in Old Age
Non-pharmacological Measures for the Prevention of Delirium in Frail Hospitalized Adults. Nursing Care (PREDELENF)
Background: Delirium is one of the most frequent, relevant, and increasing geriatric syndromes in hospitalized older adults. It is an indicator of poor prognosis, and its incidence increases with aging.
- Trial name
- PREDELENF (NCT07119385)
- Testing
- Multicomponent non-pharmacological interventions, Usual care
- Where
- Spain
- Volunteers
- 158 people
- Sponsor
- Germans Trias i Pujol Hospital
Frailty, Frailty Syndrome
Characterising Frailty Using Magnetic Resonance Imaging
Ageing is associated with the development of various negative conditions, such as frailty. Defined as a decreased ability to combat negative stressors (e.g.
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome
- Trial name
- PHENOFRIM (NCT04612686)
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Geriatric Assessment, Health Services for the Aged
Geriatric-CO-mAnagement for Cardiology Patients in the Hospital
The primary objective of the evaluation study is to determine if geriatric co-management is superior to standard of care in preventing functional decline in older patients admitted for acute heart disease or Transcatheter Aortic…
- Conditions
- Geriatric Assessment, Health Services for the Aged, Cardiovascular Diseases, Activities of Daily Living
- Trial name
- G-COACH (NCT02890927)
- Testing
- Cardio-geriatric co-management
- Where
- Belgium
- Volunteers
- 454 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pre-Frail or Frail State
Randomized Controlled Trial of Community-based Nutritional, Physical and Cognitive Training Intervention Programmes for At Risk Frail Elderly
The aims of this proposed community-based randomized controlled trial are to evaluate the effectiveness of nutritional, physical exercise and cognitive training interventions for at-risk and frail elderly, to elucidate the…
- Trial name
- FIT (NCT00973258)
- Testing
- Nutritional Intervention, Physical Exercise, Cognitive Training
- Where
- Singapore
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- National Medical Research Council (NMRC), Singapore
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Protein Metabolism
Peanut Sip Feeding Protocol
Peanuts are considered a functional food and regular consumption is associated with positive health effects. Protein is the second most common nutrient in peanuts after fat.
- Trial name
- NCT06693544
- Testing
- Peanut protein
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Cirrhosis, Liver
Comparison of the Effect of Two Interventions on Liver Frailty Index in Pre-frail and Frail Cirrhotic Patients Enlisted for Liver Transplantation
The goal of this prospective, double blind randomized clinical trial is to compare the effectiveness of two interventions in improve frailty (measured by Liver Frailty Index) and quality of life (measured by Chronic Liver Disease…
- Trial name
- NCT06149026
- Testing
- Physical and nutritional therapy
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Protein Metabolism
Anabolic Response to Beef vs Plant Protein in (Pre)Frail Older Adults Using a Novel Stable Isotope Pulse Method
Frailty is a common clinical syndrome in older adults that increases the risk for poor health outcomes including falls, disability, hospitalization, and mortality.
- Trial name
- NCT07254403
- Testing
- Beef, Tofu
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Frailty, Pre-Frailty
Frailty Improvement Through Technology With Informal Caregiver Supported Exercise (FITWISE) for Pre-frail and Frail Community-dwelling Older Adults
The goal of this pilot trial is to evaluate the feasibility and potential effectiveness of a caregiver-mediated, technology-facilitated home-based intervention named Frailty Improvement through Technology With Informal Caregiver…
- Trial name
- FITWISE (NCT07519642)
- Testing
- FITWISE, Psychosocial support, Health education control
- Where
- 2 sites in Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Polypharmacy
Structured Polypharmacy Management Before Elective Non-cardiac Surgery in Frail and Elderly People
The older segment of the population is growing faster than any other segment. Older people have surgery more often than any other age group, and these older patients often take multiple medications, including medications that may…
- Trial name
- NCT03445767
- Testing
- MedSafer
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Fall Injury, Frailty
A Personalized Video-based Exercise Program for Fall Prevention in Frail and Pre-frail Older Adult
This is a randomized interventional clinical trial, whereby 100 participants will be randomized to either follow the SAFE exercise program (experimental group) or not (control group).
- Conditions
- Fall Injury, Frailty, Old Age; Atrophy, Age-Related Atrophy
- Trial name
- NCT06363942
- Testing
- SAFE program (exercise intervention)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Frail Elderly
Effects of Remote Exercise on Physical Function in Pre-Frail Older Adults
This study aims to compare the effects of remote versus in-person exercise interventions on physical function, balance, gait stability, and fall efficacy in pre-frail older adults aged 65 years and above.
- Trial name
- NCT06672640
- Testing
- Remote Exercise Program, In-Person Exercise Program, Physical Activity Education
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Kyungdong University
Pre-frail Elderly
Effects of Metformin in Pre-frail Elderly
The purpose of this study is to investigate the effects of metformin to prevent frailty in pre-frail non-diabetic elderly. Several outcomes measured in this study are frailty status, quality of life, handgrip strength, gait…
- Trial name
- NCT02325245
- Testing
- Metformin
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- Universitas Indonesia
Frailty, Aging
AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program
Aim 1: To assess the feasibility and acceptability of delivering AGE SELF CARE through virtual medical group visits by measuring recruitment rate, adherence, and participant satisfaction.
- Conditions
- Frailty, Aging, Frailty Syndrome, Frail Elderly Syndrome
- Trial name
- NCT06079762
- Testing
- AGE SELF CARE group visit program
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Health Services for the Aged, Geriatrics
Educational Guidelines Aimed at Pre-frail Elderly: Intervention Proposal
INTRODUCTION: aging is the natural process of deterioration of the reserves of biological systems, human beings are inherent to this process.
- Trial name
- NCT04997746
- Testing
- Multiprofessional educational interventions, Measurement of anthropometric measurements
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leonardo Paroche de Matos
Aging
The Effect of Strength Training and Protein Supplementation in Old Pre-frail Individuals
The aim of this study is to investigate the effects of a lower-body strength training regime combined with protein supplementation in pre-frail elderly individuals.
- Trial name
- NCT03723902
- Testing
- Heavy-load strength training, Protein supplementation
- Where
- Norway
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Spine Degeneration, Lumbar Degenerative Disease
Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery II
This multicenter, parallel-group, assessor-blinded randomized controlled trial will enroll 248 adults aged ≥75 years with degenerative lumbar spinal diseases scheduled for elective lumbar fusion surgery, and they will be…
- Conditions
- Spine Degeneration, Lumbar Degenerative Disease, Frail Elderly, Enhanced Recovery After Surgery (ERAS) Protocol
- Trial name
- PRACTICE-2 (NCT07396077)
- Testing
- Multimodal physiological reserve optimizing prehabilitation program, Usual Care
- Where
- 4 sites in China
- Volunteers
- 248 people
- Sponsor
- Xuanwu Hospital, Beijing
Fragility
Exercise Intervention to Reverse Frailty
The objective of this study is to evaluate a multi-component exercise intervention as an effective therapy to reverse pre-frailty phenotype in females age 65 or older.
- Trial name
- ERF (NCT02952443)
- Testing
- Exercise, Control
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Dance, Older Adults
Dose-response Effect of Community Dance Programme
The goal of this interventional study is to examine the dose-response effect of Community Dance Programme (CDP) on the physical, cognitive and psychological health of pre-frail and mildly frail community-dwelling older adults.
- Conditions
- Dance, Older Adults, Frailty at Older Adults, Active Ageing
- Trial name
- NCT07081191
- Testing
- Dance, Active Control
- Where
- Singapore
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- National University of Singapore