Clinical trials: Prediabetes
Type 2 Diabetes
The Finnish Diabetes Prevention Study
The aim of this study is to clarify whether lifestyle intervention provided to people with high type 2 diabetes risk will lower the cumulative incidence of diabetes.
- Trial name
- DPS (NCT00518167)
- Testing
- Intensive lifestyle counselling
- Where
- 4 sites in Finland
- Volunteers
- 522 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Pregnancy Related, Stress, Psychological
Maternal Emotions and Diet in Pregnancy
This study seeks to understand how a mother's emotional state in pregnancy influences her biological response to food intake.
- Conditions
- Pregnancy Related, Stress, Psychological, Glucose Intolerance During Pregnancy
- Trial name
- PEDIMet (NCT03278392)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Obesity, Diabetes
Fuel Utilization, Diet Composition, and Exercise in African American Women
African American women have a high prevalence of obesity and type 2 diabetes and do not optimally burn fat and carbohydrates in response to changes in these nutrients in their diets.
- Conditions
- Obesity, Diabetes, Insulin Resistance
- Trial name
- NCT04293367
- Testing
- High Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Type 2 Diabetes, Impaired Glucose Tolerance
Effects of Pinitol on Hidrocarbonated Metabolism Parameters in Diabetic, Impaired and Normal Fasting Glucose Subjects
The purpose of this study was to assess whether pinitol improves hidrocarbonated metabolism parameters, and evaluate its effect on oxidative stress and endothelial function in diabetic, impaired and normal fasting glucose…
- Conditions
- Type 2 Diabetes, Impaired Glucose Tolerance, Healthy
- Trial name
- NCT01754792
- Testing
- Pinitol
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Pre-diabetes
The Role of Cholinergic Signaling for Mediating the Effects of GIP and/or Xenin-25 on Insulin Secretion
Glucose-dependent insulinotropic polypeptide (GIP) is a hormone produced in the intestine. It is released immediately after meal ingestion and increases insulin release. This, in turn, helps reduce blood glucose levels.
- Trial name
- NCT01951729
- Testing
- Control, Xenin-25 without atropine, GIP without atropine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
PreDiabetes
Prevention and Choice for Type 2
People living with prediabetes are advised to lose weight to prevent development of type 2 diabetes by participating in intensive lifestyle interventions (ILI's), such as PreventT2.
- Trial name
- PACT2 (NCT06377020)
- Testing
- PACT2
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Cardiovascular Diseases (CVD)
Da Qing Offspring Study
This is an observational study tracking families and offspring of three cohorts from the 1986 Da Qing study: newly diagnosed diabetes, impaired glucose tolerance, and normoglycemia groups.
- Conditions
- Diabetes Mellitus, Cardiovascular Diseases (CVD), Offspring, Adult, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- NCT06958640
- Testing
- Lifestyle interventions
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- China-Japan Friendship Hospital
Type 2 Diabetes, PreDiabetes
Butyrate-enriched Triglyceride and Diabetes Prevention
A body of animal studies as well as observational studies in humans demonstrated that butyrate is one SCFA that has pronounced positive effects on body weight control, inflammation, and insulin resistance.
- Conditions
- Type 2 Diabetes, PreDiabetes, Obesity
- Trial name
- NCT06384313
- Testing
- butyrate/hexanoate-enriched triglycerides
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes, Healthy
Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function
Pioglitazone, a drug used in treatment of type 2 diabetes has been shown to improve insulin sensitivity in skeletal muscle, liver, and fat cells.
- Conditions
- Type 2 Diabetes, Healthy, Impaired Glucose Tolerance
- Trial name
- PIO-EX (NCT00845182)
- Testing
- Pioglitazone, Exenatide, Pioglitazone and Exenatide
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity, Diabetes Mellitus
Inflammation, Diabetes, Ethnicity and Obesity Cohort
Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years.
- Conditions
- Obesity, Diabetes Mellitus, Pre Diabetes
- Trial name
- IDEO (NCT03022682)
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Prediabetic State
Medium Chain Triglycerides and Aerobic Exercise on Ketone Production in Women With or Without Prediabetes
The aim of this study is to compare the effect on ketone production of dietary an MCT supplement combined or not with physical exercise in two groups of women (N=10/group), healthy adults and patients with prediabetes.
- Trial name
- MCT+AE (NCT02678390)
- Testing
- MCT, MCT+ aerobic exercise, Aerobic exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Insulin Sensitivity, Cardiovascular Risk
Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women
Birth control pills are the most commonly used method of birth control. The purpose of this research study is to examine whether birth control pills change heart disease risk and how the body handles blood sugar when given to…
- Conditions
- Insulin Sensitivity, Cardiovascular Risk, Perimenopausal Disorder
- Trial name
- NCT01475513
- Testing
- Ortho Cyclen®
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Type 2 Diabetes Mellitus, PreDiabetes
Glucagon-like Peptide-1 Levels, Insulin Resistance and Insulin Sensitivity Index in Type 2 Diabetes Mellitus
This study is conducted to examine GLP-1, insulin resistance and insulin sensitivity portfolio in Malay, Chinese and Indian populations in Malaysia and to study the effect of DPPIV inhibitor in T2DM patients with different…
- Trial name
- GLP-1 (NCT03659461)
- Testing
- Sitagliptin
- Where
- Malaysia
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Diabetes, Impaired Glucose Tolerance
Liquid Protein Preloads With Different Carbohydrate Types Effects on the Glycaemic and Insulinaemic Response
This study hypothesizes that milk protein consumed together or shortly before a white rice or white bread carbohydrate meal exerts different influence on the glycaemic, insulinaemic responses.
- Conditions
- Diabetes, Impaired Glucose Tolerance, Obesity
- Trial name
- NCT02151188
- Testing
- Bread, Soy milk and cow milk, real-time ultrasonography (GE LOGIQ P5 ultrasound in CNRC)
- Where
- Singapore
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Impaired Glucose Tolerance
Sucralose, Stevia, Gut Microbiome and Glucose Metabolism
This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women.
- Trial name
- NCT02800707
- Testing
- Sucralose, Stevia
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cystic Fibrosis
Muscle Accrual and Function in Cystic Fibrosis-Impact of Glucose Intolerance
This study will investigate the link between glucose abnormalities and elements critical to muscle function including mass, composition and energy metabolism.
- Trial name
- NCT02776098
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Hyperglycemia, Hyperglucagonemia
Glucagon-Like Peptide-1 (GLP-1) Suppression of Alpha Cell Secretion in Type 2 Diabetes Mellitus (T2DM)
The incretin hormone glucagon-like peptide-1 (GLP-1) has known insulinotrophic and glucagonostatic properties. However, inpatients with type 2 diabetes mellitus (T2DM)it is shown, that the beta cell sensitivity towards GLP-1 is…
- Conditions
- Hyperglycemia, Hyperglucagonemia, Glucose Intolerance
- Trial name
- NCT00862589
- Testing
- GLP-1 infusion
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Obesity, Diabetes Mellitus
The Bialystok Bariatric Surgery Study
The Bialystok Bariatric Surgery Study (BBSS) is a prospective observational cohort study of patients undergoing bariatric surgery at the First Clinical Department of General and Endocrine Surgery at the Medical University of…
- Conditions
- Obesity, Diabetes Mellitus, Metabolic Syndrome, Dyslipidemias
- Trial name
- BBSS (NCT04634591)
- Testing
- Bariatric surgery
- Where
- Poland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Prediabetes
Effects of Blueberry Dry Powder on Glycemic Status in Subjects With Prediabetes
The purpose of the present study is to evaluate the effect of blueberry dry powder on glycemic status (fasting plasma glucose, 2h glucose concentration after the oral glucose tolerance test (OGTT), or HbA1c) in subjects with…
- Trial name
- NCT02023320
- Testing
- Low dose of blueberry dry powder, High dose of blueberry dry powder
- Where
- Japan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Prediabetes
Training Induced Muscle-Adipose EV Communication
This study examines how muscle cells communicate with fat cells through tiny packages called extracellular vesicles (EV) during exercise.
- Trial name
- TIMER2 (NCT07106450)
- Testing
- Acute Resistance Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yuan Wen