Clinical trials: Prebiotics Effect
Healthy
Pilot Study on the Effect of a XOS95 on the Human Gut Microbiome
The purpose of this clinical trial is to assess the efficacy of a novel prebiotic, XOS95, at two different dosages, in comparison to a placebo by assessing shifts in microbial populations after 8 weeks of supplementation…
- Trial name
- NCT03074019
- Testing
- Xylooligosaccacharide, Maltodextrin
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Prenexus Health
Cognition, Affect (Mental Function)
BiomeBakery Project
This study aims to investigate the chronic effects of prebiotic fibre-fortified functional bakery product on cognitive, affective, inflammatory, metabolic, and anthropometric outcomes in healthy adults aged 60-75 years with mild…
- Conditions
- Cognition, Affect (Mental Function), C Reactive Protein
- Trial name
- NCT06796712
- Testing
- Prebiotic fibre fortified bread roll, Regular bread roll
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Reading
Immunosenescence, Inflammation
Effect of Milk Protein and Prebiotics in Combination With Vitamin D on Innate Immunity in Elderly People
Rationale: The immune system in the ageing population becomes compromised with age (termed "Immunosenescence"). Therefore, elderly people have a decreased ability to respond to infection and vaccination.
- Trial name
- NCT03026244
- Testing
- Milk protein, prebiotics, vitamin D
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Iron-deficiency
Effect of Prebiotics on Iron Absorption in Women With Low Iron Stores
Rationale: According to the WHO, iron deficiency is still the most common and widespread nutritional disorder in the world. Current iron supplements have limitations in terms of bioavailability and tolerability.
- Trial name
- Fe_GOS_1 (NCT03325270)
- Testing
- labeled ferrous fumarate, labeled ferrous fumarate + prebiotics, labeled ferrous sulfate + prebiotics
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- Swiss Federal Institute of Technology
Bacterial Vaginosis, Bacterial Infections
Effect of PreforPro® on Urinary and Vaginal Health
This study will investigate the effects of PreforPro® (prebiotic and bacteriophages (LH01-Myoviridae, LL5-Siphoviridae, T4D-Myoviridae, and LL12-Myoviridae, greater > 6.7 X 107 PFU/gram) on bacterial vaginosis.
- Conditions
- Bacterial Vaginosis, Bacterial Infections, Bacterial Vaginosis | Vaginal | Microbiology, Vaginal Infection
- Trial name
- NCT05590195
- Testing
- Preforpro
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jeremy Burton
Glucose Intolerance During Pregnancy
Effects of Vitamin D and Prebiotic Supplementation on Glucose Control During Pregnancy
The goal of this randomized, double-blind, placebo-controlled study included pregnant women at high risk of GDM at 6-15 weeks of gestation is to investigate whether supplementation with vitamin D (1600 IU per day) or prebiotics…
- Trial name
- NCT06553729
- Testing
- Vitamin D3, Prebiotics
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Huazhong University of Science and Technology
Schizophrenia
The Effects of Prebiotics on Cognitive Functioning and Weight Gain in Psychosis
The investigators propose a maltodextrin-controlled cross over experimental medicine study that aims to examine the role of the immune system in cognitive processes and weight gain in 40 adult patients with psychosis, stable on…
- Trial name
- Prepsy (NCT03153046)
- Testing
- prebiotics, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- University of Oxford
Schizophrenia
Antipsychotic Effects of Probiotics and Prebiotics on Patients With Schizophrenia
In this study, investigators will evaluate the efficacy and related mechanism of probiotics and prebiotics as an add-on treatment in improving the antipsychotic induced psychotic syndrome, the cognitive impairment…
- Trial name
- NCT04291469
- Testing
- Probiotics（Live combined bifidobacteria, lactobacillus and maltodextrin tables), Prebiotics (Combined inulin and maltodextrin tables), maltodextrin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Change of Transit or Circulation, Obesity
The Effect of Prebiotics on Gastrointestinal Functioning and Metabolism
The study will investigate the effect of cereal based prebiotic fibres on intestinal health and functioning and host metabolism.
- Trial name
- NCT02491125
- Testing
- soluble wheat bran fibre
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Child Malnutrition
Effects of Prebiotics on Metagenomic Diversity and Abundance in Young Children With Acute Malnutrition
Malnutrition is a major global public health issue, contributing to poor health and early morbidities in children under five, particularly in developing countries.
- Trial name
- P-MAM (NCT06155474)
- Testing
- Prebiotic galacto-oligosaccharide (GOS) Powder, Starch Only, RUTF + Starch
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of the Punjab
Prebiotics
Effect of a Kefir Beverage on Immunity and Lipid Profile
This is an exploratory cluster randomized controlled trial to evaluate the effect of a kefir beverage, enriched with prebiotics components, on immunity, lipid profile and adiposity in a population-based study, using the family as…
- Trial name
- NCT03312660
- Testing
- Prebiotic group
- Where
- Spain
- Volunteers
- 158 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Constipation
Prebiotic Fructans Effect on 1-3 Years Constipated Children's Bowel Habits
The aim of the study is to confirm the effectiveness of chicory-derived prebiotic inulin-type fructans on bowel function in young children.
- Trial name
- CONSTICHILD (NCT03941925)
- Testing
- Prebiotic fructans, Non-prebiotic maltodextrin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Behaviour
Oxford Study of Prebiotics in Children
Recently, there has been an emerging interest in how manipulating gut microbiota (which is composed by microorganisms living in our digestive system) can influence learning, memory and cognition.
- Trial name
- OxPiC (NCT02926508)
- Testing
- Bimuno (BGOS), Maltodextrin
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy
Prebiotic and Anti-inflammatory Effects of a Pectin Polysaccharide
The aim of this study is to determine, quantify and understand the potential prebiotic and anti-inflammatory effects of the pecticpolysaccharide rhamnogalacturonan I (RG-I).
- Trial name
- NCT05421793
- Testing
- Fermented product of carrot derived rhamnogalacturonan I
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Constipation
Effects of Prebiotic or Probiotic Supplements on Symptoms of Functional Constipation
This study intends to evaluate the effects of three prebiotic solid beverages (mainly dietary fiber and prebiotics) and one probiotic solid beverage on the laxative effect of patients with functional constipation through…
- Trial name
- NCT04667884
- Testing
- Prebiotics or Probiotics
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Xi'an Jiaotong University
Pre-diabetic
Investigation of the Ability of a Supplement to Increase Good Bacteria in the Human Intestine and Blood Sugar Levels
This study aims to determine whether the use of a supplement called xylooligosaccharide (XOS) increases the number of good bacteria that live in human intestines and can maintain healthy blood sugar levels, and whether XOS has…
- Trial name
- XOS2 (NCT01944904)
- Testing
- Sugar Pill, XOS 2.8
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Blood Glucose Control
A Study to Evaluate the Effects of a Prebiotic Soda on Glycemic Control in Adults
The main objective of this study is to evaluate the chronic effects of replacing traditional non-diet soda with a prebiotic soda on biomarkers associated with glycemic control in adults with glucose dysregulation who are habitual…
- Trial name
- NCT07298135
- Testing
- Prebiotic Soda, Active Control
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Olipop, PBC
Head and Neck Squamous Cell Carcinoma
The Effect of Prebiotic Inulin on Patients Affected by R/M HNSCC Treated With Immune Checkpoint Inhibitors
The PRINCESS study is a hypothesis-generating, interventional, open-label, non pharmacological trial designed to characterize the translational and clinical implications of the regular assumptions of inulin on Gut Microbiota…
- Trial name
- PRINCESS (NCT05821751)
- Testing
- inulin, Pembrolizumab, Nivolumab
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Microtia
The Effect of Prebiotics on Endurance Performance
The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.
- Trial name
- NCT04946578
- Testing
- Prebiotic
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Fibromyalgia
The Effect of Probiotic and Prebiotic Use on Fibromyalgia Syndrome
The aim of the present study is to determine the effectiveness of probiotic and prebiotic treatments in patients with fibromyalgia syndrome.
- Trial name
- NCT04607278
- Testing
- Probiotic, Prebiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Ankara University