Clinical trials: Prefrontal Cortex
Neuropathic Pain
Analgesic Effects of rTMS in Peripheral Neuropathic Pain
This study aims to evaluate the long term efficacy over 25 weeks of repeated sessions of magnetic transcranial stimulation of the motor cortex or prefrontal cortex on average pain intensity, quality of life, sleep, neuropathic…
- Trial name
- TRANSNEP (NCT02010281)
- Testing
- rTMS of prefrontal or motor cortex
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cognitive Function, Working Memory
Effects of Park Golf on Working Memory and Prefrontal Cortex Activation in Older Adults
This study investigates whether a park golf program can improve working memory and prefrontal cortex activity in community-dwelling older adults.
- Trial name
- NCT07807631
- Testing
- Park Golf Program, Health Education Program
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gwangju Health University
Cognitive Change
Dopamine Dorsolateral Prefrontal Cortex Behavioural Flexibility
Behavioural or cognitive flexibility (BF) is an essential ability which allows an organism to adaptively change responses in accordance with feedback of results.
- Trial name
- NCT03068884
- Testing
- Cathodal Transcranial direct current stimulation, L-Tyrosine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Schizophrenia, Depression
Magnetic Stimulation of the Brain in Schizophrenia or Depression
The primary objective is to evaluate if repetitive transcranial magnetic stimulation (rTMS) with theta burst frequency over dorsomedial prefrontal cortex (DMPFC) is an effective treatment for negative symptoms (anhedonia and…
- Conditions
- Schizophrenia, Depression, Anhedonia, Avolition
- Trial name
- MA-SCH-DEP (NCT02905604)
- Testing
- dmPFC iTBS
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Obsessive-compulsive Disorder
Study of Sequentially Applied Repetitive Transcranial Magnetic Stimulation in Obsessive- Compulsive Disorders
The purpose of study was to investigate possible therapeutic effects and safety of sequentially combined low-frequency repetitive transcranial magnetic stimulation (rTMS) to the right dorsolateral prefrontal cortex (DLPFC) and…
- Trial name
- NCT00932204
- Testing
- repetitive transcranial magnetic stimulation (Magstim rapid magnetic stimulator)
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Severance Hospital
Healthy
Direct Current Brain Polarization of the Frontal Lobes
This study will explore what effects, if any, direct current (DC) brain polarization may produce on mental processes, such as attention, reaction time, working memory, speed of information processing and mood or emotional states.
- Trial name
- NCT00424216
- Testing
- DC Polarization
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alcohol Dependence
Anti-craving Efficacy of Right and Left Prefrontal High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in Alcohol Dependence
Null hypothesis: There will be no significant difference in the change in craving parameters between right and left prefrontal high frequency rTMS in patients with alcohol dependence.
- Trial name
- NCT01093716
- Testing
- Magstim Rapid® (rTMS)
- Volunteers
- 22 people
- Sponsor
- Central Institute of Psychiatry, Ranchi, India
Healthy
Magnetic Resonance Imaging of the Brain in Social and Emotional Reasoning
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in social and emotional reasoning. It will identify differences in brain activity during task performance between people who have a nervous…
- Trial name
- NCT00060853
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Aggressive Behavior
Brain Changes in Adolescents While Imagining and Observing Aggressive Behavior
This study will use functional magnetic resonance imaging (fMRI) to examine what happens in the brains of adolescents when they are exposed to violent media and how imagining aggressive behavior affects brain function.
- Trial name
- NCT00267891
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Disorder of Consciousness
tACS Alters EEG Microstates in DoC
Disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), remain difficult to diagnose at the bedside.
- Trial name
- NCT07699055
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Istanbul Medipol University Hospital
Depression
Brain-oscillation Synchronised Stimulation of the Prefrontal Cortex
Combining TMS and EEG, this study investigates a personalized therapeutic non-invasive brain stimulation protocol in patients with major depression, whereby the timing of the TMS pulses is synchronized with the instantaneous…
- Trial name
- BOSSFRONT (NCT02920840)
- Testing
- Intermittent theta-burst stimulation, Negative-peak-triggered-TMS, Open-loop replay TMS
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- University Hospital Tuebingen
Aging
Older Age and Generalization
The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults.
- Trial name
- NCT07440017
- Testing
- Memory decision type
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Caitlin Bowman
Prefrontal Hemodynamics, Muscle Strength
Lower Limb Strength and Power as Predictors of Brain Blood Flow During Exercise
This study aims to investigate the predictive value of lower limb muscle strength and explosive power on exercise-induced prefrontal hemodynamic responses.
- Conditions
- Prefrontal Hemodynamics, Muscle Strength, Physical Performance
- Trial name
- LLSPP (NCT07575802)
- Testing
- Standardized Lower-Limb Physical Performance Assessment and Aerobic Exercise Task
- Where
- Russia
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Lincoln University College
Depression Severe
Brain Stimulation for Severe Depression
Chronic intracalvarial cortical stimulation is a minimally invasive method involving the neurosurgical placement of an electrode above the inner table of the skull.
- Trial name
- NCT05393622
- Testing
- INTRACALVARIAL PREFRONTAL CORTICAL STIMULATION (IpCS) IN SEVERE TREATMENT-RESISTANT DEPRESSION
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Inner Cosmos Inc
Depression
rTMS Response Trajectories in Depression
Notwithstanding the cumulative evidence on the safety and efficacy of transcranial magnetic stimulation in depression care, the non-response rate to transcranial magnetic stimulation (TMS) amongst treatment-resistant depression…
- Trial name
- NCT03348761
- Testing
- rTMS group
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Attention Deficit Hyperactivity Disorder
Effects of Transcranial Photobiomodulation in ADHD
The investigators have previously shown that non-invasive methods of brain stimulation such as the administration of transcranial infrared light to the prefrontal cortex (PFC) can result in improvements to cognition and emotion…
- Trial name
- NCT07203092
- Testing
- Active transcranial photobiomodulation
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Francisco Gonzalez-Lima, PhD
Depressive Disorder, Major, Cognitive Impairment
Brain Functional Connectivity Mechanism of Cognitive Flexibility Impairment and rTMS Intervention in Major Depressive Disorder
Major depressive disorder (MDD) often involves cognitive deficits, particularly in cognitive flexibility, which is inadequately addressed by standard antidepressants.
- Trial name
- NCT07161492
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Second Xiangya Hospital of Central South University
Dyspnea
Effect of Non-invasive Magnetic Stimulation of the Brain on Breathlessness in Healthy Individuals.
The purpose of this study is to see if the front part of the brain called the "Dorsolateral Prefrontal Cortex" (DLPFC) has a role in our ability to feel breathlessness.
- Trial name
- AHrTMS (NCT05623696)
- Testing
- rTMS-L-DLPFC, rTMS-R-DLPFC
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Languages
Impact of Theta Burst Stimulation Over the Left DLPFC on Language Switching
The purpose of this study is to investigate whether theta burst stimulation (TBS) over the left dorsolateral prefrontal cortex (DLPFC) influences language switching and cognitive flexibility.
- Trial name
- NCT03148470
- Testing
- intermittent theta burst stimulation (iTBS), continuous theta burst stimulation (cTBS)
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Jean-Marie Annoni
Obesity
Noninvasive Neuromodulation of the Prefrontal Cortex in Subjects With Obesity
The overall goal of this proposal is to evaluate the efficacy of transcranial direct current stimulation (tDCS), a noninvasive neuromodulation technique, to facilitate weight loss and weight loss maintenance in obesity.
- Trial name
- NCT02953353
- Testing
- Active transcranial direct current stimulation (tDCS), Hypocaloric diet
- Where
- 3 sites in United States, Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo