Clinical trials: Predictive Model, open to volunteers
Acute Kidney Injury After Adult Cardiac Surgery, Gastrointestinal Microbiome
Development and Validation of a Risk Prediction Model for Cardiac Surgery-associated Acute Kidney Injury Based on the Gut-Kidney Axis, Incorporating Gut Microbiota and Their Metabolites
This is a single-center prospective observational cohort study enrolling adult patients scheduled for cardiac surgery. Multi-timepoint clinical indicators, stool samples for gut microbiota and metabolomics profiling and artery…
- Conditions
- Acute Kidney Injury After Adult Cardiac Surgery, Gastrointestinal Microbiome, Metabolome, Risk Assessment
- Trial name
- NCT07738796
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Ductal Adenocarcinoma
Prediction of Neoadjuvant Chemotherapy Response in Pancreatic Cancer
This study aims to develop and validate a predictive microRNA (miRNA) panel to assess the response to neoadjuvant chemotherapy (NACT) in patients with resectable and borderline resectable pancreatic ductal adenocarcinoma (PDAC).
- Trial name
- PRECEPT (NCT07226154)
- Testing
- Small RNA sequencing, PRECEPT assay (qRT-PCR validation)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- City of Hope Medical Center
Stroke Ischemic
BREMISS : Brain Resilience Minor Stroke Study
The objective of this clinical trial is to develop, based on patients' initial characteristics (in the first few weeks following the stroke), a predictive model of quality of life more than 4 years after the stroke in patients…
- Trial name
- BREMISS (NCT06995040)
- Testing
- Cerebral MRI without contrast agent injection, saliva sample, Questionnaires
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Brest
Postoperative Pain, Patiet Controlled Analgesia
Comparison of the Effects of Hydromorphone and Nalbuphine Patient Controlled Analgesia in Postoperative Pain After Cesarean Section
Cesarean section is an essential surgical procedure in obstetrics, which not only addresses dystocia and certain obstetric syndromes, ensuring the safety of the maternal participants, but also increases perinatal survival rates…
- Trial name
- NCT06716359
- Testing
- Observational study without intervention
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Huazhong University of Science and Technology
Breast Cancer, Metastatic Invasive Breast Cancer
Diagnostic Prediction Model for De Novo Metastatic Breast Cancer
The goal of this observational study is to create a tool to estimate the risk of macroscopic distant tumor spread in women with newly diagnosed breast cancer.
- Trial name
- NCT07752238
- Where
- Hungary
- Volunteers
- 925 people
- Sponsor
- Markusovszky University Teaching Hospital os County Vas
Pancreatic Cancer
A Study on a Predictive Model for Efficacy and Prognosis of Pancreatic Carcinoma Based on Multimodal Data
The goal of this observational study is to learn if combining information from CT scans, blood tests, and pathology reports can better predict how pancreatic cancer will progress.
- Trial name
- NCT07561814
- Where
- China
- Volunteers
- 1,030 people
- Sponsor
- Shanghai Zhongshan Hospital
Anastomotic Leak, Colorectal Cancer
Anastomotic Leakage After Colorectal Surgery.
Anastomotic leakage (AL) is a severe complication after colorectal surgery, with incidence rates of 2-30%. This prospective, single-center observational cohort study aims to identify and quantify independent risk factors for AL…
- Conditions
- Anastomotic Leak, Colorectal Cancer, Diverticulitis
- Trial name
- AL (NCT07144683)
- Testing
- Patients Undergoing Colorectal Resection with Anastomosis
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Patient Outcome Assessment
Effect of Predictive Model on ED Physician Assessments of Patient Disposition
The goal of this study is to measure the impact of fairness-aware algorithms on physician predictions of ED patient admission. Using an experimentally validated machine learning model tuned for equitable outcomes, the…
- Trial name
- NCT06434220
- Testing
- Baseline model, Fairness-aware model
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Oxidative Injury, Stress Physiological
TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models
The goal of this observational study is to define a personalized risk model in the super healthy and homogeneous population of Italian Air Force high-performance pilots.
- Conditions
- Oxidative Injury, Stress Physiological, Discogenic Pain, Cardiovascular Risk Factor
- Trial name
- NCT06372054
- Testing
- Biological sample collection
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Extravasation of Contrast Media
Risk Prediction Model for Iodinated Contrast Medium Extravasation
This study aims to develop a risk prediction model for iodine contrast agent extravasation from peripheral veins and to implement this model clinically to establish a risk control management system for iodine contrast agent…
- Trial name
- RPMICME (NCT06859242)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhang Wenyan
Non-small Cell Lung Cancer
The Accuracy of Targeted Lymph Node Dissection of Non-small Cell Lung Cancer Patients According to Predictive Models
Investigators combined the clinical and radiomics characteristics of resectable non-small cell lung cancer patients to construct an accurate model for preoperative prediction of mediastinal lymph node status.
- Trial name
- NCT06768853
- Testing
- Lymph node dissection based on the guidelines, Lymph node dissection based on the model
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhongnan Hospital
Speech, Autism Spectrum Disorder (ASD)
Research on Speech Development Trajectories and Predictive Models in Children With Autism Spectrum Disorder
Recent studies indicate that children with ASD have a significantly higher risk of co-occurring speech sound disorders than typically developing children.
- Trial name
- NCT07472829
- Testing
- Approaches to ASD social intervention
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Chongqing Medical University
Sciatica, Low Back Pain
Artificial Intelligence (AI)-Based Prediction of Treatment Response in Sciatica Patients Receiving Transforaminal Epidural Steroid Injection
This prospective observational study aims to develop artificial intelligence (AI)-based predictive models to estimate treatment response in patients with sciatica undergoing transforaminal epidural steroid injection (TFESI).
- Conditions
- Sciatica, Low Back Pain, Lumbar Spinal Stenosis, Radiculopathy
- Trial name
- NCT07080307
- Where
- Turkey (Türkiye)
- Volunteers
- 1,500 people
- Sponsor
- Marmara University
Sepsis, Septic Shock
Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis
Introduction: Timely and accurate antibiotic administration in emergency department (ED) patients with sepsis or septic shock is vital, given mortality rates of 20% and over 40%, respectively.
- Trial name
- NCT07167173
- Volunteers
- 10,000 people
- Sponsor
- Hospital Italiano de Buenos Aires
Scoliosis
Prospective Multicenter Evaluation of a New Predictive Model for the Progression of Adolescent Idiopathic Scoliosis
Scoliosis is a three-dimensional deformity affecting the orientation and position of the spine. Locally, the shape of the vertebra is also affected.
- Trial name
- NCT02434003
- Where
- 9 sites in United States, Canada and 4 more
- Volunteers
- 1,200 people
- Sponsor
- St. Justine's Hospital
Multi-resistant Gram-negative Bacteria Cause Infection
GRAM NEGATIVES STUDY
This is a prospective, observational, multicenter study whose main objective is to develop a predictive model of mortality in critically ill patients colonized by multidrug-resistant Gram-negative bacteria (MDR-GNB).
- Trial name
- MR-GEIPC (NCT07749508)
- Testing
- Standard of care therapy
- Where
- Spain
- Volunteers
- 1,500 people
- Sponsor
- Fundacion SEIMC-GESIDA
Critical Illness
Predictive Model for Mortality in Older People With Critical Illness
The present study aims to develop a predictive model to identify elderly patients with the highest likelihood of mortality upon admission to an intensive care unit.
- Trial name
- VITA (NCT06727903)
- Testing
- laboratory biomarker analysis
- Where
- 15 sites in Spain
- Volunteers
- 450 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Glioblastoma, Organoid
Drug Response Testing and Repurposing Using Glioblastoma Organoid
The aim of this observational study, based on a prospectively collected cohort, is to evaluate the prognostic value of patient-derived organoids in predicting responses to conventional and repurposing drugs, including…
- Trial name
- NCT06782984
- Testing
- Organoid-based drug sensitivity test
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Chungnam National University Hospital
Breast Cancer Female
Real Time Molecular Analysis of Breast Cancer Receiving Neo-adjuvant Chemotherapy
The present project aims at identifying robust candidates for drug resistance in BC patients eligible for NAC. Its originality lies upon the combination of three different and complementary prospective approaches: from the…
- Trial name
- NEO-R (NCT04504747)
- Testing
- molecular analysis of blood and tumor
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Institut Paoli-Calmettes
Hypoxemia
Frailty and Intraoperative Hypoxemia Risk in Elderly ERCP Patients
Intraoperative hypoxemia is a common and serious complication during monitored anesthesia care for elective endoscopic retrograde cholangiopancreatography (ERCP), especially in older adults.
- Trial name
- NCT07568912
- Volunteers
- 701 people
- Sponsor
- China-Japan Friendship Hospital