Clinical trials: Prediabetes
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance (Prediabetes)
Exercise Training and Glucose Metabolism in Aging
Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are…
- Trial name
- NCT00701051
- Testing
- Aerobic exercise training, Detraining (cessation of exercise)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Impaired Glucose Tolerance
Health Effects of Salmon Fishmeal in Humans
Diabetes contributes significantly to the burden of disease in Norway and cardiovascular disease is the main cause of mortality. Both lean and fatty fish are shown to have beneficial health effects.
- Trial name
- FishMeal (NCT03764423)
- Testing
- Salmon fishmeal, Microcrystalline cellulose
- Where
- Norway
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Oslo
PreDiabetes, Aging
Effects of Progressive Intensity Exercise Training on Glycemic Control in Older Adults
The purpose of this study is to compare the effects of moderate versus vigorous intensity exercise training on glycemic control in older adults.
- Trial name
- GLYDE (NCT03154073)
- Testing
- Moderate Intensity Exercise Training (MOD), Vigorous Intensity Exercise Training (VIG)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Body Weight, Obesity
Meta-analysis of the Nordic Dietary Pattern on Cardiometabolic Risk and Cardiovascular Outcomes
The Nordic Diet is a dietary pattern rich in traditional Nordic foods, including berries, grains, and fatty fish common in northern Europe.
- Conditions
- Body Weight, Obesity, Overweight and Obesity, Obesity, Abdominal
- Trial name
- NCT04094194
- Testing
- Nordic diet
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
PreDiabetes
Small Steps for Big Changes - Healthy Cities Implementation Science
Small Steps for Big Changes (SSBC) is a diet and exercise counselling program that significantly reduces the risk of developing Type 2 Diabetes (T2D).
- Trial name
- HCIS (NCT06440395)
- Testing
- Behavioural: Small Steps for Big Changes Diabetes Prevention Program
- Where
- 12 sites in Canada
- Volunteers
- 4,400 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pre-diabetes, Insulin Sensitivity
Understanding Dose Related Effects of Strawberry
The proposed research is designed to extend previous research findings building on the knowledge of strawberries as fruits that support a healthy immune and vascular system.
- Conditions
- Pre-diabetes, Insulin Sensitivity, Insulin Resistance, Inflammation
- Trial name
- STRW (NCT06173765)
- Testing
- freeze-dried whole strawberry powder 36 g powder, freeze-dried whole strawberry powder 12 g, freeze-dried control powder 0 g strawberry
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Pre-diabetes, Overweight and Obesity
A Personalized Diet Study to Reduce Glycemic Exposure
The aim of this 2-phase, randomized clinical trial will be to examine the effects of two behavioral weight loss interventions on weight loss.
- Trial name
- NCT03336411
- Testing
- mHealth, Personalized mHealth
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pre-diabetes
GluCoach - Technology-enabled Lifestyle Intervention Study
This study seeks to address two questions. Firstly, how might a suite of interventions and data feedback (activity, diet, mood*, continuous blood glucose) through coaching be effective in influencing behaviour change for…
- Trial name
- NCT04905680
- Testing
- CGM lifestyle tracking and coaching
- Where
- Singapore
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Metabolic Disturbance, Alcohol; Harmful Use
Metabolic Effects of One-weak Heavy Drinking
Examination of the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in Roskilde Festival 2016.
- Conditions
- Metabolic Disturbance, Alcohol; Harmful Use, Glucose Intolerance
- Trial name
- ROSMET (NCT04229550)
- Testing
- Festival participation
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Prediabetes, Insulin Resistance
Pilot Study on Metabolic Effects of Fish Peptides and Vitamin D
The overall goal of this study is to investigate the effects and the mechanisms of action of a fish peptide and vitamin D on glucose metabolism, insulin secretion, and cardiometabolic risk profile in overweight men.
- Trial name
- BONITO (NCT02668159)
- Testing
- Fish peptide supplement, Vitamin D supplement, Fish peptide + Vitamin D3 supplements
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Laval University
Prediabetes, Type 2 Diabetes
RISE Adult Medication Study
The RISE Adult Medication Study is a 4-arm, 3-center, clinical trial of adults with prediabetes and early type 2 diabetes to address the hypothesis that aggressive glucose lowering will lead to recovery of beta-cell function that…
- Trial name
- RISE Adult (NCT01779362)
- Testing
- Metformin, Liraglutide, Glargine
- Where
- 4 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- RISE Study Group
Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease
Healthy Liver - Healthy Brain
People with liver disease report difficulties with attention and problem-solving skills. Diet plays an important role in the development of liver disease and/or pre-diabetes.
- Conditions
- Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease, NAFLD, Pre-diabetes
- Trial name
- NCT05216796
- Testing
- Diet Intervention
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Diabetes type2
The Canadian Diabetes Prevention Program
According to Diabetes Canada ("DC"), in 2015, the estimated prevalence of prediabetes in Canada (>20 years of age) is 5.7 million people (22.1%). This rate is estimated to increase to 6.4 million people (23.2%) by 2025.
- Trial name
- CDPP (NCT05784220)
- Testing
- DPP Curriculum for Lifestyle Intervention
- Where
- Canada
- Volunteers
- 2,174 people, healthy volunteers welcome
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Congestive Heart Failure
Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes
This study will evaluate the safety and effectiveness of the drug rosiglitazone for improving heart function in patients with heart failure and glucose intolerance or type II (adult-onset) diabetes, or both.
- Trial name
- NCT00064727
- Testing
- Avandia (Rosiglitazone), Avanclia (Rosiqlitazone)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pre-diabetes, Obesity
Healthy Living Partnerships to Prevent Diabetes in Veterans Pilot Study
Diabetes and obesity are both major public health concerns and the prevalence of diabetes is even higher in the patient population of the Veterans Administration.
- Trial name
- HELP Vets (NCT02835495)
- Testing
- HELP Vets Intervention, Individual Education Program
- Where
- 2 sites in United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Gestational Diabetes Mellitus, Pre-diabetes
A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus
Our goal is to test whether shared decision making for diabetes prevention can help women with a history of gestational diabetes mellitus (GDM) who are at high risk of developing type 2 diabetes (T2DM) increase weight loss and…
- Conditions
- Gestational Diabetes Mellitus, Pre-diabetes, Diabetes Mellitus, Type 2
- Trial name
- NCT04897945
- Testing
- Shared decision-making for diabetes prevention
- Where
- 2 sites in United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Type 2 Diabetes, Pre-Diabetes
Sugar Challenge Study
This is a longitudinal study involving use of the January App which collects multiple data streams and employs machine learning techniques to offer personalized lifestyle recommendations and structured food and activity…
- Conditions
- Type 2 Diabetes, Pre-Diabetes, Healthy
- Trial name
- NCT04621656
- Testing
- January Mobile Application (Sugar AI)
- Where
- United States
- Volunteers
- 1,022 people, healthy volunteers welcome
- Sponsor
- January, Inc.
Healthy
Efficacy of Different Doses of Amino Acids in 5AA+CrPic Water on Glucose Homeostasis in a Healthy Population.
It has previously been shown that a carbonated water including a defined amount of amino acids and chromium can decrease the postprandial glucose response.
- Trial name
- NCT03411395
- Testing
- 5AA+CrPic Water
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- DoubleGood AB
Pre-diabetes
Efficacy of Whole-body Electromyostimulation (WB-EMS) Training in Participants With Pre-diabetes
The goal of this pilot study is to assess the efficacy of the intervention (WB-EMS Training) in a sedentary group of adults with pre-diabetes and to estimate the potential effect sizes.
- Trial name
- NCT06188481
- Testing
- whole-body electromyostimulation training, activity tracker, evidence-based lifestyle education program
- Where
- Germany
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
Polycystic ovary syndrome (PCOS) affects 5-10% of women in the United States. Its onset is usually at the time of puberty with manifestations of menstrual irregularity, hirsutism, and obesity.
- Trial name
- NCT00203996
- Testing
- continuous positive airway pressure (CPAP), depot leuprolide plus estrogen/progestin replacement, pioglitazone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Chicago