Clinical trials: Prefrontal Cortex
Schizophrenia, Insight Impaired
The Effects of Bimodal tDCS on Illness Severity, Insight, Functional Outcomes, Neurocognition and HRV in Schizophrenia
The study aimed to investigate the effects of bimodal anodal transcranial direct current stimulation (tDCS) over bilateral dorsolateral prefrontal cortex (DLPFC) on psychopathological symptoms, insight, psychosocial functioning…
- Conditions
- Schizophrenia, Insight Impaired, Psychotic Symptoms, Schizoaffective Disorder
- Trial name
- NCT03701100
- Testing
- tDCS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Treatment-resistant Depression, Major Depressive Disorder
Dorsomedial Prefrontal Neuromodulation in Treatment-resistant Depression
Major depressive disorder (MDD) is a common and troublesome disorder, with high risk of physical and psychiatric comorbidity. At least one-third of patients could not achieve a response after several antidepressant trials…
- Trial name
- NCT05422417
- Testing
- Prolonged intermittent theta burst stimulation (piTBS), 20Hz rTMS
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Overweight, Obesity and Other Hyperalimentation (E65-E68)
Transcranial Random Noise Stimulation in Food Addiction Treatment
Obesity is worldwide a public health problem. According to World Health Organization (WHO), overweight and obesity are the fifth death risk factor worldwide. At least 2.8 million adults die each year.
- Trial name
- tRNS-FA (NCT02717247)
- Testing
- Active tRNS
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Hôpital le Vinatier
Major Depressive Disorder, Schizophrenia
Disorder-tailored Transcranial Direct Current Stimulation (tDCS) of the Prefrontal Cortex
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Among others, deficient cognitive control over emotional distraction is a central characteristic of MDD (Ochsner \& Gross 2005; Disner et al.
- Trial name
- MRSDC1 (NCT02715128)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Schizophrenia
Paired Associative Stimulation in the Dorsolateral Prefrontal Cortex in Patients With Schizophrenia
The purpose of this study is to 1. assess the effect of PAS in schizophrenia in the dorsolateral prefrontal cortex (DLPFC) 2. assess the effect of PAS induced long-term potentiation (LTP) on the performance of patients with…
- Trial name
- NCT01545999
- Testing
- Brain Stimulation via Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Coronary Heart Disease (CHD), Anxiety Disorders
Closed-Loop Neurofeedback Targeting the Right Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronary Artery Disease With Anxiety
The goal of this clinical trial is to test whether real-time fNIRS-BCI neurofeedback targeting the right dorsolateral prefrontal cortex (right DLPFC), using active volitional control during a slow-wave auditory acoustic paradigm…
- Trial name
- HEART-SET-1 (NCT07238920)
- Testing
- Real-time fNIRS-ECG neurofeedback
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shenyang Medical College
Antisocial Behavior, Aggression
The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
This study investigates the effect of upregulating prefrontal cortex activity on antisocial and aggressive behavior and risk factors for such behavior.
- Trial name
- NCT02427672
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Occipital Cortex, Prefrontal Cortex
Brain Connectivity Between Visual Input and Movement
This study will explore how the areas in the brain are connected to link what people see to what they do; that is, how they use what they see to help guide their movements.
- Conditions
- Occipital Cortex, Prefrontal Cortex, Healthy
- Trial name
- NCT00376545
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Insomnia
Transcranial Temporal Interference Stimulation (tTIS) for Chronic Insomnia
The purpose of this exploratory randomized controlled clinical trial is to evaluate the efficacy and safety of transcranial temporal interference stimulation (tTIS) in the treatment of chronic insomnia.
- Trial name
- NCT07755852
- Testing
- Active Transcranial Temporal Interference Stimulation (tTIS)-Experimental
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Central Nervous System Diseases
The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory
The investigators hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal…
- Trial name
- NCT02006615
- Testing
- Functional near infrared spectroscopy, rTMS
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Current Major Depressive Disorder, Healthy
Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder
This study will evaluate emotional processing biases in the brain while viewing facial expressions in adults with current or remitted major depressive disorder and healthy volunteers.
- Conditions
- Current Major Depressive Disorder, Healthy, Remitted Major Depressive Disorder
- Trial name
- NCT00071123
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Sleep Wake Disorders, Lung Neoplasms
Low-Frequency rTMS for Sleep After Thoracoscopic Lung Resection
This single-center randomized, double-blind, sham-controlled trial will evaluate whether low-frequency repetitive transcranial magnetic stimulation (rTMS) improves postoperative inpatient sleep in adults undergoing elective…
- Trial name
- TMS-SLEEP-VATS (NCT07796451)
- Testing
- Active Low-Frequency Repetitive Transcranial Magnetic Stimulation
- Volunteers
- 220 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Healthy
Study of Brain Function During Cognitive Tasks
This study will use magnetic resonance imaging (MRI) to examine which areas of the brain are involved in performing certain cognitive tasks.
- Trial name
- NCT00076739
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Schizophrenia, Cognitive Dysfunction
Transcranial Direct and Alternating Stimulation of the Prefrontal Cortex for Cognitive Improvement in Schizophrenia
The purpose of this study is to investigate different stimulation intensities and frequencies of transcranial direct and alternating current stimulation over the dorsolateral prefrontal cortex for cognitive improvement in…
- Trial name
- NCT05342727
- Testing
- transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS)
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Neuropathic Pain, Chronic Neuropathic Pain
High-Frequency rTMS Over the DLPFC for Chronic Low Back Pain
Neuropathic pain is a chronic condition that significantly affects quality of life and often responds poorly to conventional pharmacological treatments.
- Trial name
- RTMS-CLBP (NCT07468799)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Hasanuddin University
Binge-Eating Disorder, Emotional Eating
Study of Emotional Regulation and Underlying Prefrontal Activity in Binge Eating Disorder
The goal of this exploratory, interventional, multicentre study is to compare the prefrontal activity during a negative emotion regulation task in women with Binge-Eating Disorder (BED) and healthy women with and without…
- Conditions
- Binge-Eating Disorder, Emotional Eating, Healthy Volunteers
- Trial name
- EmoBED (NCT06864065)
- Testing
- Emotion regulation task (fNIRS recording during the emotional regulation task)
- Where
- 3 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Schizophrenia, Cannabis-Induced Disorder
Examining tDCS Effect on Cannabis Use Disorder in Patients With Schizophrenia
Cannabis use disorder is a frequent comorbidity of schizophrenia, associated with increased symptoms and less adherence to therapy.
- Trial name
- CANNAPSYSTIM (NCT04871048)
- Testing
- Transcranial direct current stimulation (tDCS) active, Transcranial direct current stimulation (tDCS) non active
- Where
- 8 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Anorexia Nervosa
The Efficiency of Transcranial Direct Current Stimulation in the Treatment of Anorexia Nervosa
The main goal of the study (a 3-week, randomized, double-blind, and placebo-controlled study) is to determine the effect of Transcranial Direct Current Stimulation (tDCS) on the mental state and advances in nutritional…
- Trial name
- NCT05814458
- Testing
- tDCS
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Lublin
Cognitive Symptom, Healthy
The Effect of Transcranial Direct Stimulation on Cognitive Functions of Healthy Adults
Background: Transcranial direct current stimulation(tDCS) has been used to improve cognitive functions in healthy young adults. Purpose: To investigate the effect of TDCS application on different cortex regions on cognitive…
- Trial name
- NCT04873804
- Testing
- Transcranial Direct Current Stimulation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Medipol University
Multiple Sclerosis, Major Depressive Disorder
Pilot Study of the Safety and Tolerability of L-DLPFC iTBS rTMS for MDD in MS
The main purpose of this study is to investigate the safety and tolerability of intermittent Theta Burst (iTBS) repetitive transcranial magnetic stimulation (rTMS), its effectiveness in alleviating depressive symptoms as well as…
- Trial name
- NCT04621708
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre