Clinical trials: Precision Treatment
Ceftazidime-avibactam
Individualized Precision Therapy With Ceftazidime and Avibactam Guided by PK/PD in Geriatric Populations
Ceftazidime-avibactam is a β-lactam/β-lactamase inhibitor combination treatment which has been developed to address infections caused by ESBL-, AmpC- and serine carbapenemase-producing Gram-negative bacteria.
- Trial name
- NCT07494981
- Testing
- liquid chromatography-tandem mass spectrometry
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Cholangiocarcinoma of the Extrahepatic Bile Duct, Gallbladder Cancer
Chemothetapy FORFIRINOX in Advanced or Recurrent Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma
The purpose of this study is to evaluate the feasibility, efficacy and safety of FORFIRINOX in advanced or recurrent extrahepatic cholangiocarcinoma and gallbladder carcinoma.
- Trial name
- NCT03772132
- Testing
- mutation and signal pathway activation status analysis Drug: FORFIRINOX
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial
This phase II trial evaluates whether genetic testing in prostate cancer is helpful in deciding which study treatment patients are assigned.
- Trial name
- PREDICT (NCT06632977)
- Testing
- Genetic testing, Valemetostat Tosylate, Magnetic Resonance Imaging
- Where
- 108 sites in United States
- Volunteers
- 474 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Treatment Resistant Depression, Refractory Depression
Ketamine for Older Adults Pilot
This pilot study will assess the safety and feasibility of intravenous (IV) ketamine in older adults with Treatment-Resistant Depression (TRD).
- Conditions
- Treatment Resistant Depression, Refractory Depression, Therapy-Resistant Depression, Late Life Depression
- Trial name
- NCT04504175
- Testing
- Ketamine
- Where
- 5 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Irritable Bowel Syndrome (IBS)
Personalized Probiotic Treatments for Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is characterized by stomach pain and altered bowel habits. It affects about 5 million people in Canada. Doctors don't fully understand what causes IBS, so treatments often don't work well.
- Trial name
- NCT07872514
- Testing
- Probiotic containing B longum, Probiotic Lactobacillus
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Age-Related Osteoporosis
Novel Precision Medicine Approach to Treatment of Osteoporosis Based on Bone Turnover
Osteoporosis affects 24.5% of women over 65 and results in fracture-related hospital admissions exceeding those of heart attacks, strokes and breast cancer combined.
- Trial name
- NCT05151484
- Testing
- Teriparatide, Alendronate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Madhumathi Rao
Breast Cancer Recurrent
Functional Precision Oncology to Predict, Prevent, and Treat Early Metastatic Recurrence of TNBC
This is a prospective phase 2 study to use Functional Precision Oncology (FPO) to predict, prevent and treat early metastatic recurrence in subjects with HR-low/Her2 negative or triple negative breast cancer.
- Trial name
- TOWARDS-II (NCT05464082)
- Testing
- Functional Precision Oncology
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Salivary Gland Carcinoma, Precision Therapy
Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing
Patients with salivary gland carcinoma were divided into groups according to HER2, NTRK, AR, TROP-2, etc. Patients in different groups were given precision targeted therapy or chemotherapy to evaluate the efficacy (ORR rate) and…
- Trial name
- NCT06145308
- Testing
- Cohort 1 (HER2-positive, RC48-ADC), Cohort 2 (NTRK-fusion or NTRK-mutant), Cohort 3 (AR-positive, leuprolide + bicalutamide + abiraterone)
- Where
- 2 sites in China
- Volunteers
- 39 people
- Sponsor
- Peking Union Medical College
Endometrial Cancer
ctDNA Assessment in Endometrial Cancer for Adjuvant Therapy
The goal of this observational study is to evaluate whether combining postoperative circulating tumor DNA (ctDNA) testing with a novel genomic risk model can better predict recurrence risk and guide adjuvant therapy decisions in…
- Trial name
- NCT07681414
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Guizhou Provincial People's Hospital
Supracondylar Femoral Fractures, Femoral Fractures
Robot-Assisted Closed Reduction and Internal Fixation for Distal Femoral Fractures
This study aims to evaluate the clinical efficacy and safety of an intelligent robotic system for the closed reduction of extra-articular supracondylar femoral fractures (Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic…
- Trial name
- NCT07738406
- Testing
- Robot-assisted closed reduction, Conventional fracture reduction and internal fixation
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Beijing Jishuitan Hospital
Hepatitis C, HIV Coinfection
Supporting Treatment Outcomes Among PWID
The goal of this study is to improve HCV care continuum outcomes for people who inject drugs (PWID), reduce potential onward transmission to others and improve HIV outcomes among those who are HIV/HCV coinfected.
- Trial name
- STOP-C (NCT04652804)
- Testing
- Low intensity HCV treatment adherence support, Medium intensity HCV treatment adherence support, High intensity HCV treatment adherence support
- Where
- India
- Volunteers
- 3,000 people
- Sponsor
- Johns Hopkins University
Depression - Major Depressive Disorder
Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine
This project aims to integrate digital phenotyping and AI-driven iCBT into a comprehensive platform for MDD diagnosis and treatment in Taiwan.
- Trial name
- NCT07500714
- Testing
- Internet Cognitive-Behavioral Therapy
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Science and Technology Council, Taiwan
Solid Tumor, Metastatic Cancer
A Study to Examine the Clinical Value of Comprehensive Genomic Profiling Performed by Belgian NGS Laboratories: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Centre
The project, called "BALLETT" (Belgian Approach of Local Laboratory Extensive Tumor Testing), has a double goal: (1) show the relevance of broad molecular profiling to improve oncological patients care, (2) demonstrate that broad…
- Trial name
- BALLETT (NCT05058937)
- Testing
- Comprehensive genomic profiling
- Where
- 12 sites in Belgium
- Volunteers
- 936 people
- Sponsor
- The Belgian Society of Medical Oncology
Type 2 Diabetes (T2DM)
Impact of a Nutritional Intervention Based on Moroccan Dietary Habits on the Glycemic Control of Type 2 Diabetics
The goal of this study is to learn if a nutritional intervention adapted to Moroccan dietary habits can improve blood sugar control in adults with Type 2 Diabetes.
- Trial name
- NCT07404280
- Testing
- Moroccan-Adapted Nutritional Plan
- Where
- Morocco
- Volunteers
- 50 people
- Sponsor
- Avicenna Military Hospital
Cancer
AI-generated Treatment Recommendations in Precision Oncology
Non-interventional study to assess the non-inferiority of AI-generated treatment recommendations for precision oncology. Molecular tumor profiles will be assessed by local AI models to identify treatment options.
- Trial name
- AI-PRIME (NCT07897110)
- Testing
- large language model (non-interventional)
- Where
- Germany
- Volunteers
- 191 people
- Sponsor
- Charite University, Berlin, Germany
Prostate Cancer (Localized), Urinary Incontinence (C61)
Total en Bloc Urethra Preservation at Robot-assisted Prostatectomy IDEAL Stage 2a
Prospective single-arm IDEAL stage 2a feasibility study of urethra-preserving RARP in localized prostate cancer.
- Trial name
- ToP-RAP (NCT07678489)
- Testing
- ToP-RAP
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Sami-Ramzi Leyh-Bannurah
Non Small Cell Lung Cancer
18F-FDG PET/CT Radiomics Models for Precision Diagnosis and Prognosis in NSCLC
This multicenter retrospective study aims to investigate the value of 18F-FDG PET/CT radiomics features in the preoperative precision staging, pathological typing, gene mutation status prediction, and prognostic risk…
- Trial name
- PET-Rad-NSCLC (NCT07449858)
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Solid Tumor
Liquid Biopsy-informed Precision Oncology Study to Evaluate Utility of Plasma Genomic Profiling for Therapy Selection
Overall, this project has three main goals: first, to ascertain the feasibility of the approach and identify whether liquid biopsies can detect actionable mutations that can be utilized to generate precision oncology treatment…
- Trial name
- NCT05585684
- Testing
- Non-invasive Comprehensive Genomic Profiling for Cancer Treatment Selection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Rheumatoid Arthritis
PRECISion medicinE Across the Disease Continuum to Prevent and Treat Rheumatoid Arthritis
The study will recruit patients referred to the Rheumatology Out-patient departments. Patients will be recruited to the study or control groups (healthy or disease controls who will be age and sex-matched) as needed.
- Trial name
- PRECISE-RA (NCT04482335)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Bariatric Surgery Candidate, Obesity, Morbid
Metabolomics and Bariatric Surgery in Patients With Metabolically Unhealthy Obesity
The goal of this observational study is to investigate metabolic changes in individuals undergoing bariatric surgery, specifically focusing on those with obesity and varying metabolic health statuses.
- Conditions
- Bariatric Surgery Candidate, Obesity, Morbid, Obesity, Metabolically Benign
- Trial name
- NCT06297928
- Testing
- baratric surgery
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Parc de Salut Mar