Clinical trials: Prediabetes
PreDiabetes
Insulin Modelling Based on Plasma Glucose Measures Via a Minimally-Invasive Glucose Sensor
The study aims to evaluate insulin as a potential biomarker for prediabetes in Singapore Chinese subjects.
- Trial name
- NCT06119035
- Testing
- Single dose of 75 grams glucose in 200ml water
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity, Insulin Resistance
Effects of Obesity and Intensity of Exercise on Ghrelin Levels
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin…
- Conditions
- Obesity, Insulin Resistance, Cardiovascular Risk Factor
- Trial name
- NCT04581980
- Testing
- Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Mitochondrial Function, Glucose Intolerance
Dose-response Relationship Between Exercise and Health Outcomes
In this study 11 healthy volunteers will perform high intensity exercise training during 4 weeks. The exercise frequency will increase progressively during the first three weeks, followed by a fourth week with lower exercise…
- Trial name
- NCT04753021
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Prediabetes, Diabetes Mellitus
Research on Potential Biomarkers of Prediabetes and Diabetes Based on MALDI-TOF MS Platform.
Through the MALDI-TOF MS platform, explore the proteomics and peptidomics differences of fasting serum/plasma and urine between non pregnant people with normal glucose tolerance test and prediabetes /diabetes patients, pregnant…
- Conditions
- Prediabetes, Diabetes Mellitus, Gestational Diabetes Mellitus, Proteomics
- Trial name
- NCT06097065
- Testing
- Oral Glucose Tolerance Test
- Where
- China
- Volunteers
- 2,860 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Obesity, Insulin Resistance
Treating the Endothelium to Restore Insulin Sensitivity
A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes
- Trial name
- NCT00402194
- Testing
- Losartan
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Overweight and Obesity
The Effect of Extended Use of the EPITOMEE CAPSULE (ELECT)
The Effect of Extended Use of the Epitomee Capsule on BodyWeight in subjects with Overweight and Obesity with and without Prediabetes
- Trial name
- NCT04994769
- Testing
- Epitomee Capsule
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Epitomee medical
Obstructive Sleep Apnea, Pre-diabetes
CPAP and Glucose Metabolism in Non-Diabetic OSA Subjects
The purpose of the current study is to investigate whether alleviation of OSA by CPAP positively impacts glucose metabolism in non-diabetic patients.
- Trial name
- NCT05335083
- Testing
- CPAP
- Where
- 2 sites in Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Depression, Impaired Glucose Tolerance
Mood and Insulin Resistance in Adolescents At-Risk for Diabetes
Background: Type 2 diabetes is a chronic disease that puts individuals at risk for serious health problems like heart disease, kidney failure, vision problems, and stroke.
- Trial name
- NCT01425905
- Testing
- The Blues Program, Hey Durham
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Evaluating a Liquid Extract of Carob to Improve Blood Sugar in People With Prediabetes
This study evaluates whether a liquid carob extract can improve blood glucose levels in individuals with prediabetes. Participants are selected according to predefined health criteria and randomly assigned to two groups: one…
- Trial name
- GLIA (NCT07379931)
- Testing
- Carob extract, Control product
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
PreDiabetes
Study to Determine the Effect of Synbiotics in Patients With Pre-diabetes
The aim of this study is to examine the effect of Metabolic Rheostat™ and Butyrate Ultra on blood glucose levels after a liquid meal challenge in patients with prediabetes.
- Trial name
- Rheostat (NCT04428606)
- Testing
- Metabolic Rheostat, Butyrate Ultra
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhaoping Li
Obese Impaired Glucose Tolerance, Newly Diagnosed Obese Type 2 Diabetic Patients
Characterization and Mechanism Research of the Pre-disease State of Obese Type 2 Diabetes Mellitus
Establish a comprehensive evaluation system for the progression of obese impaired glucose tolerance (IGT) to type 2 diabetes mellitus (T2DM) through cross-sectional studies; Constructing and validating a T2DM risk prediction…
- Trial name
- NCT06495814
- Testing
- 1/bag of Jinlida granules, 3 times/day, taken with hot water.
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Fengmei Lian
Gestational Diabetes, Pregnancy
Comparison of Two Screening Strategies for Gestational Diabetes (GDM2)
This is a single site blinded RCT of 920 pregnant women with singleton gestation designed to compare the Carpenter-Coustan and IADPSG criteria for diagnosing gestational diabetes.
- Conditions
- Gestational Diabetes, Pregnancy, Glucose Intolerance
- Trial name
- GDM2 (NCT02309138)
- Testing
- Gestational diabetes screening with fasting 3 hour 100 gm, Gestational diabetes screening with fasting 2 hour 75g
- Where
- United States
- Volunteers
- 921 people, healthy volunteers welcome
- Sponsor
- Esa M Davis, MD MPH FAAFP
Pre Diabetes
Evaluation of an Automated Physician-Directed Messaging on Patient Engagement in the Digital Diabetes Prevention Program
This study aims to understand the effects of automated physician directed messaging on patient engagement in the digital diabetes prevention program (dDPP).
- Trial name
- NCT04773834
- Testing
- Digital diabetes prevention program (dDPP), Adapted dDPP-EHR tool
- Where
- United States
- Volunteers
- 551 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pre-diabetes, Obesity
Effect of Diet and Physical Activity on Incidence of Type 2 Diabetes
Type-2 diabetes is one of the fastest growing chronic diseases worldwide. This trend is mainly driven by a global increase in the prevalence of obesity.
- Trial name
- PREVIEW (NCT01777893)
- Testing
- High protein/ high intensity physical activity (HP-HI), High protein / moderate intensity physical activity (HP-MI), Moderate protein/ high intensity physical activity (MP-HI)
- Where
- 9 sites in Australia, Bulgaria and 6 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Anne Birgitte Raben
Diabetes type2
The Canadian Diabetes Prevention Program
According to Diabetes Canada ("DC"), in 2015, the estimated prevalence of prediabetes in Canada (>20 years of age) is 5.7 million people (22.1%). This rate is estimated to increase to 6.4 million people (23.2%) by 2025.
- Trial name
- CDPP (NCT05784220)
- Testing
- DPP Curriculum for Lifestyle Intervention
- Where
- Canada
- Volunteers
- 2,174 people, healthy volunteers welcome
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Traumatic Brain Injury
Early Digital, Analyte and Neurologic Biomarkers of Acute and Chronic Brain Injury and Recovery in CQT Instructors
Repetitive blast exposure has been shown to lead to more severe neurobehavioral impairments versus a single exposure. Blast-induced Traumatic Brain Injury (TBI) can lead to short- and long-term adverse outcomes Even mild brain…
- Trial name
- NCT05917665
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical Study
This observational study aims to understand the metabolic characteristics and long-term changes in adults with prediabetes and to identify risk and protective factors associated with progression to diabetes or return to normal…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DM-PIONEER (NCT07854002)
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Type 2 Diabetes, Obesity
The Dose Effects of Isomaltulose and Sucrose on Glycaemic and Insulinemic Response
This study will determine the glycaemic and insulinaemic response and sensory profile of the drinks with various ratios sucrose:isomaltulose.
- Conditions
- Type 2 Diabetes, Obesity, Pre Diabetes
- Trial name
- NCT04653207
- Testing
- Glucose Solution 1, Glucose Solution 2, Glucose Solution 3
- Where
- Singapore
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Weight Loss, Obesity
Weight Loss Using a Feedback Device in Obese People With the Metabolic Syndrome
The purpose of this study is to determine if a weight loss app (VA MOVE!® Coach App) along with regularly scheduled telephone counseling, will motivate obese people with metabolic syndrome to lose weight and improve the symptoms…
- Conditions
- Weight Loss, Obesity, Pre-Diabetes, Metabolic Syndrome
- Trial name
- NCT03491930
- Testing
- VA MOVE! Coach app, Telephone Coaching, Standard of Care for weight loss.
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rockefeller University
Diabetes Mellitus, Type 2, Pre-diabetes
Models of Nutrition From Continuous Glucose Monitors
With this study, researchers want to conduct ambulatory studies in which people (healthy, with T2D, or at-risk of T2D) will consume a variety of pre-set and conventional meals in free-living conditions while wearing one or more…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Diet Habit, Diet, Healthy
- Trial name
- NCT04991142
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Texas A&M University