Clinical trials: Prefrontal Cortex
Schizophrenia
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated…
- Trial name
- MESSI (NCT04807530)
- Testing
- TMS
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD)
One-Day cTBS Over the Precuneus
The goal of this clinical trial is to learn whether two forms of one-day accelerated transcranial magnetic stimulation (TMS) can reduce depressive symptoms in adults with treatment-resistant depression.
- Conditions
- Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD), Treatment Resistant Major Depression Disorder
- Trial name
- OcTOPUS (NCT07758010)
- Testing
- Precuneus-targeted continuous theta-burst stimulation, Left dorsolateral prefrontal cortex intermittent theta-burst stimulation
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Mclean Hospital
Schizophrenia
Adjuvant Therapy With Pergolide in Treating Cognitive Deficits in Schizophrenia
The objective of this study is to compare the modulation of pergolide, a D1/D2 receptor agonist, to placebo in non-acute schizophrenic subjects under concomitant therapy with atypical antipsychotics on specific PFC functions.
- Trial name
- NCT01066403
- Testing
- Pergolide
- Where
- 4 sites in Germany
- Volunteers
- 28 people
- Sponsor
- Heidelberg University
Major Depressive Disorder, Treatment-Resistant Depression
Adjuvant Accelerated piTBS for Reducing Suicidal Ideation in TRD Patients
In this double-blind, randomized, sham-controlled trial, the investigators aimed to examine the effect of accelerated piTBS on suicide risk in a group of treatment-resistant patients with MDD (i.e., TRD), using an extensive…
- Conditions
- Major Depressive Disorder, Treatment-Resistant Depression, Suicide Ideations
- Trial name
- NCT06372834
- Testing
- piTBS being delivered using the Magstim Rapid2 stimulator
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Depression
Transcranial Direct Current Stimulation for Depression
Background: Depression is a common mental disorder characterized by persistent low mood and anhedonia. Pharmacological and psychotherapeutic treatments demonstrate only moderate efficacy.
- Trial name
- NCT07500064
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Anhui Medical University
Intellectual Disability
Effects of Exercise Snacks on Physical Health and Cognitive Function in Individuals With Intellectual Disabilities
Intellectual disability (ID) is a neurodevelopmental disorder accompanied by sedentary lifestyles, which worsens cognitive function and physical health.
- Trial name
- NCT07759232
- Testing
- High-Intensity Interval Training, Exercise Snacks
- Where
- China
- Volunteers
- 24 people
- Sponsor
- University of Macau
ADHD - Attention Deficit Disorder With Hyperactivity
Brain Stimulation and Attention Control in Children With ADHD
The goal of this clinical trial is to learn if brain stimulation can help children ages 6 to 12 with attention-deficit/hyperactivity disorder (ADHD) improve their attention and self-control.
- Trial name
- NCT07182344
- Testing
- Intermittent Theta Burst Stimulation to Right DLPFC
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Neurolab Plus
Attention Deficit Hyperactivity Disorders
Low-dose vs. Normal-dose Psychostimulants on Executive Functions in Individuals With ADHD
This double-blind crossover study aims to compare cognitive performance (e.g., working memory, selective attention and cognitive flexibility) of children ages 6-18 years diagnosed with ADHD of the combined type (ADHD-C) or…
- Trial name
- NCT02167048
- Testing
- Psychostimulants
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Fibromyalgia Syndrome
A Study Comparing Real and Sham Repetitive Transcranial Magnetic Stimulation in Adults With Fibromyalgia, Assessing Effects on Pain, Fatigue, Sleep, Mood, Quality of Life, Cognition, and Walking Under Usual and Dual-task Conditions
Fibromyalgia is a chronic condition that causes widespread pain and is often accompanied by fatigue, poor sleep, mood symptoms, memory and concentration difficulties, and reduced quality of life.
- Trial name
- FMS-TMS-GAIT (NCT07685379)
- Testing
- Active repetitive transcranial magnetic stimulation
- Where
- Serbia
- Volunteers
- 30 people
- Sponsor
- Institute of Rheumatology, Serbia
Healthy
Effect of Gabapentin on GABA Concentration and Emotional Processing
This study will use magnetic resonance spectroscopy (MRS) and the drug gabapentin to examine the role of the brain chemical gamma-amino-butyric acid (GABA) in regulating emotions in healthy people.
- Trial name
- NCT00094510
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Blindness
Brain Plasticity of Verbal Memory in the Blind
This study will examine whether blind people develop changes in the brain that improve memory function. Previous studies have shown that blind people, on average, perform better in memory tasks than sighted people.
- Trial name
- NCT00059189
- Testing
- Magstim Rapid Magnetic Stimulator
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Physiological Responses to High-Intensity Exercise
Effects of the Q-Collar During High-Intensity Cycling Exercise
This study examined the effects of wearing the Q-Collar during high-intensity cycling exercise. Eleven recreationally trained male participants completed two 5-kilometer cycling time trials: one while wearing the Q-Collar and one…
- Trial name
- NCT07808710
- Testing
- Q-Collar™
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Northern Iowa
Chronic Pain, Opiate Dependence
Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Effective control of chronic pain is a top priority in the United States, as approximately 10% of adults have severe chronic pain - most of which is chronic lower back pain (CLBP).
- Conditions
- Chronic Pain, Opiate Dependence, Lower Back Pain
- Trial name
- NCT03681769
- Testing
- iTBS to the left dlPFC, cTBS to the mPFC
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Executive Function
Modulation of Cognitive Control Signals in Prefrontal Cortex by Rhythmic Transcranial Magnetic Stimulation
Purpose: In this study, the investigators will provide causal evidence for the role of alpha and theta oscillations in cognitive control.
- Trial name
- NCT03828734
- Testing
- Theta TMS, Alpha TMS, Arrhythmic TMS
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Major Depression
Multicenter Comparative Study of the Activity of the Medial Prefrontal Cortex in Vulnerability to Depression
To examine whether the medial prefrontal cortex displays an increased activity during self-referential processing among remitted depressed patients compared to healthy controls
- Trial name
- CORVAD (NCT02171923)
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multitasking Behavior and Neural Representations Associated With Multitasking Ability, Healthy Volunteers
Cognitive Control & the Functional Organization of the Frontal Cortex
The goal of this basic experimental clinical trial is to understand the effect of multitasking practice on the structure of neural representations of tasks in the human lateral prefrontal cortex and control brain regions.
- Conditions
- Multitasking Behavior and Neural Representations Associated With Multitasking Ability, Healthy Volunteers, Executive Function
- Trial name
- NCT06436209
- Testing
- Multitask Practice Intervention (MPI), Single-task Practice Intervention (SPI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brown University
Major Depressive Disorder
The BIomarker Guided (BIG) Study for Depression
Cognitive impairments contribute significantly to psychosocial dysfunction in major depressive disorder (MDD) and respond poorly to conventional antidepressants, yet selective treatments targeted to these impairments are lacking.
- Trial name
- NCT04181736
- Testing
- Guanfacine Tablets
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Stanford University
Cognitive Change
Dopamine Dorsolateral Prefrontal Cortex Behavioural Flexibility
Behavioural or cognitive flexibility (BF) is an essential ability which allows an organism to adaptively change responses in accordance with feedback of results.
- Trial name
- NCT03068884
- Testing
- Cathodal Transcranial direct current stimulation, L-Tyrosine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Sports Fatigue
Effects of Dual-site Anodal Transcranial Direct Current Stimulation on Attention, Decision-making and Working Memory During Sports Fatigue in Elite Soccer Athletes
Investigation of the effects of dual-site anodal transcranial direct current stimulation over the dorsolateral prefrontal cortex or primary motor cortex on attention, decision-making and working memory during sports fatigue in…
- Trial name
- NCT06594978
- Testing
- dual-site anodal tDCS over the M1, dual-site anodal tDCS over the DLPFC
- Where
- China
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Bipolar Depression
Double Blind Randomized Controlled, H1 Coil In Subjects With Bipolar Depression
The purpose of the study is to explore the efficacy and safety of H1-Coil deep brain rTMS in subjects with bipolar depression , currently treated with mood stabilizer and previously unsuccessfully treated with antidepressant…
- Trial name
- NCT00657735
- Testing
- H-Coil deep TMS
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Shalvata Mental Health Center