Clinical trials: Prebiotic
Obesity
Effect of a Synbiotic Supplement on a High-protein Diet
The objective of the trial is to study how a synbiotic treatment will affect weight loss and management in individuals enrolled in weight loss diet Profile®.
- Trial name
- NCT03123510
- Testing
- Bifidobacterium spp plus bimuno- galacto-oligosaccharides
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Sleep
Evaluating the Effects of Prebiotics on Sleep, the Gut Microbiome, Cognition, Immune Function and Stress
The aim of the proposed randomised, double-blind, controlled, parallel groups trial is to assess the sleep, gut microbiome, cognitive, immune and stress effects of 56 days administration of three formulations of a prebiotic-based…
- Trial name
- NCT05239845
- Testing
- Prebiotic, Control
- Where
- 2 sites in United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Osteoporosis, Inflammation
Synbiotic to Attenuate Resorption of the Skeleton
This randomized, double blind, placebo controlled clinical trial will test the efficacy of a probiotic/prebiotic combination ("synbiotic") on the skeleton in older women.
- Conditions
- Osteoporosis, Inflammation, Aging
- Trial name
- STARS (NCT06389539)
- Testing
- SBD111 medical food
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Overweight and Obesity
Gastrointestinal And Metabolic Effects From a Prebiotic, Lifting, and Aerobic iNtervention
This study aims to determine the independent and combined effects of prebiotic fiber supplementation and exercise on the gut microbiome and human health.
- Trial name
- GAMEPLAN (NCT05207488)
- Testing
- Fructooligosaccharides (FOS), Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Healthy
A Study to Evaluate the Effect of Diet on the Tolerability of FOS in Healthy Volunteers
The primary objective of this study is to determine the 5-day tolerability of one commercially available prebiotic food ingredient, FOS, in healthy human subjects with and without diet control.
- Trial name
- NCT02628678
- Testing
- FOS
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Kaleido Biosciences
Microbiota, Cognitive Change
Healthy Prebiotic and Postbiotic Effects of Peanuts and Peanut Butter: College Intervention Trial
Nuts have a prebiotic effect mainly due to their content of fiber and polyphenols, which provide substrates for the human gut microbiota.
- Trial name
- ARISTOTLE (NCT04324749)
- Testing
- Roasted peanuts (group A), Peanut butter (group B), Control (group C)
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Healthy
Effects of Arabinoxylan-Oligosaccharides Compared to Other Prebiotics in Healthy Subjects
The purpose of the study is to evaluate the effects of arabinoxylan-oligosaccharides (AXOS) on the colonic metabolism and microbial composition, and to compare these effects with the reference prebiotic fructo-oligosaccharide…
- Trial name
- NCT00853034
- Testing
- FOS-IN, AXOS
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Infant Development, Healthy
Prebiotic EffecT InfanTs
The study aims to confirm the effectiveness of chicory-derived prebiotic inulin-type fructans on stool consistency in infants.
- Conditions
- Infant Development, Healthy, Diet, Healthy
- Trial name
- PETIT (NCT04791956)
- Testing
- Prebiotic
- Where
- 2 sites in Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Hypercholesterolemia, Flatulence
Fabulous Fibre Study - Effect of Wheat Bran Extract on Gut and General Health in Healthy Aging Subjects (FFS)
This is a placebo controlled, cross-over, randomized, double blinded study. The intervention food products will be taken as diet prebiotic supplements: 1.
- Conditions
- Hypercholesterolemia, Flatulence, Intestinal Diseases
- Trial name
- FFS (NCT02693782)
- Testing
- Fibre supplement
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Polyphenols, Obesity
Effect of a Low-calorie Diet With a Prebiotic Supplement on Health of Overweight-obese Subjects.
The main objective of this project is to evaluate the effect of prebiotic supplementation on weight loss and other physiological and metabolic parameters related to excess weight in overweight/obese adult men and women, as well…
- Conditions
- Polyphenols, Obesity, Weight Loss
- Trial name
- POSTBIOTICS (NCT06710106)
- Testing
- Prebiotic + hypocaloric diet
- Where
- Spain
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Stress, Psychological, Gut Bacteria
Polyphenols, Prebiotics, the Gut Microbiome and Stress
The aim of this study is to evaluate how different combinations of prebiotics and polyphenols affect the gut microbiota and perceived cognitive state.
- Trial name
- NCT05528575
- Testing
- Blueberry, cranberry, green tea extract, cocoa, GOS, Inulin, RS2, prebiotics and polyphenols
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Reading
Iron Deficiency, HIV
Potential of Prebiotic Galacto-oligosaccharides in Improving Efficacy and Safety of Oral Iron Supplementation in HIV-infected Children
The objectives of this randomized controlled trial in virally suppressed HIV-positive children with anemia and/or depleted iron stores are to determine the effect of prebiotic galacto-oligosaccharides (GOS) as adjunct treatment…
- Trial name
- NCT04931641
- Testing
- Galacto-oligosaccharides, Maltodextrin, Ferrous fumarate
- Where
- South Africa
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Obesity
Prebiotic Fiber as a Modifier of Satiety Hormones and Body Weight in Overweight and Obese Adults
The purpose of this study is to determine if oligofructose supplementation promotes weight loss in overweight and obese adults.
- Trial name
- NCT00522353
- Testing
- Oligofructose
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Healthy Adult Participants
Safety and Efficacy of a Prebiotic Blend in Healthy Humans
The GRASP Trial is a 30-day, randomized, double-blind, placebo-controlled study (Protocol No.: GW-2025-02) designed to evaluate the safety and tolerability of a novel multi-fiber prebiotic blend in healthy adult volunteers (age…
- Trial name
- GRASP (NCT07514741)
- Testing
- Fiber Blend 1 (Low Dose), Fiber Blend 2 (High Dose)
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- LOAM Science
Non-alcoholic Fatty Liver Disease
Prebiotic Fibre Supplementation and Gut Microbiota in Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is a condition where accumulation of fat in the liver leads to metabolic dysfunction. Currently there are no approved treatments for NAFLD.
- Trial name
- NCT02568605
- Testing
- Prebiotic fibre, Weight Loss
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Constipation
Mixed Natural Prebiotic-Fibers Impact on Stool Frequency and Fecal Microbiota in Constipated Thai Adults
Mixed Natural Prebiotic-Fibers Impact on Stool Frequency and Fecal Microbiota in Constipated Thai Adults: A Randomized Clinical Trial.
- Trial name
- NCT06274242
- Testing
- Haruna
- Where
- Thailand
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Mood
Effects of Prebiotics on Intestinal Colonization and Mood in a University Cohort
There is a growing interest within the scientific community of whether prebiotics can aid in clinical outcomes including mood via modulation of the gut microbiota and its resulting metabolites via the gut-brain axis.
- Trial name
- NCT05212545
- Testing
- Prebiotic supplement, Prebiotic combination, Prebiotic oligosaccharides
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Sensory Perceptual Characteristics, User Acceptability of Gel Delivery System
Perception & Acceptability of a Cervical Cancer Prevention Prebiotic Device
PreBioGyn will be compared to market leading vaginal pH buffering gels using established forearm test methods associated with vaginal lubricity sensation in 42 women.
- Trial name
- NCT04841629
- Testing
- PreBioGyn Gel, Trimosan Gel, RepHresh Gel
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Glyciome, LLC
Healthy
What's Hopping? Cricket Protein and Human Gut Microbiota
Edible insects are often considered a nutritious, protein-rich, environmentally sustainable alternative to traditional meat. They represent a new food for North American consumers.
- Trial name
- HOP (NCT03383341)
- Testing
- Cricket Protein Powder
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Iron-deficiency
How Does a Synbiotic Supplement Affect Iron Status During Iron Repletion in Iron Depleted Female Athletes?
Iron deficiency (ID) affects ~30% of female athletes, and its consequences are highly relevant to athletic performance. Poor iron (Fe) uptake remains a major factor in the development of ID.
- Trial name
- NCT03793959
- Testing
- Synbiotic Supplement
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Marywood University