Clinical trials: PreDiabetes, completed
Type 2 Diabetes Mellitus
Efficacy and Safety of Alogliptin Combined With Pioglitazone in Treating Subjects With Type 2 Diabetes Mellitus.
The purpose of this study is to evaluate the safety and efficacy of alogliptin, once daily (QD), taken in combination with pioglitazone in adults with type 2 diabetes mellitus.
- Trial name
- NCT00328627
- Testing
- Alogliptin, Pioglitazone
- Where
- 90 sites in United States, Australia and 17 more
- Volunteers
- 1,554 people
- Sponsor
- Takeda
Lifestyle-related Condition, Obesity
MyLife: A Digital Health Coaching Program
Lifestyle behaviors such as sleep, diet, and physical activity, are implicated in a number of chronic conditions including hypertension, obesity, diabetes, heart failure, and obstructive sleep apnea.
- Conditions
- Lifestyle-related Condition, Obesity, Sedentary Lifestyle, PreDiabetes
- Trial name
- NCT03529903
- Testing
- Health Coaching
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Prediabetes
Habit Building Software Application to Increase Engagement of Vulnerable Populations in the National Diabetes Prevention Program (NDPP) Lifestyle Change Program (LCP)
The goal of this clinical trial is to learn whether a companion software application can improve program engagement in the National Diabetes Prevention Program in adults with prediabetes.
- Trial name
- NCT06656273
- Testing
- FT LCP
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- The Institute for Iterative Thinking
Cardiovascular Diseases, Prevention
Cardiovascular Health Promotion Among African-Americans by FAITH!
Given the importance of healthy lifestyle practices to cardiovascular disease (CVD) prevention and the utility of church-based interventions in African-American adults, the investigators developed a theory-informed…
- Conditions
- Cardiovascular Diseases, Prevention, Physical Activity, Diet Modification
- Trial name
- FAITH! (NCT03084822)
- Testing
- FAITH! App digital intervention
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Overweight, Obesity
Effects of Obex in Overweight and Obese Patients
Obesity is an important and growing public health worldwide Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer An extensive body of evidence from efficacy trials has…
- Trial name
- NCT02145442
- Testing
- Obex
- Where
- Cuba
- Volunteers
- 40 people
- Sponsor
- Catalysis SL
Diabetes
Relation of White Blood Cell Function to Diabetes
Background: Patients who are pre-diabetic or have adult onset (type 2) diabetes have a significantly greater risk of developing heart, blood vessel, or kidney diseases.
- Trial name
- NCT00570154
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus, Type 2, Prediabetes
RCT of the Naturopathic Anti-Inflammatory Diet
The purpose of this study is to determine if the naturopathic Anti-Inflammatory Diet results in reduced inflammation and a better response by the immune system when compared to a standard diabetic diet based on the current…
- Trial name
- NCT00334919
- Testing
- Diet (Anti-Inflammatory or standard diabetic diet)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National University of Natural Medicine
Pre-diabetes, Impaired Glucose Tolerance
The Effect of Real Time Continuous Glucose Monitoring in Subjects With Pre-diabetes
This study will investigate whether real-time continuous glucose monitoring can be used as a tool for behavior change in people with pre-diabetes.
- Trial name
- CGM PreDM (NCT01741467)
- Testing
- RT-CGM
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Walter Reed National Military Medical Center
Diabetes, PreDiabetes
Effects of Miracle Fruit Pill Application on Food Likings and Energy Intake in Diabetic or Prediabetic Patients
The high prevalence of diabetes and prediabetes has increased the demand for nonnutritive sweeteners in recent years. Miracle fruit has been considered a healthy alternative sweetener for diabetic patients due to its…
- Trial name
- NCT05468411
- Testing
- Oral application of miracle fruit pill, Oral application of sugar candy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Queens College, The City University of New York
Back Pain Lower Back Chronic, Back Pain
Assessing the Effects of HbA1c Reduction on Alleviating Nonspecific Back Pain
Prediabetes, characterized by elevated HbA1c levels, is a common precursor to type 2 diabetes mellitus. Recent studies have suggested a potential link between prediabetes and nonspecific back pain.
- Conditions
- Back Pain Lower Back Chronic, Back Pain, Pre Diabetes, Diabetes
- Trial name
- NCT06064058
- Testing
- Ghazwan program, Standard management
- Where
- Iraq
- Volunteers
- 90 people
- Sponsor
- University of Baghdad
Type 2 Diabetes
Outpatient Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT02346344
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Foundation for the National Institutes of Health
Metabolism Disorder, Lipid, Metabolism Disorder, Glucose
Compare the Impact of Xuezhikang and Atorvastatin on Glucose Metabolism in Dyslipidemia Patients With Prediabetes
This study is a prospective, randomized, open-label, multi-center trial. The primary objective of the study is to assess whether XZK 1200mg/d, compared to atorvastatin 20mg/d, has a favorable impact on HbA1c levels at 24 weeks of…
- Trial name
- XTREME (NCT05238012)
- Testing
- Xuezhikang Capsule, Atorvastatin Calcium Tablets
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Heart Health Research Center
Prediabetes, Type-2 Diabetes
Dietary Intervention Replacing Carbohydrate With Protein and Fat Has Greater Effect on Peripheral Blood Mononuclear Cell Metabolites Than on Plasma Metabolites in Patients With Prediabetes or Type-2 Diabetes
This study examined whether dietary-induced reductions in lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in peripheral blood mononuclear cells (PBMC) and plasma affected metabolic profiles in PBMCs and plasma.
- Trial name
- NCT02191644
- Testing
- Dietary intervention-refined rice, Dietary intervention-whole grains and legumes
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Yonsei University
Healthy, Pre Diabetes
Millet-based Muffins, Glycaemic Response, Insulinemic Response and Gastric Emptying
Millet is a functional grain that has attracted the attention of scientists for many years due to its significant benefits to human health.
- Trial name
- NCT04599738
- Testing
- Wheat muffin, Finger millet grain muffin
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Type 2 Diabetes, Impaired Glucose Tolerance
Effects of Pinitol on Hidrocarbonated Metabolism Parameters in Diabetic, Impaired and Normal Fasting Glucose Subjects
The purpose of this study was to assess whether pinitol improves hidrocarbonated metabolism parameters, and evaluate its effect on oxidative stress and endothelial function in diabetic, impaired and normal fasting glucose…
- Conditions
- Type 2 Diabetes, Impaired Glucose Tolerance, Healthy
- Trial name
- NCT01754792
- Testing
- Pinitol
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Pre-diabetes, Diabetes
Multi-Channel Automated Diet and Physical Activity Intervention for Pre-Diabetics
The trial will test whether the Alive multi-channel delivery health behavior program can positively affect weight and glucose level in pre-diabetics.
- Conditions
- Pre-diabetes, Diabetes, Obesity
- Trial name
- NCT01479062
- Testing
- Alive-PD, Usual Care
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Berkeley Analytics, Inc.
PCOS
Sitagliptin Improved Beta Cell Function and Prevented a Conversion Rate to Impaired Glucose Tolerance and Type 2 Diabetes in Metformin Intolerant Obese Women With Polycystic Ovary Syndrome
Metformin is the first-line therapy for PCOS with high metabolic risk, yet a large proportion of patients cannot tolerate it due to associated gastrointestinal adverse events.
- Trial name
- NCT03122041
- Testing
- Sitagliptin, Lifestyle intervention
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Insulin Resistance, Glucose Intolerance
Is Insulin Resistance and/or Glucose Intolerance Pathogenetic in the Development of a Reduced Incretin Effect
The purpose of this study is to examine whether there is a causal relationship between insulin resistance and/or glucose intolerance in the development of a defect incretin effect.
- Trial name
- NCT00784745
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Metabolic Syndrome, PreDiabetes
Lean Beef Consumption and Insulin Sensitivity in Men and Women With Risk Factors for Diabetes
The objective of this trial is to compare the effects of a healthy, lean beef diet and an average American, United States Department of Agriculture (USDA) style diet, that is low in saturated fatty acids (SFA), on insulin…
- Trial name
- NCT03202680
- Testing
- USDA Style Diet, Lean Beef Diet
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Pre-diabetes, Diabetes
RCT of SMS for Drivers With Pre-DM
The purpose of this study is to prevent the professional drivers from pre-diabetes to diabetes.
- Trial name
- NCT01556880
- Testing
- Short Message Service (SMS)
- Where
- 3 sites in Hong Kong
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong