Clinical trials: Prediction Model
Osteoporotic Vertebral Fracture, Prediction Model
Construction and Validation of a Risk Prediction Model for Secondary Vertebral Fracture in Patients With Osteoporotic Vertebral Compression Fractures After Percutaneous Vertebroplasty
"Retrospectively collecting clinical data from post-PVA (Percutaneous Vertebroplasty) patients, recording incidences of secondary vertebral fractures, and conducting statistical analysis to create a risk prediction model for…
- Trial name
- NCT06172179
- Testing
- No interventions
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hepatocellular Carcinoma (HCC), Liver Transplantation
Validation of the TRAIN-AI for the Risk of HCC Recurrence After Liver Transplantation
Liver transplantation (LT) is the best treatment option for patients with early stages of hepatocellular carcinoma (HCC).1 However, the use of LT depends on maintaining a balance between the risk of post-transplant recurrence or…
- Conditions
- Hepatocellular Carcinoma (HCC), Liver Transplantation, Deep Learning Model
- Trial name
- TRAIN-AI (NCT06799468)
- Testing
- liver transplantation
- Volunteers
- 1,769 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Lung Cancer, Venous Thromboembolism
Development and Application of a Thrombosis Risk Prediction Model in Lung Cancer Patients Treated With Immune Checkpoint Inhibitors
The purpose of this observational study is to explore the incidence, risk factors, and relationship with therapeutic outcomes of VTE (venous thromboembolism) and ATE (arterial thromboembolism) associated with immune checkpoint…
- Conditions
- Lung Cancer, Venous Thromboembolism, Arterial Thromboembolism, Immune Checkpoint Inhibitors (ICIs)
- Trial name
- NCT06950697
- Where
- 5 sites in China
- Volunteers
- 2,400 people
- Sponsor
- Beijing Chao Yang Hospital
Dementia, Cognitive Impairment
A Technology-Driven Intervention to Improve Early Detection and Management of Cognitive Impairment
Most experts advocate for early detection of cognitive impairment (CI) so that patients and caregivers can be prepared for making difficult decisions and to improve quality of life, but studies show that screening alone isn't…
- Trial name
- CI Wizard (NCT05723523)
- Testing
- CI-CDS
- Where
- 2 sites in United States
- Volunteers
- 3,230 people
- Sponsor
- HealthPartners Institute
Cardiovascular Diseases
Identification and Validation of a Prediction Model for CARDIOvascular Events
Background: Cardiovascular risk stratification is a cornerstone of modern preventive medicine, particularly in patients with multiple comorbidities, where risk estimation is inherently complex.
- Trial name
- CARDIO-COM (NCT06952062)
- Where
- Italy
- Volunteers
- 2,400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Papillary Thyroid Carcinoma, Lymph Node Metastasis
Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Based on Ultrasound and Cytological Images
Rising thyroid carcinoma rates, with papillary thyroid carcinoma (PTC) as the main type (85-90% of cases), often show early cervical lymph node spread. This increases the risk of PTC patients for recurrence and death.
- Trial name
- NCT06399159
- Testing
- Thyroidectomy and lymph node dissection
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanchong Central Hospital
Healthy, Surgery
Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model
in healthy patients undergoing elective surgery, after a very slow induction, using Eleveld's kinetics as a reference, after loss of consciousness (LOC) and intubation, proceed to infuse propofol until 1% burst suppression ratio…
- Trial name
- Eleved PD (NCT06417645)
- Testing
- fixed propofol infusion 15 mg/kg/h until 1% BSR (burst suppression ratio)
- Where
- Chile
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Chronic Atrophic Gastritis
Objective Study on Tongue Diagnosis of Chronic Atrophic Gastritis
Chronic atrophic gastritis with intestinal metaplasia or dysplasia is called precancerous lesions of gastric cancer ( PLGC ). It is an important stage in the transformation of normal mucosa to gastric cancer and is significantly…
- Trial name
- NCT06489132
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Anesthesiology, Anesthesiology Management
Machine Learning-Based Model for Individualized Drug Dose Prediction for Propofol
The goal of this observational study is to develop an individualized prediction model for drug dosage during propofol-induced loss of consciousness in anticipation of advances in research in this area.
- Trial name
- NCT06703879
- Testing
- Anesthesia induction with propofol
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Low Anterior Resection Syndrome, Radiotherapy
Development and Validation of The Post-RT LARS Prediction Model (PORTLARS)
Bowel dysfunction is common after a restorative rectal cancer resection. Neoadjuvant radiotherapy is an influential factor that impairs bowel function and quality of life.
- Conditions
- Low Anterior Resection Syndrome, Radiotherapy, Rectal Cancer
- Trial name
- PORTLARS (NCT05129215)
- Testing
- Questionnaire
- Where
- China
- Volunteers
- 901 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Adult Congenital Heart Disease, Symptom Clusters
AI-Enabled Frailty Risk Prediction in Adult Congenital Heart Disease
The goal of this three-year mixed-methods observational study with an embedded randomized controlled trial is to develop and validate a frailty risk prediction model and evaluate an artificial intelligence-based voice emotion…
- Conditions
- Adult Congenital Heart Disease, Symptom Clusters, Frailty, Risk Prediction Model
- Trial name
- NCT07479654
- Testing
- AI-Based Voice Emotion Detection-Guided Counselling, Usual Care (Control)
- Volunteers
- 410 people
- Sponsor
- Mackay Memorial Hospital
Congenital Heart Disease (CHD), Ventricular Septal Defects (VSD)
A Multimodal AI Prediction Model for Complications After Transcatheter Closure of Perimembranous VSD in Children
The goal of this observational study is to develop and validate a multimodal artificial intelligence prediction model for treatment-related complications in children with perimembranous ventricular septal defect (pmVSD)…
- Conditions
- Congenital Heart Disease (CHD), Ventricular Septal Defects (VSD), Cardiac Catheterization, Postoperative Complications
- Trial name
- NCT07375602
- Where
- China
- Volunteers
- 5,249 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Anesthesia for Elective Surgery Patients, Anesthesia Brain Monitor
Reevaluation Prediction of the Effect Site Propofol Eleveld Model Using Slow and Fast Induction
Patients ASA1-2, 18 to 70 years old, scheduled for elective surgery with personal conset to participate, will be randomised into two groups using different induction mode.
- Conditions
- Anesthesia for Elective Surgery Patients, Anesthesia Brain Monitor, Pharmacodynamics
- Trial name
- fast or slow E (NCT07237477)
- Testing
- Evaluation of the prediction of from the propofol PKPD model including in TCI pumps using fast (Effect site mode TCI) or slow (plasma TCI mode) induction
- Where
- Chile
- Volunteers
- 70 people
- Sponsor
- Pablo O. Sepulveda
Trigeminal Neuralgia
Risk Factors for Recurrence of Trigeminal Neuralgia After Percutaneous Balloon Compression
The goal of this observational study is to develop and validate a machine learning-based model for predicting pain recurrence risk after percutaneous balloon compression (PBC) in adult patients with primary trigeminal neuralgia…
- Trial name
- NCT07238244
- Testing
- Percutaneous Balloon Compression
- Volunteers
- 700 people
- Sponsor
- Second Xiangya Hospital of Central South University
Liver Transplant Disorder
Developing Prediction Models for Allograft Failure After Liver Transplantation
Prompt identification of allograft failure (AF) is highly desirable to address patients to liver retransplantation, in order to maximize results and preserve patients safety.
- Trial name
- IMPROVEMENT (NCT05289609)
- Testing
- Liver Transplantation
- Where
- 18 sites in United States, Argentina and 9 more
- Volunteers
- 5,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Type 2 Diabetes, Insulin Resistance
Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）
This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Cognitive Impairment
- Trial name
- T2DM (NCT06912321)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Ulcerative Colitis (Disorder), Crohn Disease (CD)
Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic Prediction
This observational study evaluates whether adding Traditional Chinese Medicine (TCM)-related clinical features improves the performance of machine-learning models that estimate disease risk before colonoscopy.
- Conditions
- Ulcerative Colitis (Disorder), Crohn Disease (CD), Inflammatory Bowel Diseases, Colorectal Neoplasms
- Trial name
- NCT07784114
- Volunteers
- 1,500 people
- Sponsor
- Beijing University of Chinese Medicine
Unruptured Intracranial Aneurysm, Intracranial Aneurysm Rupture
Prospective Observational Cohort Study for Predicting Unruptured Intracranial Aneurysm Rupture Risk Using Blood Pressure Variability and 3D Structural Evolution
This is a single-center, prospective, longitudinal observational cohort study in adults with unruptured intracranial aneurysms (UIAs) who are managed by conservative observation rather than immediate surgery or endovascular…
- Trial name
- NCT07893574
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
The Establishment and Analysis of the Clinical Prediction Model of Acupuncture and Moxibustion for Stroke Recovery
Electronic health records of stroke convalescent patients will be selected from the third affiliated hospital of Zhejiang Chinese Medical University from January 2012 to December 2019.
- Trial name
- NCT03946566
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Uterine Cervical Neoplasms
A Prospective Cohort Study Comparing AI Prediction Model With Imaging Assessment to Diagnose Lymph Node Metastasis in Cervical Cancer
The goal of this prospective cohort study is to learn whether artificial intelligence multimodal fusion prediction models are effective in diagnosing pelvic lymph node metastasis in cervical cancer.
- Trial name
- NCT06541288
- Testing
- AI Prediction Model, Conventional Imageing Assessment
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University