Clinical trials: Prediabetes or Overweight
Overweight, Obesity
Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study)
Type 2 diabetes and prediabetes, which are mainly caused by a lack of physical activity and excess weight, put people at an increased risk of cardiovascular disease.
- Conditions
- Overweight, Obesity, Type 2 Diabetes, Prediabetes
- Trial name
- SHAPE3 (NCT00928005)
- Testing
- Weight loss diet, Weight loss diet plus exercise
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy, Overweight and Obesity
Strategies To OPpose Sugars With Non-nutritive Sweeteners Or Water (STOP Sugars NOW) Trial
Health authorities recommend a reduction in added sugars from sugar-sweetened beverages (SSBs) due to risk of obesity and diabetes. As a sugar-reduction strategy, finding the ideal SSB replacement is of the utmost importance.
- Conditions
- Healthy, Overweight and Obesity, Metabolic Syndrome, PreDiabetes
- Trial name
- NCT03543644
- Testing
- Sugar-sweetened beverage (SSB), Non-nutritive sweetened beverages (NSB), Water
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Overweight, Obesity
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight
This is a study of tirzepatide in participants with overweight and obesity. The main purpose is to learn more about how tirzepatide affects body weight. The study has two phases: A main phase and an extension phase.
- Trial name
- SURMOUNT-1 (NCT04184622)
- Testing
- Tirzepatide
- Where
- 118 sites in United States, Argentina and 8 more
- Volunteers
- 2,539 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes, Overweight or Obesity
Effect of Low-calorie Diets With Different Macronutrient Composition and Macronutrient Distribution in Shift Workers With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
Background and Aims: Shift work, particularly involving night shifts, is associated with increased risk of metabolic disturbances such as type 2 diabetes mellitus (T2DM).
- Conditions
- Type 2 Diabetes, Overweight or Obesity, PreDiabetes
- Trial name
- NCT06912555
- Testing
- Diet
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad de Zaragoza
Overweight, Diabetes
Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects w/o Type 2 Diabetes
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing the Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects without or with Type 2 Diabetes
- Conditions
- Overweight, Diabetes, PreDiabetes, Obesity
- Trial name
- LIGHT-UP (NCT03058029)
- Testing
- Gelesis200
- Where
- 30 sites in United States, Canada and 6 more
- Volunteers
- 300 people
- Sponsor
- Gelesis, Inc.
Obesity, NAFLD
Low-Calorie Diet in People With Prediabetes/Metabolic Syndrome
Significant weight reduction, achieved by low-calorie diet (LCD), will mobilise ectopic fat (visceral and particularly liver fat), improving insulin sensitivity and other metabolic syndrome components, with secondary beneficial…
- Conditions
- Obesity, NAFLD, Fatty Liver, Pre Diabetes
- Trial name
- CALIBRATE (NCT04786418)
- Testing
- Standard of care, Low-calorie diet
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Type 2 Diabetes, Obese
The Effects of the GOLO for Life® Plan With Release Supplement on Glycemic Control and Weight in Overweight and Obese Adults With Prediabetes or Type 2 Diabetes
The objective of this study is to investigate the efficacy and safety of the GOLO for Life® Plan (G4LP) and Release supplementation on glycemic control and weight in overweight and obese adults with Prediabetes or Type 2…
- Conditions
- Type 2 Diabetes, Obese, Overweight, Prediabetes
- Trial name
- NCT05844644
- Testing
- Release
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Golo
Type 2 Diabetes, PreDiabetes
Digital Lifestyle Intervention For Diabetes/Pre-Diabetes
The study aims to evaluate the acceptability, feasibility, and preliminary efficacy of a digital lifestyle intervention, called Fitness Digital (FitD), for individuals with prediabetes or type 2 diabetes.
- Conditions
- Type 2 Diabetes, PreDiabetes, Obesity
- Trial name
- NCT05247437
- Testing
- Digital Intensive Lifestyle Intervention, Digital Self-Help Control Condition
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong
Fatty Liver, Overweight/Obesity
Effects of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Overweight/Obese Men With T2DM or Prediabetes and Hypogonadism
The epidemics of obesity, MeTSy, T2DM and CVD are increasing worldwide. Non-alcoholic fatty liver disease (NAFLD) is becoming recognized as a condition possibly involved in the pathogenesis of these diseases.
- Conditions
- Fatty Liver, Overweight/Obesity, Prediabetes/Type2 Diabetes Mellitus, Hypogonadism, Male
- Trial name
- Test2Func (NCT03851627)
- Testing
- Testosterone Undecanoate
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Alexandra Kautzky-Willer
Weight Loss, Obesity
A Study to Assess the Effect of a Normal vs. High Protein Diets in Carbohydrates Metabolism in Obese Subjects With Diabetes or Prediabetes
The objective of the study is to assess the effect of low-calorie diets with normal (18%) vs. high (35%) protein (mainly coming from animal source) composition on body weight and carbohydrates metabolism in overweight and obese…
- Conditions
- Weight Loss, Obesity, Diabetes, Diet, Reducing
- Trial name
- NCT02559479
- Testing
- Weight loss interventional study with a low-calorie 18%-protein diet, Weight loss interventional study with a low-calorie 35%-protein diet
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto Aragones de Ciencias de la Salud
Overweight and Obesity, Pre Diabetes
Time Restricted EATing (TREAT) Pilot Study
The TREAT Pilot is a 3 months open-label pilot study to examine the effect of restricting the duration of eating (Time Restricted EATing) in metabolically unhealthy adults with overweight or obesity.
- Trial name
- NCT03956290
- Testing
- TREAT pilot intervention
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Columbia University
Diabetes, Hypertension
Mobile Phone-based Intervention for Promoting Healthy Habits and Weight Loss
A self administered 16 weeks plus follow up study to explore the efficacy of mobile phone driven apps for stress reduction coupled with guidance for healthy living among obese and overweight populations.
- Conditions
- Diabetes, Hypertension, Pre-diabetes, Overweight
- Trial name
- NCT02621008
- Testing
- Stress Reduction& Healthy living
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Eco Fusion
Blood Glucose, Blood Insulin
Impact of Fluid Milk on Post-meal Glycemia and Insulinemia in Overwt/Obese Adults
Blood sugar and insulin levels after a meal may be altered by the food and beverages a person consumes. Keeping a healthy blood sugar level may help prevent and manage type 2 diabetes and related diseases.
- Trial name
- S37 (NCT01951287)
- Testing
- Acute beverage (water) consumption, Acute beverage (Black Coffee) consumption, Acute beverage (Orange Juice) consumption
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Purdue University
Glucose Metabolism Disorders (Including Diabetes Mellitus), Overweight and Obesity
Effect of Two Alcohol-free Beers With Different Carbohydrates Composition on Lipids and Glucose Metabolism
This a controlled, double-blind, randomized, cross designed study to determine the effect of an alcohol-free beer with low glycemic index carbohydrates (isomaltulose) and a resistant maltodextrin, comparing to an alcohol-free…
- Trial name
- NCT03337828
- Testing
- Alcohol-free beer with regular composition, Alcohol-free beer with modified composition
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Instituto Aragones de Ciencias de la Salud
Chronic Disease, Adolescent Asthma
Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being
The goal of this pilot clinical trial is to learn if a community referral program can improve services for youth with mental health and chronic health conditions in a predominantly Native Hawaiian and Pacific Islander community.
- Conditions
- Chronic Disease, Adolescent Asthma, Obesity & Overweight, Youth Mental Health
- Trial name
- Kamaehu (NCT07536256)
- Testing
- Community Referral to Kaiona Programs
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Waianae Coast Comprehensive Health Center
Glucose Intolerance, Obesity
Effect of a Low-carb Dietary Intervention in Obese Patients: a Pilot Trial
Effects of a 6 months low-carb dietary intervention on glycemic control, body composition and gut-brain interaction in obese and lean patients with and without glucose intolerance or diabetes
- Trial name
- NCT04234373
- Testing
- Low Carb diet
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Effect of a Very Low-Calorie Ketogenic Diet on Gut Microbiota and Fat Distribution
Short-term interventions that use very low-calorie ketogenic diets and meal replacements may be prescribed for selected overweight or obese patients with type 2 diabetes or prediabetes.
- Trial name
- NCT04019431
- Testing
- Whey protein, vegetable protein or animal protein
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Roma La Sapienza
Overweight, Prediabetic State
A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk of obesity-related conditions, including type 2 diabetes, hypertension, and…
- Conditions
- Overweight, Prediabetic State, Prehypertension, Obesity, Abdominal
- Trial name
- ATTAIN-NOW (NCT07794579)
- Testing
- Orforglipron
- Where
- 180 sites in United States, Argentina and 10 more
- Volunteers
- 2,001 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes, PreDiabetes
Promote Health With Digital Tools Among Adults With Type 2 Diabetes/Prediabetes and/or Hypertension
The goal of this hybrid type II effectiveness-implementation trial is to evaluate whether an intersectoral, digitally enabled, family-based intervention can prevent and manage type 2 diabetes mellitus (T2DM) and hypertension…
- Conditions
- Type 2 Diabetes, PreDiabetes, Hypertension, Obesity & Overweight
- Trial name
- DigiCare4You (NCT05648383)
- Testing
- mHealth self-management intervention, Standard care
- Where
- 4 sites in Albania, Bulgaria and 2 more
- Volunteers
- 1,215 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Prediabetic State, Body Weight
Development of PI-ML Algorithm for Prediction of the Real-time Risk for Developing Pre-diabetes
In this prospective, non-randomized, monocentric study, data will be collected from otherwise healthy individuals with overweight/obese grade I to increase data availability in the pre-diabetes field (impaired glucose…
- Conditions
- Prediabetic State, Body Weight, Overweight or Obesity, Life Style, Healthy
- Trial name
- PRAESIIDIUM (NCT06195566)
- Where
- Latvia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Jelizaveta Sokolovska