Clinical trials: Prebiotic
Periodontitis
Effects of Prebiotic Oral Healthcare Products as an Adjunct to Non-surgical Periodontal Therapy
The aim of this study is to determine the impact of a prebiotic toothpaste and mouthrinse in periodontitis patients as an adjunct to scaling and rootplaning.
- Trial name
- NCT02520375
- Testing
- Prebiotic, Control
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Changes in Gut Microbiota Bifidobacterial Levels
Effect of an Oral Nutritional Supplement (ONS) with Prebiotic Fibre Compared to a Non-fibre Containing ONS Equal in Energy and Protein Content on Gut Microbiota in Older Adults with or At Risk of Disease Related Malnutrition
This study assesses the effects of an oral nutritional supplement (ONS) with fibre compared to a non-fibre containing ONS equal in energy and protein content on gut microbiota bifidobacteria in older adults with or at risk of…
- Trial name
- BISON (NCT06645171)
- Testing
- Fibre drink
- Volunteers
- 62 people
- Sponsor
- Nutricia Research
Quorum Sensing, Prebiotics
Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals
It has recently been discovered that bacteria are able to communicate using specialised molecules known as Quorum Sensing Signalling Molecules (QSSMs).
- Conditions
- Quorum Sensing, Prebiotics, Probiotics, Sepsis
- Trial name
- NCT01201577
- Testing
- Bifidobacterium longum BB536, Active hexose correlated compound (AHCC), Bifidobacterium longum BB536 and Active hexose correlated compound (AHCC)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Preterm, Neurodevelopmental Disorders
Dietary Pattern Intervention for Neurodevelopment in Preterm Infants
The purpose of this randomized controlled trial is to evaluate the effect of a structured, high-prebiotic dietary pattern on the neurodevelopmental outcomes of preterm infants.
- Conditions
- Preterm, Neurodevelopmental Disorders, Dysbiosis
- Trial name
- NCT07702734
- Testing
- Structured High-Prebiotic Dietary Pattern
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Fudan University
Growth
Safety and Tolerance of a Partly Fermented Infant Formula With Prebiotic Oligosaccharides in Healthy Infants
A randomised, controlled, double-blind, parallel group, multi-country study to investigate the safety and tolerance of a partly fermented infant formula containing prebiotic oligosaccharides in healthy term infants.
- Trial name
- VOYAGE (NCT03476889)
- Testing
- Infant formula
- Where
- Poland
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Healthy
Effect of Daily Consumption of a Novel Biscuit Enriched With Edible Mushrooms, on Intestinal Health-related Parameters
The purpose of the study is to assess the effect of dietary intervention that includes the daily consumption of a novel biscuit (enriched with the selected mushrooms rich in β-glucans) on gut health related parameters of healthy…
- Trial name
- FUNglucan (NCT04759625)
- Testing
- Novel biscuit enriched with mushroom powder containing 3g of β-glucans
- Where
- Greece
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Gastrointestinal Disorder, Immunologic Diseases in Children
Whole Grain, Gluten-containing Cereal and PROBIOtics to Evaluate Digestive TOLERAance and Immuno-inflammatory Response
This study will assess the development of gastrointestinal health in terms of digestive tolerability and immune-inflammatory response at the intestinal level comparing a conventional gluten-free cereal with a new cereal with…
- Trial name
- PROBIOTOLERA (NCT04021303)
- Testing
- Experimental cereal, Conventional cereal
- Where
- Spain
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Laboratorios Ordesa
Multiple Myeloma, Lymphoma
Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Cellular Therapy
Higher gut microbiome diversity has been associated with improved survival following autologous stem cell transplantation in multiple myeloma and lymphoma.
- Trial name
- NCT05135351
- Testing
- Resistant Starch, Maltodextrin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Obesity
Evaluation of the Efficacy of the Composite WM Formula in Body Weight Change
This study aims to evaluate the effects of the combined formula WM Formula, used as a dietary supplement, with a focus on improvements in glycemic and lipid parameters, body composition, and gut microbiota profiles.
- Trial name
- NCT07097974
- Testing
- WM formula liquid drink
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Eating Behavior, Stress
The Gut Microbiota in Stress, Mood and Eating Behaviours.
Diet has a considerable influence on microbiota composition and the intake of either prebiotics (microbiota-specific food or probiotics (live microbiota species) has been shown to induce positive effects in both anxiety and…
- Conditions
- Eating Behavior, Stress, Mood
- Trial name
- NCT03482258
- Testing
- Prebiotic, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Constipation
Pre-biotics and Probiotics for Constipation in Parkinson's Disease
Constipation is the most frequent (prevalence, about 60%) dysautonomic non motor symptom affecting Parkinson's disease (PD) patients.
- Trial name
- NCT02459717
- Testing
- Probiotics and prebiotic
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Emanuele Cereda
Dysbiosis
Prebiotic Effects of a Polyphenol-rich Food Product
The specific aim for this project will be to investigate a cranberry beverage as a means to restore balance in terms of the relative proportions of the various bacteria that inhabit the large intestine.
- Trial name
- NCT03659240
- Testing
- Cranberry beverage
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Colitis, Ulcerative
Diet Intervention Treatment for Active Ulcerative Colitis
The purpose of this study is to determine if a sustainable non-elemental diet can be used as a probiotic tool to alter the dysbiotic microbiome found in individuals with ulcerative colitis and thereby decrease disease activity.
- Trial name
- NCT04121806
- Testing
- UC intervention diet
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Mount Sinai Hospital, Canada
Change of Transit or Circulation, Obesity
The Effect of Prebiotics on Gastrointestinal Functioning and Metabolism
The study will investigate the effect of cereal based prebiotic fibres on intestinal health and functioning and host metabolism.
- Trial name
- NCT02491125
- Testing
- soluble wheat bran fibre
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Constipation
Effects of Prebiotic or Probiotic Supplements on Symptoms of Functional Constipation
This study intends to evaluate the effects of three prebiotic solid beverages (mainly dietary fiber and prebiotics) and one probiotic solid beverage on the laxative effect of patients with functional constipation through…
- Trial name
- NCT04667884
- Testing
- Prebiotics or Probiotics
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Xi'an Jiaotong University
Iron-deficiency
Determination of a Dose-dependent Effect of GOS on Iron Absorption, and Addition of Vitamin C
Iron deficiency is still the most common and widespread nutritional disorder in the world according to WHO. In a recent iron absorption study in adult women with low iron stores in our lab (publication under review), we found…
- Trial name
- Fe_GOS_2 (NCT03762148)
- Testing
- ferrous fumarate, ferrous sulphate, ferric pyrophosphate
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- Isabelle Herter-Aeberli
Modulation of the Human Gut Microbiota by Prebiotic Galactooligosaccharides (GOS)
The Effect of Galactooligosaccharides (GOS) on the Gut Microbiota of Lactose Intolerance Individuals
The purpose of this study was to identify specific microbes that change with supplementation with galactooligosaccharides-prebiotics that are associated with alleviation of lactose intolerance symptoms in lactose-intolerant human…
- Trial name
- NCT06915129
- Testing
- Prebiotic galactooligosaccharides (GOS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Prebiotics, Honey
Medically-Graded Honey Supplementation Formula To Preterm Infants
Honey is a natural product that contains multiple nutrients; it is composed of fructose, glucose and fructooligosaccharides that can potentially serve prebiotic functions.
- Conditions
- Prebiotics, Honey, Premature Infants, Intestinal Microbiota
- Trial name
- Honey (NCT02679183)
- Testing
- Medically-Graded Honey, Premature Milk Formula
- Volunteers
- 40 people
- Sponsor
- Cairo University
Iron Deficiency, HIV
Potential of Prebiotic Galacto-oligosaccharides in Improving Efficacy and Safety of Oral Iron Supplementation in HIV-infected Children
The objectives of this randomized controlled trial in virally suppressed HIV-positive children with anemia and/or depleted iron stores are to determine the effect of prebiotic galacto-oligosaccharides (GOS) as adjunct treatment…
- Trial name
- NCT04931641
- Testing
- Galacto-oligosaccharides, Maltodextrin, Ferrous fumarate
- Where
- South Africa
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Diabetes Mellitus, Type 2
Effects of Vitamin D3 and Prebiotics Supplementation on Cardiovascular Risk Factors in Patients With Type 2 Diabetes
The goal of this randomized, double-blind, placebo-controlled, 6-month supplementation study in individuals with type 2 diabetes is to investigate whether taking daily dietary supplements of vitamin D3 (1600 IU) or prebiotics…
- Trial name
- NCT06351566
- Testing
- Vitamin D3, Prebiotics
- Where
- 2 sites in China
- Volunteers
- 190 people
- Sponsor
- Huazhong University of Science and Technology