Clinical trials: Prediabetes
Prediabetes
Almond Effects on Glucose Intolerance Study
Diabetes is a major cause of morbidity and mortality worldwide. Prevention of diabetes is an important goal. The progression from impaired glucose tolerance to diabetes is thought to be promoted by the toxic effects of…
- Trial name
- AEGIS (NCT02260895)
- Testing
- Almond pre-test snack
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Memorial Hermann Health System
Oxidative Stress, Healthy Aging
Efficacy of Solarplast for Health and Oxidative Stress
Solarplast is a unique mixture of antioxidant enzymes and single antioxidant molecules that are capable of attack oxidants that cause damage to the cells in the human body and cause premature aging.
- Conditions
- Oxidative Stress, Healthy Aging, Skin Health
- Trial name
- NCT04144777
- Testing
- Solarplast
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes
Diabetes Mellitus, Type 2, Pre-diabetes
Tau PET Imaging in the Northern Manhattan Study of Metabolism and Mind.
This is a single center brain Positron Emission Tomography (PET) study of 18F-MK-6240. Eligible participants are persons from Northern Manhattan who self-identify as Hispanic, non-Hispanic Black, or Non-Hispanic White, who are 55…
- Trial name
- NOMEM-Tau (NCT03389100)
- Testing
- 18F-MK6240 injection
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Columbia University
Prediabetes
Trial of an Herb and Mineral Combination Product on Fasting Glucose in Adults at Risk for Developing Diabetes
This is a multi-center, randomized, double-blind, placebo-controlled study in approximately 104 subjects (52 per group) to evaluate the effectiveness of an herb and mineral combination product on fasting serum glucose levels in…
- Trial name
- NCT02146157
- Testing
- herb and mineral combination product
- Where
- 6 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- NewChapter, Inc.
Type 2 Diabetes, Prediabetes
Seum Bile Acid Profile in Type 2 Diabetes and Association Between Bile Cid Profile and Adipokine or Oxidative Stress
"The goal of this work is to critically test the hypothesis that there exists a different profile of bile acids (BAs) in patient with type 2 diabetes mellitus (T2DM) compared with normal controls.
- Conditions
- Type 2 Diabetes, Prediabetes, Non-alcoholic Fatty Liver Disease, Metabolic Syndrome
- Trial name
- NCT02650830
- Where
- South Korea
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Prediabetes, Impaired Glucose Tolerance
Step Up For Health Study: A Pedometer and Website Intervention in Those With Prediabetes
This study will examine whether a physical activity program, specifically increasing walking steps, offered over the internet is able to increase physical activity in adults with prediabetes.
- Trial name
- NCT05412264
- Testing
- Website intervention
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Alberta
PreDiabetes, Overweight and Obesity
Effect of a Probiotic on the Glycemic Profile and the Fecal Microbiota of Prediabetic Subjects (PREDIABETCARE)
According to the data from the Di@bet.es study, which is part of the National Diabetes Strategy, the prevalence of type 2 diabetes among Spanish population is 13.8%.
- Trial name
- PREDIABETCAR (NCT04863313)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Nutrition, Pediatric Obesity
Metabolic and Genetic Impacts of Energy Drinks in Youth
Caffeine containing energy drinks (CCED) are beverages that typically contain mixtures of simple sugars, caffeine and may contain vitamin, mineral and/or herbal preparations.
- Conditions
- Nutrition, Pediatric Obesity, Pediatric, Caffeine
- Trial name
- NCT03512496
- Testing
- Acute energy drink - Caffein, Acute energy drink - Decaf
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Calgary
Diabetes Mellitus, Hyperglycemia
Durban Diabetes Study:A Study of the Epidemiology of Diabetes Mellitus in Urban South Africans of African Descent (DDS)
Type 2 diabetes (T2D) is an emerging epidemic in sub-Saharan Africa, with an estimated prevalence of 6%. With around seven million cases of T2D in 2000, it is anticipated that over 18 million Africans will have the disease by…
- Conditions
- Diabetes Mellitus, Hyperglycemia, Hereditary Diseases, Glucose Intolerance
- Trial name
- DDS (NCT02416440)
- Testing
- blood sample
- Where
- South Africa
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Body Weight, Impaired Glucose Tolerance in Obese
Effect of Cabergoline on Weight and Glucose Tolerance
The aim of this study is to determine the efficacy of cabergoline, a long-acting dopamine receptor agonist, on body weight and blood glucose in healthy obese adults. This is a randomized double-blind placebo controlled study.
- Trial name
- NCT01395602
- Testing
- Cabergoline
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Impaired Glucose Tolerance, Type 2 Diabetes
Impact of 3-year Lifestyle Intervention on Postprandial Glucose Metabolism: the SLIM Study
To evaluate the effect of a 3-year diet- and exercise lifestyle intervention, based on general public health recommendations, on glucose tolerance, insulin resistance and metabolic cardiovascular risk factors in Dutch subjects…
- Trial name
- NCT00381186
- Testing
- diet- and exercise intervention
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Gestational Diabetes Mellitus, Pre-diabetes
A Shared Decision Making Intervention for Diabetes Prevention in Women With a History of Gestational Diabetes Mellitus
Our goal is to test whether shared decision making for diabetes prevention can help women with a history of gestational diabetes mellitus (GDM) who are at high risk of developing type 2 diabetes (T2DM) increase weight loss and…
- Conditions
- Gestational Diabetes Mellitus, Pre-diabetes, Diabetes Mellitus, Type 2
- Trial name
- NCT04897945
- Testing
- Shared decision-making for diabetes prevention
- Where
- 2 sites in United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pre Diabetic
A Pilot Study to Determine the Effect of a Cobiotic Formulation on the Gastrointestinal Microbiome
This study aims to investigate the effect of a cobiotic formulation, prepared as a smoothie beverage, on the ratio of intestinal microbiota of the Bacteroidetes phylum to those of the Firmicutes phylum in the stool as well as the…
- Trial name
- NCT01724736
- Testing
- NM504:
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- NuMe Health
Pre-diabetes, Obesity
The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics
The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant human research participants, and this is further…
- Trial name
- NCT05051436
- Testing
- Mirabegron 50 MG, Tadalafil 10 MG
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Respiratory Disorder, Cardiovascular Diseases
Study of RE.DOCTOR Vitals® Software Accuracy
The purpose of this observational trial is to advance digital health monitoring through the analysis of Photoplethysmography (PPG) waveforms collected via RE.DOCTOR Vitals software.
- Conditions
- Respiratory Disorder, Cardiovascular Diseases, Diabetes, Pre-Diabetes
- Trial name
- RE-VITAL (NCT06237322)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- RE.DOCTOR LLC
Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy
Effects of a Non-nutritive Sweetener Reduction Intervention in Pregnancy and Lactation on Maternal and Infant Outcomes
The effects of consuming non-nutritive sweeteners (NNS) during pregnancy and lactation on infant obesity and cardiometabolic disease risk are not well understood.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy, Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation
- Trial name
- NCT06548828
- Testing
- NNS Restriction Intervention, Control Intervention
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- George Washington University
Prediabetes, Obesity
The Effect of Hypocaloric Diet Associated With tDCS on Weight Loss and Metabolic Profile
To compare four weeks of transcranial direct current stimulation (tDCS) versus placebo associated with a reduced caloric diet on weight loss, glycemic control and regulators of hunger and satiety in overweight or obese subjects…
- Conditions
- Prediabetes, Obesity, Weight Loss, Diabetes
- Trial name
- NCT02683902
- Testing
- Active tDCS, Hypocaloric diet
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Glucose Intolerance, Type 2 Diabetes Mellitus
Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes
The purpose of the randomized trial is to quantify the effect of vitamin D and calcium supplementation on beta-cell function, insulin sensitivity, glucose tolerance and systemic inflammation and other cardiometabolic outcomes in…
- Conditions
- Glucose Intolerance, Type 2 Diabetes Mellitus, Metabolic Syndrome
- Trial name
- CaDDM (NCT00436475)
- Testing
- Vitamin D3 2,000 IU orally once daily, Calcium Carbonate 400 mg orally twice daily
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Healthy
To Identify Anytime Hyperglycaemia in Subjects With Normoglycaemia and Prediabetes
To test these hypotheses, The Investigators will recruit 100 overweight and obese adolescents with HbA1c ranging across the ADA classification spectrum from normal to prediabetes,(nearly 40:normoglycemi, 30: IFG, 30:1GT) measure…
- Trial name
- NCT05939895
- Testing
- Medtronic G3 sensor
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India