Clinical trials: PreDiabetes, completed
Prediabetic State, Obesity
The PRE-D Trial: Effect of Dapagliflozin, Metformin and Physical Activity in Pre-diabetes
The overall objective is to compare the short-term (3 months) effectiveness of three glucose-lowering interventions (dapagliflozin, metformin and physical activity) on glucose variability, body composition, and cardiometabolic…
- Trial name
- NCT02695810
- Testing
- Dapagliflozin, Metformin, Exercise
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Prediabetes
Mitochondrial-related Platelet Transcript Expression Levels in Pre-diabetic Subjects Randomized to Metformin or Placebo
Diabetes mellitus (DM) imposes an approximate 2-fold increased risk of atherothrombosis. Patients with type 2 DM have a 2- to 4-fold increase in the risk of coronary artery disease (CAD) and atherothrombotic complications.
- Trial name
- MAP-2 (NCT02682121)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Utah
Impaired Glucose Tolerance, Diabetes
Progression to Impaired Glucose Tolerance and Type 2 Diabetes in the Korean People-based KNDP Study
Impaired glucose tolerance is a metabolic state between normal glucose homeostasis and diabetes. Previously, prospective studies have shown higher progression rates from IGT to diabetes in other country.
- Trial name
- NCT01034826
- Volunteers
- 500 people
- Sponsor
- Korea University Guro Hospital
Pre-diabetes
A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With Pre-diabetes
This is an exploratory study to assess whether vildagliptin, an unapproved drug, can increase insulin secretion in subjects with pre-diabetes who have a defect in the insulin response and elevated levels of fasting glucose.
- Trial name
- NCT00312130
- Testing
- Vildagliptin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Novartis
Dysglycemia, Obesity
Effects of Cinnamon Supplementation on Glucose Metabolism in Patients With Pre-diabetes
The transition from normal glucose tolerance to overt type 2 diabetes mellitus (T2D) encompasses a variety of glycemic abnormalities that are commonly referred to as 'prediabetes'.
- Trial name
- Cinnamon (NCT03219411)
- Testing
- Cinnamon
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Joslin Diabetes Center
Overweight or Obesity, Pregnancy
DPP Feasibility Study of Breastfeeding - eMOMS 2.0
The purpose of this study is to investigate the impact of a comprehensive intervention that combines breastfeeding support with a diabetes prevention-based program (DPP) on postpartum weight retention and lactation duration among…
- Trial name
- NCT06372860
- Testing
- Diabetes Prevention Program, Breastfeeding, Usual Care
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Kansas Medical Center
Prediabetes, Newly Diagnosed Type 2 Diabetes
The Effects of Jerusalem Artichoke and Fermented Soybean Powder Mixture Supplementation on Glucose Control
The purpose of this randomized, double-blind, placebo-controlled study was to determine whether jerusalem artichoke and fermented soybeans powder mixture is effective in the control of blood glucose level in subjects with…
- Trial name
- NCT02506582
- Testing
- jerusalem artichoke and fermented soybeans powder mixture
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hypertension
Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study)
High blood pressure, also referred to as hypertension, is a blood pressure level of 140/90 mm Hg or higher. Along with lifestyle changes, various medications are currently used to treat people with hypertension.
- Trial name
- MEAD (NCT00887510)
- Testing
- Hydrochlorothiazide, Trandolapril
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Healthy
Identification of Biometric Marker(s) Capable of Detecting Early Prediabetes: Clinical Trial 1
The proposed clinical trial is a controlled study of n=24 healthy adult individuals tested in both the Meal-Induced Insulin Sensitization (MIS) state and, following atropine blockade, Absence of Meal-Induced Insulin Sensitization…
- Trial name
- NCT04625088
- Testing
- Standardized liquid test meal, Atropine + Standardized liquid test meal
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SciMar Ltd.
Prediabetes
Prevention of Type 2 Diabetes With Vitamin D Supplementation
PREVENT-WIN study has three components. The work plan will have the following S\&T components. Component 1: Cross-sectional Study Cross-sectional study will be of 1.5 years where 400 women from rural will be screened randomly for…
- Trial name
- PREVENT-WIN (NCT02513888)
- Testing
- vitamin D + diet and lifestyle
- Where
- India
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
PreDiabetes, Type 2 Diabetes
Linagliptin Response to OGTT in Prediabetes and Type 2 Diabetes Mellitus
There are studies that suggest glycemic response to incretin-based therapies differs between Asians and Caucasians, whereby Asians have better response compared to Caucasians.
- Trial name
- NCT05290506
- Testing
- Dipeptidyl-Peptidase IV Inhibitors
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- National University of Malaysia
Diabetes Mellitus
Using of Ice Cream for Diagnosis of Diabetes Mellitus
The overall global prevalence of type 2 diabetes mellitus (DM) is rising. Based on the latest Thai National Health Examination Survey, an estimated 3.2 million people had DM, of whom one-third was undiagnosed.
- Trial name
- NCT02854111
- Testing
- ice cream, 75 g-glucose
- Where
- Thailand
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Diabetes Mellitus, Type 2
Long-term Study of Nateglinide+Valsartan to Prevent or Delay Type II Diabetes Mellitus and Cardiovascular Complications
This study is a test of the safety and effectiveness of two drugs, one for diabetes and one for hypertension, in keeping patients with high lab values of glucose from progressing to frank diabetes and developing cardiovascular…
- Trial name
- Navigator (NCT00097786)
- Testing
- Valsartan 160 mg + nateglinide 60 mg
- Where
- 38 sites in United States, Argentina and 36 more
- Volunteers
- 9,306 people
- Sponsor
- Novartis Pharmaceuticals
Prediabetes
Establishing a Virtual Health Community Management Model for Pre-Diabetes Patients
This study builds upon the previously developed virtual health community platform, aiming to address the group characteristics and psychological traits of prediabetic patients.
- Trial name
- NCT07354997
- Testing
- Pre-diabetes Virtual Community
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Reactive Hypoglycemia
Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism
The purpose of this study is to determine whether sitagliptin is effective in the treatment of reactive hypoglycemia by dysinsulinism.
- Trial name
- NCT00847080
- Testing
- Sitagliptin phosphate
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hypertension, Impaired Glucose Tolerance
Telmisartan and Losartan in Hypertensive IGT
Inhibition of RAS delays onset of diabetes in clinical studies. Preliminary evidence suggests that telmisartan may have unique metabolic properties compared to other ARB due to activation of PPARγ.
- Trial name
- NCT00407862
- Testing
- Telmisartan 80 mg, Losartan 50 mg
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
Hyperglycemia, Coronary Heart Disease
Paleolithic Diet in the Treatment of Glucose Intolerance
The purpose of this study is to determine whether a paleolithic diet improves glucose tolerance and insulin sensitivity in people with coronary heart disease and impaired glucose tolerance.
- Trial name
- NCT00419497
- Testing
- Paleolithic diet vs Mediterranean diet
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Lund University Hospital
Prediabetes
Effect of Fermentable Carbohydrate on Glucose Homeostasis
The rise in the prevalence of type 2 diabetes is related to recent lifestyle changes leading to a rise in obesity. Obesity is a risk factor for Impaired Glucose Tolerance (IGT) and diabetes.
- Trial name
- FermCarb (NCT01841073)
- Testing
- Inulin, Cellulose
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Imperial College London
Pre Diabetes
Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity
The purpose of this study is to determine the effects of oral abscisic acid (ABA) on glucose metabolism in subjects with defined prediabetes.
- Trial name
- ABA (NCT04722354)
- Testing
- Hyperinsulemic euglycemic clamp, Muscle Biopsy, Oral abscisic acid (ABA)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Diabetes Mellitus, Type 2, PreDiabetes
Continuous Glucose Monitoring in Diabetes and Prediabetes
Evaluate the use of brief serial real time continuous monitoring (RT-CGM) as a behavior modification tool in obese patients with prediabetes and diabetes.
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Obesity
- Trial name
- NCT03805412
- Testing
- DEXCOM G6 RT-CGM
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Nicole Ehrhardt, MD