Clinical trials: Prediabetes
PreDiabetes
Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care
A large body of research has demonstrated that intensive lifestyle interventions and metformin are effective treatments to prevent or delay diabetes among high-risk adults, yet neither treatment is routinely used in practice.
- Trial name
- BEGIN (NCT04869917)
- Testing
- Decision Aid intervention, Text Messaging intervention, Usual Care
- Where
- United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Prediabetic State
Clinical Study to Assess the Long-term Effect of Pep2Dia® on Glucose Homeostasis in Prediabetic Subjects
The goal is to assess the long-term effect of Pep2Dia® compared to placebo intake on blood glucose homeostasis. Respective improvements will be assessed by changes in glycated haemoglobin (HbA1c) before and after the 12-weeks…
- Trial name
- NCT05391854
- Testing
- Pep2dia
- Where
- Germany
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Ingredia S.A.
Impaired Glucose Tolerance, Diabetes Mellitus, Type 2
The Interaction Between Metformin and Physical Training
Physical activity is a first line treatment for patients with type 2 diabetes (T2D), however, the vast majority of patients with T2D do not achieve satisfying glycemic control with physical activity alone, which is why…
- Trial name
- NCT03316690
- Testing
- Metformin treatment, Physical training
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kristian Karstoft
Prediabetes
Effects of Chili Pepper on Inflammation and Glycemic Control in Southern New Mexico
Diabetes is a major health epidemic facing the United States and New Mexico. Currently, 11.6% of the US population (38.4 million) has diabetes, and 38.0% of US adults have prediabetes.
- Trial name
- NCT06376890
- Testing
- Red chili peppers, Green Chili Pepper
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- New Mexico State University
Impaired Glucose Tolerance
Effect of High Fiber and Sugar Free Biscuits in Prediabetics Population
The increase in diabetic population of the world is among the top ten causes of death; with diabetes always high on the list of causes of death. Diabetes is always relative to other major causes of death, (e.g.
- Trial name
- NCT01330550
- Testing
- High fiber sugar free biscuit
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Diabete Type 2, Pre Diabetes
Investigation of PJ vs. Sugar on Glucose Levels in Healthy and Prediabetic Subjects
Pomegranate fruits and products, including juice, tea, wine and extracts are widely consumed and recognized for their health benefits.
- Trial name
- PSW (NCT04591782)
- Testing
- PomJuice, Water, Sugar Water
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cardiovascular Risk Factor, Insulin Resistance
Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology
This platform will enable investigation the cardiovascular risk reduction and the increase in participant engagement in their heart-healthy goals, through the use of virtual care/telemedicine with a digital platform that connects…
- Conditions
- Cardiovascular Risk Factor, Insulin Resistance, PreDiabetes, Diabetes
- Trial name
- HealthPals (NCT03167996)
- Testing
- Use of HealthPals (Telemedicine supported by digital health platform)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type2 Diabetes Mellitus
Study of Association of Salivary Adipokines With Prediabetes and Type 2 Diabetes Mellitus
India has more than 65 million adults with Type 2 Diabetes Mellitus (T2DM) and also has a large number with subclinical stages of glycaemia including impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).
- Trial name
- NCT03901248
- Testing
- No Intervention
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals
Metabolic Syndrome, Overweight and Obesity
The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
Strategies to reduce sugar-sweetened beverages (SSB) have become one of the leading public health targets to address the epidemics of obesity and diabetes.
- Conditions
- Metabolic Syndrome, Overweight and Obesity, PreDiabetes, Diabetes
- Trial name
- NCT05191160
- Testing
- Soy Milk, Cow's Milk, Sugar Sweetened Beverages
- Where
- Canada
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus, Endocrine System Diseases
Soluble Epoxide Hydrolase Inhibition and Insulin Resistance
The purpose of this study is to test how soluble epoxide hydrolase (sEH) inhibition with GSK2256294 affects tissue sEH activity and insulin sensitivity.
- Conditions
- Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders, PreDiabetes
- Trial name
- NCT03486223
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity, NAFLD
Low-Calorie Diet in People With Prediabetes/Metabolic Syndrome
Significant weight reduction, achieved by low-calorie diet (LCD), will mobilise ectopic fat (visceral and particularly liver fat), improving insulin sensitivity and other metabolic syndrome components, with secondary beneficial…
- Conditions
- Obesity, NAFLD, Fatty Liver, Pre Diabetes
- Trial name
- CALIBRATE (NCT04786418)
- Testing
- Standard of care, Low-calorie diet
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Prediabetic State
Effectiveness of a Nurse-led Personalized Telephone Intervention on Lifestyle Changes in Diabetes Prevention.
A randomized, 9-months, parallel-group study comparing the effectiveness of a nurse-led telephone personalized lifestyle intervention versus automated SMSs on nutritional and physical activity advice in the reduction of fasting…
- Trial name
- PREDIPHONE (NCT04735640)
- Testing
- nurse-led teleconsultation, SMS
- Where
- Spain
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Hyperglycemia, Hyperglucagonemia
Glucagon-Like Peptide-1 (GLP-1) Suppression of Alpha Cell Secretion in Type 2 Diabetes Mellitus (T2DM)
The incretin hormone glucagon-like peptide-1 (GLP-1) has known insulinotrophic and glucagonostatic properties. However, inpatients with type 2 diabetes mellitus (T2DM)it is shown, that the beta cell sensitivity towards GLP-1 is…
- Conditions
- Hyperglycemia, Hyperglucagonemia, Glucose Intolerance
- Trial name
- NCT00862589
- Testing
- GLP-1 infusion
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes, Metabolic Syndrome
Role of Growth Hormone Antagonism in Modulating Insulin Sensitivity in Subjects With Pre-diabetes
Growth hormone is well known to cause changes in glucose regulation. People with Laron syndrome are born without the growth hormone receptor and are protected from diabetes.
- Conditions
- Diabetes, Metabolic Syndrome, Insulin Resistance
- Trial name
- PEGIR (NCT02023918)
- Testing
- pegvisomant
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Prediabetic State
Medium Chain Triglycerides and Aerobic Exercise on Ketone Production in Women With or Without Prediabetes
The aim of this study is to compare the effect on ketone production of dietary an MCT supplement combined or not with physical exercise in two groups of women (N=10/group), healthy adults and patients with prediabetes.
- Trial name
- MCT+AE (NCT02678390)
- Testing
- MCT, MCT+ aerobic exercise, Aerobic exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Metabolic Disturbance
Concurrent Training and Prediabetes Control
Despite exercise training decrease blood fasting glicaemy in 'average' terms, there is a wide inter-individual variability after exercise training explored mainly in adults but not in adults with prediabetes comorbidities.
- Trial name
- NCT03502304
- Testing
- Endurance training plus resistant training
- Where
- Chile
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Type 2 Diabetes, PreDiabetes
Recreational Basketball to Increase Participation in Diabetes Prevention
The purpose of this study is to assess the efficacy of adapting the National Diabetes Prevention Program (NDPP) to include recreational sports in effort to increase physical activity (PA) and promote lifestyle changes that can…
- Trial name
- DPPHoops (NCT05066542)
- Testing
- NDPP + Basketball (BB), NDPP Standard of Care SOC
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obesity, Pre-diabetic
Personalized Glucose Optimization Through Nutritional Intervention
Maintaining well-controlled blood glucose concentrations is essential in the prevention of chronic cardiometabolic diseases. The blood glucose response to dietary and/or lifestyle patterns may vary between individuals.
- Conditions
- Obesity, Pre-diabetic, Type 2 Diabetes Mellitus
- Trial name
- PERSON (NCT03708419)
- Testing
- Optimal diet, Suboptimal diet
- Where
- 2 sites in Netherlands
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pre-Diabetes
Full-fat Yogurt and Glucose Tolerance
This study determines if substituting full-fat yogurt (i.e., whole, 3.25% fat) for non-fat yogurt in the diet can reduce the risk of type 2 diabetes and inflammation in association with changes in the composition of the…
- Trial name
- NCT03577119
- Testing
- Full-fat yogurt, Non-fat yogurt
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Impaired Glucose Tolerance
Sucralose, Stevia, Gut Microbiome and Glucose Metabolism
This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women.
- Trial name
- NCT02800707
- Testing
- Sucralose, Stevia
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota