Clinical trials: Prediabetes
Prediabetes
Effects of Hourly Stair-Climbing Exercise Snacks on Metabolic and Vascular Health in Adults With Prediabetes
This study will examine whether very short bouts of stair climbing performed throughout the day can improve blood sugar control and cardiovascular health in adults with prediabetes.
- Trial name
- RISE UP (NCT07847684)
- Testing
- Hourly 3-Minute Light Walking Breaks, Hourly Stair-Climbing Exercise Snacks
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Louis University
Diabetes Mellitus, Type 2, PreDiabetes
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease.
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Metabolic Syndrome
- Trial name
- TRANSFORM (NCT06112418)
- Testing
- The Cleerly CAD Staging System
- Where
- 125 sites in United States
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- Cleerly, Inc.
Pancreatic Neoplasms, Pancreatic Cysts
Studies of Blood Glucose and the Microbiome in Tumors and Cysts of the Pancreas
This prospective, single-center observational study investigates whether continuous glucose monitoring (CGM, 14 days) and gut microbiota composition (from a fecal sample) reveal patterns specific to pancreatic cancer, aiming to…
- Conditions
- Pancreatic Neoplasms, Pancreatic Cysts, Hyperglycemia, Prediabetes
- Trial name
- NCT07843147
- Volunteers
- 100 people
- Sponsor
- Umeå University
Prediabetes or Overweight
Whole Food Fibers for Support of Key Gut Bacteria for Human Health
The purpose of this supplementation study is to understand how whole food fibers may affect gut microbiota composition and overall health. The investigators will enroll up to 24 people in this study.
- Trial name
- NCT07840170
- Testing
- Whole food fiber mixture, inulin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Purdue University
Prediabetes
Returning to Normoglycemia With Targeted Use of Real-time CGM Data and Nutrition-focused Lifestyle Changes
The purpose of the ReTURN study is to understand how glycemia, specifically percent of time above 140 mg/dL (TA140), changes over time in people who are randomized to receive either continuous glucose monitoring (CGM)-guided care…
- Trial name
- RETURN (NCT07832474)
- Testing
- CGM-guided care
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- HealthPartners Institute
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Moringa Leaf Powder for Prediabetes
The goal of this clinical trial was to learn whether Moringa oleifera leaf powder could lower fasting blood glucose in adults aged 25 to 55 years with prediabetes. It also assessed unwanted health effects during the intervention.
- Trial name
- NCT07833397
- Testing
- Moringa Oleifera Leaf Powder
- Where
- Indonesia
- Volunteers
- 114 people
- Sponsor
- Maranatha Christian University
Prediabetes, Obesity / Overweight
Very-Low-Carbohydrate Diet for Prediabetes and Obesity
Prediabetes is a condition where blood sugar is higher than normal but not yet high enough to be called type 2 diabetes. It is common in adults who are overweight or obese, and without treatment it often progresses to diabetes…
- Conditions
- Prediabetes, Obesity / Overweight, VERY LOW CARBOHYDRATE DIET
- Trial name
- VLCBD (NCT07830121)
- Testing
- Standard Dietary Advice, Very-Low-Carbohydrate Diet (VLCBD)
- Where
- Malaysia
- Volunteers
- 33 people
- Sponsor
- Universiti Teknologi Mara
Weight Reduction, Prediabetes
Georgia CEAL RESTORES Family Diabetes Study
The goal of this clinical trial is to determine whether a family-based lifestyle intervention reduces the risk of type 2 diabetes (T2D) among parents and their children.
- Trial name
- GA CEAL (NCT07808723)
- Testing
- Family Diabetes Prevention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Weight Loss, Blood Pressure
Feasibility & Implementation of a Plant-Based Weight-Loss Program in an Office-Based Setting
This prospective study aims to assess the feasibility and implementation of a plant-based, weight-loss program in an office setting.
- Conditions
- Weight Loss, Blood Pressure, Lipid Disorder, PreDiabetes
- Trial name
- NCT04091516
- Testing
- Low-fat plant-based diet
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Physicians Committee for Responsible Medicine
Obesity, Diabetes Mellitus, Type 2
Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology
The primary aim is to test the effectiveness of an innovative 24-month pragmatic and scalable weight-loss centric approach using a collaborative care model that connects patients with a non-Primary Care Practitioner (PCP) health…
- Conditions
- Obesity, Diabetes Mellitus, Type 2, PreDiabetes
- Trial name
- PROPEL-IT (NCT05523375)
- Testing
- Intensive Lifestyle Intervention
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Pennington Biomedical Research Center
Prediabetes, Cystic Fibrosis (CF)
CGM Dynamic Index for Predicting Prediabetes in Cystic Fibrosis
The primary objective of this pilot study is to develop a CGM-based model to predict the progression from prediabetes to diabetes in individuals with cystic fibrosis.
- Conditions
- Prediabetes, Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes
- Trial name
- NCT06642610
- Testing
- CGM Dynamic Index (CDI)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Indiana University
Impaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes)
Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation
This 12-week, double-blind, placebo-controlled trial will examine whether daily supplementation with the Lab4P probiotic can improve cognitive performance and metabolic health in overweight adults aged 18 to 40 with impaired…
- Conditions
- Impaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes), Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Overweight (BMI > 25)
- Trial name
- ProCog (NCT07073781)
- Testing
- Lab4p Probiotic Consortium
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Leeds Beckett University
Prediabetes, Diabetes Prevention
Optimizing Implementation of the Intensive Diabetes Prevention Program
The goal of this clinical trial is to explore the effectiveness and implementation outcomes of the optimized Intensive Diabetes Prevention Program (IDPP) in District Health Centres.
- Conditions
- Prediabetes, Diabetes Prevention, Implementation Science
- Trial name
- NCT07412912
- Testing
- Standard IDPP, Optimized IDPP
- Volunteers
- 170 people
- Sponsor
- The Hong Kong Polytechnic University
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Efficacy and Safety of Oral Controlled-release Nicotinic Acid (CIR-NA) for the Remission of Prediabetes. (CONCEPT)
The goal of this clinical trial is to prevent the change from prediabetes (a pre-stage of type 2 diabetes mellitus (T2DM)) to T2DM in participants with prediabetes using oral CIR-NA (a nicotinic acid formulation that is designed…
- Trial name
- CONCEPT (NCT07286747)
- Testing
- controlled-ileal-release nicotinic acid as multiple dose 100 mg/day, controlled-ileal-release nicotinic acid as multiple dose 200 mg/day
- Where
- 6 sites in Germany
- Volunteers
- 390 people
- Sponsor
- University Hospital Schleswig-Holstein
Type2diabetes, PreDiabetes
SGLT2 Inhibition in Addition to Lifestyle Intervention and Risk for Complications in Subtypes of Patients With Prediabetes
More than 50% of patients with type 2 diabetes develop micro- and/or macrovascular complications during the course of the disease.
- Conditions
- Type2diabetes, PreDiabetes, Renal Failure
- Trial name
- NCT06054035
- Testing
- Dapagliflozin (Forxiga®), Lifestyle Intervention
- Where
- 9 sites in Germany
- Volunteers
- 170 people
- Sponsor
- University Hospital Tuebingen
Prediabetes
Effects of a Mediterranean Diet With Sequential Cycling and Rowing Exercise on Blood Sugar in Women With Prediabetes or Prediabetes Remission
The goal of this clinical trial is to learn how a Mediterranean-style diet, with and without added exercise, affects blood sugar control in women with prediabetes.
- Trial name
- NCT07326891
- Testing
- Mediterranean Diet, Supervised Sequential Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Begüm Yücesoy Güneysu
Prediabetes / Type 2 Diabetes
Health Assessment of Low Glycaemic Index - High Protein Rice to Enhance Glycemic Control Through Nutrition
Type 2 Diabetes (T2D) represents a critical public health challenge in Singapore, with prevalence projected to reach one million residents by 2050.
- Trial name
- HARVEST (NCT07663123)
- Testing
- Functional rice variaties
- Volunteers
- 225 people
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Obesity, Prediabetes
The Effect of Time-Restricted Eating in 24-hour Metabolic Homeostasis and Diurnal Rhythm
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no food intake during the rest of the day. In animals, TRE improves metabolic function without caloric restriction.
- Trial name
- Rhythm (NCT07820384)
- Testing
- Time restricted eating, Healthy Eating, Extended eating window
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Prediabetes
Development of Smart Food /Nutraceutical Solutions Dedicated to Cardiometabolic Disorders in Ageing
Describe the anthropometric measurements and informations relating to body composition, blood chemistry tests, blood glucose monitoring, and dietary habits of the volunteers participating in the study before and after taking…
- Trial name
- NutriAge (NCT07817290)
- Testing
- Probiotic
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Prediabetes, Overweight , Obesity
Exercise, Chronotype, and Prediabetes
The goal of this clinical trial is to find out whether exercising at the right time of day, based on a person's natural body clock, leads to greater health benefits in people living with prediabetes.
- Trial name
- NCT07389005
- Testing
- Timing of exercise, Control
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- German Diabetes Center