Clinical trials: Prefrontal Cortex
Cognitive Aging
Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
This proposal aims to determine whether low does of the alpha-2A-adrenoceptor agonist guanfacine can improve deficits in prefrontally-mediated cognitive functions in healthy elderly subjects.
- Trial name
- NCT00935493
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy
Magnetic Resonance Imaging of Calculus Problem Solving
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in solving algebraic math problems. It will examine brain activation according to the level of difficulty and the number of steps required to…
- Trial name
- NCT00060658
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy, Neurofeedback
Real-time Neurofeedback Training of the Medial Prefrontal Cortex Based on Imagined Social Support
Randomized active-sham controlled between-subject real-time fMRI neurofeedback trial aiming to modulate activity in the medial prefrontal cortex (mPFC) to improve subjective negative anticipation.
- Trial name
- NCT07364084
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Mental Fatigue, Near Infrared Spectroscopy
The Effect of Mental Fatigue on the Cerebral Oxygenation During Endurance Exercise
The experiment will consist of 3 consecutive trials performed in a sound-insulated climate chamber (20°C and 40% RH) at the VUB. Participants will be asked to return 3 successive weeks.
- Conditions
- Mental Fatigue, Near Infrared Spectroscopy, NIRS, Condition
- Trial name
- NCT05355493
- Testing
- Time to Exhaustion cycling test, Go/NoGo task
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Volunteers, Cognitive Function
Self-regulation of Prefrontal Cortex During Emotional Cognitive Control
Deficits in emotional cognitive control are present in a number of clinical psychiatric populations including depression, anxiety, and PTSD.
- Trial name
- SPrC (NCT04543500)
- Testing
- Real-time functional magnetic resonance neurofeedback (rtfMRI-nf)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Major Depressive Disorder
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated…
- Trial name
- NCT05194098
- Testing
- TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- San Francisco Veterans Affairs Medical Center
Healthy
Positron Emission Tomography Imaging of Dopamine Receptors Using the Tracer [11C]NNC-112
This study will investigate the use of [11C]NNC-112 in positron emission tomography (PET) scanning. PET is a technique that uses radioactive isotopes called tracers to provide images of the brain.
- Trial name
- NCT00088517
- Testing
- [11C]NNC-112
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Loneliness
The Effects of Transcranial Direct Current Stimulation (tDCS) in Older Lonely Individuals
This randomized clinical trial aims to test the effects of 10 sessions of transcranial direct current stimulation (tDCS) on social and emotional functions in lonely older adults.
- Trial name
- NCT05937022
- Testing
- Experimental Transcranial Direct Current Stimulation (tDCS)
- Where
- Hong Kong
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dyspnea
Effect of Non-invasive Magnetic Stimulation of the Brain on Breathlessness in Healthy Individuals.
The purpose of this study is to see if the front part of the brain called the "Dorsolateral Prefrontal Cortex" (DLPFC) has a role in our ability to feel breathlessness.
- Trial name
- AHrTMS (NCT05623696)
- Testing
- rTMS-L-DLPFC, rTMS-R-DLPFC
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Normal Physiology, fMRI
The Effect of Transcranial Magnetic Stimulation on Learning With Reward in Healthy Humans
Background: Two areas on the surface of the brain, the dorsolateral prefrontal cortex (DLPFC) and motor cortex (MC), play a key role during learning.
- Trial name
- NCT01260740
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
Exploring the Cortical Hemodynamic Response of Excitatory Brain Stimulation: a Pilot Study
Intermittent theta-burst stimulation (iTBS) is a promising treatment for major depressive disorder. However, fewer than 50% of patients show sufficient response. Therefore, the optimal treatment protocol is worth investigating.
- Trial name
- NCT05427552
- Testing
- Intermittent theta-burst stimulation (iTBS)
- Where
- Hong Kong
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Ischemic Stroke, Acute, Post-stroke Anxiety
Benson Relaxation for Anxiety, Depression, and Insomnia After Stroke
Stroke is a leading cause of disability worldwide. Many patients experience anxiety, depression, and sleep disturbances in the early recovery phase, which can slow rehabilitation.
- Conditions
- Ischemic Stroke, Acute, Post-stroke Anxiety, Post-stroke Depression, Sleep
- Trial name
- BRT-Stroke (NCT07731282)
- Testing
- Benson Relaxation Technique, Structured Health Education
- Where
- 2 sites in China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Changchun University of Traditional Chinese Medicine
Aggression
Transcranial Direct Current Stimulation and Antisocial Behavior
The main objective of this study is to investigate the causal relationship between prefrontal cortex activity and antisocial behavior, as well as risk factors for antisocial behavior.
- Trial name
- NCT04204759
- Testing
- Transcranial direct current stimulation
- Where
- Singapore
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Language
Effect of rTMS of the Dorsolateral Prefrontal Cortex on Language Production in Healthy Participants
The purpose of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) on language production.
- Trial name
- NCT02840396
- Testing
- rTMS
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Jean-Marie Annoni
Effect of tDCS on Memory in Older and Younger Adults
Effect of Noninvasive Electrical Brain Stimulation on Memory at Different Times of Day in Younger and Older Adults
This study will investigate the extent to which tDCS to dorsolateral prefrontal cortex (or dlPFC) impacts memory performance as a function of time-of-day in younger and older adults.
- Trial name
- NCT03723850
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Bipolar Disorder Type II, Mood Depressive Disorder
Exploration of Differences in Metabolite Concentrations by NMR Spectroscopy in the Ventral Striatum, Anterior Cingulate Cortex and Prefrontal Cortex in Euthymic Patients With Unipolar and Bipolar Type II Mood Disorders, as Well as in Healthy Subjects
The presented project is an open and controlled single-center prospective exploratory study, evaluating the metabolic concentrations in the ventral striatum (VS), the Anterior cingulate cortex (ACC) and the prefrontal cortex…
- Trial name
- RMN-UNIBI (NCT05650788)
- Testing
- NMR spectrometry
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pain Relief
Repetitive Transcranial Magnetic Stimulation and the Development of Ongoing Muscle Pain
The main purpose of the study is to assess the mechanisms of repeated sessions of repetitive trancranial magnetic stimulation (rTMS) applied on left dorsolateral prefrontal cortex on the development of pain in a prolonged muscle…
- Trial name
- NCT03263884
- Testing
- Repetitive trancranial magnetic stimulation (rTMS) group
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Schizophrenia
Effects of Brain Stimulation on Higher-Order Cognition
The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current…
- Trial name
- NCT03814967
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of California, Davis