Clinical trials: Prediabetes
Diabetes, Prediabetes
The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk
The hypertriglyceridemia at fasting status has been known to be an important risk factor for cardiovascular disease (CVD). Recently, postprandial triglyceride (TG) levels draw an attention as a superior predictor of CVD because…
- Trial name
- NCT01972542
- Testing
- Oral fat tolerance test
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Healthy, Hypercholesterolemia
In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and therapeutic target for hypercholesterolemia and atherosclerotic cardiovascular disease (CVD).
- Conditions
- Healthy, Hypercholesterolemia, Hypertension, Overweight
- Trial name
- NCT06675994
- Testing
- PCSK9 Antibody, PCSK9 Enzyme
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Prediabetic State
A Pharmacist-Coordinated Implementation of the Diabetes Prevention Program
This proposed project will translate evidence-based strategies for diabetes prevention within the framework of an existing and highly utilized pharmacist-led diabetes care program.
- Trial name
- NCT02384109
- Testing
- Shared decision-making with pharmacists, Standard care from primary care providers
- Where
- 20 sites in United States
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Prediabetes
The Association Between Body Constitution and Meridian Energy in Prediabetes
Traditional Chinese medicine (TCM) theories assert that body constitution and meridian energy are the foundations for disease prevention. However, few studies have incorporated TCM concepts into risk factors.
- Trial name
- NCT05475587
- Testing
- Routine care
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Electroretinography
The Electroretinogram in Healthy and Glucose Intolerant Young Men
The purpose is to investigate the electroretinogram (ERG) in young, healthy men in the normoglycaemic and hyperglycaemic state before and after intervention with corticosteroids treatment, high calorie diet and exercise restraint.
- Trial name
- NCT01140932
- Testing
- Prednisolone, Lifestyle change
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Aging
Metformin in Longevity Study (MILES).
Metformin, an FDA approved first-line drug for the treatment of type 2 diabetes, has known beneficial effects on glucose metabolism.
- Trial name
- MILES (NCT02432287)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Adipose Tissue, Brown, Glucose Intolerance
L-arginine and Brown Adipose Tissue
The South Asian population is facing an epidemic of type 2 diabetes, of which the underlying cause is still unknown. It is currently hypothesized that an ethnic susceptibility towards a disturbed energy metabolism may underlie…
- Conditions
- Adipose Tissue, Brown, Glucose Intolerance, Nitric Oxide
- Trial name
- ArgMB (NCT02291458)
- Testing
- L-arginine
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pre-diabetes
Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin
Early Phase Pre-Clinical and Initial Clinical Research on (+)- Epicatechin.
- Trial name
- Epicatechin (NCT02330276)
- Testing
- (+)-Epicatechin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Veterans Medical Research Foundation
Diabetes Mellitus, Type 2, Insulin Resistance
Exercise to Restore 24h Rhythms in Metabolism
This study will investigate the effect of exercise training on 24h rhythms in substrate metabolism in overweight subjects with impaired glucose tolerance. Subjects will perform exercise training for 12 weeks.
- Trial name
- RESTORE (NCT04565418)
- Testing
- High-intensity interval training
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Prediabetes, Diabetes Type 1
An Exploratory Clinical Trial to Generate Whole Blood Samples for Analysing Genetic Polymorphisms
G (guanine nucleotide binding) proteins associating with G protein-coupled receptors (GPCR) are key players in the pathogenesis of obesity and diabetes and are targets of pharmacotherapeutic inter-ventions.
- Conditions
- Prediabetes, Diabetes Type 1, Diabetes Type 2
- Trial name
- NCT02057497
- Volunteers
- healthy volunteers welcome
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
PreDiabetes
2-A-Day Study: Twice a Day Meals Study.
Caloric restriction increases lifespan and/or healthspan across multiple species. However implementation of long-term CR in humans is problematic and unacceptable to many individuals.
- Trial name
- NCT03809299
- Testing
- Ad libitum meal timing, Twice a day meals
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Diabetes Mellitus, Pre Diabetes
Glucose Tolerance and Prevention of Diabetes Mellitus Type 2 by Polyherbal Formulation
Primary protocol to this study is to develop a natural remedy to prevent diabetes mellitus in pre-diabetic state and elaborate the effectiveness of polyherbal formulation for carrying out Phase-II, III and IV.
- Trial name
- Phase-1 (NCT03884920)
- Testing
- Polyherbal formulation
- Where
- 2 sites in Pakistan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Islamia University of Bahawalpur
PreDiabetes
Prevention and Choice for Type 2
People living with prediabetes are advised to lose weight to prevent development of type 2 diabetes by participating in intensive lifestyle interventions (ILI's), such as PreventT2.
- Trial name
- PACT2 (NCT06377020)
- Testing
- PACT2
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Prediabetic State & High Risk Individuals on the Basis of Diabetes Risk Score
(Pakistan Diabetes Prevention Program PDPP)
The Karachi-based Pakistan Diabetes Prevention Study aims to address key issues in the prevention of type 2 diabetes. Approximately 20,000 people From four communities will be screened for diabetes risk factors using a…
- Trial name
- PDPP (NCT01530165)
- Testing
- Life style intervention
- Where
- Pakistan
- Volunteers
- 1,564 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Impaired Glucose Tolerance
The Role of Pulsatile Insulin Secretion (A Study Investigating the Effects of Partial Pacreatectomy on Glucose Metabolism)
The purpose of this study is to examine changes in sugar metabolism that may occur in subjects who have previously had part of their pancreas removed due to a benign lesion.
- Trial name
- Pilot OGTT (NCT00841867)
- Testing
- All subjects will undergo a 120 minute Oral Glucose Tolerance Test at study visit 2.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Prediabetes
Trial of an Herb and Mineral Combination Product on Fasting Glucose in Adults at Risk for Developing Diabetes
This is a multi-center, randomized, double-blind, placebo-controlled study in approximately 104 subjects (52 per group) to evaluate the effectiveness of an herb and mineral combination product on fasting serum glucose levels in…
- Trial name
- NCT02146157
- Testing
- herb and mineral combination product
- Where
- 6 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- NewChapter, Inc.
Type 2 Diabetes
Quantitative 18F-AV-133 PET Imaging in Subjects With Diabetes and Healthy Controls
To evaluate 18F-AV-133 imaging of the pancreas in patients with early type 2 diabetes, late type 2 diabetes, subjects with pre-diabetes and in healthy overweight/obese control subjects.
- Trial name
- NCT01710371
- Testing
- 18F-AV-133, 10% Arginine Hydrochloride-R-Gene 10
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
PreDiabetes
Prediabetes and Metabolic Parameters Among Young Adults at Assiut University Hospital
Prediabetes is a major public health problem that increases the risk of developing type 2 diabetes mellitus and cardiovascular complications.
- Trial name
- NCT07259954
- Testing
- No intervention
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pre-Diabetes, Diabetes
A1c FIT TEST: An Epidemiological Study Correlating Hemoglobin A1c With Results of the Air Force Physical FITness TEST.
The purpose of this study is to evaluate the prevalence of pre-diabetes and diabetes among those Air Force personnel who have not passed the Air Force physical fitness test (AFPT) and to evaluate the usefulness of the AFPT as a…
- Conditions
- Pre-Diabetes, Diabetes, Cardiovascular Risks
- Trial name
- NCT01301339
- Where
- United States
- Volunteers
- 535 people, healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
Cardiovascular Disease, Insulin Resistance
A Trial of Tadalafil and Glycemic Traits
The purpose of this study is to find out if tadalafil can help overweight and obese people metabolize blood sugar more efficiently.
- Conditions
- Cardiovascular Disease, Insulin Resistance, Glucose Intolerance, Obesity
- Trial name
- NCT01444651
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Thomas J. Wang, MD