Clinical trials: Prebiotic
Dysbiosis
Effect of Lentils and Chickpeas on Gut Microbiome and Metabolic Health
The primary goal of this research is to evaluate the effect of daily whole-cooked chickpea and lentil consumption for 8-weeks on gut health, including microbiome-metabolome arrays and gut epithelial/barrier function, in healthy…
- Trial name
- NCT06914375
- Testing
- Goya Foods - Canned Chickpeas, Goya Foods - Canned Lentils, Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Microtia
The Effect of Prebiotics on Endurance Performance
The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.
- Trial name
- NCT04946578
- Testing
- Prebiotic
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Periodontitis
Effects of Prebiotic Oral Healthcare Products as an Adjunct to Non-surgical Periodontal Therapy
The aim of this study is to determine the impact of a prebiotic toothpaste and mouthrinse in periodontitis patients as an adjunct to scaling and rootplaning.
- Trial name
- NCT02520375
- Testing
- Prebiotic, Control
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diet Prevention of Metabolic Diseases
Prebiotic Effects on Glucose Tolerance
The primary purpose of this project is to evaluate effects in healthy humans on glucose tolerance of cereal products with high amounts of fermentable dietary fibre.
- Trial name
- NCT03944343
- Testing
- Cereal based products
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Lund University
Infant Nutrition
Effects of a Synbiotics-containing Starter Formula on Infant Growth
In this study the investigators want to evaluate the satiety of two infant formulas, one containing prebiotics and the other containing synbiotics.
- Trial name
- NCT01010113
- Testing
- Standard infant formula with prebiotics, Infant formula with synbiotics
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Infection, Microbial Colonization
Long-term Safety and Efficacy of Prebiotic Enriched Infant Formula
The primary objective of the present study was to evaluate the effects of long-term supplementation of an infant formula supplemented with prebiotic inulin-type oligosaccharides on immunological-health related outcomes.
- Conditions
- Infection, Microbial Colonization, Healthy
- Trial name
- NCT04441359
- Testing
- Supplemented formula, Standard formula
- Where
- 8 sites in Belgium, Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Hypertension, Resistant Hypertension
Evaluation of Intestinal Microbiota Manipulation to Treat Resistant Hypertension
The gastrointestinal tract begins its colonization shortly after birth. During the first two years of life, gut microbiota is unstable and less diverse than in adulthood.
- Trial name
- VALORIS (NCT04398693)
- Testing
- Prebiotic
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Sarcopenia
Dietary Strategy to Tackle Sarcopenia in Early Elderly Subjects (FOOP-Sarc)
The main objective of the present study is to add knowledge of the potential health effects and mechanism of action by a dietary strategy based on a VOO rich in phenolic compounds (156 mg hydroxytyrosol and tyrosol/kg oil) alone…
- Trial name
- FOOP-Sarc (NCT05485402)
- Testing
- Refined olive oil (38.6 mg hydroxytyrosol and tyrosol/kg oil), Virgin olive oil rich in phenolic compounds (156 mg hydroxytyrosol and tyrosol/kg oil), Maltodextrin
- Where
- Spain
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Brain Injuries
The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter the Gut Microbiome and Neurologic Symptoms
The aim of this study is to characterize the microbiome of patients undergoing post-acute residential neurorehabilitation compared to community controls and to determine if a dietary fiber, Inulin, can create a shift in the…
- Trial name
- NCT06607523
- Testing
- Inulin
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Microbiota
Prebiotic Effects of Isomalto-oligosaccharide
The primary purpose of this study is to evaluate the effect of an IMO nutritional supplement on gut microbiome, gut health, and body weight.
- Trial name
- NCT02433873
- Testing
- Isomalto-oligosaccharide
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- George Mason University
Bacterial Vaginosis, Bacterial Infections
Effect of PreforPro® on Urinary and Vaginal Health
This study will investigate the effects of PreforPro® (prebiotic and bacteriophages (LH01-Myoviridae, LL5-Siphoviridae, T4D-Myoviridae, and LL12-Myoviridae, greater > 6.7 X 107 PFU/gram) on bacterial vaginosis.
- Conditions
- Bacterial Vaginosis, Bacterial Infections, Bacterial Vaginosis | Vaginal | Microbiology, Vaginal Infection
- Trial name
- NCT05590195
- Testing
- Preforpro
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jeremy Burton
IBS - Irritable Bowel Syndrome
Study to Evaluate the Efficacy of Poppi Apple Cider Vinegar Prebiotic Soda to Improve Gut Health In Participants
This exploratory observational trial provides the opportunity to gather information on the effect of daily consumption of Poppi Apple Cider Vinegar Prebiotic Soda on gut health and digestion.
- Trial name
- NCT05418439
- Testing
- Drink Poppi Soda
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Drink Poppi
Healthy
Effect of Prebiotics on Intestinal Gas Production, Microbiota and Digestive Symptoms
Non-absorbable, fermentable residues in the diet increase intestinal gas production and induce gas-related symptoms, such as flatulence, abdominal bloating and distention; however, prebiotics, which are also fermented by colonic…
- Trial name
- NCT02618239
- Testing
- Bimuno Galacto-oligo-saccharide
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Immunosenescence
The Effect of Prebiotic B-GOS on the Immune Function, Metabolism and Gut Microbiota of Elderly People
The purpose of this study is to determine the effects of prebiotic B-GOS on the immune function, metabolism and gut microbiota of elderly people
- Trial name
- PRIMES (NCT01303484)
- Testing
- Bi2muno® GOS, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Clasado
Healthy
Intestinal Microbiota Adaptation to Prebiotic Administration
Non-absorbable, fermentable residues in the diet increase intestinal gas production and induce gas-related symptoms, such as flatulence, abdominal bloating and distention; however, prebiotics, which are also fermented by colonic…
- Trial name
- NCT04164914
- Testing
- Prebiotic
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Healthy Adult Participants
Safety and Efficacy of a Prebiotic Blend in Healthy Humans
The GRASP Trial is a 30-day, randomized, double-blind, placebo-controlled study (Protocol No.: GW-2025-02) designed to evaluate the safety and tolerability of a novel multi-fiber prebiotic blend in healthy adult volunteers (age…
- Trial name
- GRASP (NCT07514741)
- Testing
- Fiber Blend 1 (Low Dose), Fiber Blend 2 (High Dose)
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- LOAM Science
Gastrointestinal Problems
Assessment of Efficacy and Tolerance of a Follow-On Milk Containing a Mixture of Prebiotics Fed to Young Children in Salvador, Bahia, Brazil
This clinical study will evaluate the effect on incidence of diarrhea, respiratory illness, stool patterns and growth of two cow's milk-based beverages for children.
- Trial name
- NCT01177605
- Testing
- Nutritional vanilla flavored beverage - 1) Milk-based beverage containing prebiotics 2) Milk-based beverage containing no prebiotics
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Obesity
Evaluation of the Efficacy of the Composite WM Formula in Promoting GLP-1 Secretion
The goal of this clinical trial is to evaluate the physiological effects of a WM Formula on glucagon-like peptide-1 (GLP-1) secretion and glycemic regulation in adults with elevated body fat percentage.
- Trial name
- NCT07097987
- Testing
- WM formula Group, Control group
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Healthy
Coffee Consumption, the Gut Microbiome, and the Microbiota-Gut-Brain Axis
The aim of this study is to investigate the potential of coffee to act as a prebiotic to alter gut microbiota and improve mood, memory and cognitive performance.
- Trial name
- NCT05927038
- Testing
- Caffeinated coffee, Decaffeinated coffee
- Where
- Ireland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University College Cork
Prebiotics
Integrative Personal Omics Profiling for Dynamic Molecular Phenotypes Monitoring During Fiber Supplementation
The investigators propose a comprehensive, multiomic study that will integrate longitudinal data associating changes in specific gut bacteria and host in response to prebiotic fiber supplementation.
- Trial name
- NCT04706858
- Testing
- Dietary fiber supplementation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Stanford University