Clinical trials: Precision Treatment
Ovarian Cancer, Fallopian Tube Cancer
ChemoFx® PRO - A Post-Market Data Collection Study
This study will collect patient demographic, oncology history, and physician reported outcome information following the initial round of chemotherapy received after a commercial ChemoFx® Final Report for the generation of…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer, Uterine Neoplasms
- Trial name
- NCT00669422
- Where
- 67 sites in United States
- Volunteers
- 2,756 people
- Sponsor
- Precision Therapeutics
Lung Cancer
Stereotactic Radiosurgery in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer
RATIONALE: Stereotactic radiosurgery can send x-rays directly to the tumor and cause less damage to normal tissue. PURPOSE: This phase I trial is studying the side effects and best dose of stereotactic radiosurgery in treating…
- Trial name
- NCT00852644
- Testing
- computed tomography, fludeoxyglucose F 18, hypofractionated radiation therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Medical Center
Salivary Gland Carcinoma, Precision Therapy
Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing
Patients with salivary gland carcinoma were divided into groups according to HER2, NTRK, AR, TROP-2, etc. Patients in different groups were given precision targeted therapy or chemotherapy to evaluate the efficacy (ORR rate) and…
- Trial name
- NCT06145308
- Testing
- Cohort 1 (HER2-positive, RC48-ADC), Cohort 2 (NTRK-fusion or NTRK-mutant), Cohort 3 (AR-positive, leuprolide + bicalutamide + abiraterone)
- Where
- 2 sites in China
- Volunteers
- 39 people
- Sponsor
- Peking Union Medical College
Bladder Cancer
The Application Value of Artificial Intelligence in MRI Precision Diagnosis and Treatment of Bladder Cancer
This study was a prospective, multicenter observational clinical study, A total of 150 patients with bladder malignant tumor who was admitted to the urology department of each center for treatment and underwent electric resection…
- Trial name
- NCT05096533
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Leukemia, Acute, Leukemia, T Cell
Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL
ETP-ALL is a recently recognized high-risk subgroup and the optimal therapeutic approaches are poorly characterized. Based on the pediatric-inspired, PEG-L-asparaginase-intensified and MRD-directed PDT-ALL-2016 protocol, this…
- Conditions
- Leukemia, Acute, Leukemia, T Cell, Leukemia, Lymphoblastic
- Trial name
- NCT03553238
- Testing
- Chidamide, Dexamethasone, vincristine
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Aging, Stroke
Precision Vibration Therapy for Neuromuscular and Functional Improvement in Older Adults and Stroke Survivors
To address muscle weakness, sensory degradation, functional decline, and pain caused by geriatric syndromes in older adults and stroke survivors, this project proposes a series of studies aimed at improving neuromuscular…
- Trial name
- NCT07351877
- Testing
- Precision Vibration Therapy, Conventional Rehabilitation
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Health Research Institutes, Taiwan
Liver Cancer
Radical Surgery Followed by Immunotherapy Using Precision T Cells Specific to Multiple Common Tumor-Associated Antigen for the Treatment of Hepatocellular Carcinoma
Objectives: The purpose of this study is to evaluate the safety and efficacy of radical surgery combined with dendritic cell-precision multiple antigen T cells in reducing the recurrence and metastasis of liver cancer Methods…
- Trial name
- NCT02632188
- Testing
- Postoperative routine treatment, DC-PMAT treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Military Medical University
Acute Respiratory Distress Syndrome
Validation and Precision Treatment of Inflammatory Subphenotypes in Acute Respiratory Distress Syndrome: A Multicenter Cohort Study
Acute respiratory distress syndrome (ARDS) is a common and life-threatening condition in intensive care units, characterized by substantial biological and clinical heterogeneity.
- Trial name
- VATIC (NCT07289711)
- Testing
- ARDS Inflammatory Subphenotypes
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Southeast University, China
Type 2 Diabetes
Randomized Controlled Trial of Digital Twin Precision Treatment: A Novel Whole Body Digital Twin Enabled Precision Treatment for Type 2 Diabetes
This is a randomized study comparing outcomes of patients diagnosed with Type 2 Diabetes (T2D) who are enrolled into the Twin Health Precision Treatment (TPT) system versus usual care.
- Trial name
- TPT (NCT05181449)
- Testing
- Twin Precision Treatment
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Cleveland Clinic
Liver Metastasis, Gastric Cancer
Immunotherapy Using Pluripotent Killer-Human Epidermal Growth Factor Receptor-2 (PIK-HER2) Cells for the Treatment of Advanced Gastric Cancer With Liver Metastasis
Objectives: The purpose of this study is to evaluate the safety and efficacy of PIK-HER2 cells in the treatment of advanced Her2 high expressed gastric cancer with liver metastasis patients.
- Trial name
- NCT02632201
- Testing
- PIK-HER2, DC-PMAT
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Military Medical University
Personalized Medicine, Oligometastatic Disease
Feasibility Trial of Darwin OncoTreat and OncoTarget Precision Medicine Testing
This is a feasibility trial to assess use of OncoTarget and OncoTreat testing in a basket design of patients with oligmetastasis across various solid tumor histology.
- Conditions
- Personalized Medicine, Oligometastatic Disease, Feasibility
- Trial name
- NCT06842030
- Testing
- Darwin OncoTarget and OncoTreat
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Good Samaritan Hospital Medical Center, New York
Recurrence Tumor, Metastatic Cancer
Immunotherapy for the Treatment of Advanced Solid Tumor
The purpose of this study is to evaluate the safety, side effects and benefits of autologous tumor infiltrating lymphocytes (TIL) specific to personalized Neo-antigens in the treatment of patients with recurrent, metastatic and…
- Conditions
- Recurrence Tumor, Metastatic Cancer, Solid Tumor
- Trial name
- NCT03658785
- Testing
- TIL, Aldesleukin, Cyclophosphamide
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Tongji Hospital
Lung Cancer, Gene Abnormality
iCAGES-guided Precision Therapy for Cancers in Contrast to Standard Care or IHC-guided Theray
This study prospectively evaluates whether the use of iCAGES (integrated CAncer GEnome Score) tool in guiding the treatment of advanced cancers is superior to current standard care or IHC-guided therapy in progress free survival…
- Conditions
- Lung Cancer, Gene Abnormality, Gene Product Sequence Variation, Cancer
- Trial name
- NCT03192501
- Testing
- inhibitors, ADC drugs such as tarceva, capmatinib, padcev et al for A/C group.
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Subjects With Hyperuricemia
Prebiotics and the Management of Hyperuricemia
Hyperuricemia is a major risk factor for many chronic diesease. Recently, gut mcirobiota has been identified as a novel theraputic target for hyperuricemia.
- Trial name
- NCT06420401
- Testing
- araboxylan, inulin, inulin and araboxylan
- Where
- 2 sites in China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
The PRECISION II Study: Evaluating the Accuracy of the LabPatch Glucose Sensing System
The purpose of this study is to evaluate the accuracy of the Cambridge Medical Technologies, LLC second generation (2nd Gen) LabPatch glucose sensing system compared to a laboratory glucose analyzer (YSI 2300 STAT Plus) and 2…
- Trial name
- NCT05754281
- Testing
- 2nd Gen LabPatch Glucose Sensing System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joslin Diabetes Center
VT Ablation, Arrhythmic Burden
Treatment Based on High Precision Cardiac Mapping
APOLO-VT aims to evaluate the feasibility, safety, and clinical impact of an integrated multimodal mapping workflow combining non-invasive structural and functional substrate characterization using Volumetric Electrocardiographic…
- Conditions
- VT Ablation, Arrhythmic Burden, Implantable Cardioverter-Defibrillator (ICD) Therapies, Slow-conduction Substrate
- Trial name
- APOLO-VT (NCT07746336)
- Testing
- ACORYS Mapping System
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Clinic of Barcelona
Osteoarthritis, Hip, Arthritis, Rheumatoid
Benefit of Orthopedic Navigation in the ARThroplasty of the Hip
This study was initiated to investigate the impact of the computer based image free navigation on the precision of the cup implantation.
- Conditions
- Osteoarthritis, Hip, Arthritis, Rheumatoid, Femur Head Necrosis
- Trial name
- BONARTH (NCT01496300)
- Testing
- Manual Intervention, Navigated Intervention
- Where
- Germany
- Volunteers
- 89 people
- Sponsor
- Aesculap AG
Advanced or Metastatic Solid Tumors
PRISM-NK: Precision-Matched Allogeneic Single- or Dual-Target CAR-NK Cells for Advanced Solid Tumors
This Phase 1/2, open-label, biomarker-guided platform study evaluates the safety, tolerability, and preliminary anti-tumor activity of banked allogeneic donor-derived chimeric antigen receptor natural killer (CAR-NK) cells in…
- Trial name
- PRISM-NK (NCT07510828)
- Testing
- EB-PT-CAR-NK-S, EB-PT-CAR-NK-D, Lymphodepleting chemotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Biotech
Major Depressive Disorder
Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD).
- Trial name
- NCT05523817
- Testing
- Intermittent Theta Burst Stimulation (iTBS)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Lymphoma, Non-Hodgkin, Multiple Myeloma
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a…
- Conditions
- Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors
- Trial name
- TAPUR (NCT02693535)
- Testing
- Sunitinib (CLOSED TO ENROLLMENT), Trastuzumab and Pertuzumab (CLOSED TO ENROLLMENT), Vemurafenib and Cobimetinib (CLOSED TO ENROLLMENT)
- Where
- 181 sites in United States, Puerto Rico
- Volunteers
- 4,200 people
- Sponsor
- American Society of Clinical Oncology