Clinical trials: Preeclampsia Severe
Severe Preeclampsia
Role of Postpartum Furosemide in Recovery of Patients With Severe Preeclampsia
This randomized controlled trial will compare oral furosemide with placebo for improving blood pressure control in women with severe preeclampsia after delivery.
- Trial name
- NCT07861685
- Testing
- Furosemide and Potassium
- Where
- Pakistan
- Volunteers
- 434 people
- Sponsor
- Lady Reading Hospital, Pakistan
Preeclampsia Severe, Preeclampsia Postpartum
Biomarkers in Management of Post Partum Preeclampsia
Participants are recruited for a research study about how lab values change following delivery in people with Preeclampsia with Severe Features.
- Trial name
- NCT07478055
- Testing
- Magnesium Sulfate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Alexander Harrison
Preeclampsia, Severe Preeclampsia
Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women
The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals.
- Trial name
- NCT07265336
- Testing
- Arterial Blood gases
- Where
- Panama
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia, Severe Preeclampsia
Identification of Genes of Interest for Severe Forms of Preeclampsia
Preeclampsia is a pregnancy complication characterized by high blood pressure associated with damage to various organs, especially the kidneys.
- Trial name
- PRE-OMIQUES (NCT07703826)
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Severe Preeclampsia
Algorithm-Based Timing of Delivery Using the sFlt-1/PlGF Ratio in Early-Onset Severe Preeclampsia. (MAP 2 Study : Management Based on Angiogenic Markers in Preeclampsia 2 Study )
Preeclampsia is a serious pregnancy complication caused by abnormal placental development and function. It can lead to high blood pressure and damage to organs such as the liver, kidneys, brain, or cardiovascular system.
- Trial name
- MAP 2 (NCT07665112)
- Testing
- sFlt-1/PlGF ratio-guided management algorithm, Usual Care
- Where
- Spain
- Volunteers
- 386 people
- Sponsor
- Hospital Clinic of Barcelona
Preeclampsia Severe, Preeclampsia Postpartum
Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial
A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on…
- Trial name
- PANDA (NCT03978767)
- Testing
- Ibuprofen 600 mg, Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- Washington University School of Medicine
Severe Preeclampsia
Furosemide vs Placebo in Severe Preeclampsia Postpartum
This randomized, double-blind, placebo-controlled trial evaluates whether oral furosemide 40 mg, initiated 12 hours postpartum, reduces hospital length of stay compared to placebo (folic acid 5 mg) in postpartum women with severe…
- Trial name
- FUROPE (NCT07648251)
- Testing
- Furosemide, Folic Acid 5 MG
- Where
- Honduras
- Volunteers
- 186 people
- Sponsor
- Universidad Nacional Autonoma de Honduras
Severe Preeclampsia
Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia
This study evaluates the use of AMAG-423 (Digoxin Immune Fab) in addition to expectant management in the treatment of severe preeclampsia as compared to placebo.
- Trial name
- NCT03008616
- Testing
- AMAG-423 (digoxin immune fab)
- Where
- 18 sites in United States, Poland and 1 more
- Volunteers
- 58 people
- Sponsor
- AMAG Pharmaceuticals, Inc.
Severe Preeclampsia
Factors Associated With Blood Pressure Control Failure to Intravenous Labetalol in Severe Preeclampsia
Severe preeclampsia is a serious pregnancy complication that can lead to severe maternal and fetal outcomes, particularly when blood pressure is not adequately controlled.
- Trial name
- RELAPSE (NCT07547046)
- Where
- 14 sites in France
- Volunteers
- 350 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia, Preeclampsia Postpartum
Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound
This study explores a novel approach to improving care for postpartum patients with preeclampsia, a pregnancy-related condition characterized by high blood pressure, protein in the urine, and organ dysfunction.
- Conditions
- Preeclampsia, Preeclampsia Postpartum, Preeclampsia Severe or Mild
- Trial name
- PPPOCUS (NCT07167862)
- Testing
- Butterfly iQ3 ultrasound system for determination of postpartum volume status, Oral furosemide, Intravenous furosemide
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of California, Irvine
Preeclampsia Severe, Toxemia Of Pregnancy
LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention
Preeclampsia is a major cause of maternal and perinatal morbidity and mortality worldwide. Low-dose aspirin started in the first trimester reduces the risk of preeclampsia in high-risk women.
- Conditions
- Preeclampsia Severe, Toxemia Of Pregnancy, Preeclampsia, Pregnancy Complications
- Trial name
- preGO (NCT07361679)
- Testing
- Aspirin, Tinzaparin
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Alexandra Hospital, Athens, Greece
Severe Preeclampsia, Eclampsia Preeclampsia
Levetiracetam Compared to Magnesium Sulfate for Prevention of Eclamptic Seizure
The goal of this study is to compare levetiracetam to magnesium sulfate for the prevention of eclamptic seizures in pregnant persons with severe preeclampsia that are 32 or more weeks pregnant.
- Trial name
- LEVMag (NCT07220902)
- Testing
- Levetiracetam, magnesium sulfate
- Where
- United States
- Volunteers
- 1,240 people
- Sponsor
- Nebraska Methodist Health System
Preeclampsia, Preeclampsia Severe
Preeclampsia Educational Program Study (PrEPS)
Preeclampsia complicates approximately 8% of all pregnancies. A critical factor of outpatient monitoring is patient education; specifically, education regarding nature of the disease, ongoing short- and long-term risks, and…
- Conditions
- Preeclampsia, Preeclampsia Severe, Preeclampsia Mild, Preeclampsia Postpartum
- Trial name
- PrEPS (NCT06373367)
- Testing
- Illustration based application, Text based application
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- MemorialCare Health System
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Severe Preeclampsia
The Association Between Different Markers With Development of Maternal and Neonatal Complications in Women With Severe Preeclampsia
pregnant women diagnosed with severe preeclampsia were subjected to • Full history taking including a detailed history of the hypertension state during the current pregnancy (onset, course, current medication, and whether the…
- Trial name
- NCT07125599
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Cairo University
Inflammatory Markers, Preeclampsia Severe
Assessment of Maternal and Fetal Serum Biomarkers in Women With Pre-eclampsia
The findings of markers of placental dysfunction in women with preeclampsia may suggest that these biomarkers may be useful tools for early detection of preeclampsia
- Conditions
- Inflammatory Markers, Preeclampsia Severe, Preeclampsia Mild, Umbilical Cord Issue
- Trial name
- NCT06712550
- Where
- Iraq
- Volunteers
- 204 people
- Sponsor
- SHAHLA KAREEM ALALAF
Preeclampsia Severe, Pre-Eclampsia
Metformin and Esomeprazole in Preterm Pre-eclampsia
The purpose of this study is to better understand diagnosis and treatment of preterm preeclampsia. Currently, there are limited laboratory tests that can be used to diagnosis preeclampsia.
- Conditions
- Preeclampsia Severe, Pre-Eclampsia, Preeclampsia, Preeclampsia Second Trimester
- Trial name
- NCT06359015
- Testing
- Metformin, Esomeprazole
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Christiana Care Health Services
Preeclampsia Severe, Optic Nerve Sheath Diameter
Optic Nerve Sheath Diameter in Pre-Eclamptic Parturient Receiving Magnesium Sulfate Combined With Dexmedetomidine
Dexmedetomidine was reported to effectively reduce cerebral metabolism and ICP by decreasing cerebrospinal fluid pressure in patients with cerebral tumors or head injuries that require craniotomy.
- Trial name
- NCT05610774
- Testing
- Dexmedetomidine, Saline
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Preeclampsia Severe
Intravenous Labetalol Versus Hydralazine in Preeclampsia
We study the effect of intravenous labetalol versus hydralazine in sever preeclampsia patients on cerebral blood flow and neurological outcome
- Trial name
- NCT06360601
- Testing
- Labetalol Injection, HydrALAZINE Injection
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Fetal Growth Restriction, Preeclampsia Severe
Expanded NIPT for Pregnancy Complications
This study evaluates the utility of expanded panel non-invasive prenatal testing (NIPT) in detecting confined placental mosaicism of rare autosomal trisomies among pregnancies with placentally-mediated complications, including…
- Trial name
- NCT04311749
- Testing
- Expanded panel cell free DNA testing (non-invasive prenatal testing), Placental biopsy, Umbilical cord blood
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco