Clinical trials: Prediabetes
Diabetes Mellitus, Type 2, Obesity
Microbiome and Health Indicators in People With Obesity, Prediabetes and Type 2 Diabetes Undergoing a Lifestyle Intervention
The incidence of type 2 diabetes worldwide is growing rapidly, being one of the fastest growing global health emergencies of the 21st century according to the International Diabetes Federation.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, PreDiabetes
- Trial name
- MicrobiAr (NCT05372445)
- Testing
- Non-intensive intervention, Intensive intervention
- Where
- Argentina
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Glucose Intolerance, Glucose Metabolism Disorders (Including Diabetes Mellitus)
Effects of Almonds on Glycemia in Adults With Elevated Hemoglobin A1c Concentrations
This study will examine the effects of regular almond consumption by individuals with elevated HbA1c on long-term glycemic control.
- Trial name
- NCT05176197
- Testing
- Almond, Control
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Purdue University
Continuous Glucose Monitoring, Diabetes, Gestational
Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY
The goal of this clinical trial is to examine how daily behavioral patterns in early pregnancy, including sleep, physical activity, and meal timing, influence continuous glucose dynamics and subsequent risk of gestational…
- Conditions
- Continuous Glucose Monitoring, Diabetes, Gestational, Diet During Pregnancy, Meal Time
- Trial name
- NCT07534670
- Testing
- Continuous glucose monitor (CGM), Wrist actigraphy device, AI-based dietary and meal timing logging mobile application
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Spinal Cord Injuries (SCI), Prediabetes / Type 2 Diabetes
Neuromodulation for Metabolic Dysfunction
This study evaluates the use of noninvasive transcutaneous spinal cord stimulation (tSCS) to improve glucose regulation and metabolic function in individuals with and without spinal cord injury (SCI) across a spectrum of…
- Trial name
- NCT07597161
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rahul Sachdeva
PreDiabetes, Elevated Blood Sugar
Microlearning Application for Diabetes Prevention
The purpose of this study is to test the effectiveness of a mobile application diabetes prevention program delivered with microlearning and microcoaching.
- Trial name
- NCT05071820
- Testing
- Health U mobile application, National Diabetes Prevention Program
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Stanford University
Patients With Type 2 Diabetes (FSG: More Than 7.1 and Not Higher Than 15.8 mmol/L)
Short-term Effect of Pomegranate Juice on Blood Sugar and Its Controlling Hormones in Pre-diabetic and Type II Diabetic Patients.
Fresh pomegranate juice at 1.5 mL/kg of body weight was administered by recruited healthy individuals and patients with type 2 diabetes of fasting serum glucose between 7.1 and 15.8 mmol/L after approximately 12 hours fasting.
- Trial name
- NCT03902288
- Testing
- Fresh pomegranate juice
- Where
- Jordan
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
PreDiabetes
The Effect of Traditional Chinese Medicine Regimen-based Lifestyle Mobile Health APP in Prediabetes
Prediabetes is a major risk factor for diabetes. The Lifestyle Modification Mobile Health Application (APP) could not only help to decrease blood sugar among individuals with prediabetes but it could also prevent a later…
- Trial name
- NCT04096989
- Testing
- Traditional Chinese medicine regimen-based lifestyle mobile health APP, Lifestyle mobile health APP
- Where
- Taiwan
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Pre-diabetes, Obesity
Project Plant Protein: the P3 Study in Humans
The objective of this study is to compare the effects of adding three plant-based proteins (rice, oats and pea proteins) to a breakfast beverage on the glycemic response, appetite and subsequent food intake of healthy adults.
- Trial name
- NCT02933424
- Testing
- Protein Powder
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Glucocorticoids Toxicity, Glucose Intolerance
Pharmacogenomics of the Variability in the In Vivo Response to Glucocorticoids
This study evaluates the effect of acute administration of oral prednisone in white blood cells counts and glucose tolerance and the relationship of these measures with changes in gene expression in healthy volunteers.
- Trial name
- NCT03023891
- Testing
- Prednisone
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Prediabetes
Effect of Science Research Wellness Ndo1 on Glycaemia in Adults With Pre-diabetes
The objective of this study is to test the effect of 12 weeks of supplementation SRW Ndo1 on metabolic health and general health in adults with prediabetes.
- Trial name
- NCT06897462
- Testing
- SRW Ndo1
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wellizen Australia
Obesity, Insulin Resistance
The Effects of Exenatide on Post-Meal Sugar Peaks and Vascular Health in Obese/Pre-Diabetic Young Adults
The primary aim of this study is to evaluate the effect of exenatide on daily glycemic excursions obtained by continuous glucose monitoring system (CGMS).
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Cardiovascular Disease
- Trial name
- NCT00845559
- Testing
- Exenatide
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Continuous Glucose Monitoring, Prediabetic State
Effect of Real-time Continuous Glucose Monitoring System in Overweight or Obese Adults With Prediabetes
In Korea, 5 million adults aged 30 years or older have diabetes. The development and expansion of Korea's economy and society, has led to dramatic chances in people's lifestyle and diet habits, and an increase in life expectancy.
- Conditions
- Continuous Glucose Monitoring, Prediabetic State, Obesity
- Trial name
- NCT04099550
- Testing
- RT-CGM, SMBG
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Diabetes Mellitus, Type 2, Insulin Resistance
Exercise to Restore 24h Rhythms in Metabolism
This study will investigate the effect of exercise training on 24h rhythms in substrate metabolism in overweight subjects with impaired glucose tolerance. Subjects will perform exercise training for 12 weeks.
- Trial name
- RESTORE (NCT04565418)
- Testing
- High-intensity interval training
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Weight Loss, Metabolic Syndrome
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Metabolic syndrome and resulting downstream health effects remains a growing health concern. In published trials, the use of continuous glucose monitoring (CGM) assists behavioral changes efforts, leading to improved adherence…
- Conditions
- Weight Loss, Metabolic Syndrome, Pre-diabetes, Central Obesity
- Trial name
- NCT05121844
- Testing
- Continuous Glucose Monitor Device
- Where
- United States
- Volunteers
- 31,187 people, healthy volunteers welcome
- Sponsor
- Signos Inc
Type 2 Diabetes, Impaired Glucose Tolerance
Efficiency and Cost-effectiveness of a Culturally Adopted Lifestyle Intervention Program - the MEDIM Study.
An increasing proportion of Sweden's population comprises non-European immigrants, who constitute a high risk-population for T2D.
- Conditions
- Type 2 Diabetes, Impaired Glucose Tolerance, Obesity, Physical Activity
- Trial name
- MEDIM (NCT01420198)
- Testing
- Lifestyle intervention
- Where
- Sweden
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Region Skane
Prediabetic State
Investigation of Milk Peptides (Pep2Dia®) on Postprandial Blood Glucose Profile in Prediabetic Subjects
The goal is to investigate the 180 min postprandial response on blood glucose and insulin levels after intake of Pep2Dia® in two different dosages compared to placebo in the context of a meal challenge test, providing 75 g of…
- Trial name
- NCT04375449
- Testing
- Pep2dia, maltodextrin
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ingredia S.A.
Prediabetes
Effect of Coadministration of Ume Paste (Prunus Mume) and Ginger Powder
This study is designed to evaluate the effect of ume paste and ginger powder on glucose metabolism in prediabetic subjects.
- Trial name
- NCT02213549
- Testing
- Ume paste and ginger powder
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Pre-diabetes
Common Genetic Variation and Type 2 Diabetes
Type 2 diabetes is a common metabolic disorder arising from a complex interaction between genetic predisposition and the environment.
- Trial name
- NCT00707616
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sleep-Disordered Breathing, Glucose Intolerance
Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing
Sleep disordered breathing is associated with impaired glucose tolerance and incident diabetes. Nocturnal hypoxemia is a potential stimulus of glucose intolerance.
- Trial name
- NCT05462834
- Testing
- Compressed Air, Supplemental Oxygen
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Glucose Tolerance Impaired in Pregnancy
Women With Minor Degrees of Glucose Intolerance and the Postpartum Glucose Tolerance Test
The aim of this study is to offer a 75g postpartum glucose tolerance test to women with minor degrees of glucose intolerance and to assess if these women are significantly different from women who were diagnosed as GDM…
- Trial name
- NCT03623412
- Testing
- 75g oral glucose tolerance test, 75g GTT
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services