Clinical trials: Precision Treatment
Asthma
Use of fenoTRACK Device for Monitoring Changes of Fractional Exhaled Nitric Oxide (FeNO) in Uncontrolled Asthma Subjects and Controlled Asthma Subjects
This study incorporates objectives directed at two subject cohorts: 1. Uncontrolled Adult and Pediatric Asthma Subjects: To demonstrate a statistically significant and clinically meaningful decline in Point Of Care (POC) FeNO as…
- Trial name
- NCT07228026
- Testing
- fenoTRACK Device
- Where
- 13 sites in United States
- Volunteers
- 160 people
- Sponsor
- Biometry Inc
TNBC - Triple-Negative Breast Cancer, Triple Negative Breast Cancer
Randomized Study of Stereotactic Body Radiation Therapy (SBRT) in Patients With Oligoprogressive Metastatic Cancers of the Breast and Lung
The purpose of this study is determine if receiving stereotactic body radiation(SBRT) when participants' metastatic tumors have just begun to grow increase the length of time before disease gets worse
- Conditions
- TNBC - Triple-Negative Breast Cancer, Triple Negative Breast Cancer, NSCLC, NSCLC Stage IV
- Trial name
- NCT03808662
- Testing
- Sterotactic Body Radiotherapy/SBRT, Standard of care
- Where
- 10 sites in United States, Canada
- Volunteers
- 107 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Post Traumatic Stress Disorder, Traumatic Brain Injury
Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI
This will be a randomized placebo controlled study to test the efficacy of cannabidiol (CBD) as a treatment for symptoms of post-traumatic stress disorder (PTSD).
- Trial name
- NCT04550377
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Gastrointestinal Cancers
DPD Guided 5-FU Precision Treatment in Gastro-intestinal Cancer Patients
Rationale: Fluorouracil (5-FU) are broadly used in chemotherapeutic regimens for the treatment of cancers. Dihydropyrimidine dehydrogenase (DPD) is a major enzyme in the 5-FU metabolism pathway.
- Trial name
- COMBIGaPP (NCT06782022)
- Testing
- 5-Fluoro-Uracil
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Jan Gerard Maring
Radiculopathy Lumbar, Radiculopathy Sacral
Precision Treatment of Lumbar Spine Surgery Through Advanced Nerve Root Blockade
The overall purpose of the study is to investigate whether selective spinal nerve root blocks can improve diagnostics of radiculopathy due to lumbar disc herniation (LDH), foraminal stenosis (FS), and recess stenosis (RS), and…
- Conditions
- Radiculopathy Lumbar, Radiculopathy Sacral, Herniated Disc, Foraminal Stenosis
- Trial name
- PLAN (NCT06143813)
- Testing
- Selective nerve root block (SNRB)
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- University of Aarhus
Pancreatic Ductal Adenocarcinoma
A Registry to Capture Patient Outcomes With KRAS G12R Altered Advanced Pancreatic Ductal Adenocarcinoma Treated With MEK Inhibitor-based Combination Therapy
This is an observational precision oncology study designed to collect and analyze data that allows us to characterize the safety and efficacy of several different mitogen-activated protein kinase kinase inhibitor (MEKi) -based…
- Trial name
- NCT05630989
- Testing
- combination therapy with no MEKi, combination therapy with MEKi-HCQ, combination therapy with MEKi-EGFRi
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mandana Kamgar, MD
Colorectal Adenoma, Artificial Intelligence (AI)
Development and Demonstration of a Precision Prevention and Treatment System for Colorectal Tubular Adenomas Lesions
This study is a prospective,multi-center and observational clinical study.Investigators would like to innovatively construct a "trinity" database of colorectal tubular adenomas based on white light - magnifying chromo …
- Trial name
- NCT07073430
- Testing
- AI models with NBI
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Renmin Hospital of Wuhan University
Pancreatic Cancer
Radiation Therapy (RT) and Chemotherapy for the Treatment of Pancreatic Cancer with Homologous Recombination Deficiency That Has Spread to the Liver
The researchers are doing this study to test the combination of radiation therapy (RT) and low dose chemotherapy in people with metastatic pancreatic cancer that has a homologous recombination deficiency (HRD) and has spread to…
- Trial name
- NCT05182112
- Testing
- Whole liver irradiation (WLI), Gemcitabine and Cisplatin
- Where
- 7 sites in United States
- Volunteers
- 1 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Overweight, Healthy
Precision Exercise Therapeutics (PET-pilot)
The aim of this randomized cross-over study is to collect information for the design of a precision exercise therapy cohort that will predict what modality of physical activity a physically inactive individual with overweight…
- Trial name
- NCT05718089
- Testing
- Continuous aerobic exercise, High intensity interval training, Resistance training
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
High-Risk Prostate Cancer
A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss
The purpose of this study is to learn about how an investigational drug intervention completed before doing prostate surgery (specifically, radical prostatectomy with lymph node dissection) may help in treatment of high risk…
- Trial name
- SNARE (NCT05593497)
- Testing
- Capivasertib, abiraterone acetate
- Where
- 9 sites in United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Locally Advanced Thyroid Gland Carcinoma
Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer
The current study aims to explore the potential advantages of anti-cancer therapy that is implemented based on drug sensitivity testing.
- Trial name
- NCT06482086
- Testing
- Anlotinib, Lenvatinib, Sorafenib
- Where
- China
- Volunteers
- 75 people
- Sponsor
- West China Hospital
Obsessive-Compulsive Disorder
Neuroinflammation in Patients With OCD
The goal of this study is to examine whether measurements of inflammation from brain scanning and blood tests can predict how much benefit patients with obsessive-compulsive disorder (OCD) will have from treatment with an…
- Trial name
- NCT04786548
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- New York State Psychiatric Institute
Isavuconazole, Invasion Pulmonary Mycosis
Individualized Precision Isavuconazole Therapy Guided by PK/PD Principles for the Geriatric Population
Esconazole, as a novel triazole antifungal drug, has broad-spectrum antifungal activity, good tissue penetration and low toxicity risk.
- Trial name
- NCT07496008
- Testing
- Liquid chromatography-tandem mass spectrometry
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Locally Advanced Rectal Cancer
Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study
To investigate the efficacy and safety of short-course radiotherapy sequential fruquintinib in combination with adebrelimab and CAPOX (full course neoadjuvant therapy) in patients with locally advanced rectal cancer.
- Trial name
- NCT06234007
- Testing
- Fruquintinib, Adebrelimab, Oxaliplatin, Capecitabine
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (ICC)
An Exploratory Study on Developing an Integrated Approach Combining Multimodal Imaging and Multi-omics Characterization of Tumor Heterogeneity for Precision Diagnosis and Treatment Optimization in Liver Cancer.
Primary liver cancer, mainly including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), represents the third leading cause of cancer-related mortality.
- Conditions
- Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (ICC), Primary Liver Cancer
- Trial name
- NCT07101237
- Testing
- Multi-modal ultrasonic imaging system for liver cancer
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Cancer, Stage IIB, Cervical Cancer Stage IIIA
Clinical Trial of Laparoscopic Pelvic and Para-aortic Lymphadenectomy and Uterine Blood Vessel Blocking for Precision Diagnosis and Treatment in Advanced Cervical Cancer
Cervical cancer is the most common reproductive malignancy in developing country. Due to local invasion, radical hysterectomy cannot be performed in advanced cervical cancer (FIGO IIB - IVA) , so that radiation combined with…
- Conditions
- Cervical Cancer, Stage IIB, Cervical Cancer Stage IIIA, Cervical Cancer Stage IIIB, Cervical Cancer, Stage IVA
- Trial name
- NCT02950350
- Volunteers
- 50 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Rehabilitation, Pain, Shoulder
Precision Medicine for Sng/Pain Control
Patients have different response to different treatment modalities, and sore/pain medicine is no exception. In our experience, low-level laser (LLL), ultrasound, and prolotherapy can reduce sore /pain through different genetic…
- Conditions
- Rehabilitation, Pain, Shoulder, Pain, Chronic
- Trial name
- SNG (NCT05154695)
- Testing
- LASER, A.therapeutic ultrasound group, B.prolotherapy group
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Kidney Cancer, Renal Cell Carcinoma
Proteomic Guided First-line Precision Treatment of Renal Clear Cell Carcinoma
Based on different subtypes, subjects will be placed in one of three treatment groups to explore individual efficacy and safety of various treatment regimen.
- Conditions
- Kidney Cancer, Renal Cell Carcinoma, Renal Clear Cell Carcinoma
- Trial name
- NCT06211790
- Testing
- Anlotinib, Everolimus and Tislelizumab
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Fudan University
Uncontrolled Asthma
Impact of GDMT in Uncontrolled Asthma Patients Receiving MHD Inhaled Corticosteroids + Long-acting β2 Agonist
The primary objective of this study is to evaluate whether GDMT can bring significant benefits to disease management in uncontrolled asthma patients receiving medium- to high-dose ICS-LABA.
- Trial name
- PRECISION (NCT07718724)
- Testing
- Intervention group
- Where
- 20 sites in China
- Volunteers
- 540 people
- Sponsor
- AstraZeneca
Depressive Disorder, Major, Treatment Outcome
Precision Medicine in the Depression Treatment
The BrainDrugs-D study uses multimodal neuroimaging combined with self-report measures, clinical and molecular markers to identify clinically relevant predictors that can identify subtypes of major depressive disorder (MDD) and…
- Conditions
- Depressive Disorder, Major, Treatment Outcome, Cognitive Dysfunction, Cognitive Behavioral Therapy
- Trial name
- BDD (NCT05616559)
- Testing
- Treatment Package for First-Episode Depression
- Where
- Denmark
- Volunteers
- 800 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet