Clinical trials: Prefrontal Cortex
PTSD, Post Traumatic Stress Disorder
High-Frequency Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in PTSD
The purpose of this study is to compare two slightly different methods of transcranial magnetic stimulation (TMS) to treat Post Traumatic Stress Disorder (PTSD)
- Trial name
- rTMS (NCT02873299)
- Testing
- 10 Hz rTMS of the right dorsolateral prefrontal cortex, 20 Hz rTMS of the right dorsolateral prefrontal cortex
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Healthy
Effects of Transcranial Direct Current Stimulation Over the Left VLPFC on Cognitive Reappraisal
This study aims to investigate the role of the left ventrolateral prefrontal cortex (VLPFC) on cognitive reappraisal, using the reinterpretation strategy.
- Trial name
- NCT03224897
- Testing
- Cathodal tDCS, Anodal tDCS
- Where
- 2 sites in Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Prefrontal Hemodynamics, Muscle Strength
Lower Limb Strength and Power as Predictors of Brain Blood Flow During Exercise
This study aims to investigate the predictive value of lower limb muscle strength and explosive power on exercise-induced prefrontal hemodynamic responses.
- Conditions
- Prefrontal Hemodynamics, Muscle Strength, Physical Performance
- Trial name
- LLSPP (NCT07575802)
- Testing
- Standardized Lower-Limb Physical Performance Assessment and Aerobic Exercise Task
- Where
- Russia
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Lincoln University College
Healthy
Investigating the Cognitive Processes That Underlie Social Knowledge and Behavior
The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex.
- Trial name
- NCT00061334
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Exploratory Behavior
Neural Effects of Green Tea Extract on Dorsolateral Prefrontal Cortex
Green tea is being recognized as a beverage with potential benefits for human health and on cognitive function. In vitro and in vivo studies provide preliminary evidence that green tea intake may play a positive role in improving…
- Trial name
- NCT01615289
- Testing
- Single intragastric instillation of 250 ml green tea extract, Single intragastric instillation of 500 ml green tea extract, Single intragastric instillation of 250 ml control solution
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Intracranial Central Nervous System Disorder, Mental Disorder
Test of A Model of Representational Knowledge Stored in the Human Prefrontal Cortex
This study will examine the underlying mental processes that determine how people understand social behavior, remember information, and think.
- Conditions
- Intracranial Central Nervous System Disorder, Mental Disorder, Healthy
- Trial name
- NCT00024908
- Where
- United States
- Volunteers
- 949 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Schizophrenia
The Effects of tDCS on the Neuronal Mechanisms of Cognitive Control in Schizophrenia
The purpose of this study is to better understand the neural correlates of cognitive control (CC) deficits in schizophrenia and determine how these mechanisms can be modulated by transcranial direct current stimulation (tDCS).
- Trial name
- NCT03077347
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Exercise Performance of Fit Athletes
Carbohydrate Mouth Rinsing and Cognitive Response During Exercise
This study investigates whether rinsing the mouth with a carbohydrate solution can improve brain oxygenation and cognitive function during high-intensity exercise.
- Trial name
- NCT07099807
- Testing
- Carbohydrate Mouth Rinse, Music Listening
- Where
- South Korea
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- CHA University
Posttraumatic Stress Disorder (PTSD), Intrinsic and Novelty-related Sensory Cortical (SC) Disinhibition
A Neurosensory Account of Anxiety and Stress (Study 1)
This study will take a basic neuroscience approach to investigate pathological mechanisms underlying PTSD. Additionally, the study aims to identify how Transcranial Alternating Current Stimulation (tACS) brain stimulation can…
- Trial name
- NCT05895006
- Testing
- Alternating Current Stimulation (tACS), Transcranial Random Noise stimulation (tRNS)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity
The Effect of Brain Stimulation (tDCS) in Food Cravings Control in Overweight/Obese Women
This study is a randomized clinical trial to test the effect of a type of non-invasive brain stimulation on the response to a behavioral intervention designed to enhance cognitive control over food cravings in obese and…
- Trial name
- NCT04420767
- Testing
- tDCS, Go-No GO task
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy, Memory Impairment
The Effects AZD8529 on Ketamine-induced Impairment of Working Memory in Healthy Volunteers
The purpose of this study is to assess if ketamine will induce, in healthy volunteers, impairment of working memory and if the drug AZD8529 will block the effects of ketamine on working memory as assessed by functional magnetic…
- Trial name
- NCT00985933
- Testing
- AZD8529
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Nicotine Dependence
Transcranial Direct Current Stimulation in a Smoking Cessation Trial
The purpose of this study is to determine the effectiveness of transcranial direct current stimulation (tDCS) plus nicotine patch as a viable smoking cessation program for nicotine dependent smokers.
- Trial name
- tDCS (NCT01710410)
- Testing
- active transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Memory Deficits, tACS
tACS Improves Memory in Elders With Subjective Memory Complaints
Subjective memory complaints (SMC), the main cognitive component of which is event memory, is a predictor of Alzheimer's disease in elderly people.
- Trial name
- NCT05569902
- Testing
- active tACS
- Where
- Iran
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Tehran
Stress Reaction, Stress Related Disorder
Research on the Effects of Combined Neurostimulation Protocols on Stress
The study examines the effects of the combined use of two different non-invasive brain stimulation (NIBS) techniques targeting the DLPFC on stress reactivity and recovery.
- Conditions
- Stress Reaction, Stress Related Disorder, Major Depressive Disorder
- Trial name
- NCT03722095
- Testing
- active tDCS, iTBS
- Where
- Belgium
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Ghent
Schizophrenia
Transcranial Direct Current Stimulation Influences on Cognitive Inhibition in Schizophrenia
A deficit in cognitive suppression is a trait of patients with schizophrenia. Cognitive suppression is the ability to control or suppress irrelevant responses and to adopt relevant responses instead.
- Trial name
- NCT01971073
- Testing
- transcranial direct current stimulation
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bar-Ilan University, Israel
Brain Electrical Reactivity to BTL-699-2 Stimulation
EEG Changes After rTMS Stimulation
The goal of this clinical trial is to explore the brain's electrical reactivity, monitored using EEG, following the EXOMIND (BTL-699-2) stimulation across various stimulation locations.
- Trial name
- NCT07179224
- Testing
- Treatment with EXOMIND (BTL-699-2)
- Where
- Czechia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Healthy Participants, Magnetic Stimulation
Study of the Correlation Between Cortical Excitability and Cytoarchitectonics of Prefrontal Cortex in Healthy Adult Participants, Using Transcranial Magnetic Stimulation Coupled to EEG and High-field MRI
Repeated transcranial magnetic stimulation (rTMS) is mainly used to treat mood disorders by addressing differences in brain function, particularly in the dorsolateral prefrontal cortex (DLPFC), which affects emotions and…
- Conditions
- Healthy Participants, Magnetic Stimulation, MRI, EEG
- Trial name
- FrontalProbe (NCT07071259)
- Testing
- TMS Stimulation
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Depression Minor
Probing Homeostatic Plasticity With Priming Theta-burst Stimulation of the Dorsolateral Prefrontal Cortex
Priming stimulation is a highly promising tool to boost the beneficial effects of therapeutic repetitive transcranial magnetic stimulation (rTMS) in psychiatry.
- Trial name
- NCT04031105
- Testing
- Theta-burst stimulation (TBS)
- Where
- Hong Kong
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Dr Georg Kranz
Healthy
The Role of Different Prefrontal Areas in Visual Metacognition
The study will use transcranial magnetic stimulation (TMS) to investigate the causal role of different brain regions during visual perception. TMS is a well-established technique used by hundreds of labs in the world.
- Trial name
- NCT04263766
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Dual-task, Healthy Adults
Cortical Activation and Cognitive-Motor Learning
The purpose of this research study is to assess the effects of dual-task training using a dynamic balance task and an auditory reaction time task on dual-task performance in healthy young adults and to assess the cortical…
- Trial name
- Co-ACT&LEARN (NCT04666181)
- Testing
- Dual-task training
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- East Carolina University