Clinical trials: PreDiabetes, completed
Prediabetes, Insulin Resistance
The Metabolic Effects of Almond Consumption in Adults With Pre-Diabetes
Study Hypothesis: Daily consumption of almonds over 16 weeks will produce a decrease in hemoglobin A1c (HbA1c) levels in adults with pre-diabetes.
- Conditions
- Prediabetes, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT00270985
- Testing
- Almonds in a calorie controlled diet, Nut free diet
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Latent Autoimmune Diabetes in Adult
Genetics of Latent Autoimmune Diabetes in Adults
This is a prospective study that will study adults and has the objective of examining 'Latent Autoimmune Diabetes in Adults' (LADA) to understand how this trait is influenced by genetic factors.
- Trial name
- LADA (NCT01793974)
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 205 people
- Sponsor
- Children's Hospital of Philadelphia
Prediabetic State, Substrate Oxidation
Effects of 2 Weeks Treatment With Dapagliflozin in Subjects With an Impaired Glucose Homeostasis on Nocturnal Substrate Oxidation
The purpose of this study is to investigate the effect of 2 weeks dapagliflozin treatment in individuals with a disrupted glucose homeostasis on the switch between carbohydrate and lipid oxidation during the night
- Trial name
- MaasFlex (NCT03721874)
- Testing
- Dapagliflozin 10mg
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Glucose Intolerance
Kori-tofu Proteins and Blood Glucose Response
The study is a randomized, cross-over, double blind, controlled trial in which study participants will visit the research facility on two occasions under fasting conditions with a minimum of 1 week between visits.
- Trial name
- KoPro (NCT04233281)
- Testing
- Kori tofu, Whey protein
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Wageningen University and Research
Overweight and Obesity
The Effect of Epitomee Capsule on Body Weight in Patients With Overweight and Obesity
The effect of Epitomee Capsule on body weight in patients with overweight and obesity with and without Prediabetes
- Trial name
- RESET (NCT04222322)
- Testing
- Epitomee Capsule
- Where
- 9 sites in United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Epitomee medical
Diabetes Mellitus, Type 2, Prediabetic State
Diabetes Screening & Prevention for People With Learning (Intellectual) Disabilities:STOP Diabetes Study
People with learning (intellectual) disabilities have more health problems than the rest of the population; they are less likely to access help and have lifestyles that may increase their risk of getting diabetes (for example…
- Conditions
- Diabetes Mellitus, Type 2, Prediabetic State, Intellectual Disability
- Trial name
- NCT02513277
- Where
- United Kingdom
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Overweight, Pre Diabetes
DPP4 Activity, Microvascular Reactivity and Inflammation
Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides involved in inflammation, immunity and vascular function.
- Conditions
- Overweight, Pre Diabetes, Diabetes Mellitus Type 2 Without Complication
- Trial name
- DPP4 (NCT03178019)
- Testing
- Laser-Doppler methods
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Impaired Glucose Tolerance
ACute and Chronic Effects of Saxagliptin
Glucose ACCES study will explore the acute and long term (12-week treatment) effects of saxagliptin in patients with impaired glucose tolerance during fasting and after a standardised breakfast.
- Trial name
- ACCES (NCT01521312)
- Testing
- saxagliptin
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Prehypertension
Weight Inclusive and Adaptive Strategies to Enhance Cardiometabolic Health in Black Adults
The proposed 6-month pilot Sequential Multiple Assignment Randomize Trial (SMART) has two aims. The first and primary aim is to determine the feasibility of conducting a full-scale SMART to compare weight-focused (i.e., weight…
- Conditions
- Obesity, Prehypertension, Hypertension, PreDiabetes
- Trial name
- WISE Health (NCT06284681)
- Testing
- Weight-focused health coaching, Weight-neutral health coaching, Intensify lifestyle approach
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Alabama at Birmingham
PreDiabetes
Avocado Snacks in a Prediabetic Population
Compare the effects of three evening snacks on morning fasting and postprandial glucose and insulin concentrations in individuals with prediabetes.
- Trial name
- AVOC4 (NCT05263011)
- Testing
- Avocado, low fat yogurt, low fat yogurt + fiber +fat
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Dysfunction of Vestibular System, Glucose Intolerance
Vestibular Dysfunction and Glucose Metabolism
Introduction: the global sugar consumption has increased in the past 50 years and their abusive intake is responsible for the insulin resistance and causes the metabolic syndrome - obesity, diabetes mellitus, hypertension and…
- Trial name
- NCT02226536
- Testing
- fractioned diet without glucose
- Volunteers
- 51 people
- Sponsor
- University of Sao Paulo General Hospital
PreDiabetes
Diabetes Prevention and Prediabetes Management in Adult
Currently, an estimated 3.9 million Malaysians continue to live with diabetes with many more who live with prediabetes. Diabetes was the one of the leading causes of death in the Malaysia and the leading cause for kidney failure…
- Trial name
- PRIME (NCT05214209)
- Testing
- Digital health supported, Usual care
- Where
- Malaysia
- Volunteers
- 10 people
- Sponsor
- Monash University
Diabetes Mellitus, Type 2, Pre Diabetes
Resistant Starch, Gut Bacteria and Diabetes
The aim of the study is to investigate, if resistant starch type III increases butyrate-producing bacteria in the gut of (pre-) diabetic subjects. Diabetic blood parameters are also of interest.
- Trial name
- RSDD (NCT03057444)
- Testing
- SymbioIntest
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- University of Hohenheim
Type 2 Diabetes Mellitus (T2DM), Cognitive Function
Prediabetes and Type 2 Diabetes in Aging
This case-control study will evaluate the effects of geriatric individuals on cognitive status, physical function and fatigue. Our study aims to compare the effects of geriatric individuals with prediabetes and type 2 diabetes…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Cognitive Function, Dual Task, Fatigue
- Trial name
- NCT06953609
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Uşak University
Metabolic Syndrome, Impaired Glucose Tolerance
Prevention of Type 2 Diabetes Mellitus by L-Arginine in Patients With Metabolic Syndrome
Aim The principal objective of this project is: To evaluate the efficacy of long term (18 months) L-Arginine therapy in preventing or delaying clinical onset of type 2 diabetes mellitus in subjects with impaired glucose tolerance…
- Conditions
- Metabolic Syndrome, Impaired Glucose Tolerance, Insulin Resistance, Endothelial Dysfunction
- Trial name
- L-arginine (NCT00917449)
- Testing
- L-arginine
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- IRCCS San Raffaele
Pre Diabetes, Diabetes
Comparing Diabetes Prevention Programs
The purpose of this study is to compare the effectiveness and costs of two programs,the Diabetes Prevention Program and the community-developed Healthy Living Program, delivered in an primary care practice.
- Trial name
- NCT01409889
- Testing
- Diabetes Prevention Program, Healthy Living Program
- Where
- 4 sites in United States
- Volunteers
- 92 people
- Sponsor
- University of Rochester
Diabetes, Pregnancy
Early Screening and Treatment of Women With Prediabetes in Pregnancy
The investigators hope to learn whether treatment with medical nutrition therapy (MNT) for pregnant women with prediabetes decreases the rate and severity of impaired glucose tolerance later in pregnancy and improves perinatal…
- Trial name
- NCT01552213
- Testing
- Minimum intervention control group, Treatment for glucose intolerance
- Where
- 2 sites in United States
- Volunteers
- 95 people
- Sponsor
- Stanford University
Left Ventricular Hypertrophy, Insulin Resistance
MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease
Thickening of the heart muscle (left ventricle) known medically as Left Ventricular Hypertrophy (LVH) is very common in patients with heart disease. This increases risk of cerebrovascular/cardiovascular event.
- Conditions
- Left Ventricular Hypertrophy, Insulin Resistance, Coronary Artery Disease, PreDiabetes
- Trial name
- MET-REMODEL (NCT02226510)
- Testing
- Metformin XL
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- University of Dundee
Impaired Glucose Tolerance, Diabetes Mellitus, Type 2
The Interaction Between Metformin and Physical Training
Physical activity is a first line treatment for patients with type 2 diabetes (T2D), however, the vast majority of patients with T2D do not achieve satisfying glycemic control with physical activity alone, which is why…
- Trial name
- NCT03316690
- Testing
- Metformin treatment, Physical training
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kristian Karstoft
Prediabetes, Type 2 Diabetes
Beta Cell Restoration Through Fat Mitigation
Weight loss achieved through gastric banding will be superior to treatment with metformin in preserving or restoring pancreatic beta cell function in people with prediabetes or mild type 2 diabetes.
- Conditions
- Prediabetes, Type 2 Diabetes, Obesity
- Trial name
- BetaFat (NCT01763346)
- Testing
- Metformin, gastric banding
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Southern California