Clinical trials: PreDiabetes, completed
Obesity, Insulin Resistance
Effects of Obesity and Intensity of Exercise on Ghrelin Levels
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin…
- Conditions
- Obesity, Insulin Resistance, Cardiovascular Risk Factor
- Trial name
- NCT04581980
- Testing
- Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Coronary Heart Disease, Susceptibility to, 5, Prediabetic State
Genetic Risk and Health Coaching for Type 2 Diabetes and Coronary Heart Disease
The purpose of this study is to examine whether the use of genetic test information and/or health coaching in patient risk counseling for heart disease and diabetes affect health behaviors and health outcomes in active-duty Air…
- Trial name
- NCT01884545
- Testing
- Health coaching, Genetic risk counseling, Standard risk assessment
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Duke University
Glucose Intolerance
Effects of Two Doses of Thylakoids on OGTT
This cross-over intervention study aims to investigate the effect of two doses of thylakoids to an oral glucose tolerance test (OGTT) on glucose and insulin homeostasis as well as appetite regulating hormones in healthy…
- Trial name
- NCT02702245
- Testing
- Experimental: Thylakoids 5 g, Experimental: Thylakoids 10 g
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Region Skane
Glucose Intolerance
Glycemic Index of Mango and Pear in Different Solid Products and Drinks
The purpose of this study is to compare the glycemic index of a beverage made of natural concentrated mango puree with natural concentrated pear juice with other five different products based on natural mango and pear ingredients…
- Trial name
- NCT01929551
- Testing
- Mango puree and pear juice beverage, Commercial mango juice, Fresh natural mango
- Where
- Mexico
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey
PreDiabetes
Optimisation of Exercise Intensity During High-Intensity Interval Training for Glucose Control in Prediabetes
The aim of the current study is to identify the optimal exercise intensity of the high-intensity phase during a bout of High-Intensity Interval Training (HIIT) to increase glucose clearance in a prediabetic population.
- Trial name
- NCT04256005
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Aberystwyth University
Pre-diabetes, Obesity
Inflammatory Axis and Sirtuins' in Overweight Pre-diabetics Patients
In obese patients the superficial adipose tissue works as an endocrine active tissue to express different cytokines, and multiple molecular pathways implied in the cross talking with different part of the human body, such as the…
- Trial name
- NCT03491241
- Testing
- hypocaloric diet therapy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Glucose Intolerance
Metabolic Adaptations in Response to High Intensity Interval Training in Obese Adults
The overall objectives are to: 1. Assess mechanisms underlying HIIT-induced improvements in insulin resistance at the whole-body, tissue, and cellular levels. 2.
- Trial name
- HT (NCT02706093)
- Testing
- High Intensity Interval Training (HIIT), Moderate-intensity continuous training (MICT)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Michigan
Obesity, Impaired Glucose Tolerance
Effects of Rosiglitazone on the Metabolic Phenotype of Impaired Glucose Tolerance in Youth
The purpose of the study is to determine whether treatment of children and adolescents with Impaired Glucose Tolerance (IGT) with rosiglitazone will lead to improvements in insulin sensitivity and glucose tolerance.
- Conditions
- Obesity, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT00413335
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Metabolic Syndrome X, Prediabetic State
Education, Counseling, and Drug Therapy to Reduce Symptoms of Metabolic Syndrome
This study will determine the effects of a supplement in reducing symptoms of metabolic syndrome, a collection of symptoms that increase the risk for developing heart disease, stroke, and diabetes.
- Conditions
- Metabolic Syndrome X, Prediabetic State, Insulin Resistance, Obesity
- Trial name
- NCT00129792
- Testing
- Dietary supplement for weight loss, Education and counseling for weight loss
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Oregon Health and Science University
Insulin Sensitivity, Glucose Intolerance
Effect of Dairy Products on Insulin Resistance
The objective of the study is to determine the effect of dairy consumption on insulin sensitivity in overweight and obese adults with prediabetes. Men and women (30-65 y) will be recruited from the greater Montreal area.
- Conditions
- Insulin Sensitivity, Glucose Intolerance, PreDiabetes
- Trial name
- NCT05421390
- Testing
- Reduced fat dairy, Regular fat dairy
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hypertension
The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose
This study is being done to see if the blood pressure and metabolic effects of an approved drug nebivolol is comparable to that of another approved drug hydrochlorothiazide (HCTZ) and placebo in hypertensive patients.
- Trial name
- NCT00673790
- Testing
- Nebivolol with concomitant losartan or lisinopril, HCTZ with concomitant losartan or lisinopril
- Where
- 88 sites in United States
- Volunteers
- 537 people
- Sponsor
- Forest Laboratories
PreDiabetes
Continuous Glucose Monitoring as Adjunct to Lifestyle Modification in Prediabetes
This is a 12-month prospective, open-label, non-masked, two arm randomized controlled trial comparing intermittently-viewed continuous glucose monitoring (iCGM) in addition to lifestyle modification programme (LMP) as compared…
- Trial name
- FlashLMP (NCT04588896)
- Testing
- Continuous glucose monitoring, Lifestyle modification programme
- Where
- Hong Kong
- Volunteers
- 177 people
- Sponsor
- Chinese University of Hong Kong
Prediabetes / Type 2 Diabetes
Effects of Exercise Prediabetic Individuals
The aim of this study was to determine the effects of two different exercise protocols on body composition, aerobic capacity, blood lipid profile, some biomarkers, quality of life and exercise beliefs in participants at risk of…
- Trial name
- NCT06831266
- Testing
- High Intensity Interval Training (HIIT), Moderate Intensity Continuous Training (MICT)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Eastern Mediterranean University
Obesity, Uric Acid Stones
Phentermine/Topiramate for Uric Acid Stones
The investigator proposes an 18 month, feasibility pilot study, randomizing obese and diabetic individuals with pure uric acid nephrolithiasis (UAN) or mixed calcium oxalate (CO) UAN to either phentermine/topiramate or a…
- Conditions
- Obesity, Uric Acid Stones, Type 2 Diabetes Mellitus in Obese, Pre-Diabetes
- Trial name
- NCT04621929
- Testing
- Phentermine / Topiramate Oral Product, Citrate Salts, Allopurinol, Diet
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
PreDiabetes, Insulin Resistance
Brown Seaweed Extract on Glycemic Control and Body Weight
The overall goal of this study is to investigate the effects of a daily dietary supplement of brown seaweed (2 capsules of InSea2®) on body weight, glycemic control and insulin secretion in overweight prediabetic men and women in…
- Trial name
- Algues (NCT03075943)
- Testing
- InSea2
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Laval University
Overweight and Obesity, Prediabetes
Effects of Biofunctional Orange Juice on Cardiometabolic Risk Markers
The effects of orange juice enriched with vitamin D3 and encapsulated probiotics (Lacticaseibacillus casei Shirota and Lacticaseibacillus rhamnosus GG) compared to conventional orange juice on several cardiometabolic and…
- Conditions
- Overweight and Obesity, Prediabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06114576
- Testing
- Orange juice enriched with vitamin D3 and encapsulated probiotics, Conventional orange juice
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Agricultural University of Athens
Metabolic Disturbance, Alcohol; Harmful Use
Metabolic Effects of One-weak Heavy Drinking
Examination of the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in Roskilde Festival 2016.
- Conditions
- Metabolic Disturbance, Alcohol; Harmful Use, Glucose Intolerance
- Trial name
- ROSMET (NCT04229550)
- Testing
- Festival participation
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
PreDiabetes
The Effect of Traditional Chinese Medicine Regimen-based Lifestyle Mobile Health APP in Prediabetes
Prediabetes is a major risk factor for diabetes. The Lifestyle Modification Mobile Health Application (APP) could not only help to decrease blood sugar among individuals with prediabetes but it could also prevent a later…
- Trial name
- NCT04096989
- Testing
- Traditional Chinese medicine regimen-based lifestyle mobile health APP, Lifestyle mobile health APP
- Where
- Taiwan
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Pre Diabetes, Diabetes
Comparing Diabetes Prevention Programs
The purpose of this study is to compare the effectiveness and costs of two programs,the Diabetes Prevention Program and the community-developed Healthy Living Program, delivered in an primary care practice.
- Trial name
- NCT01409889
- Testing
- Diabetes Prevention Program, Healthy Living Program
- Where
- 4 sites in United States
- Volunteers
- 92 people
- Sponsor
- University of Rochester
Acute Myocardial Infarction, Diabetes Mellitus
Coronary Flow Reserve and Glucometabolic State
Diabetes mellitus is a major risk factor for the development of ischemic heart disease, and patients with diabetes mellitus have a worse outcome following an acute myocardial infarction than non-diabetic patients.
- Conditions
- Acute Myocardial Infarction, Diabetes Mellitus, Prediabetes
- Trial name
- NCT00845468
- Where
- Denmark
- Volunteers
- 190 people
- Sponsor
- Medicinsk Forsknings Afdeling