Clinical trials: Prediabetes
Diabetes
Study of the Prevalence of Diabetes and Pre-diabetes in Réunion Island
In view of the new priority given to diabetes in Réunion and the implementation of an ambitious plan to combat the disease at regional level, which includes the identification and management of pre-diabetes, the need for…
- Trial name
- PREVADIABRUN (NCT06473584)
- Testing
- Diabetes detection
- Where
- Reunion
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Type 2 Diabetes, Cardiovascular Diseases
Pistachios Blood Sugar Control, Heart and Gut Health
A two-period randomized crossover study will be conducted to evaluate the effect of nighttime pistachio consumption (i.e., after dinner and before sleep) on fasting blood sugar levels, longer-term blood sugar control, and risk…
- Trial name
- NCT04056208
- Testing
- Pistachio, Usual care
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Penn State University
Obesity, Diabetes
Studying the Effect of Capsinoids on Brown Fat Using Infrared Thermal Imaging.
The primary hypothesis of this study is that consumption of capsinoids increases brown adipose tissue activity, detectable by infrared thermal imaging.
- Conditions
- Obesity, Diabetes, Impaired Glucose Tolerance
- Trial name
- NCT01961674
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Atherosclerosis
Vitamin D Supplementation on Surrogate Markers of Atherosclerosis
For this study, our sample population is individuals with prediabetes, who are at an increased risk for atherosclerosis. In this proposed randomized placebo-controlled prospective trial, we would be enrolling 120 subjects with…
- Trial name
- NCT05478291
- Testing
- Vitamin D supplementation
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Glucose Intolerance
Acetylcarnitine and Metabolic Flexibility
Insulin resistant subjects and type 2 diabetic patients are characterized by a decreased metabolic flexibility: a reduced capability to switch from fat oxidation in the basal state to carbohydrate oxidation in the…
- Trial name
- NCT02072759
- Testing
- Carnitine supplement
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Glucose Intolerance, Sleep Deprivation
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
- Conditions
- Glucose Intolerance, Sleep Deprivation, Sleep
- Trial name
- NCT04868539
- Testing
- Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Overweight, Pre-hypertension
Short Term Intermittent Fasting and Mediterranean Diet
The purpose of this research study is to evaluate the effects of intermittent fasting in subjects that are eating a Mediterranean diet or a Western diet.
- Conditions
- Overweight, Pre-hypertension, Hypertension, Hypercholesterolemia
- Trial name
- NCT02148458
- Testing
- Mediterranean diet, Control group
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Central Insulin Resistance, Diabetes Mellitus, Type 2
Central Insulin Sensitivity in Individuals With Type 2 Diabetes (T2D) and at Risk for Developing T2D
Beside well described peripheral effects, insulin can also affect the human central nervous system. Centrally acting insulin seems to have an influence e.g. on whole-body metabolism and food intake.
- Conditions
- Central Insulin Resistance, Diabetes Mellitus, Type 2, PreDiabetes
- Trial name
- NCT05856877
- Testing
- Human nasal insulin
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
PreDiabetes, Overweight and Obesity
Zein Nanoparticles for Glycemic Control
The use of zein nanoparticles as vehicles for drug delivery is under study, but of the effects observed in empty nanoparticles, in laboratory animals, the reduction of glucose levels was something worth studying.
- Conditions
- PreDiabetes, Overweight and Obesity, Adult ALL
- Trial name
- GLUCOCAPS (NCT05560412)
- Testing
- Zein nanocapsules, control
- Where
- Spain
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Prediabetes
Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Milk
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function and increase the risk of CVD.
- Trial name
- NCT02482675
- Testing
- Glucose, Glucose with Non-fat Milk, Glucose with Whey Protein Isolate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Cardiovascular Risk Factor, Prediabetes
Active You: A Novel Exercise Program for African Americans
Barriers to physical activity (PA) among African Americans (AAs) have been extensively studied, yet there is a paucity of innovative PA interventions designed to address them.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04280783
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Prediabetic State, Body Weight
Development of PI-ML Algorithm for Prediction of the Real-time Risk for Developing Pre-diabetes
In this prospective, non-randomized, monocentric study, data will be collected from otherwise healthy individuals with overweight/obese grade I to increase data availability in the pre-diabetes field (impaired glucose…
- Conditions
- Prediabetic State, Body Weight, Overweight or Obesity, Life Style, Healthy
- Trial name
- PRAESIIDIUM (NCT06195566)
- Where
- Latvia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Jelizaveta Sokolovska
Prediabetes
Prevention of Type 2 Diabetes Mellitus by Changes in Diet
investigators evaluated the efficacy of two types of diet with different macronutrients, on prevention or delaying the onset of type 2 diabetes in subjects with either impaired fasting glucose (IFG) or impaired glucose tolerance…
- Trial name
- NCT02250066
- Testing
- Diet
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Ilam University of Medical Sciences
Diabetes, Prediabetic State
The Effect of Vitamin K Supplementation on Glucose Metabolism
The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response.
- Trial name
- NCT00960973
- Testing
- Menatetrenone
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pre-diabetes, Obesity
Vascular Function, Endothelin, and Inflammation in Pre-diabetic Obesity Versus Lean Healthy Controls
Aims: 1. Does inflammation contribute importantly to concurrent defects in vascular and metabolic dysfunction in human pre-diabetic obesity? 2.
- Trial name
- NCT00837590
- Testing
- Chronic salsalate, Acute Salsalate
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dyslipidemia, Impaired Glucose Tolerance
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose
The investigators evaluated dietary modulation of LIPC rs1800588 (-514 C/T) for lipids and glucose using a randomized cross-over design comparing a high-fat Western diet and a low-fat traditional Hispanic diet in Caribbean…
- Trial name
- NCT02938091
- Testing
- High-fat diet, Low-fat diet
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tufts University
PreDiabetes, Metabolic Syndrome
Strawberries and Risk of Diabetes in Adults
Strawberries can be categorized as a functional food based on results from several clinical trials in improving cardiometabolic health beyond providing nutrition.
- Trial name
- NCT05362968
- Testing
- Freeze-dried strawberry powder
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
PreDiabetes, Obesity
The Time-Restricted Intake of Meals Study
TRIM is a randomized, controlled feeding study to evaluate if eating earlier in the day vs. later in the day impacts weight and glucose homeostasis.
- Trial name
- TRIM (NCT03527368)
- Testing
- Time-restricted feeding, Usual feeding pattern
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Prediabetes, Diabetes Type 1
An Exploratory Clinical Trial to Generate Whole Blood Samples for Analysing Genetic Polymorphisms
G (guanine nucleotide binding) proteins associating with G protein-coupled receptors (GPCR) are key players in the pathogenesis of obesity and diabetes and are targets of pharmacotherapeutic inter-ventions.
- Conditions
- Prediabetes, Diabetes Type 1, Diabetes Type 2
- Trial name
- NCT02057497
- Volunteers
- healthy volunteers welcome
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Impaired Glucose Tolerance
Vitamin D for the Prevention of Diabetes Type 2
The prevalence of type 2 diabetes is increasing, which for most societies has considerable consequences not only regarding health but also economy.
- Trial name
- NCT00685594
- Testing
- cholecalciferol
- Where
- Norway
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- University of Tromso