Clinical trials: Preeclampsia and Eclampsia
Vitamin D Deficiency, Pre-Eclampsia
Effect of Vitamin D3 Supplementation in Pregnancy on Risk of Pre-eclampsia
Vitamin D deficient pregnant ladies were selected and randomized into 2 groups for routine daily dose of multivitamin (400IU vitamin D3) versus maximum safest treatment daily dose (4000IU vitamin D3).
- Trial name
- NCT03101150
- Testing
- 400 IU Vitamin D3, 4000 IU Vitamin D3
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- King Fahad Medical City
Weight Loss, Postpartum Weight Retention
Postpartum Weight Loss for Women at Elevated Cardiovascular Risk
The aim of this study is to test the feasibility and effectiveness of a 16-week online behavioral weight loss program compared to usual care to promote weight loss in the postpartum period among women with cardiovascular risk…
- Conditions
- Weight Loss, Postpartum Weight Retention, Hypertension in Pregnancy, Diabetes Mellitus in Pregnancy
- Trial name
- EMPOWER-Mom (NCT04914819)
- Testing
- Online Behavioral Weight Loss Program, Virtual weigh-in
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Pennsylvania
Brain Health, Gestational Hypertension
Brain Health in Midlife
The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.
- Conditions
- Brain Health, Gestational Hypertension, Alzheimer Disease, Dementia
- Trial name
- ADORE BRAIN (NCT06640842)
- Testing
- A combination of various tests and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy on brain health in midlife.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Pregnancy Complications, Obesity
Acute Exercise Effects in Obese Pregnancy
Obesity before and during pregnancy is associated with a higher risk for a number of obstetric and metabolic complications in women and their offspring.
- Conditions
- Pregnancy Complications, Obesity, Pre-Eclampsia, Gestational Diabetes
- Trial name
- NCT03750695
- Testing
- Resistance exercise, Aerobic Exercise, Rest
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Preeclampsia
Oral Progesterone and Low Dose Aspirin in the Prevention of Preeclampsia
This study investigates whether low dose aspirin combined with progesterone will decrease the risk of preeclampsia in pregnant women with a history of preeclampsia in a previous pregnancy.
- Trial name
- NCT00719537
- Testing
- Aspirin, Progesterone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- John Uckele
Pre-Eclampsia, Pre-Term
Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes
Women who had an adverse pregnancy outcome (APO), such as preeclampsia, preterm birth, or gestational diabetes, have a higher risk for heart disease.
- Conditions
- Pre-Eclampsia, Pre-Term, Intrauterine Growth Restriction, Hypertension in Pregnancy
- Trial name
- VIA (NCT04633551)
- Testing
- Anti-inflammatory supplement
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Preeclampsia
Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS)
Preeclampsia is one of the most common complications of pregnancy and is characterized by high blood pressure and protein in the urine. This can cause problems in the second half of pregnancy for both the mother and fetus.
- Trial name
- CAPPS (NCT00135707)
- Testing
- Dietary Supplement/Vitamins
- Where
- 16 sites in United States
- Volunteers
- 10,154 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Pre Eclampsia
Pilot Assessment of an Auto Blood Pressure Monitor
The purpose of the study is to help make a lower cost automatic blood pressure monitor device for diagnosis and monitoring of pre-eclampsia in pregnant women, where automatic blood pressure monitoring is limited or not available.
- Trial name
- NCT02258256
- Testing
- Sphygmo
- Where
- Malawi
- Volunteers
- 11 people
- Sponsor
- William Marsh Rice University
Preeclampsia
ToRsemide for pOstpartum HYpertension
Currently there is no intervention to prevent persistent postpartum hypertension in preeclamptic women. Physiologically, the use of a pharmacokinetically predictable loop-diuretic is a reasonable intervention to increase…
- Trial name
- TROPHY (NCT02813551)
- Testing
- Torsemide
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Hypertension, Pregnancy-Induced
Postpartum Management of Gestational Hypertensive Disorders Using Furosemide
The main purpose of this study is to learn if incorporating a loop diuretic such as furosemide along with labetalol in the routine management of postpartum gestational hypertensive disorders could lower the need for additional…
- Trial name
- NCT04343235
- Testing
- furosemide, labetalol
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wright State University
Preeclampsia Postpartum, Adverse Pregnancy Outcomes
A Community Health Worker Intervention to Address Adverse Pregnancy Outcomes
United States maternal mortality and preterm birth rates are among the highest among high-income countries due in part to a combination of racial, regional and socioeconomic disparities in access to care and overall health.
- Trial name
- AW2H (NCT06353256)
- Testing
- usual postpartum care, usual postpartum care + community health worker intervention
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pre Eclampsia
Accuracy Assessment of an Automatic Blood Pressure Measurement Device in Adult Volunteers
The research team has developed an automatic blood pressure monitor (Sphygmo) to be used for the monitoring and diagnosis of pre-eclampsia in pregnant women, particularly in low-resource settings where current monitoring is…
- Trial name
- NCT02267577
- Testing
- Sphygmo: Automatic Blood Pressure Monitor, GE Dinamap ProCare Automatic Blood Pressure Monitor
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- William Marsh Rice University
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pre-eclampsia
Phenylephrine Versus Ephedrine in Pre-eclampsia
Phenylephrine administration is associated with reductions in CO and SctO2 compared with ephedrine when used for blood pressure management in women with pre-eclampsia undergoing cesarean delivery under spinal anesthesia.
- Trial name
- NCT02025426
- Testing
- Phenylephrine, Ephedrine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Severe Preeclampsia
Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia
This study evaluates the use of AMAG-423 (Digoxin Immune Fab) in addition to expectant management in the treatment of severe preeclampsia as compared to placebo.
- Trial name
- NCT03008616
- Testing
- AMAG-423 (digoxin immune fab)
- Where
- 18 sites in United States, Poland and 1 more
- Volunteers
- 58 people
- Sponsor
- AMAG Pharmaceuticals, Inc.
Pre-Eclampsia
Restrictive Fluid Therapy in Severe Preeclampsia
Introduction: Pre-eclampsia is a multifactorial syndrome which occurs in hypertension and proteinuria in pregnant women over 20 weeks gestation.
- Trial name
- NCT02214186
- Testing
- Restrictive Fluid Therapy
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Preeclampsia
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT03482440
- Testing
- Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Pregnant Women, Preeclampsia
Antioxidant Supplementation in Pregnant Women
The purpose of this study is to investigate the benefit of several micro nutrients of antioxidants (using milk) in a cohort of women with low antioxidant status and the changes in cell-free mRNA.
- Trial name
- ASIP1 (NCT01232205)
- Testing
- micronutrient antioxidant, Control
- Where
- Indonesia
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Showa University
Pre-Eclampsia, Pregnancy Related
Study of Nicotinamide in Early Onset Preeclampsia
Phase II Study of 2.5 gm of nicotinamide, given daily in 3 divided doses, to measure effect on maternal blood pressure in women with early onset preeclampsia and to determine peak and trough levels of nicotinamide.
- Trial name
- NCT03419364
- Testing
- nicotinamide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Preeclampsia
The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia
Low dose aspirin (LDA) is used for preeclampsia (PE) prevention in high risk women, but the precise mechanism and optimal dose is not known.
- Trial name
- NCT03735433
- Testing
- 162mg aspirin dose
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Ohio State University