Clinical trials: PreDiabetes, completed
PreDiabetes, Overweight and Obesity
Walnuts to Achieve Lasting NUTrition to Prevent Diabetes
Prediabetes is a precursor of type 2 diabetes and an independent risk factor for cardiovascular disease, and currently affects one-quarter of the population of the United States.
- Trial name
- NCT03334175
- Testing
- Walnuts
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, San Francisco
PreDiabetes
Diabetes Prevention and Prediabetes Management in Adult
Currently, an estimated 3.9 million Malaysians continue to live with diabetes with many more who live with prediabetes. Diabetes was the one of the leading causes of death in the Malaysia and the leading cause for kidney failure…
- Trial name
- PRIME (NCT05214209)
- Testing
- Digital health supported, Usual care
- Where
- Malaysia
- Volunteers
- 10 people
- Sponsor
- Monash University
Pre Diabetes, Polycystic Ovary Syndrome
Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
There is a growing need to develop pharmacologic interventions to improve metabolic function in women with polycystic ovary syndrome (PCOS).
- Conditions
- Pre Diabetes, Polycystic Ovary Syndrome, Obesity Android
- Trial name
- SAXAPCOS (NCT03480022)
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Woman's
Pre-Diabetes, Metabolic Syndrome
Integrating Lifestyle Therapy for Diabetes Prevention Into Primary Care
An educational intervention in the General Medicine Clinic aimed at both primary care providers (PCPs) and their patients with metabolic syndrome/pre-diabetes (MetSyn/PDM).
- Conditions
- Pre-Diabetes, Metabolic Syndrome, Type 2 Diabetes
- Trial name
- NCT00853801
- Testing
- Lifestyle intervention and provider feedback
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Cook County Health
Pre-diabetes
A Study for Pre-diabetic Patients With Cholesterol Lowering Drugs
The purpose of this research study is to examine if a combination of a cholesterol lowering-drug, simvastatin, with a sugar-lowering drug called rosiglitazone is more effective in improving vascular inflammation (irritation of…
- Trial name
- SIROCO (NCT00831129)
- Testing
- Rosiglitazone, Simvastatin
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Chicago
PreDiabetes
Does Flaxseed Supplementation Improve Glycemic Control in Individuals With Pre-diabetes?
This project is a clinical intervention trial that will determine the role of a functional food, flaxseed, on the control of blood glucose levels in people with pre-diabetes.
- Trial name
- NCT01698112
- Testing
- Flaxseed High Dose, Flaxseed Low Dose
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Colorado, Colorado Springs
Type 2 Diabetes Mellitus, Hypercholesterolemia
Effects of Metformin Hydrochloride (HCl) in Combination With Colesevelam HCl, Compared to Metformin HCl Alone, in Patients With Type 2 Diabetes Mellitus and the Effects of Colesevelam HCl on Lipids and Glucose on Pre-diabetic Patients.
This is a 16-week double-blind, placebo-controlled (for colesevelam hydrochloride (HCl)) study in the type 2 diabetic subjects and pre-diabetic subjects.
- Conditions
- Type 2 Diabetes Mellitus, Hypercholesterolemia, Pre-diabetes
- Trial name
- NCT00570739
- Testing
- Metformin HCl tablets and Colesevelam tablets, Colesevelam
- Where
- 31 sites in United States, Colombia and 2 more
- Volunteers
- 502 people
- Sponsor
- Daiichi Sankyo
Hyperglycemia, Diabetes Mellitus
Lantus in Prediabetes
To assess the safety, tolerability, and efficacy of Lantus® (insulin glargine) in prediabetes (IFG or IGT).
- Trial name
- NCT00348972
- Testing
- Lantus® (insulin glargine)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sanofi
Prediabetic State, Impaired Glucose Tolerance
Effect of Linagliptin + Metformin on Patients Who do Not Achieve Normoglucemia With Metformine
The goal of this protocol is to evaluate the effect of addhing linagliptin to patients with prediabetes who do not reverse to normoglycemia after 12 months of treatment with metformin alone.
- Conditions
- Prediabetic State, Impaired Glucose Tolerance, Insulin Resistance
- Trial name
- RESCATHEME (NCT04088461)
- Testing
- Linagliptin / Metformin Oral Tablet, Metformin
- Where
- Mexico
- Volunteers
- 31 people
- Sponsor
- Universidad de Guanajuato
Body Weight, Impaired Glucose Tolerance in Obese
Effect of Cabergoline on Weight and Glucose Tolerance
The aim of this study is to determine the efficacy of cabergoline, a long-acting dopamine receptor agonist, on body weight and blood glucose in healthy obese adults. This is a randomized double-blind placebo controlled study.
- Trial name
- NCT01395602
- Testing
- Cabergoline
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Coronary Heart Disease Complicated With Impaired Glucose Tolerance
Can Platelets/Lymphocytes Rate Be New Serological Index for Prognosis of Coronary Heart Disease Complicated With Impaired Glucose Tolerance: Basic Principles and Experimental Design
Background About 2/3 patients of coronary heart disease (CHD) are complicated with disorder of carbohydrate metabolism which results in hyperglycemia and subsequent abnormality of coagulation system and inflammation.
- Trial name
- NCT02149056
- Testing
- observation, Impaired Glucose Tolerance
- Volunteers
- 447 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Hebei University
Type 2 Diabetes, Cardiovascular Diseases
Pistachios Blood Sugar Control, Heart and Gut Health
A two-period randomized crossover study will be conducted to evaluate the effect of nighttime pistachio consumption (i.e., after dinner and before sleep) on fasting blood sugar levels, longer-term blood sugar control, and risk…
- Trial name
- NCT04056208
- Testing
- Pistachio, Usual care
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Penn State University
Impaired Glucose Tolerance
Prevention of Type 2 Diabetes in Children With a Family-based Healthy Lifestyle Program
The purpose of this study is to determine if the Bright Bodies (BB) Healthy Lifestyle Program can help reverse early abnormalities in glucose metabolism and prevent the progression to type 2 diabetes (T2DM) in high-risk, obese…
- Trial name
- NCT01030978
- Testing
- Bright Bodies Healthy Lifestyle Program, Control
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Yale University
Insulin Resistance
Novel Therapy for Glucose Intolerance in HIV Disease
This research is to investigate the nutritional supplement chromium picolinate. The investigators are testing to see how effective this supplement is in treating insulin resistance associated with HIV disease.
- Trial name
- NCT02006914
- Testing
- Chromium Picolinate
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Stony Brook University
Pre Diabetes
Nasturtium (Tropaeolum Majus L) Intake and Biochemical Parameters in Pre-diabetic Subjects in Bogota Colombia
Brassicaceae plant family have a high content of bioactive compounds such as e.g. glucosinolates (GSLs) and isothiocyanates (ICTs) associated, recently, with diabetes prevention.
- Trial name
- NCT05346978
- Testing
- Nasturtium (Tropaeolum majus)
- Where
- Colombia
- Volunteers
- 10 people
- Sponsor
- Javeriana University
Prediabetic State, Non-alcoholic Fatty Liver Disease
ORION: Effects of Cenicriviroc on Insulin Sensitivity in Subjects With Prediabetes or Type 2 Diabetes Mellitus (T2DM) and Suspected NAFLD
A Phase 2a, randomized, double-blind, placebo-controlled, multi-center study of cenicriviroc (CVC) to be conducted in approximately 50 adult obese subjects [body mass index (BMI) ≥ 30 kg/m^2] with prediabetes or type 2 diabetes…
- Conditions
- Prediabetic State, Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus
- Trial name
- NCT02330549
- Testing
- Cenicriviroc 150 mg
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 45 people
- Sponsor
- Tobira Therapeutics, Inc.
Obesity
Antidiabetic Properties of Rose Hip
The purpose of this study is to determine whether daily intake of a drink containing rose hip powder reduces risk markers of type diabetes and cardiovascular disease.
- Trial name
- NCT01316016
- Testing
- Rose hip
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Lund University
Healthy, Overweight and Obesity
Strategies To OPpose Sugars With Non-nutritive Sweeteners Or Water (STOP Sugars NOW) Trial
Health authorities recommend a reduction in added sugars from sugar-sweetened beverages (SSBs) due to risk of obesity and diabetes. As a sugar-reduction strategy, finding the ideal SSB replacement is of the utmost importance.
- Conditions
- Healthy, Overweight and Obesity, Metabolic Syndrome, PreDiabetes
- Trial name
- NCT03543644
- Testing
- Sugar-sweetened beverage (SSB), Non-nutritive sweetened beverages (NSB), Water
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Prediabetic State, Type 2 Diabetes Mellitus With Oral Complications
Undiagnosed Diabetes in a Dental Setting
In an ongoing study new dental patients are screened to determine their risk of having undiagnosed pre-diabetes or diabetes based on risk factors readily known by the patient and signs of gum disease.
- Conditions
- Prediabetic State, Type 2 Diabetes Mellitus With Oral Complications, Periodontal Pocket, Tooth Loss
- Trial name
- NCT01711385
- Testing
- Enhanced intervention
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Columbia University
PreDiabetes, Hyperglycemia
Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs
The purpose of this research study is to compare the effectiveness of a fully automated digital diabetes prevention program to standard of care human coach-based diabetes prevention programs for promoting clinically meaningful…
- Conditions
- PreDiabetes, Hyperglycemia, Glucose, High Blood, Overweight
- Trial name
- NCT05056376
- Testing
- Digital Diabetes Prevention Program (dDPP), Human Coach-based Diabetes Prevention Program (hDPP)
- Where
- 2 sites in United States
- Volunteers
- 368 people
- Sponsor
- Johns Hopkins University