Clinical trials: PreDiabetes, completed
Continuous Glucose Monitoring, Oral Glucose Tolerance
Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes
Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control.
- Conditions
- Continuous Glucose Monitoring, Oral Glucose Tolerance, Insulin Sensitivity, Inflammatory Markers
- Trial name
- NCT05337098
- Testing
- Non-Nutritive Sweetener Intake and impact on glucose homeostasis
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Virginia Polytechnic Institute and State University
Body Composition, Beneficial, Paresis
Meal Patterning on Weight Loss With Changes to Body Comp, Muscle and Metabolic Health
About two-thirds of adults in the United States are overweight or obese with likely adverse health consequences. A Moderate weight loss by dieting and exercise is recommended to improve health.
- Conditions
- Body Composition, Beneficial, Paresis, Impaired Glucose Tolerance
- Trial name
- S38 (NCT02066948)
- Testing
- wt loss, Meal Pattern, even
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Purdue University
Diabetes Mellitus, Type 2, PreDiabetes
Mastering Diabetes Study
This is a program evaluation that will evaluate the effectiveness of Mastering Diabetes, a therapeutic lifestyle change (TLC) program to control prediabetes and type 2 diabetes.
- Trial name
- NCT04454957
- Testing
- Mastering Diabetes
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Ohio University
Diabetes Mellitus, Prediabetes
Perioperative Continuous Glucose Monitoring in Patients Undergoing an Abdominal Surgery
The purpose of this study it to assess whether the continuous glucose monitor system Dexcom G6® can be reliably used for perioperative glucose monitoring in 20 prediabetic or diabetic patients undergoing abdominal surgery in…
- Trial name
- GluPop (NCT03935919)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Prediabetes, microRNA
Effect of Exercise on MiR-126 in Individuals With Prediabetes
This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes.
- Conditions
- Prediabetes, microRNA, Exercise
- Trial name
- EMiR-126-PD (NCT06809257)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
PreDiabetes, Impaired Glucose Tolerance
Almonds and Health Effects on Metabolism, Vascular Function and Cognition
The primary objective of the proposed study is to examine and understand the impact of long-term almond consumption on chronic glucose metabolism in subjects with impaired glucose tolerance and/or impaired fasting glucose.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Impaired Fasting Glucose, Overweight and Obesity
- Trial name
- NCT03419702
- Testing
- Almonds
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Maastricht University Medical Center
PreDiabetes
The Effects of Hesperidin and Flaxseed in Prediabetes
To study the effects of Hesperidin and flaxseed supplement in patients with prediabetes, 50 patients will be randomly allocated to control group or 2 capsules Hesperidin and 30 gram flaxseed for 12 weeks; both groups will be…
- Trial name
- NCT03737422
- Testing
- hesperidin and flaxseed, control
- Where
- Iran
- Volunteers
- 48 people
- Sponsor
- National Nutrition and Food Technology Institute
PreDiabetes
Efficacy and Safety of Digital Therapeutic in Adults With Prediabetes
The study aims to evaluate the efficacy and safety of a digital therapeutic (TH-001) for adult individuals with prediabetes.
- Trial name
- NCT05668819
- Testing
- TH-001
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Tesu Saglik Teknolojileri A.S.
Prediabetes, Impaired Fasting Glucose
Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes
Prediabetes is a term that refers to alterations in glucose homeostasis, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both, involving a higher risk of progression type 2 diabetes mellitus (T2DM).
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT02700334
- Testing
- Dapagliflozin
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
Blood Glucose, Blood Insulin
Impact of Fluid Milk on Post-meal Glycemia and Insulinemia in Overwt/Obese Adults
Blood sugar and insulin levels after a meal may be altered by the food and beverages a person consumes. Keeping a healthy blood sugar level may help prevent and manage type 2 diabetes and related diseases.
- Trial name
- S37 (NCT01951287)
- Testing
- Acute beverage (water) consumption, Acute beverage (Black Coffee) consumption, Acute beverage (Orange Juice) consumption
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Purdue University
Aging
Metformin in Longevity Study (MILES).
Metformin, an FDA approved first-line drug for the treatment of type 2 diabetes, has known beneficial effects on glucose metabolism.
- Trial name
- MILES (NCT02432287)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
PreDiabetes, Obesity, Morbid
Metabolic Effects of a Low Carbohydrate Versus a Standard Diet in Morbidly Obese With Prediabetes
To investigate the metabolic effects of a low carbohydrate versus energy-matched standard diet in morbidly obese individuals with prediabetes awaiting bariatric surgery.
- Conditions
- PreDiabetes, Obesity, Morbid, Bariatric Surgery Candidate
- Trial name
- CaPrO (NCT03880162)
- Testing
- Low carbohydrate diet, Energy-matched standard diet
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Type 2 Diabetes Mellitus
Insulin Sensitivity and Metabolomics During Oral Administration of Glucose and Graded Intravenous Infusion
Bariatric surgery has been proven to be an effective treatment of type 2 diabetes and it has highlighted to role of the small intestine in glucose homeostasis.
- Trial name
- NCT03223129
- Testing
- Oral glucose tolerance test, Graded intravenous glucose infusion
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Catholic University of the Sacred Heart
Prediabetes
Evaluation of Empagliflozin vs Standard Care in Veterans With Prediabetes
Prediabetes effects 96 million people 18 years of age or older. It is important to identify treatment options to slow or prevent progression to diabetes.
- Trial name
- PREVNT (NCT06828731)
- Testing
- Empagliflozin 10mg daily, Lifestyle education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Charles George VA Medical Center
Diabetes, Pre-Diabetes
Cinnamon Trial-lIfestyle iNtervention Plus Water-soluble Cinnamon Extract On loweriNg Blood Glucose in Pre-diabetics
The purpose of this study is to assess whether water-soluble cinnamon extract plus aggressive lifestyle intervention is effective in lowering blood glucose in pre-diabetic patients when compared to aggressive lifestyle therapy…
- Trial name
- Cinnamon (NCT01301521)
- Testing
- water-soluble cinnamon extract (Cinnulin PF)
- Where
- 4 sites in United States
- Volunteers
- 229 people
- Sponsor
- Mike O'Callaghan Military Hospital
Diabetes, Obesity
A Study of the Function of Hormones Present In Taste Buds
The purpose of this study is to find out whether the hormones in the taste buds are affected by tasting and eating food, and also whether these hormone levels are affected by an increase in body weight or type 2 diabetes.
- Conditions
- Diabetes, Obesity, Pre-Diabetes, Metabolic Syndrome
- Trial name
- NCT00233298
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Blood Pressure, Glucose Intolerance
Effect of Dragon Fruit Consumption in Individuals at Risk of Type 2 Diabetes
In this project, an edible product based on dragon fruit will be tested to determine its effect on blood glucose levels and blood pressure in individuals at risk of type 2 diabetes.
- Trial name
- NCT05199636
- Testing
- Dragon fruit product
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
IGT - Impaired Glucose Tolerance, T2D
Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes
Type 2 Diabetes (T2D) in obese youth is often preceded by a prediabetic state called: Impaired Glucose Tolerance (IGT), which is associated with a pre-existing defect in insulin secretion.
- Trial name
- NCT03195400
- Testing
- Oral Glucose Tolerance Test, Hyperglycemic Clamp, Isoglycemic Intravenous Glucose Test
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Sleep Apnea, PreDiabetes
Technology-Supported Treatment of Sleep Apnea in Prediabetes
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular…
- Conditions
- Sleep Apnea, PreDiabetes, Overweight or Obesity
- Trial name
- TECH (NCT04225507)
- Testing
- Diet and exercise coaching, CPAP Treatment
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Chicago
Diabetes Mellitus, Type 2, PreDiabetes
A Comparison Between the Effects of Conventional Diets vs Intermittent Fasting Diabetic and Pre-diabetic Patients
This research aims to find an effective dietary intervention among the Pakistani population. According to WHO, diabetes is on the rise in developing countries; the current prevalence among the Pakistani population is 11.2% which…
- Trial name
- NCT04463277
- Testing
- Calorie Restriction, Time Restricted Feeding, Time Restricted Feeding with Calorie Restriction
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Usman Bin Hameed