Clinical trials: PreTerm Neonate
Retinopathy of Prematurity (ROP)
Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care
Retinopathy of prematurity (ROP) is a disorder of development of the retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime.
- Trial name
- (BabySTEPS3) (NCT07738874)
- Testing
- Ultra-widefield Optical Coherence Tomography (UWF-OCT), Wide-field ophthalmic imaging system
- Where
- 2 sites in United States
- Volunteers
- 175 people
- Sponsor
- Duke University
Microbial Colonization, Ventilator Associated Pneumonia
Frequent Standardized Oral Care to Improve Health Outcomes in Premature Infants in the Neonatal Intensive Care Unit
Premature very low birth weight (VLBW) infants are susceptible to complications related to infrequent and non-standardized oral care.
- Trial name
- NCT05167318
- Testing
- frequent standardized oral care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Florida
Infant, Extremely Premature, Acute Lung Injury
Intra-tracheal Instillation of Budesonide to Prevent Chronic Lung Disease
Preterm infants are randomized to received either Intra-tracheal instillation of budesonide using surfactant as vehicle or a placebo.
- Conditions
- Infant, Extremely Premature, Acute Lung Injury, Chronic Lung Disease of Prematurity, Budesonide
- Trial name
- STOPCLD (NCT05364385)
- Testing
- Infants in the study group (S/B group) will receive surfactant 2.5 mls/kg and Budesonide 0.5 mg (1mL)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Arizona
Preg Complications: Hemorrhagic, Infant, Premature, Diseases
Maternal & Infant Morbidity and Mortality
The purpose of this project is to evaluate maternal and infant outcomes based on race at UVA hospital. Health inequities are influenced by a combination of Social, Political, and Clinical determinants of health.
- Conditions
- Preg Complications: Hemorrhagic, Infant, Premature, Diseases, Preg Complications: Hemorrhagic Intervillous of Placenta, Preg Complications: Bleeding From Female Genital Tract
- Trial name
- NCT06145568
- Testing
- Pregnant Women
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Osteopenia Of Prematurity
A Preliminary Study of Bone Density in Neonates
The study is to measure how dense or solid the infant's bones are using a new ultrasound machine and how that density changes over time.
- Trial name
- NCT00631397
- Testing
- Ultrasound machine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Cerebral Hypoxia
Neonatal Brain Oxygenation Study
Implementing target ranges for regional cerebral saturations in extremely preterm infants in the first week of life may improve neurodevelopmental outcomes at 22-26 months corrected age compared to those without targeted cerebral…
- Trial name
- BOX (NCT04439968)
- Testing
- Clinical algorithm
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Ventilator-Induced Lung Injury, Respiratory Distress Syndrome
Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome
The purpose of this study is to determine, in preterm infants less than 37 weeks gestation with respiratory distress who are ventilated in the first 48 hours after birth, if mid frequency ventilation strategy using ventilator…
- Conditions
- Ventilator-Induced Lung Injury, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Infant
- Trial name
- MIDAS (NCT03231735)
- Testing
- Mid frequency ventilation, Standard frequency ventilation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia
Seattle-PAP Bubble Nasal CPAP and Work of Breathing
The investigators propose to test the hypothesis that Seattle bubble nasal continuous positive airway pressure (Seattle-PAP) supports respiratory physiology in very low birth weight (VLBW) infants more effectively than standard…
- Conditions
- Respiratory Distress Syndrome In Premature Infants, Bronchopulmonary Dysplasia, Newborn Primary Sleep Apnea
- Trial name
- Seattle-PAP (NCT02210026)
- Testing
- Seattle-PAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seattle Children's Hospital
Preterm Birth, Premature Birth
Exposure to Plasticisers in the Neonatal Intensive Care Unit
Neonatal intensive care relies on indwelling plastic medical devices fundamental in respiratory support, intravenous catheterization, and nutrition.
- Conditions
- Preterm Birth, Premature Birth, Neurodevelopmental Disorders, Pulmonary Disease
- Trial name
- PLASTIC-NICU (NCT05404815)
- Where
- Belgium
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Preterm Birth, Prematurity
Parent-child Interactions, Child Developmental Health, and Health System Costs at 6 Months Corrected Age
The aim of this novel health services research proposal is to assess the longer-term outcomes, to 6 months corrected age, of an adapted Family Integrated Care (FICare) model of care for moderate and late preterm infants admitted…
- Conditions
- Preterm Birth, Prematurity, Infant,Premature, Infant Development
- Trial name
- NCT03357458
- Testing
- Family Integrated Care
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of Calgary
Infant, Premature Development
The Impact of Implementing NIDCAP on the Developmental Sensitivity of Nurses Caring for Preterm Infants
The purpose of this study is to determine whether implementing the Newborn Individualized Developmental Care and Assessment Program increases NICU nurses' sensitivity in meeting the developmental care needs of preterm infants.
- Trial name
- NCT00179985
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Immune System Diseases, Premature Infant Disease
Oral Colostrum and Its Effect on Immune System
The purpose of this project is to increase the serum immunological defenses of premature infants less then 32 weeks of gestation by administrating colostrum in the oropharyngeal mucosa versus placebo
- Conditions
- Immune System Diseases, Premature Infant Disease, Immunoglobulin Deficiency
- Trial name
- NCT03578341
- Testing
- Orally Colostrum
- Where
- 2 sites in Mexico
- Volunteers
- 96 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Hypoglycemia, Infant, Small for Gestational Age
Dextrose Gel Does Not Prevent Neonatal Hypoglycemia
This was a quasi-experimental pilot study comparing blood glucose values 30 minutes after feeding alone or feeding + dextrose gel in newborns at risk for transient neonatal hypoglycemia.
- Conditions
- Hypoglycemia, Infant, Small for Gestational Age, Premature Birth of Newborn, Fetal Macrosomia
- Trial name
- NCT02523222
- Testing
- 40% Dextrose gel
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Baylor College of Medicine
Intrauterine Growth Restriction, Preterm Birth
Respiratory Morbidity of Late-Preterm Vs Intrauterine Growth Retarded Infants at School Age
Background: It is increasingly recognized that late preterm infants have increased respiratory morbidity in the neonatal period as well as decreased lung function in later life.
- Trial name
- NCT04849494
- Testing
- ATS-DLD-78-C and ISAAC questionnaires
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Marmara University
Pain, Infant ALL
The Effect of Non-pharmacological Methods on Pain
The research will be conducted using a randomized controlled experimental method.The preterm newborns included in the study will be randomized into three groups using the sealed envelope method.
- Conditions
- Pain, Infant ALL, Preterm
- Trial name
- NCT06455631
- Testing
- Facilitated Tucking, Oral Breast Milk , Kangaroo Care
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
PPROM, Respiratory Distress Syndrome in Premature Infants
Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?
The purpose of this study is to determine if a repeat course of betamethasone given to pregnant women with preterm premature rupture of membranes (PPROM) will decrease the infant's length of stay in the neonatal intensive care…
- Trial name
- NCT02939742
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Respiratory Distress Syndrome, Transient Tachypnea of Newborn
The Possible Effect Of Amniotic Fluid pH On Neonatal Morbidities In Maternal Inflammation/Infection Associated Pregnancies
Amniotic fluid (AF) pH can be affected by the maternal and/or fetal conditions such as PPROM, prematurity or fetal distress. It is known that fetal urine is the major content of AF since 20th gestational week.
- Conditions
- Respiratory Distress Syndrome, Transient Tachypnea of Newborn, Intrauterine Growth Retardation
- Trial name
- NCT02691559
- Testing
- Amniotic fluid analysis by blood gas device
- Where
- Turkey (Türkiye)
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pregnancies
Preterm Delivery Prevention in Twins With Progesterone
Twin pregnancies have very high preterm delivery rate. Until now, no RCT has proven benefit of progesterone in this population. In contrast, singleton pregnancies are treated with this hormone.
- Trial name
- NCT01927029
- Testing
- Progesterone
- Volunteers
- 213 people
- Sponsor
- Universidad del Desarrollo
Neonatal Sepsis
Outcomes and Predictors of Mortality Among Preterm Infants With Neonatal Sepsis
A prospective cross-sectional study of outcomes and predictors of mortality among preterm infants with neonatal sepsis admitted in NICU of Assiut University Children's Hospital
- Trial name
- NCT06113653
- Testing
- Prospective study
- Volunteers
- 50 people
- Sponsor
- Assiut University
Preterm, Premature
Effects of Kinesiotaping on Respiratory Muscles in Very Preterm Infants
This study aimed to evaluate the effects of kinesio taping on blood gas parameters, respiratory rate, heart rate, oxygen saturation, and pressure limits in preterm infants with RDS who are on NIV.
- Conditions
- Preterm, Premature, Infant, Newborn, Diseases, Respiratory Distress Syndrome
- Trial name
- NCT06285669
- Testing
- kinesiotaping application
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ondokuz Mayıs University
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